Skip to main content
Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress

Fig. 4

SEC63 is associated with prognosis of HCC patients. A Representative immunohistochemistry staining of SEC63 in 139 cases of HCC tissues and 20 cases of non-tumorous tissues. Scale bars, 50 μm. B Summary of SEC63 expression in HCC tissues and their non-tumorous counterparts. C-D Kaplan–Meier survival curve for OS (C) and DFS (D) of the HCC patients with different level of SEC63. E–F The OS and DFS curve of the HCC patients with different SEC63 mRNA levels from TCGA-LIHC were analyzed by Kaplan–Meier analyses. G Representative immunostaining of SEC63 in HCC tissues with metastasis (Yes) or without metastasis (No). Staining scores of SEC63 and ACLY in HCC tissues with (n = 76) or without metastasis (n = 63) were showed in histograms. H The correlation between SEC63 staining and ACLY staining in the HCC tissues was analyzed. I Western blot analysis of SEC63 and ACLY expression in 12 individual paired HCC tissues. J Univariate analyses of prognostic factors in terms of OS of HCC patients. K Multivariate analyses of prognostic factors in terms of OS of HCC patients. L-M OS (L) and DFS (M) curves of HCC patients were plotted against the SEC63 and/or ACLY expression levels using the Kaplan–Meier method. The difference between the survival curves was analyzed using the log-rank test

Back to article page