Table 2 Most common grade 3 (Gr3) and grade 4 (Gr4) adverse events (AEs) in all patients

Dose Level 1

1 mg/kg

n = number of events in 4 patients/

12 doses

Dose Level 2

2 mg/kg

n = number of events in 7 patients/

34 doses

Dose Level 1.5

1.5 mg/kg

n = number of events in 6 patients/

23 doses

Cumulative Incidence

n = number of events in 17 patients/

69 doses (%)

Adverse Event

Gr 3

Gr 4

Gr 3

Gr 4

Gr 3

Gr 4