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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy

Fig. 8

The METTL3 inhibitor STM2457 reverses chemoresistance in SCLC cells in vitro and in vivo. A-B CCK-8 assay shows that STM2457 (6.25 μM) decreased the IC50 values of chemotherapeutic agents for chemoresistant H69AR and H446DDP cells. *P < 0.05; **P < 0.01; ***P < 0.001. C-D Cell apoptosis and arrest were evaluated by flow cytometry in STM2457-treated (6.25 μM) SCLC cells after chemotherapeutic drug treatment. E-F Effect of STM2457 (6.25 μM) on resistance to chemotherapeutic drugs in nude mice with implanted tumours and measurement of tumour weights for different treatment groups. ***P < 0.001. G Mechanism diagram: The m6A methyltransferase METTL3 promotes SCLC chemoresistance by targeting DCP2, which regulates mitophagy and mitochondrial damage via the Pink1-Parkin pathway

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