Fig. 10

In vivo therapeutic efficacy of CT26 subcutaneous tumor in situ recurrence model. (A) The image of tumor volume of groups. (B) The tumor growth curve. (C) Statistical analysis of tumor weight after surgical of primary tumors. (D) and (E) The expression and grayscale analysis of PKM2 of tumor tissues. (F) The level of lactate in tumor tissues. The relative fold change of MDSCs (Gr-1⁺) (G), NK (NK1.1⁺CD49b⁺) (H), the CT8⁺T cells (CD8⁺Ki67⁺) (I), and cytotoxicity CD8⁺ T cells (CD8⁺Granzyme B⁺ and CD8⁺IFNγ⁺) (J and K). Data are presented as mean ± SD (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001