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Table 2 Outcomes of five individuals with uLMS treated with PARPi

From: Targeting homologous recombination deficiency in uterine leiomyosarcoma

Patient

Time on PARPi

OSa

cuLMS#122 olaparib; + cisplatin; ± RT

49 mob

49 mob

duLMS#227 olaparib (ceased); chemotherapy

4 mo

9 mo

cuLMS#347 olaparib; RT

19 mob

19 mob

cuLMS#438 olaparib; + carboplatin

19 mob

19 mob

cuLMS#683 olaparib;

3 mob

3 mob

  1. mo months
  2. asince commencement of PARPi (olaparib) therapy
  3. bcontinuing on therapy
  4. cBRCA2 deletion
  5. dCOSMIC signature 3