Fig. 3

YAP, TP63 and TEADs co-regulate genes associated with carcinogenesis pathways in HBECs. a Correlation plot summarizes the GSEA results of genes associated with YAP/TAZ, TEAD and TP63 siRNA treatments in HBECs. Rank lists were generated by arranging genes in order of t-statistics for their association with siRNA treatment comparing to the controls in HBECs. Genes significantly up or down-regulated with the siRNA treatments were used as gene sets (absolute logFC > 0.5 and FDR < 0.05). **p < 0.01, ***p < 0.001. b TEAD and TP63 ChIP-seq tracks shows the representative co-binding associated TEAD-TP63 direct target genes. Overlapped peak regions are shown in red strips. The grey rectangles indicate the fragment regions in pcHi-C and the black arcs show the long-range interactions between distal elements and promoter regions. Only the direct target genes are plotted. c Heatmap of gene expression significantly altered in siYAP/TAZ, siTEAD and siTP63 treatment (absolute logFC > 0.5 and FDR < 0.05). Genes annotated on the right are associated with interferon response pathways or shown to be canonical target genes of Hippo or TP63 pathways. d Top enriched functional pathways associated with the TEAD-TP63 direct repressed (top) and induced (bottom) target genes