Fig. 10From: Toosendanin targeting eEF2 impedes Topoisomerase I & II protein translation to suppress esophageal squamous cell carcinoma growthThe mechanism schematic diagram of TSN suppressed ESCC growth. First: eEF2 bond with GTP, ribosome and mRNA formed the translation complex; second: the amino which locating at P and A site were hybrid; third: eEF2 hydrolyzed GTP to GDP, resulting its conformation changes, thus ensuring the elongation with the unidirectional mRNA reading frameBack to article page