Fig. 7

The clinical correlation between CLDN6, WIP and LC3 expression in breast cancer patients. A The mRNA expression of CLDN6, WIP and LC3 in adjacent normal and breast cancer tissues in the GEO database GSE103512. B The mRNA expression of CLDN6, WIP and LC3 in primary breast tumor tissues and metastatic tissues in the GEO database GSE191230. C Representative IHC images of low and high CLDN6, WIP and LC3 expression in breast cancer tissues. Scale bar, 200 µm (left), 20 µm (right). D-F Correlation analysis between CLDN6 and WIP (D), CLDN6 and LC3 (E), and WIP and LC3 (F) in breast cancer tissue microarray. Pearson correlation test, n = 58. G Percentage of high and low expression of WIP in breast cancer patients with lymph node-negative (n = 26) and node-positive (n = 22). *P < 0.05, ***P < 0.001, and ****P < 0.0001