Fig. 9From: Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted deliveryIn vivo therapeutic efficacy of a mouse model with advanced liver metastasis of colorectal cancer and subcutaneous recurrence. (A) Therapeutic schedule. (B) The image of liver nodules of groups and the statistical analysis in (C). (D) The H&E strain and immunohistochemistry of PKM2, E-cadherin, CD31, and VEGF in liver tissues. Data are presented as mean ± SD (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001Back to article page