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  1. Evidence suggests that fatty acid receptor FFAR4 plays a tumor-promoting role in adipose tissue-adjacent malignancies, but its clinical relevance remains unexplored. Here, we investigated the clinical signific...

    Authors: Xiao Chu, Qi Zhou, Yingchun Xu, Jingting Jiang, Qing Li, Qianjun Zhou, Qiong Wu, Min Jin, Hui Wang, Yuting Gu, Xue Wang, Bei Wang, Songbing He, Xiaozhou He, Changping Wu, Fengchun Zhang…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:100
  2. Glioma, characterized by its undesirable prognosis and poor survival rate, is a serious threat to human health and lives. MicroRNA-9 (miR-9) is implicated in the regulation of multiple tumors, while the mechan...

    Authors: Xu Chen, Fan Yang, Tianze Zhang, Wei Wang, Wenjin Xi, Yufang Li, Dan Zhang, Yi Huo, Jianning Zhang, Angang Yang and Tao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:99
  3. Circular RNAs (circRNAs) play important roles in tumourigenesis and tumour progression. However, the expression profiles and functions of circRNAs in hepatocellular carcinoma (HCC) are largely unclear.

    Authors: Liangliang Xu, Xinfu Feng, Xiangyong Hao, Peng Wang, Yanfang Zhang, Xiaobo Zheng, Lian Li, Shengsheng Ren, Ming Zhang and Mingqing Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:98
  4. Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients...

    Authors: Daniela Criscuolo, Francesco Morra, Riccardo Giannella, Roberta Visconti, Aniello Cerrato and Angela Celetti
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:91
  5. Epithelial-mesenchymal transition (EMT)-associated proteins play key roles in cancer progression and metastasis with the involvement of microRNAs (miRNAs). This study aims to assess the role of miR-506 working...

    Authors: Tian-Song Liang, Ying-Juan Zheng, Juan Wang, Jing-Yi Zhao, Dao-Ke Yang and Zhang-Suo Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:97
  6. Drug resistance is common in cancer chemotherapy. This study investigates the role of Glycerol kinase 5 (GK5) in mediating gefitinib resistance in NSCLC.

    Authors: Jian Zhou, Guimei Qu, Ge Zhang, Zuoren Wu, Jing Liu, Dawei Yang, Jing Li, Meijia Chang, Hengshan Zeng, Jie Hu, Tao Fang, Yuanlin Song and Chunxue Bai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:96
  7. Brain metastasis (BM) is associated with poor prognosis, recurrence, and death in patients with non-small cell lung cancer (NSCLC). Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been reported to be in...

    Authors: Chunhua Wei, Xiaomin Dong, Hui Lu, Fan Tong, Lingjuan Chen, Ruiguang Zhang, Jihua Dong, Yu Hu, Gang Wu and Xiaorong Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:95
  8. Breast cancer is one the most common cancers, making it the second leading cause of cancer-related death among women. Long non-coding RNAs (lncRNAs), with tightly regulated expression patterns, also serve as t...

    Authors: Dian-Hui Xiu, Gui-Feng Liu, Shao-Nan Yu, Long-Yun Li, Guo-Qing Zhao, Lin Liu and Xue-Feng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:94

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:204

  9. Zoledronic acid is the most potent osteoclast inhibitor and is widely used for advanced cancer patients with bone metastasis, but its role on cancer stem cells (CSCs) remains unclear. In the present study, we ...

    Authors: Li Wang, Yanyang Liu, Yueling Zhou, Jiantao Wang, Li Tu, Zhen Sun, Xiujie Wang and Feng Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:93
  10. Hepatocellular carcinoma (HCC) with stemness features are pivotal for tumorigenesis, chemoresistance, and progression. Long non-coding RNAs have been implicated in the regulation of HCC stemness features; howe...

    Authors: Yi Zhang, Bo Tang, Jun Song, Shuiping Yu, Yang Li, Huizhao Su and Songqing He
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:92
  11. The muscle invasive form of urothelial bladder cancer (UBC) is a deadly disease. Currently, the therapeutic approach of UBC is mostly based on surgery and standard chemotherapy.

    Authors: Francesco Morra, Francesco Merolla, Daniela Criscuolo, Luigi Insabato, Riccardo Giannella, Gennaro Ilardi, Aniello Cerrato, Roberta Visconti, Stefania Staibano and Angela Celetti
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:90
  12. Targeting the c-Met signaling pathway has become a therapeutic strategy in multiple types of cancer. We unveiled a novel c-Met regulating mechanism that could be applied as a modality for oral squamous cell ca...

    Authors: Wei-Chieh Huang, Te-Hsuan Jang, Shiao-Lin Tung, Tzu-Chen Yen, Shih-Hsuan Chan and Lu-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:89
  13. Over-expression and over-activation of immunosuppressive enzyme indoleamine 2, 3 -dioxygenase 1 (IDO1) is a key mechanism of cancer immune escape. However, the regulation of IDO1 has not been fully studied. Th...

    Authors: Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang and Qing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:88
  14. PD-1/PD-L1 checkpoint blockades have achieved significant progress in several kinds of tumours. Pembrolizumab, which targets PD-1, has been approved as a first-line treatment for advanced non-small cell lung c...

    Authors: Xin Wang, Gaochao Guo, Hui Guan, Yang Yu, Jie Lu and Jinming Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:87
  15. Diffuse large B cell lymphoma (DLBCL) is the most common form of lymphoma. Although durable remissions can be achieved in more than half of these patients, DLBCL remains a significant clinical challenge, with ...

    Authors: Yizi He, Jiao Li, Ning Ding, Xiaogan Wang, Lijuan Deng, Yan Xie, Zhitao Ying, Weiping Liu, Lingyan Ping, Chen Zhang, Yuqin Song and Jun Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:86
  16. Despite the increasing progress in targeted and immune based-directed therapies for other solid organ malignancies, currently there is no targeted therapy available for TNBCs. A number of mechanisms have been ...

    Authors: Murugan Kalimutho, Debottam Sinha, Deepak Mittal, Sriganesh Srihari, Devathri Nanayakkara, Shagufta Shafique, Prahlad Raninga, Purba Nag, Kate Parsons and Kum Kum Khanna
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:85
  17. A promising arsenal of histone deacetylase (HDAC)-targeted treatment has emerged in the past decade, as the abnormal targeting or retention of HDACs to DNA regulatory regions often occurs in many cancers. Head...

    Authors: Leilei He, Lixia Gao, Chloe Shay, Liwei Lang, Fenglin Lv and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:84
  18. The bromodomain and extra-terminal domain (BET) inhibitor is a type of anti-tumor agent, currently being evaluated in phase I and II clinical trials for cancer therapy. It can decrease MYC expression levels an...

    Authors: Yalei Yin, Mingju Sun, Xi Zhan, Changqing Wu, Pengyu Geng, Xiaoyan Sun, Yunsong Wu, Shuijun Zhang, Jianhua Qin, Zhengping Zhuang and Yang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:83
  19. Aberrant EVI1 expression is frequently reported in cancer studies; however, its role in nasopharyngeal carcinoma (NPC) has not been examined in detail. The aim of the present study is to investigate the involv...

    Authors: Yaoyong Lu, Yingying Liang, Xin Zheng, Xubin Deng, Wendong Huang and Gong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:82
  20. How exosomal microRNAs (miRNAs) derived from macrophages contribute to the development of drug resistance in the context of the hypoxic tumor microenvironment in epithelial ovarian cancer (EOC) remains poorly ...

    Authors: Xiaolan Zhu, Huiling Shen, Xinming Yin, Meiling Yang, Hong Wei, Qi Chen, Fan Feng, Yueqin Liu, Wenlin Xu and Yuefeng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:81
  21. The differentiation-based therapy for acute promyelocytic leukemia (APL) is an inspiring example for the search of novel strategies aimed at treatment of other subtypes of acute myeloid leukemia (AML). Thus, t...

    Authors: Alejandro Pérez-Fernández, Guillermo López-Ruano, Rodrigo Prieto-Bermejo, Carla Ijurko, María Díez-Campelo, Fermín Sánchez-Guijo and Ángel Hernández-Hernández
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:80
  22. Personalized cancer vaccines based on neoantigens have reached the clinical trial stage in melanoma. Different vaccination protocols showed efficacy in preclinical models without a clear indication of the qual...

    Authors: Luigi Aurisicchio, Erika Salvatori, Lucia Lione, Silvio Bandini, Matteo Pallocca, Roberta Maggio, Maurizio Fanciulli, Francesca De Nicola, Frauke Goeman, Gennaro Ciliberto, Antonella Conforti, Laura Luberto and Fabio Palombo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:78
  23. Metformin, a first-line drug for type 2 diabetes, could induce apoptosis in cancer cells. However, the concentration of glucose affects the effect of metformin, especially low glucose in the culture medium can...

    Authors: Liwei Ma, Jianwei Wei, Junhu Wan, Weiwei Wang, Li Wang, Yongjie Yuan, Zijun Yang, Xianzhi Liu and Liang Ming
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:77
  24. S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that specifically recognizes phosphorylated cell cycle regulator proteins and mediates their ubiquitination. Programmed cell d...

    Authors: Ce Li, Lutao Du, Yidan Ren, Xiaoyan Liu, Qinlian Jiao, Donghai Cui, Mingxin Wen, Chuanxin Wang, Guangwei Wei, Yunshan Wang, Aiguo Ji and Qin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:76
  25. The abnormal expression of leucine-rich-alpha-2-glycoprotein 1 (LRG-1) is reported to be associated with multiple malignancies, but its role in the progression of pancreatic ductal adenocarcinoma (PDAC) remain...

    Authors: Zhi-Bo Xie, Yi-Fan Zhang, Chen Jin, Yi-Shen Mao and De-Liang Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:75
  26. MicroRNAs have an important role in diverse biological processes including tumorigenesis. MiR-223 has been reported to be deregulated in several human cancer types. However, its biological role has not been fu...

    Authors: Peng Luo, Qi Wang, Yuanyuan Ye, Ju Zhang, Dapeng Lu, Longqiang Cheng, Hangcheng Zhou, Mingran Xie and Baolong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:74
  27. The drug-resistance and relapse of diffuse large B-cell lymphoma (DLBCL), which are related to mesenchymal stem cells (MSCs), have become increasingly common. However, the underlying mechanisms remain elusive.

    Authors: Weijie Zhong, Zhigang Zhu, Xin Xu, Hui Zhang, Huabao Xiong, Qingshan Li and Yaming Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:73
  28. Damage-regulated autophagy modulator 2(DRAM2) is associated with autophagy processes. However, the role of DRAM2 in the progression of human neoplasms is still unknown. Here, we show that DRAM2 may act as an onco...

    Authors: Muli Wudu, Hongjiu Ren, Linping Hui, Jun Jiang, Siyang Zhang, Yitong Xu, Qiongzi Wang, Hongbo Su, Xizi Jiang, Runa Dao and Xueshan Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:72
  29. The efficacy and safety of multikinase inhibitor anlotinib have been confirmed in the treatment of advanced non-small cell lung cancer (NSCLC). However, the direct functional mechanisms of tumor lethality medi...

    Authors: Lijun Liang, Kaiyuan Hui, Chenxi Hu, Yixuan Wen, Shikun Yang, Panrong Zhu, Lei Wang, Youyou Xia, Yun Qiao, Wen Sun, Jiayan Fei, Ting Chen, Fenghua Zhao, Baocheng Yang and Xiaodong Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:71
  30. Hepatocellular carcinoma (HCC) is the most major type of primary hepatic cancer. Serine hydroxymethyltransferase 1 (SHMT1) is recently found to play critical roles in human cancers including lung cancer, ovari...

    Authors: Changwei Dou, Qiuran Xu, Jie Liu, Yufeng Wang, Zhenyu Zhou, Weifeng Yao, Kai Jiang, Jian Cheng, Chengwu Zhang and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:70
  31. Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 a...

    Authors: Vid Mlakar, Simona Jurkovic Mlakar, Laurence Lesne, Denis Marino, Komal S. Rathi, John M. Maris, Marc Ansari and Fabienne Gumy-Pause
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:69
  32. Glioma is the most common intracranial neoplasm with vasculogenic mimicry formation as one form of blood supply. Many RNA-binding proteins and long non-coding RNAs are involved in tumorigenesis of glioma.

    Authors: Xiaozhi Li, Yixue Xue, Xiaobai Liu, Jian Zheng, Shuyuan Shen, Chunqing Yang, Jiajia Chen, Zhen Li, Libo Liu, Jun Ma, Teng Ma and Yunhui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:68
  33. Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular mechanism for lysosomal degradation of damaged cellular components. The specific degradation of nuclear componen...

    Authors: Yunong Li, Xiuxing Jiang, Yanhao Zhang, Ziyi Gao, Yanxia Liu, Jinjiao Hu, Xiaoye Hu, Lirong Li, Jingshan Shi and Ning Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:67
  34. Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types. It is very urgent to study the development mechanisms of thi...

    Authors: Xuhui Ma, Boya Li, Jie Liu, Yan Fu and Yongzhang Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:66
  35. Angiogenesis plays a critical role in the progression of glioma. Previous studies have indicated that RNA-binding proteins (RBPs) interact with RNAs and participate in the regulation of the malignant behaviors...

    Authors: Zhenwei He, Xuelei Ruan, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Jun Ma, Lianqi Shao, Di Wang, Shuyuan Shen, Chunqing Yang and Yixue Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:65
  36. CFLARL, also known as c-FLIPL, is a critical anti-apoptotic protein that inhibits activation of caspase 8 in mammalian cells. Previous studies have shown that arginine 122 of CFLARL can be mono-methylated. Howeve...

    Authors: Mingyue Li, Wentao An, Linyan Xu, Yidan Lin, Ling Su and Xiangguo Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:64
  37. Interleukin-11 (IL-11), a dominant IL-6 family cytokine, is involved in tumorigenesis, tumor progression and differentiation in colon cancer cells. IL-11 signaling has been recently identified as a potential t...

    Authors: Jia Wei, Ling Ma, Yi-Hui Lai, Ruijie Zhang, Huameng Li, Chenglong Li and Jiayuh Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:63

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:374

  38. To investigate the lung cancer-promoting mechanism of mesenchymal stem cell-secreted extracellular vesicles (MSC-EV).

    Authors: Weihua Ren, Jianfeng Hou, Chenguang Yang, Hanjun Wang, Shuangting Wu, Yabin Wu, Xingpeng Zhao and Chao Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:62
  39. Ionizing radiation (IR) is one of the major clinical therapies of cancer, although it increases the epithelial-mesenchymal transition (EMT) of non-small cell lung cancer (NSCLC), unexpectedly. The cellular and...

    Authors: Wenjuan Wang, Yajie Xiong, Xinyuan Ding, Long Wang, Yifan Zhao, Yao Fei, Ying Zhu, Xiao Shen, Caihong Tan and Zhongqin Liang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:61
  40. Long non-coding RNA LINC00346 has been recently suggested as a prognostic marker in pancreatic cancer. However, its biological function in pancreatic cancer has not yet been determined. In this study, we attem...

    Authors: Weidong Shi, Chenyue Zhang, Zhouyu Ning, Yongqiang Hua, Ye Li, Lianyu Chen, Luming Liu, Zhen Chen and Zhiqiang Meng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:60
  41. Long non-coding RNAs has been reported in tumorigenesis and play important roles in regulating malignant behavior of cancers, including glioma.

    Authors: Han Li, Yixue Xue, Jun Ma, Lianqi Shao, Di Wang, Jian Zheng, Xiaobai Liu, Chunqing Yang, Qianru He, Xuelei Ruan, Zhen Li and Yunhui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:59
  42. Focal adhesion kinase (FAK) is a cytoplasmatic protein tyrosine kinase that associates with both integrins and growth factor receptors toward the adhesion, migration and invasion of cancer cells. The G-protein...

    Authors: Damiano Cosimo Rigiracciolo, Maria Francesca Santolla, Rosamaria Lappano, Adele Vivacqua, Francesca Cirillo, Giulia Raffaella Galli, Marianna Talia, Lucia Muglia, Michele Pellegrino, Nijiro Nohata, Maria Teresa Di Martino and Marcello Maggiolini
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:58
  43. Several members of the tripartite motif-containing (TRIM) protein family have been reported to serve as vital regulators of tumorigenesis. Recent studies have demonstrated an oncogenic role of TRIM 14 in multi...

    Authors: Shuang Feng, Xiaomin Cai, Yangyang Li, Xiaoguang Jian, Linxin Zhang and Bin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:57
  44. Melanoma is the most aggressive and deadly form of skin cancer with increasing case numbers worldwide. The development of inhibitors targeting mutated BRAF (found in around 60% of melanoma patients) has marked...

    Authors: Christiane Margue, Demetra Philippidou, Ines Kozar, Giulia Cesi, Paul Felten, Dagmar Kulms, Elisabeth Letellier, Claude Haan and Stephanie Kreis
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:56
  45. Dysregulated miR-7 and aberrant NF-κB activation were reported in various human cancers. However, the expression profile, clinical relevance and dysregulated mechanism of miR-7 and NF-κB RelA/p65 in human gast...

    Authors: Tingbo Ye, Meihua Yang, Daochao Huang, Xin Wang, Bingqian Xue, Na Tian, Xiaohui Xu, Liming Bao, Huajian Hu, Tiewei Lv and Yi Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:55
  46. Multiple myeloma (MM) accounts for 10% of all hematological malignancies. Dysregulation of microRNAs (miRNAs) or long non-coding RNAs (lncRNAs) has important impacts on progression of MM. Circular RNAs (circRN...

    Authors: Yashu Feng, Ling Zhang, Jieying Wu, Bijay Khadka, Zhigang Fang, Jiaming Gu, Baoqiang Tang, Ruozhi Xiao, Guangjin Pan and Jiajun Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:54
  47. Gastric cancer (GC) has a clear predilection for metastasis toward the omentum which is primarily composed of adipose tissue, indicating that fatty acids may contribute to this phenomenon. However their functi...

    Authors: Jiaomeng Pan, Zhiyuan Fan, Zhenqiang Wang, Qingqiang Dai, Zhen Xiang, Fei Yuan, Min Yan, Zhenggang Zhu, Bingya Liu and Chen Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:52
  48. Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated...

    Authors: Lin Tuo, Jin Xiang, Xuanming Pan, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang, Kai Wang and Ni Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:50
  49. As the selective inhibitor of BRAF kinase, vemurafenib exhibits effective antitumor activities in patients with V600 BRAF mutant melanomas. However, acquired drug resistance invariably develops after its initi...

    Authors: Jiaojiao Hao, Wenhua Fan, Yizhuo Li, Ranran Tang, Chunfang Tian, Qian Yang, Tianhua Zhu, Chaoliang Diao, Sheng Hu, Manyu Chen, Ping Guo, Qian Long, Changlin Zhang, Ge Qin, Wendan Yu, Miao Chen…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:48

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