Table 3 Classification of intracellular elements of tumor cells that influence pancreatic cancer stemness plasticity

Epigenetic regulators

FTO, SIRT1, CRL4B, MBD3, UCHL5, GALNT3, B3GNT3, EZH2, BMI-1

Metabolic regulators

OPA1, DRP1, MYC, PGC-1α, LKB1, PGC-1β, NAF-1

Signaling pathway regulators

Tetraspanin-8, FAM83A, RER1

MicroRNAs (miRNAs)

OncomiRNAs:

miR-10b, miR-17-5p, miR-21, miR-27a, miR-221, miR-338-5p, miR-520 h, miR-1246

Tumor suppressor miRNAs:

miR-34a, miR-101, miR-145, miR-146a, miR-146b-3p, miR-183, miR-200a/c, miR-203, miR-429

Long non-coding RNAs (lncRNAs)

GAS5, HOTAIR, XIST, DYNC2H1-4