Fig. 9
DDD107498 suppresses ESCC growth in vivo and in vitro. A The chemical structure of DDD107498. B IC50 of DDD107498 base on ESCC cell viability effects. C The binding ability between DDD107498 and eEF2 with the passage of time. D The variation of response intensity with the difference concentrations of DDD107498. E The representative tumor pictures of LEG367 after sacrificing the mice. F The tumor volume of LEG367 after treatment. G The average body weight of mice after treatment. H The tumor weight of LEG367 after treatment. I The analysis of tumor growth inhibition rate compared with control group. J Represent IHC staining pictures of Ki67, TOP1, TOP2 expression in LEG367 case. K Analysis of Ki67, TOP1, TOP2 expression in LEG367 case. Statistical analysis was performed using Student’s unpaired t test in (F, H, K). Error bars represent the mean ± SD