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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: miR-92a-1-5p enriched prostate cancer extracellular vesicles regulate osteoclast function via MAPK1 and FoxO1

Fig. 1

miR-92a-1-5p enriched EVs are successfully constructed. A Upregulation of miR-92a-1-5p in MDA PCa 2b cells transfected with miR-92a-1-5p-overexpressing lentivirus. B miR-92a-1-5p upregulation in EVs derived from MDA PCa 2b cells stably overexpressing miR-92a-1-5p. C Schematic representation of the designed experiment. Confocal microscopy revealed miR-92a-1-5p enriched EVs internalization by Raw264.7 cells after 90 min of co-culture at 37 °C. Scale bar = 20 μm. D-E qPCR analysis of mature miR-92a-1-5p and pre-miR-92a-1-5p in Raw264.7 cells at different time points after treatment with 10 μg EVs. Data were analyzed using t test. *, P < 0.05; ***, P < 0.001

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