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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy

Fig. 4

ER-stress induces XBP1/PDIA4/VEGFA regulatory axis in GBM. A The Pearson correlation analysis between XBP1 and PDIA4 IHC scores of clinical GBM samples reveals a strong positive correlation. B The Pearson correlation analysis between XBP1 expression and GSVA score of angiogenesis hallmark of GBM samples in the TCGA cohort. C The VEGFA secretion levels of LV-Ctrl and LV-PDIA4 U87 GBM cells with or without 10 μg/mL TM treatment. **P < 0.01. D The VEGFA secretion levels of sh-Ctrl and sh-PDIA4 LN229 GBM cells with or without 10 μg/mL TM treatment. ns P > 0.05; **P < 0.01. E–F The VEGFA secretion levels of XBP1 knock-down U87 (E) and LN229 (F) cells with or without 10 μg/mL TM treatment. ns P > 0.05; **P < 0.01. G The VEGFA secretion levels of XBP1 knock-down in LV-Ctrl and LV-PDIA4 U87 cells under 10 μg/mL TM induced ER stress. *P < 0.05; **P < 0.01. H The VEGFA secretion levels of XBP1 knock-down in sh-Ctrl and sh-PDIA4 LN229 cells under 10 μg/mL TM induced ER stress. ns P > 0.05; ***P < 0.001. I PDIA4 expression in high pro-operation edema GBMs is higher than low pro-operation edema GBMs. *P < 0.05

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