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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression

Fig. 4

TEAD-TP63 direct target genes are associated with human bronchial PML progressive pathology and early immune evasion. a Correlation plot shows the relationship between the expression levels of transcription factors and metagene scores of TEAD-TP63 direct induced and repressed target genes (calculated with GSVA) in the Beane et al. Discovery cohort. The color and the size of the circles indicate the Pearson correlation coefficients. ***Pearson correlation, FDR < 0.005. b The metagene scores of TEAD-TP63 direct repressed (left) and induced (right) target gene sets across human bronchial PML data by histological grades in the Beane et al. Discovery cohort (Mild/Mod/Sev Dysp = Mild/Moderate/Severe Dysplasia; CIS = carcinoma in situ). c Enrichment plot for TEAD-TP63 direct repressed target genes among genes ranked by tstatistics comparing the regressive PML samples to the progressive/persistent ones of the Proliferative subtypes in the Beane et al. Discovery cohort (positive t-statistics indicate upregulation among the regressive lesions). d Bubble plot shows the enrichment of TEAD-TP63 direct repressed and induced target gene sets among human bronchial PML co-expressed gene modules. The color and the size of the squares indicate the odds ratio. ***Fisher’s exact test p-value < 0.001. e Violin plots show the summarized expression of TEAD-TP63 direct repressed (left) and induced (right) target genes (calculated using AUCell) in the healthy human airway scRNA-seq data from Deprez et al. and human lung scRNA-seq data from Travaglini et al. ***one-tail Wilconxon test, p-value < 0.001

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