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  1. Content type: Research

    Fas/FasL system is a major regulator of apoptosis. The mechanisms by which Fas mediates cisplatin resistance remain unclear. The aim of this study is to explore the effect of Fas over-expression on cisplatin r...

    Authors: Wei Wu, Hai-dong Wang, Wei Guo, Kang Yang, Yun-ping Zhao, Yao-guang Jiang and Ping He

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:49

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  2. Content type: Research

    Glypican 3 (GPC-3) is an oncofoetal protein that is expressed in most hepatocellular carcinomas (HCC). Since it is a potential target for T cell immunotherapy, we investigated the generation of functional, GPC...

    Authors: James O'Beirne, Farzin Farzaneh and Phillip M Harrison

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:48

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  3. Content type: Review

    The main hindrance to the diffusion of proton therapy facilities is the high cost for gantry installations. An alternative technical option is provided by fixed-beam treatment rooms, where the patient is rotat...

    Authors: Salvatore Devicienti, Lidia Strigari, Marco D'Andrea, Marcello Benassi, Vincenzo Dimiccoli and Maurizio Portaluri

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:47

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  4. Content type: Research

    A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin exp...

    Authors: Dan-Dan Yu, Chun-Ting Wang, Hua-Shan Shi, Zhi-Yong Li, Li Pan, Qing-Zhong Yuan, Fei Leng, Yuan Wen, Xiang Chen and Yu-Quan Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:46

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  5. Content type: Research

    We performed expression profiling of two neuroblastoma cell lines, SK-N-BE(2) and SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and inhibitors of lipoxygenases (LOX) and cyclooxygenases (C...

    Authors: Petr Chlapek, Martina Redova, Karel Zitterbart, Marketa Hermanova, Jaroslav Sterba and Renata Veselska

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:45

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  6. Content type: Research

    To detect the expression of isocitrate dehydrogenase 1 (IDH1) and transformation-related protein 53 (p53) in osteosarcoma and analyze the correlation between them and the clinico-pathological features.

    Authors: Xiang Hu, Ai-Xi Yu, Bai-Wen Qi, Tao Fu, Gang Wu, Min Zhou, Jun Luo and Jun-Hua Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:43

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  7. Content type: Research

    Calcifying epithelioma of Malherbe, or Pilomatricoma, is considered an uncommon cutaneous neoplasia, normally occurring in children as a solitary, firm, asymptomatic, hard, subcutaneous, slowly growing nodule ...

    Authors: Francesco M Solivetti, Fulvia Elia, Alessandra Drusco, Chiara Panetta, Ada Amantea and Aldo Di Carlo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:42

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  8. Content type: Research

    In our previous study, it was well defined that IGFBP7 was an important tumor suppressor gene in colorectal cancer (CRC). We aimed to uncover the downstream molecules responsible for IGFBP7's behaviour in this st...

    Authors: Wenjing Ruan, Yinghong Wang, Yu Ma, Xiaoming Xing, Jie Lin, Jing Cui and Maode Lai

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:41

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  9. Content type: Research

    The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated...

    Authors: Vanessa F Bernardes, Frederico O Gleber-Netto, Sílvia F Sousa, Tarcília A Silva and Maria Cássia F Aguiar

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:40

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  10. Content type: Research

    Definitions of basal-like breast cancer phenotype vary, and microarray-based expression profiling analysis remains the gold standard for the identification of these tumors. Immunohistochemical identification o...

    Authors: Radzislaw Kordek, Piotr Potemski, Renata Kusinska, Elzbieta Pluciennik and Andrzej Bednarek

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:39

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  11. Content type: Research

    The objective of this study was to evaluate the efficacy and safety of pemetrexed plus cisplatin/carboplatin in locally advanced or metastatic non-small cell lung cancer (NSCLC) patients previously treated wit...

    Authors: Guan-Zhong Zhang, Shun-Chang Jiao and Zhao-Ting Meng

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:38

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  12. Content type: Research

    To investigate whether dendritic cell (DC) precursors, recruited by injection of chemokine ligand 3 (CCL3) and CCL20, induce anti-tumor immunity against gastric cancer induced by a DC vaccine expressing melanoma ...

    Authors: Songbing He, Liang Wang, Yugang Wu, Dechun Li and Yanyun Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:37

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  13. Content type: Research

    Analysis of gene expression and gene mutation may add information to be different from ordinary pathological tissue diagnosis. Since samples obtained endoscopically are very small, it is desired that more sens...

    Authors: Koji Nonogaki, Akihiro Itoh, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroshi Matsubara, Yuya Itoh, Yosuke Nakamura, Masanao Nakamura, Ryoji Miyahara, Naoki Ohmiya, Masatoshi Ishigami, Yoshiaki Katano, Hidemi Goto and Yoshiki Hirooka

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:36

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  14. Content type: Research

    This study explored the response of nasopharyngeal carcinoma cells to TGF-β1-induced growth suppression and investigated the roles of the TGF-β/Smad signaling pathway in nasopharyngeal carcinoma cells.

    Authors: Jian Xiao, Qi Xiang, Ye-Chen Xiao, Zhi-Jian Su, Zhi-Feng Huang, Qi-Hao Zhang, Yi Tan, Xiao-Kun Li and Ya-Dong Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:35

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  15. Content type: Research

    PIK3CA is one of the genes most frequently mutated in human cancers and it is a potential target for personalized therapy. The aim of this study was to assess the frequency and type of PIK3CA mutations in gastric...

    Authors: Stefano Barbi, Ivana Cataldo, Giovanni De Manzoni, Samantha Bersani, Simona Lamba, Silvia Mattuzzi, Alberto Bardelli and Aldo Scarpa

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:32

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  16. Content type: Research

    In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is crucial to understand what factors are involved in pr...

    Authors: Ke Zheng, Hong-Yuan Li, Xin-Liang Su, Xiao-Yi Wang, Tian Tian, Fan Li and Guo-Sheng Ren

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:31

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  17. Content type: Review

    The past two decades have witnessed an increasing appreciation of the role of the tumor microenvironment, of genetic and epigenetic alterations in normal cells adjacent to tumors and of the migration of normal...

    Authors: Razvan T Radulescu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:30

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  18. Content type: Research

    MicroRNAs are non-coding RNA molecules that posttranscriptionally regulate expression of target genes and have been implicated in the progress of cancer proliferation, differentiation and apoptosis. The aim of...

    Authors: Bao Song, Chuanxi Wang, Jie Liu, Xingwu Wang, Liyan Lv, Ling Wei, Li Xie, Yan Zheng and Xianrang Song

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:29

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  19. Content type: Research

    The secreted protein acidic and rich in cysteine (SPARC) plays a pivotal role in regulating cell-matrix interactions and tumor angiogenesis, proliferation, and migration. Detection of SPARC gene methylation may b...

    Authors: Jun Gao, Jian Song, Haojie Huang, Zhaoshen Li, Yiqi Du, Jia Cao, Minghui Li, Shunli Lv, Han Lin and Yanfang Gong

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:28

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  20. Content type: Research

    Circulating bone marrow-derived endothelial progenitor cells (EPCs) have been reported to participate in tumor angiogenesis and growth; however, the role of circulating EPCs in tumor progression is controversi...

    Authors: Yajuan Su, Lei Zheng, Qian Wang, Weiqi Li, Zhen Cai, Shilong Xiong and Jie Bao

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:27

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  21. Content type: Research

    Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression activate Wnt signaling aberrantly and induce the development of var...

    Authors: Zhuanyi Yang, Ying Wang, Jiasheng Fang, Fenghua Chen, Jinfang Liu, Jun Wu and Yanjin Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:26

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  22. Content type: Research

    Giant cell tumor is an infrequent and unpredictable bony lesion. Although numerous attempts have been made to predict the behaviour of GCT, there are no definite biological or histological parameters to determ...

    Authors: Faisham W Ismail, Aminudin M Shamsudin, Zulmi Wan, Salzihan M Daud and Mutum S Samarendra

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:25

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  23. Content type: Review

    Perineural invasion is a common path for cholangiocarcinoma (CCA) metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It is often an early event in a disease that is commo...

    Authors: Fang-Zhen Shen, Bing-Yuan Zhang, Yu-Jie Feng, Zhuo-Xia Jia, Bing An, Chang-Chang Liu, Xi-Yun Deng, Anil D Kulkarni and Yun Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:24

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  24. Content type: Research

    Anti-HER-2 antibodies targeting distinct epitopes have different biological functions on cancer cells. In a previous study, we demonstrated that anti-HER-2 engineering antibody ChA21 was able to bind to subdom...

    Authors: AnLi Zhang, Hua Xue, XiaoGuang Ling, Yi Gao, Feng Yang, LianSheng Cheng, Jing Liu and Qiang Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:23

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  25. Content type: Research

    It is known that thiazolidinediones are involved in regulating the expression of various genes, including the vascular endothelial growth factor (VEGF) gene via peroxisome proliferator-activated receptor γ (PP...

    Authors: Takayuki Yoshizaki, Wataru Motomura, Sachie Tanno, Shima Kumei, Yumiko Yoshizaki, Satoshi Tanno and Toshikatsu Okumura

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:22

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  26. Content type: Research

    Taurolidine (TRD) represents an anti-infective substance with anti-neoplastic activity in many malignant cell lines. So far, the knowledge about the cell death inducing mechanisms and pathways activated by TRD...

    Authors: Ansgar M Chromik, Adrien Daigeler, Daniel Bulut, Annegret Flier, Christina May, Kamran Harati, Jan Roschinsky, Dominique Sülberg, Peter R Ritter, Ulrich Mittelkötter, Stephan A Hahn and Waldemar Uhl

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:21

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  27. Content type: Research

    To retrospectively review the incidence, treatment efficacy, we followed up newly diagnosed chronic myelogenous leukemia (CML) patients residing in Shanghai during 2001-2006.

    Authors: Ai-Hua Wang, Yan-Yan Wang, Yu Yao, Zi-Zhen Xu, Li Zhou, Li Wang, Li Zhang, Yu Chen, Zhi-Xiang Shen, Jiong Hu and Jun-Min Li

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:20

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  28. Content type: Research

    Hereditary hemochromatosis (HH) is an autosomal recessive disorder mainly associated with homozygosity for the C282Y and H63D mutations in the hemochromatosis (HFE) gene. The reports about the C282Y and H63D m...

    Authors: Fei Jin, Li-Shuai Qu and Xi-Zhong Shen

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:18

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  29. Content type: Research

    To better search for potential markers for hepatocellular carcinoma (HCC) invasion and metastasis, proteomic approach was applied to identify potential metastasis biomarkers associated with HCC.

    Authors: Long Wu, Chun-Wei Peng, Jin-Xuan Hou, Yan-Hua Zhang, Chuang Chen, Liang-Dong Chen and Yan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:17

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  30. Content type: Research

    The chemokine receptors CXCR4 and CCR7 play an important role in cancer invasion and metastasis. This study investigated the expression of CXCR4, CCR7, CXCL12, CCL21, and EGFR to illustrate the role of these b...

    Authors: Yixin Liu, Ru Ji, Jingyong Li, Qiang Gu, Xiulan Zhao, Tao Sun, Jinjing Wang, Jiangbo Li, Qiuyue Du and Baocun Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:16

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  31. Content type: Research

    The combination of gemcitabine (GEM) and S-1, an oral 5-fluorouracil (5-FU) derivative, has been shown to be a promising regimen for patients with unresectable pancreatic cancer.

    Authors: Bunzo Nakata, Ryosuke Amano, Shigetomi Nakao, Tatsuro Tamura, Osamu Shinto, Toshiki Hirakawa, Yoshihiro Okita, Nobuya Yamada and Kosei Hirakawa

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:15

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  32. Content type: Research

    Genome-wide RNA interference screening study revealed that loss of expression of insulin-like growth factor binding protein 7 (IGFBP7) is a critical step in development of a malignant melanoma (MM), and this s...

    Authors: Rong-Yi Chen, Hong-Xiang Chen, Jia-Xi Lin, Wei-Bing She, Ping Jiang, Li Xu and Ya-Ting Tu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:13

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  33. Content type: Research

    Prospective, randomized, pilot clinical study was conducted to evaluate the beneficial effects of inositol hexaphosphate (IP6) + Inositol in breast cancer patients treated with adjuvant therapy.

    Authors: Ivan Bačić, Nikica Družijanić, Robert Karlo, Ivan Škifić and Stjepan Jagić

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:12

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  34. Content type: Research

    The Sézary syndrome is an aggressive leukemic form of cutaneous T cell lymphoma and there is no cure of this disease. Until now there is no true animal model for Sézary syndrome, by which new drugs against the...

    Authors: Udo Doebbeling

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:11

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  35. Content type: Research

    SIAH proteins are the human members of an highly conserved family of E3 ubiquitin ligases. Several data suggest that SIAH proteins may have a role in tumor suppression and apoptosis. Previously, we reported th...

    Authors: Heriberto Bruzzoni-Giovanelli, Plinio Fernandez, Lucía Veiga, Marie-Pierre Podgorniak, Darren J Powell, Marco M Candeias, Samia Mourah, Fabien Calvo and Mónica Marín

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:10

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  36. Content type: Research

    Accelerated hypofractionation is an attractive approach for adjuvant whole breast radiotherapy. In this study we evaluated the adverse effects at least 3 years post an accelerated hypofractionated whole breast...

    Authors: Paola Pinnarò, Antonella Soriani, Valeria Landoni, Carolina Giordano, Maria Papale, Annelisa Marsella, Laura Marucci, Giorgio Arcangeli and Lidia Strigari

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:9

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  37. Content type: Research

    Survivin is known playing a role in drug resistance. However, its role in bortezomib-mediated inhibition of growth and induction of apoptosis is unclear. There are conflicting reports for the effect of bortezo...

    Authors: Xiang Ling, Diane Calinski, Asher A Chanan-Khan, Muxiang Zhou and Fengzhi Li

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:8

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  38. Content type: Research

    The knowledge of Epidermal growth factor receptor (EGFR) expression in metastases of NSCLC was limited. In receptor-mediated targeted nuclide radiotherapy, tumor cells are killed with delivered radiation and t...

    Authors: Chuangzhou Rao, Qiongge Hu, Jianhua Ma, Jian Li, Chen Zhang, Li Shen and Qichun Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:7

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  39. Content type: Research

    The Tientsin Albino 2 (TA2) mouse is an inbred strain originating from the Kunming strain. It has a high incidence of spontaneous breast cancer without the need for external inducers or carcinogens. Until now,...

    Authors: Yanjun Gu, Shiwu Zhang, Qiang Wu, Shaoyan Xu, Yanfen Cui, Zhengduo Yang, Xiulan Zhao and Baocun Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:6

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  40. Content type: Review

    Lymph node status is an important prognostic factor and a criterion for adjuvant therapy in uterine cancers. While detection of micrometastases by ultrastaging techniques is correlated to prognosis in several ...

    Authors: Corinne Bézu, Charles Coutant, Marcos Ballester, Jean-Guillaume Feron, Roman Rouzier, Serge Uzan and Emile Daraï

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:5

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  41. Content type: Research

    Endometriosis is a common disease characterized by the presence of a functional endometrium outside the uterine cavity, causing pelvic pain, dysmenorrheal, and infertility. This disease has been associated to ...

    Authors: Daniel E Machado, Plínio T Berardo, Celia Y Palmero and Luiz E Nasciutti

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:4

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  42. Content type: Research

    bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth. Correspondingly, gliomas have been shown to have reduced, or ...

    Authors: Biao Zhang, Xuequan Feng, Jinhuan Wang, Xinnu Xu, Hongsheng Liu and Na Lin

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:3

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  43. Content type: Research

    Renal cell carcinoma (RCC) is a cancer of increasing incidence and mortality. Currently, there are no immunohistochemical prognostic markers for RCCs in routine use. The aim of this study was to examine for th...

    Authors: Hanna Ronkainen, Saila Kauppila, Pasi Hirvikoski and Markku H Vaarala

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:2

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  44. Content type: Research

    The aim of this study is to examine the safety and distribution of Ad-EGFP-MDR1, an adenovirus encoding human multidurg resistance gene (human MDR1), in the mice colon carcinoma model.

    Authors: ZhenZhen Zhao, Wei Liu, YuXi Su, Jin Zhu, GaiHuan Zheng, Qing Luo and XianQing Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:1

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  45. Content type: Research

    Epigenetic silencing of tumor suppressor genes associated with promoter methylation is considered to be a hallmark of oncogenesis. RASSF1A is a candidate tumor suppressor gene which was found to be inactivated...

    Authors: Tao Wang, Hongli Liu, Yeshan Chen, Wei Liu, Jing Yu and Gang Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:160

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