Fig. 8

Two major compounds in CRA, CRDG and CRG, effectively induced B cell differentiation and triggered IL-21 production from T cells. Panel A. Cell population of plasma cells in CRA, CRDG, or CRG-treated mouse splenocytes. Panel B. Cell population of plasma cells in CRA, CRDG, or CRG-treated mouse splenocytes with anti-CD40 antibody/IL-4 stimulation. Panel C. Effects of CRDG or CRG on IL-21 release from splenic T cells. Panel D. E. F. The effects of CRDG or CRG on Stat3, cMaf, and Bcl6 expression in splenic T cells. Splenic T cells were treated with different doses of CRDG or CRG for 24 h. The expression of Stat3, cMaf, and Bcl6 was determined by qPCR