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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling

Fig. 1

Hepatocyte-specific deletion of Ufl1 or Ufbp1 in mice results in liver injury. A Ufl1 floxed allele and generation of hepatic Ufl1 knockout mice. B Ufbp1 floxed allele and generation of hepatic Ufbp1 knockout mice. C Representative gross anatomy of liver tissues extracted from 2-month-old Ufl1Δ/Δhep, Ufbp1Δ/Δhep, and control mice. D Survival curve of Ufl1Δ/Δhep, Ufbp1Δ/Δhep, and control mice (n = 30 mice/group). E Histochemical analysis of liver tissues extracted from 2-month-old Ufl1Δ/Δhep, Ufbp1Δ/Δhep, and control mice by HE analysis. Arrows indicate injury positions. F Representative TEM image of liver tissues extracted from 2-month-old Ufl1Δ/Δhep, Ufbp1Δ/Δhep, and control mice. Stars indicate apoptotic cells. G Apoptosis analysis of liver tissues extracted from 2-month-old Ufl1Δ/Δhep, Ufbp1.Δ/Δhep, and control mice by TUNEL staining. TUNEL-positive cells were quantified (n = 5 mice/group) and are shown in the lower panel. H Apoptosis of primary mouse hepatocytes measured by flow analysis. Representative results and quantitative data (n = 5 mice/group) are shown in the upper and lower panels, respectively. ** p < 0.01

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