Fig. 6
From: Targeting PHB1 to inhibit castration-resistant prostate cancer progression in vitro and in vivo
Schematic diagram showing the mechanism by which PHB1 promotes castration resistance and FL3 inhibits CRPC. ADT induces the translocation of PHB1 from nucleus to mitochondria and plasma membrane in ADPC, thereby facilitates reactivation of AR signaling, stabilization of mitochondria and activation of MAPK signaling. While FL3 promotes the translocation of PHB1 from plasma membrane and mitochondria to nucleus in CRPC, thereby inhibits the AR signaling through PHB1-AR interaction as well as MAPK signaling but promotes apoptosis