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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization

Fig. 2

LINC00240 promotes malignant proliferation of gastric cancer cells in vitro and in vivo. A, B Relative expression of LINC00240 in HGC-27 and MGC80-3 gastric cancer cell lines with stably silenced LINC00240 (shL240-1 or shL240-2) or with stably forced-expressed LINC00240 (LINC00240). C Silencing of LINC00240 significantly repressed viability of HGC-27 and MGC80-3 cells. D Overexpression of LINC00240 significantly promoted proliferation of gastric cancer cells. E, F In colony formation assays, silencing of LINC00240 markedly inhibited clone formation of HGC-27 and MGC80-3 cells. Overexpressed LINC00240 remarkably increased clonogenicity of gastric cancer cells. G Silencing of LINC00240 significantly promoted apoptosis of gastric cancer cells. H-J Evidently decreased growth and tumor weights of the HGC-27 xenografts with stably depleted LINC00240 were observed compared to the controls. K-M The xenografts stably over-expressing LINC00240 grew much faster and showed an obvious increase in tumor weight compared to the control xenografts. Data are shown as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001 by unpaired Student’s t test (A-J)

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