Fig. 6

Model for YAP/TAZ-TEAD-TP63 transcriptional complexes in bronchial PMLs. YAP/TAZ, TEAD and TP63 associate on genomic regions that control gene expression important for the growth of bronchial basal cells and the evasion of adaptive immune responses. CITIIA, a key regulator of MHCII genes, is repressed by YAP/TAZ-TEAD-TP63, and CITIIA repression is associated with decreased CD8 T cell recruitment and decreased Th1 T cell responses that track with PML progression