Fig. 1

LINC00240 is a significantly elevated lncRNA in gastric cancer specimens and associated with shortened survival time of patients. A Relative expression of three candidate lncRNAs transcribed from the 6p22.1 risk locus (LINC00240, LINC01012, and ZNRD1-AS1) in paired gastric cancer specimens and normal tissues of Discovery cohort (n = 96). B, C Significantly upregulated expression of LINC00240 in gastric cancer specimens of Validation cohort (n = 30) and another Chinese gastric cancer cohort (GSE54129) compared to normal tissues. D, E In Discovery cohort and Validation cohort, there were much higher LINC00240 expression levels in cancerous tissues from gastric cancer patients with high-grade diseases compared to malignant tissues from patients with low-grade diseases. F, G The gastric cancer patients with higher LINC00240 expression had a shorter PFS or OS compared to patients with lower LINC00240 expression (Discovery cohort). Data are shown as mean ± SD. **P < 0.01; ***P < 0.001 by paired Student’s t test (A, B), or by unpaired Student’s t test (C, D, E). ns: not significant. Log-rank test was used for survival comparison (F, G)