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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Targeting inhibition of prognosis-related lipid metabolism genes including CYP19A1 enhances immunotherapeutic response in colon cancer

Fig. 1

Differential expression analysis of LMGs and functional annotation in colon cancer. A Volcano plot of the differentially expressed lipid metabolism-related genes (LMGs) analysis in the colon cancer tissues (n = 453) and adjacent normal tissues (n = 41). Red/blue dots represent upregulated/downregulated genes according to the criteria: adjusted P-value < 0.05 and |log2 (fold change) |> 1. B Principal components analysis (PCA) based on the differentially expressed LMGs. C Protein–protein interaction network of differentially expressed lipid metabolism-related genes. D Gene ontology (GO) enrichment analysis of the differentially expressed LMGs. “BP” stands for “biological process”, “CC” stands for “cellular component” and “MF” stands for “molecular function”. E Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the differentially expressed LMGs. The color represents the statistical significance of the term. The size indicates the counts of enriched genes

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