Fig. 5
From: Targeting homologous recombination deficiency in uterine leiomyosarcoma
HRP uLMS PDX does not respond to PARPi. A Timeline of uLMS147 patient history. B CIRCOS plot generated from patient WGS data showing intra-chromosomal rearrangements, and (C) Copy number profile, where total CN is shown in black and minor CN in red. D Immunohistochemistry panel showing concordant protein expression between primary patient sample and PDX. H&E = Haematoxylin and Eosin, α-SMA = alpha smooth muscle actin. Scale bars represent 200 μm. E PDX tumour growth curves and survival on treatment with vehicle, caelyx (pegylated doxorubicin; 1.5 mg/kg 1, 8 and 18), olaparib (150 mg/kg, daily Monday to Friday or Monday to Sat, 6 weeks) and cisplatin (4 mg/kg day 1, 8 and 18). Data is shown as mean with shaded areas representing 95% confidence intervals