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  1. Cancer stem cells (CSCs) require stromal signals for maintaining pluripotency and self-renewal capacities to confer tumor metastasis. Resolvin D1 (RvD1), an endogenous anti-inflammatory lipid mediator, has rec...

    Authors: Liankang Sun, Yufeng Wang, Liang Wang, Bowen Yao, Tianxiang Chen, Qing Li, Zhikui Liu, Runkun Liu, Yongshen Niu, Tao Song, Qingguang Liu and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:170
  2. FGFR3 plays an important role in the development of bladder cancer (BCa). Hsa_circ_0068871 is a circRNA generated from several exons of FGFR3. However, the potential functional role of hsa_circ_0068871 in BCa ...

    Authors: Weipu Mao, Xin Huang, Longsheng Wang, Ziwei Zhang, Mengnan Liu, Yan Li, Ming Luo, Xudong Yao, Jie Fan and Jiang Geng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:169
  3. Chimeric antigen receptor (CAR)-engineered T cells have displayed outstanding performance in the treatment of patients with hematological malignancies. However, their efficacy against solid tumors has been lar...

    Authors: Yitian Wang, Wei Yu, Jian Zhu, Junjie Wang, Kaishun Xia, Chengzhen Liang and Huimin Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:168
  4. Xenotropic and polytropic retrovirus receptor 1 (XPR1), a previously identified cellular receptor for several murine leukemia viruses, plays a role in many pathophysiological processes. However, the role of XP...

    Authors: Wei-chao Chen, Qiu-li Li, Qimei Pan, Hua-yong Zhang, Xiao-yan Fu, Fan Yao, Jian-ning Wang and An-kui Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:167
  5. Acquired drug resistance is a constraining factor in clinical treatment of glioblastoma (GBM). However, the mechanisms of chemoresponsive tumors acquire therapeutic resistance remain poorly understood. Here, w...

    Authors: Zhuoran Zhang, Jianxing Yin, Chenfei Lu, Yutian Wei, Ailiang Zeng and Yongping You
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:166
  6. miRNAs play crucial role in the progression of K-Ras-mutated nonsmall cell lung cancer (NSCLC). However, most studies have focused on miRNAs that target K-Ras. Here, we investigated miRNAs regulated by mutant ...

    Authors: Hua Jin, Yoonjeong Jang, Nian Cheng, Qing Li, Peng-Fei Cui, Zhi-Wei Zhou, Hu-Lin Jiang, Myung-Haing Cho, Kenneth D. Westover, Qun-You Tan and Cheng-Xiong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:165
  7. Metastasis remains the main cause of cancer-related death for gastric cancer (GC) patients, but the mechanisms are poorly understood. Using The Cancer Genome Atlas (TCGA) data base and bioinformatics analyses,...

    Authors: Jia-Xing Zhang, Wei-Ling He, Zi-Hao Feng, Dong-Liang Chen, Ying Gao, Ying He, Kai Qin, Zhou-San Zheng, Cui Chen, Hui-Wen Weng, Miao Yun, Sheng Ye, Rui-Hua Xu and Dan Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:164
  8. ALKBH5 regulated the malignant behavior of breast cancer and glioblastoma. However, the expression and function of ALKBH5 in epithelial ovarian cancer have not yet been determined. In the present study, we inv...

    Authors: Hongtao Zhu, Xiaoling Gan, Xingwei Jiang, Shuai Diao, Huan Wu and Jianguo Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:163
  9. Pancreatic cancer is one of the most lethal type of cancers, with an overall five-year survival rate of less than 5%. It is usually diagnosed at an advanced stage with limited therapeutic options. To date, no ...

    Authors: Chin-King Looi, Felicia Fei-Lei Chung, Chee-Onn Leong, Shew-Fung Wong, Rozita Rosli and Chun-Wai Mai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:162
  10. Long non-coding RNAs (lncRNAs) have been identified to play an important role in the development and progression of various tumors, including colorectal cancer (CRC). However, the regulatory molecular mechanis...

    Authors: Jing Li, Meirong He, Wen Xu and Silin Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:161
  11. Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to En...

    Authors: Luigi Mele, Marcella la Noce, Francesca Paino, Tarik Regad, Sarah Wagner, Davide Liccardo, Gianpaolo Papaccio, Angela Lombardi, Michele Caraglia, Virginia Tirino, Vincenzo Desiderio and Federica Papaccio
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:160
  12. Tripartite motif 47 (TRIM47), a member of the TRIM family proteins, plays a key role in many types of cancers including colorectal cancer (CRC). We found that levels of TRIM47 mRNA and protein were increased s...

    Authors: Qian Liang, Chaotao Tang, Mingyu Tang, Qingwei Zhang, Yunjie Gao and Zhizheng Ge
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:159
  13. RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). Such effects are partly due to the inactivation of the anti-migrat...

    Authors: Maureen Keller, Fatéméh Dubois, Sylvain Teulier, Alexandre P. J. Martin, Jérôme Levallet, Elodie Maille, Solenn Brosseau, Nicolas Elie, Alexander Hergovich, Emmanuel Bergot, Jacques Camonis, Gérard Zalcman and Guénaëlle Levallet
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:158
  14. Prostate cancer (PCa) remains a challenge worldwide. Due to the development of castration-resistance, traditional first-line androgen deprivation therapy (ADT) became powerlessness. Epidermal growth factor rec...

    Authors: Yuning Liao, Zhiqiang Guo, Xiaohong Xia, Yuan Liu, Chuyi Huang, Lili Jiang, Xuejun Wang, Jinbao Liu and Hongbiao Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:157
  15. Cancer is currently the second leading cause of death globally and is expected to be responsible for approximately 9.6 million deaths in 2018. With an unprecedented understanding of the molecular pathways that...

    Authors: N. A. Seebacher, A. E. Stacy, G. M. Porter and A. M. Merlot
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:156
  16. As most lung cancer patients present with invasive, metastatic disease, it is vital to investigate anti-metastatic treatments for non-small cell lung cancer (NSCLC). Houttuynia cordata is commonly used as a Chine...

    Authors: Rilei Jiang, Cheng Hu, Qian Li, Ziyu Cheng, Ling Gu, Hongxiao Li, Yuanyuan Guo, Qirui Li, Yueyang Lu, Ke Li, Meijuan Chen and Xu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:155
  17. Metabolic reprogramming is one of the hallmarks of cancer cells. The pentose phosphate pathway (PPP), a branch of glycolysis, is an important metabolic pathway for the survival and biosynthesis of cancer cells...

    Authors: Zhaoyu Qin, Chan Xiang, Fan Zhong, Yang Liu, Qiongzhu Dong, Kai Li, Wenhao Shi, Chen Ding, Lunxiu Qin and Fuchu He
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:154
  18. Hepatocellular carcinoma (HCC) is the major histological type of liver cancer with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNA) has been proved to be associated with various cancer type...

    Authors: Yu-Gang Wang, Tao Wang, Min Shi and Bo Zhai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:153
  19. With the rapid development of the high throughput detection techniques, tumor-related Omics data has become an important source for studying the mechanism of tumor progression including breast cancer, one of t...

    Authors: Fen Lin, Yu-Jie Xie, Xin-Ke Zhang, Tie-Jun Huang, Hong-Fa Xu, Yan Mei, Hu Liang, Hao Hu, Si-Ting Lin, Fei-Fei Luo, Yan-Hong Lang, Li-Xia Peng, Chao-Nan Qian and Bi-Jun Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:152
  20. Head and neck cancer (HNC) is one of the most common deadly diseases worldwide. An increasing number of studies have recently focused on the malignant functions of cancer-associated fibroblasts (CAFs) in numer...

    Authors: Xiaoning Wang, Xing Qin, Ming Yan, Jianbo Shi, Qin Xu, Zhihui Li, Wenjun Yang, Jianjun Zhang and Wantao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:151
  21. Deregulated ErbB signaling plays an important role in tumorigenesis of pancreatic cancer. However, patients with pancreatic cancer benefit little from current existed therapies targeting the ErbB signaling. He...

    Authors: Tingting Lin, Qun Ren, Weimin Zuo, Ruxue Jia, Linhui Xie, Rong Lin, Hu Zhao, Jin Chen, Yan Lei, Ping Wang, Huiyue Dong, Lianghu Huang, Jinquan Cai, Yonghai Peng, Zongyang Yu, Jianming Tan…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:150
  22. The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mech...

    Authors: Mingjing Shen, Zhonghua Xu, Weihua Xu, Kanqiu Jiang, Fuquan Zhang, Qifeng Ding, Zhonghen Xu and Yongbing Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:149
  23. Recent Clinical trials of administration of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in combination with standard first-line chemotherapy have failed to improve survival in patie...

    Authors: Tianze Liu, Lizi Jin, Wenjing Lu, Hairun Gan, Zhidong Lin, Miao Chen, Jiani Liu, Fan Zhang, Siyang Wang, Hongyu Zhang, Wuguo Deng and Hongtao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:148
  24. Ionizing radiation (IR) therapy is the standard first-line treatment for newly diagnosed patients with glioblastoma (GBM), the most common and malignant primary brain tumor. However, the effects of IR are limi...

    Authors: Yinfang Wang, Yanli Hou, Weiwei Zhang, Angel A. Alvarez, Yongrui Bai, Bo Hu, Shi-Yuan Cheng, Kun Yang, Yanxin Li and Haizhong Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:147

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:331

  25. The recent developments in immuno-oncology have opened an unprecedented avenue for the emergence of vaccine strategies. Therapeutic DNA cancer vaccines are now considered a very promising strategy to activate ...

    Authors: Alessandra Lopes, Gaëlle Vandermeulen and Véronique Préat
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:146
  26. Abnormal expression or distribution of connexin 32 (Cx32) is associated with hepatocarcinogenesis, but the role of Cx32 and the underlying mechanisms are still unclear.

    Authors: Yuke Xiang, Qin Wang, Yunquan Guo, Hui Ge, Yile Fu, Xiyan Wang and Liang Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:145
  27. The authors are retracting this article [1] because it overlaps significantly with a previously published article by Moody et al. [2] without proper citation. All authors agree with this retraction.

    Authors: Ke-ting Que, Yun Zhou, Yu You, Zhen Zhang, Xiao-ping Zhao, Jian-ping Gong and Zuo-jin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:144

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:268

  28. Bladder cancer (BC) is a common type of cancer that involves tumors of the urinary system and poses a serious threat to human health. Long noncoding RNAs (lncRNAs) have emerged as crucial biomarkers and regula...

    Authors: Liying Miao, Hong Yue Liu, Cuixing Zhou and Xiaozhou He
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:143

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:103

  29. In the publication of this article [1], there is an error in Fig. 5G (panel 2, group of InmiR-26a + siSCR in HCT-8/5-FU, treated with 284.3 μM).

    Authors: Bing Liu, Shimeng Pan, Yang Xiao, Qianqian Liu, Jingchao Xu and Li Jia
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:142

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:316

  30. Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer worldwide. They are typically characterized by a high incidence of local recurrence, which is the most common cause of death in HNSCC p...

    Authors: Mahrou Vahabi, Claudio Pulito, Andrea Sacconi, Sara Donzelli, Marco D’Andrea, Valentina Manciocco, Raul Pellini, Paola Paci, Giuseppe Sanguineti, Lidia Strigari, Giuseppe Spriano, Paola Muti, Pier Paolo Pandolfi, Sabrina Strano, Shahrokh Safarian, Federica Ganci…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:141
  31. Autophagy, a process for degrading intracellular substances to maintain basal metabolic turnover, is known to be perturbed in gastric cancer. Programmed cell death-1 (PD-1) with its ligand (PD-L1) are importan...

    Authors: Xiaojuan Wang, William K. K. Wu, Jing Gao, Zhongwu Li, Bin Dong, Xiaoting Lin, Yilin Li, Yanyan Li, Jifang Gong, Changsong Qi, Zhi Peng, Jun Yu and Lin Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:140
  32. Nuciferine (NF), extracted from the leaves of N. nucifera Gaertn, has been shown to exhibit anti-tumor and anti-viral pharmacological properties. It can also penetrate the blood brain barrier (BBB). However, the ...

    Authors: Zizhuo Li, Yaodong Chen, Tingting An, Pengfei Liu, Jiyuan Zhu, Haichao Yang, Wei Zhang, Tianxiu Dong, Jian Jiang, Yu Zhang, Maitao Jiang and Xiuhua Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:139
  33. SOX11 is a transcription factor that plays an important role in mantle cell lymphoma development. However, its functional role in head and neck squamous cell carcinoma (HNSCC) remains unknown.

    Authors: Junwei Huang, Eoon Hye Ji, Xinyuan Zhao, Li Cui, Kaori Misuno, Mian Guo, Zhigang Huang, Xiaohong Chen and Shen Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:138
  34. There is growing evidence that tripartite motif-containing protein 44 (TRIM44) plays crucial role in tumor development. However, the underlying mechanism of this deubiquitinating enzyme remains unclear.

    Authors: Chuan-Yuan Wei, Lu Wang, Meng-Xuan Zhu, Xin-Yi Deng, Dao-He Wang, Si-Min Zhang, Jiang-Hui Ying, Xin Yuan, Qiang Wang, Tian-Fan Xuan, An-Qi He, Fa-Zhi Qi and Jian-Ying Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:137
  35. Mitochondrial Ca2+ plays a critical role in tumorigenesis, including cell proliferation and metastasis. Mitochondrial calcium uniporter regulator 1 (MCUR1) has been shown to be frequently upregulated in HCC and p...

    Authors: Mingpeng Jin, Jiaojiao Wang, Xiaoying Ji, Haiyan Cao, Jianjun Zhu, Yibing Chen, Jin Yang, Zheng Zhao, Tingting Ren and Jinliang Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:136
  36. Immune checkpoint inhibitor therapy has changed clinical practice for patients with different cancers, since these agents have demonstrated a significant improvement of overall survival and are effective in ma...

    Authors: Francesca Di Modugno, Cristina Colosi, Paola Trono, Giuseppe Antonacci, Giancarlo Ruocco and Paola Nisticò
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:117
  37. The transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) signaling pathways are both constitutively activated in triple-negative breast cancer (TNBC). We are interested in isolating the nat...

    Authors: Lei Di, Li-Juan Liu, Yong-Ming Yan, Rong Fu, Yi Li, Ying Xu, Yong-Xian Cheng and Zhao-Qiu Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:134
  38. Glioblastoma multiforme (GBM) is the most common and aggressive form of astrocytoma among adult brain tumors. Multiple studies have shown that long non-coding RNAs (lncRNAs) play important roles in acting as m...

    Authors: Weining Wu, Tianfu Yu, Youzhi Wu, Wei Tian, Junxia Zhang and Yingyi Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:133
  39. Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed, we elaborated the impact of CD44v6 and Tspan8 on the ...

    Authors: Zhe Wang, Hanxue Sun, Jan Provaznik, Thilo Hackert and Margot Zöller
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:132
  40. Dysfunction of p53 is a key cause of cancer development, while CCDC106 can reduce p53 stability and is associated with lung cancer. However, the roles of CCDC106 in other cancer types and its upstream regulato...

    Authors: Yichong Ning, Chunqing Wang, Xin Liu, Yan Du, Shunlian Liu, Kaili Liu, Jianlin Zhou and Chang Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:131
  41. Human hepatocellular carcinoma (HCC) lacks effective curative therapy and there is an urgent need to develop a novel molecular-targeted therapy for HCC. Selective tyrosine kinase inhibitors have shown promise ...

    Authors: Teng Luo, Shou-Guo Zhang, Ling-Fei Zhu, Fei-Xiang Zhang, Wei Li, Ke Zhao, Xiao-Xue Wen, Miao Yu, Yi-Qun Zhan, Hui Chen, Chang-Hui Ge, Hui-Ying Gao, Lin Wang, Xiao-Ming Yang and Chang-Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:130
  42. Non-small cell lung cancer (NSCLC) patients with sensitive epidermal growth factor receptor (EGFR) mutations are successfully treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs); however, resistance to tr...

    Authors: Quanfu Huang, Qiuguo Wang, Dong Li, Xiao Wei, Yijuan Jia, Zheng Zhang, Bo Ai, Xiaonian Cao, Tao Guo and Yongde Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:129
  43. Cell-to-cell communication has a critical role during tumor development and progression, allowing cancer cell to re-program not only the surrounding tumor microenvironment, but also cells located at distant si...

    Authors: Claudia Chiodoni, Maria Teresa Di Martino, Francesca Zazzeroni, Michele Caraglia, Massimo Donadelli, Stefania Meschini, Carlo Leonetti and Katia Scotlandi
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:128

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:425

  44. Mechanistic target of rapamycin (mTOR) pathway is essential for the growth of gastric cancer (GC), but mTOR inhibitor everolimus was not effective for the treatment of GCs. The Cancer Genome Atlas (TCGA) resea...

    Authors: Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:127
  45. Cancer stem cells (CSCs) play an important role in the development of pancreatic cancer. We previously showed that the microRNA miR-137 is downregulated in clinical samples of pancreatic cancer, and its expres...

    Authors: Zhiwei He, Xingjun Guo, She Tian, Changhao Zhu, Shiyu Chen, Chao Yu, Jianxin Jiang and Chengyi Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:126
  46. Folate receptors and transporters and one-carbon metabolism continue to be important areas of study given their essential roles in an assortment of diseases and as targets for treatment of cancer and inflammat...

    Authors: Barbara Frigerio, Claudia Bizzoni, Gerrit Jansen, Christopher P. Leamon, Godefridus J. Peters, Philip S. Low, Larry H. Matherly and Mariangela Figini
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:125
  47. Gastric cancer is the second most common cause of cancer-related mortality; thus, the mechanisms underlying tumor metastasis and growth in gastric cancer need to be extensively explored.

    Authors: Duan-Bo Shi, Ran-Ran Ma, Hui Zhang, Feng Hou, Xiang-Yu Guo and Peng Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:124
  48. Though immune checkpoint blockade (ICB) against PD-1 has shown success in the treatment of lung cancer, not all patients respond. We have previously shown that adoptive transfer of double negative T (DNT) cell...

    Authors: Linan Fang, Dalam Ly, Si-si Wang, Jong Bok Lee, Hyeonjeong Kang, Hao Xu, Junlin Yao, Ming-sound Tsao, Wei Liu and Li Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:123
  49. Metastatic lung cancer is a life-threatening condition that develops when cancer in another area of the body metastasizes, or spreads, to the lung. Despite advances in our understanding of primary lung oncogen...

    Authors: Yuanping Xiong, Leilei He, Chloe Shay, Liwei Lang, Jenni Loveless, Jieqing Yu, Ron Chemmalakuzhy, Hongqun Jiang, Manran Liu and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:122

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