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  1. Colorectal cancer is a one of the most common alimentary malignancies. Survivin has been proved by many studies to be an ideal target for cancer gene therapy because of its strong anti-apoptotic effect. The re...

    Authors: Wei Shen, Chun-Yi Wang, Xue-Hu Wang and Zhong-Xue Fu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:81

    Content type: Research

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  2. The incidence of hepatocellular carcinoma is increasing in many countries. The estimated number of new cases annually is over 500,000, and the yearly incidence comprises between 2.5 and 7% of patients with liv...

    Authors: AlaaEddeen M Seufi, Safinz S Ibrahim, Tarek K Elmaghraby and Elsayed E Hafez

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:80

    Content type: Research

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  3. FBG2 (F-BOX6) gene is an important member in ubiquitin metabolic system F-BOX family, and forms E3 complex with the other members in the family. But its role in gastric cancer is still not clear. In the presen...

    Authors: Lin Zhang, Yanhong Hou, Mengwei Wang, Benyan Wu and Nan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:78

    Content type: Research

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  4. opioid and somatostatin receptors (SSTRs) that can assemble as heterodimer were individually reported to modulate malignant cell proliferation and to favour apoptosis. Materials and methods: SSTRs and opioid r...

    Authors: Céline Kerros, Thibault Cavey, Brigitte Sola, Philippe Jauzac and Stéphane Allouche

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:77

    Content type: Research

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  5. We observed that paclitaxel altered the pharmacokinetic properties of gemcitabine in patients with non-small cell lung cancer (NSCLC) and limited the accumulation of gemcitabine and its metabolites in various ...

    Authors: Stacy S Shord and Shitalben R Patel

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:76

    Content type: Research

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  6. Angiogenesis plays an important role in tumor growth, invasion, and eventually metastasis. Antiangiogenic strategies have been proven to be a promising approach for clinical therapy for a variety of tumors. As...

    Authors: Li-Ping Yang, Ping Cheng, Xing-Chen Peng, Hua-Shan Shi, Wei-Hong He, Feng-Yu Cui, Shun-Tao Luo, Yu-Quan Wei and Li Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:75

    Content type: Research

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  7. Centromere protein H (CENP-H) is one of the fundamental components of the human active kinetochore. Recently, CENP-H was identified to be associated with tumorigenesis. This study was aimed to investigate the ...

    Authors: Wen-Ting Liao, Chun-Ping Yu, Dong-Hui Wu, Ling Zhang, Li-Hua Xu, Gui-Xiang Weng, Mu-Sheng Zeng, Li-Bing Song and Jin-Song Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:74

    Content type: Research

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  8. Reactive oxygen species (ROS) are closely associated with the intracellular signal cascade, thus strongly implicating involvement in tumor progression. However, the mechanism by which ROS are generated and how...

    Authors: Kyung Hee Lee, Sang Woon Kim and Jae-Ryong Kim

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:73

    Content type: Research

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  9. The relapse of cancer after radiotherapy is a clinical knotty problem. Previous studies have demonstrated that the elevation of several factors is likely in some way to lead to the development of treatment tol...

    Authors: Degang Shi, Genming Shi, Gang Huang, Jiren Zhang and Eric Lartigau

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:72

    Content type: Research

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  10. Hepatocellular carcinoma (HCC) is a lethal malignancy with high rate of metastasis and poor prognosis. There are no effective managements to block metastasis of HCC. Programmed cell death 4 (PDCD4) is found to...

    Authors: Shuhong Zhang, Jianfeng Li, Ying Jiang, Yijun Xu and Chengyong Qin

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:71

    Content type: Research

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  11. Insulin-like growth factor binding protein (IGFBPs) have been as potential tumor suppressors in the occurrence and development of tumors. Cellular Fas-associated death domain-like interleukin-1β-converting enz...

    Authors: Xue-Jing Hou, You-Zhong Zhang, Xin Liu, Li-Hua Meng and Yun-Bo Qiao

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:70

    Content type: Research

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  12. Chemo-radiotherapy, a combination of chemotherapy and radiotherapy, is the most frequent treatment for patients with esophageal cancer. In the process of radiotherapy, the radiosensitive cancer will become a r...

    Authors: Li Xie, Xianrang Song, Jinming Yu, Ling Wei, Bao Song, Xingwu Wang and Liyan Lv

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:68

    Content type: Research

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  13. The α6β4 integrin is overexpressed in the basal subtype of breast cancer and plays an important role in tumor cell motility and invasion. EGFR is also overexpressed in the basal subtype of breast cancer, and c...

    Authors: Michael Z Gilcrease, Xiao Zhou, Xiaolin Lu, Wendy A Woodward, Brian E Hall and Phillip J Morrissey

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:67

    Content type: Research

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  14. Molecularly targeted agents for the treatment of solid tumors had entered the market in the last 5 years, with a great impact upon both the scientific community and the society. Many randomized phase III trial...

    Authors: Emilio Bria, Massimo Di Maio, Paolo Carlini, Federica Cuppone, Diana Giannarelli, Francesco Cognetti and Michele Milella

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:66

    Content type: Review

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  15. An increasing number of studies have shown that ERK and PI3-K/AKT signaling pathways are involved in various human cancers including hepatocellular carcinoma and cholangiocarcinoma. However, few studies have e...

    Authors: Qinglong Li and Zhulin Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:65

    Content type: Research

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  16. Non-coding RNA molecules, such as microRNAs, may play an important role in carcinogenesis. Recent studies have indicated that microRNAs are involved in initiation and progression of various malignancies. Howev...

    Authors: Tao Yu, Xiao-yi Wang, Ren-guo Gong, An Li, Sen Yang, Yu-tang Cao, Yu-ming Wen, Chang-mei Wang and Xin-zhu Yi

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:64

    Content type: Research

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  17. A novel multi-drug resistance gene named as HA117 has been screened and cloned in multidrug resisitant leukemia cell lines in our previous research, but its function is still unknown. In this study, HA117 gene...

    Authors: Yuxia Guo, Gaihuan Zheng, Xianqing Jin, Youhua Xu, Qing Luo, Xiaomei Liu, Zhenzhen Zhao and Yong Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:63

    Content type: Research

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  18. The pathogenesis of biliary cancers is ill-defined. This study investigates changes in gene expression and copy number in biliary cancers and correlates these changes with anatomical site of origin, histopatho...

    Authors: George Miller, Nicholas D Socci, Deepti Dhall, Michael D'Angelica, Ronald P DeMatteo, Peter J Allen, Bhuvanesh Singh, Yuman Fong, Leslie H Blumgart, David S Klimstra and William R Jarnagin

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:62

    Content type: Research

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  19. Seizure control doesn't represent the only challenging goal in patients with brain tumor-related epilepsy. Side effects have often taken precedence for patients' quality of life.

    Authors: Marta Maschio, Loredana Dinapoli, Antonello Vidiri, Andrea Pace, Alessandra Fabi, Alfredo Pompili, Maria Carmine Carapella and Bruno Jandolo

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:60

    Content type: Research

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  20. There are around 350 million of hepatitis B surface antigen (HBsAg) carriers worldwide, and among them, high risk of developing hepatocellular carcinoma (HCC) has been identified by epidemiological studies. To...

    Authors: Xiaochen Tian, Jinjun Li, Zhang-Mei Ma, Chao Zhao, Da-Fang Wan and Yu-Mei Wen

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:58

    Content type: Research

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  21. Immunocytochemistry and RT-PCR have been widely used for the detection of circulating tumor cells in patients with breast cancer but their specificity is limited. Our purpose is to utilize a convenient and spe...

    Authors: Lili Wang, Yanyan Wang, Yajing Liu, Min Cheng, Xu Wu and Haiming Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:57

    Content type: Research

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  22. Tumorigenesis is thought to be the consequence of gene mutation and disordered gene expression. However, the detailed molecular mechanism underlying the development and progress of colon cancer have not been e...

    Authors: Bo Zhang, Xukai Wang and Yan Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:56

    Content type: Research

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  23. To investigate influencing factors of the metastatic lymph nodes ratio (MLR) and whether it is related to survival in patients with gastric adenocarcinoma.

    Authors: Ji-wei Yu, Ju-gang Wu, Lin-hai Zheng, Biao Zhang, Xiao-chun Ni, Xiao-qiang Li and Bo-jian Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:55

    Content type: Research

    Published on:

  24. Correction to Kleiner HE, Krishnan P, Tubbs J, Smith M, Meschonat C, Shi R, Lowery-Nordberg M, Adegboyega P, Unger M, Cardelli J et al: Tissue microarray analysis of eIF4E and its downstream effector proteins in ...

    Authors: Heather E Kleiner, Prasad Krishnan, Jesse Tubbs, Mark Smith, Carol Meschonat, Runhua Shi, Mary Lowery-Nordberg, Patrick Adegboyega, Marcia Unger, James Cardelli, Quyen Chu, J Michael Mathis, John Clifford, Arrigo De Benedetti and Benjamin DL Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:54

    Content type: Erratum

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2009 28:5

  25. Patients received electrochemotherapy often associated with unpleasant sensations mainly result from low-frequency electric pulse induced muscle contractions. Increasing the repetition frequency of electric pu...

    Authors: Xiao-Jun Yang, Jun Li, Cai-Xin Sun, Fei-Yun Zheng and Li-Na Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:53

    Content type: Research

    Published on:

  26. RhoA and RhoC are deregulated by over expression in many human tumors, including colorectal cancer. Some reports show that they play a pivotal role in the carcinogenesis, tumor development and infiltration met...

    Authors: Xiang-ping Liu, Hai-bo Wang, Kun Yang, Ai-hua Sui, Qiang Shi and Shen Qu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:52

    Content type: Research

    Published on:

  27. Because in vitro studies suggest that low levels of electromagnetic fields may modify cancer cell growth, we hypothesized that systemic delivery of a combination of tumor-specific frequencies may have a therapeut...

    Authors: Alexandre Barbault, Frederico P Costa, Brad Bottger, Reginald F Munden, Fin Bomholt, Niels Kuster and Boris Pasche

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:51

    Content type: Research

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  28. Considering that HTB140 melanoma cells have shown a poor response to either protons or alkylating agents, the effects of a combined use of these agents have been analysed.

    Authors: Aleksandra M Ristić-Fira, Lela B Korićanac, Jelena J Žakula, Lucia M Valastro, Gioacchin Iannolo, Giuseppe Privitera, Giacomo Cuttone and Ivan M Petrović

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:50

    Content type: Research

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  29. Endometriosis is a gynecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Women with endometriosis have an increased risk of different types of ...

    Authors: Pietro G Signorile, Feliciano Baldi, Rossana Bussani, Mariarosaria D'Armiento, Maria De Falco and Alfonso Baldi

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:49

    Content type: Research

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  30. Uveal melanoma (UM) cell lines, when exposed to blue light in vitro, show a significant increase in proliferation. In order to determine if similar effects could be seen in vivo, we investigated the effect of ...

    Authors: Sebastian Di Cesare, Shawn Maloney, Bruno F Fernandes, Claudia Martins, Jean-Claude Marshall, Emilia Antecka, Alexandre N Odashiro, William W Dawson and Miguel N Burnier Jr

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:48

    Content type: Research

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  31. The literature supporting high-dose rate brachytherapy (HDR) in the treatment of cervical carcinoma derives primarily from retrospective series. However, controversy still persists regarding the efficacy and s...

    Authors: Gustavo A Viani, Gustavo B Manta, Eduardo J Stefano and Ligia I de Fendi

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:47

    Content type: Research

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  32. Previous evidence implicates polymorphisms of GSTM1 and GSTT1, candidates of phase II enzymes, as risk factors for various cancers. A number of studies have conducted on the association of GSTM1 and GSTT1 poly...

    Authors: Xianlu Zhuo, Lei Cai, Zhaolan Xiang, Qi Li and Xueyuan Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:46

    Content type: Research

    Published on:

  33. Progress in developing effective surgical techniques, such as scapular allograft reconstruction, enhance shoulder stability and extremity function, in patients following scapular tumor resection.

    Authors: Kaiwei Zhang, Hong Duan, Zhou Xiang and Chongqi Tu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:45

    Content type: Research

    Published on:

  34. Multinucleated cells are frequently seen in association with a malignant neoplasm. Some of these multinucleated cells are considered to be neoplastic. The mechanism of neoplastic multinucleation remains unknow...

    Authors: Takashi Ariizumi, Akira Ogose, Hiroyuki Kawashima, Tetsuo Hotta, Hajime Umezu and Naoto Endo

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:44

    Content type: Research

    Published on:

  35. Tumor cells need large energy and nucleic acids to proliferate and grow. For most of their energy needs, cancer cells depend more on glycolysis. For most of their nucleic acids needs, cancer cells depend more ...

    Authors: Hui Chen, Jian-Xin Yue, Shou-Hua Yang, Hui Ding, Rong-Wei Zhao and Song Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:43

    Content type: Research

    Published on:

  36. Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. ...

    Authors: Ramachandran Meenakshisundaram and Claudia Gragnoli

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:42

    Content type: Research

    Published on:

  37. The study aimed to calculate chest-wall skin dose associated with different frequencies of bolus applications in post-mastectomy three-dimensional conformal radiotherapy (3D-CRT) and to provide detailed inform...

    Authors: Fundagul Andic, Yasemin Ors, Rima Davutoglu, Sule Baz Cifci, Emine Burcin Ispir and Mehmet Ertugrul Erturk

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:41

    Content type: Research

    Published on:

  38. The role of angiogenesis in the pathogenesis of renal cell carcinoma is well recognized, however, the influence of tumor cells in this activity has not yet been fully clarified. The aim of this study was to an...

    Authors: Gordana orević, Koviljka Matušan-Ilijaš, Emina Babarović, Ita Hadžisejdić, Maja Grahovac, Blaženka Grahovac and Nives Jonjić

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:40

    Content type: Research

    Published on:

  39. Studies on activated cell-signaling pathways responsible for neoplastic transformation are numerous in solid tumors and in adult leukemias. Despite of positive results in the evolution of pediatric hematopoiet...

    Authors: Velia D'Angelo, Stefania Crisci, Fiorina Casale, Raffaele Addeo, Maria Giuliano, Elvira Pota, Paola Finsinger, Alfonso Baldi, Roberto Rondelli, Alberto Abbruzzese, Michele Caraglia and Paolo Indolfi

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:39

    Content type: Research

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  40. The paper reports a quantitative analysis of the perfusion maps of 22 patients, affected by gliomas or by metastasis, with the aim of characterizing the malignant tissue with respect to the normal tissue. The ...

    Authors: Anna Maria Di Nallo, Antonello Vidiri, Simona Marzi, Alessandra Mirri, Alessandra Fabi, Carmine Maria Carapella, Andrea Pace and Marcello Crecco

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:38

    Content type: Research

    Published on:

  41. The genes of base excision repair (BER) pathway have been extensively studied in the association with various human cancers. We performed a case-control study to test the association between two common single ...

    Authors: Michal Kowalski, Karolina Przybylowska, Pawel Rusin, Jurek Olszewski, Alina Morawiec-Sztandera, Anna Bielecka-Kowalska, Wioletta Pietruszewska, Wojciech Mlynarski, Szemraj Janusz and Ireneusz Majsterek

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:37

    Content type: Research

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  42. Secretory pituitary adenomas are very common brain tumors. Historically, the treatment armamentarium for secretory pituitary adenomas included neurosurgery, medical management, and fractionated radiotherapy. I...

    Authors: Heng Wan, Ohye Chihiro and Shubin Yuan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:36

    Content type: Research

    Published on:

  43. Serum levels of IGF-I in patients affected with multiple myeloma (MM) have been scarcely studied. The present study is aimed to explore this point comparing 55 healthy subjects, 71 monoclonal gammopaties of un...

    Authors: Claudia Greco, Gaetano Vitelli, Giuseppe Vercillo, Rosa Vona, Diana Giannarelli, Isabella Sperduti, Francesco Pisani, Ettore Capoluongo, Maria Concetta Petti and Franco Ameglio

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:35

    Content type: Research

    Published on:

  44. This phase II study was designed to evaluate the activity and safety of a combination of epirubicin, oxaliplatin and docetaxel in metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma.

    Authors: Luigi Di Lauro, Laura Giacinti, Maria Grazia Arena, Domenico Sergi, Silvia Ileana Fattoruso, Diana Giannarelli and Massimo Lopez

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:34

    Content type: Research

    Published on:

  45. It has been suggested that polymorphisms in glutathione-S-transferases (GST) could predispose to prostate cancer through a heritable deficiency in detoxification pathways for environmental carcinogens. Yet, studi...

    Authors: Monika Sivoňová, Iveta Waczulíková, Dušan Dobrota, Tatiana Matáková, Jozef Hatok, Peter Račay and Ján Kliment

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:32

    Content type: Case study

    Published on:

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