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  1. Preclinical toxicity of adaphostin has been related to oxidative stress. This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant r...

    Authors: Nicole D Fer, Robert H Shoemaker and Anne Monks

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:91

    Content type: Research

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  2. MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies have shown altered expression levels of several microRNAs in renal cell carcinoma.

    Authors: Ondrej Slaby, Jana Jancovicova, Radek Lakomy, Marek Svoboda, Alexandr Poprach, Pavel Fabian, Leos Kren, Jaroslav Michalek and Rostislav Vyzula

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:90

    Content type: Research

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  3. ECRG4 has been shown to be a candidate tumor suppressor in several tumors, but its role in glioma remains poorly understood. In this study, we examined the mRNA expression of ECRG4 and investigated its biologi...

    Authors: Wei Li, Xinrui Liu, Bo Zhang, Dongxue Qi, Lihong Zhang, Yuhong Jin and Hongfa Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:89

    Content type: Research

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  4. This study explored the expression and function of Slug in human extrahepatic hilar cholangiocarcinoma (EHC) to identify its role in tumor progression.

    Authors: Ke-jun Zhang, Dong-sheng Wang, Shao-yan Zhang, Xue-long Jiao, Chun-wei Li, Xin-sheng Wang, Qin-chao Yu and Hai-ning Cui

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:88

    Content type: Research

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  5. Thymoquinone (TQ) is a compound extracted from Black Caraway seeds of Nigella Sativa and is active against various cancers. Cisplatin (CDDP) is the most active chemotherapeutic agent in Lung Cancer. Here we repor...

    Authors: Syed H Jafri, Jonathan Glass, Runhua Shi, Songlin Zhang, Misty Prince and Heather Kleiner-Hancock

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:87

    Content type: Research

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  6. Various strains of Bacillus thuringiensis (Bt) have been found to produce parasporal proteins that are cytotoxic to human cancer cells. This study aims to establish the binding affinity of purified Bt 18 toxin fo...

    Authors: Rebecca SY Wong, Shar M Mohamed, Vishna D Nadarajah and Ibrahim Azmi T Tengku

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:86

    Content type: Research

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  7. To determine the expression of bone morphogenetic protein-2 (BMP-2) and its receptors BMPRIA, BMPRIB, and BMPRII in epithelial ovarian cancer (EOC) and to analyze their influence on the prognosis of ovarian ca...

    Authors: Ying Ma, Lin Ma, Quan Guo and Shulan Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:85

    Content type: Research

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  8. Orthotopic models are important in cancer research. Here we developed orthotopic xenograft mouse model of metastatic lung cancer and glioblastoma with a specially designed system.

    Authors: Xi Feng Fei, Quan Bin Zhang, Jun Dong, Yi Diao, Zhi Min Wang, Ru Jun Li, Zi Cheng Wu, Ai Dong Wang, Qing Lan, Shi Ming Zhang and Qiang Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:84

    Content type: Research

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  9. The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of non-surgical therapy...

    Authors: Tatsuya Tanaka, Hideyuki Ishiguro, Yoshiyuki Kuwabara, Masahiro Kimura, Akira Mitsui, Takeyasu Katada, Midori Shiozaki, Yasuhiro Naganawa, Yoshitaka Fujii and Hiromitsu Takeyama

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:83

    Content type: Research

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  10. Breast cancer is one of the most common diseases affecting women. Inherited susceptibility genes, BRCA1 and BRCA2, are considered in breast, ovarian and other common cancers etiology. BRCA1 and BRCA2 genes have b...

    Authors: Safinaz S Ibrahim, Elsayed E Hafez and Mervat M Hashishe

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:82

    Content type: Research

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  11. We have previously reported that Myeov (MYEloma OVerexpressed gene) expression is enhanced in colorectal cancer (CRC) and that it promotes CRC cell proliferation and invasion. The role of Myeov in CRC migratio...

    Authors: Garrett Lawlor, Peter P Doran, Padraic MacMathuna and David W Murray

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:81

    Content type: Research

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  12. Breast cancer stem cells (BCSCs) have been recently identified in breast carcinoma as CD44+CD24- cells, which exclusively retain tumorigenic activity and display stem cell-like properties. Using a mammosphere cul...

    Authors: Mingzhu Huang, Yuqing Li, Huanle Zhang and Feifei Nan

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:80

    Content type: Research

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  13. Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. Cx26 is considered to be a tumor suppressor gene. However, recent studies revealed that over expression of Cx26 ...

    Authors: Shinya Nomura, Kiyoshi Maeda, Eiji Noda, Toru Inoue, Shinya Fukunaga, Hisashi Nagahara and Kosei Hirakawa

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:79

    Content type: Research

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  14. Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (D...

    Authors: Feng Ye, Yan Yu, Yuting Hu, Weiguo Lu and Xing Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:78

    Content type: Research

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  15. Total thyroidectomy is the treatment of choice in the majority of thyroid malignancies, preventing the risk of reoperative surgery due to recurrences. In order to assess the usefulness of such an approach, exp...

    Authors: Guglielmo Ardito, Luca Revelli, Alma Boninsegna, Alessandro Sgambato, Francesca Moschella, Maria Cristina Marzola, Erica Giustozzi, Nicola Avenia, Mauro Castelli and Domenico Rubello

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:77

    Content type: Research

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  16. Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and un...

    Authors: Xian-ping Liu, Sheng-tao Zhou, Xing-yi Li, Xian-cheng Chen, Xia Zhao, Zhi-yong Qian, Li-na Zhou, Zhi-yong Li, Yu-mei Wang, Qian Zhong, Tao Yi, Zheng-yu Li, Xiang He and Yu-quan Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:76

    Content type: Research

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  17. Recent studies have shown that microRNAs (miRNAs) play roles in tumorigenesis and are reliable classifiers of certain cancer types and subtypes. However, the role of miRNAs in the pathogenesis and diagnosis of...

    Authors: Liqin Du, Jeoffrey J Schageman, Irnov, Luc Girard, Scott M Hammond, John D Minna, Adi F Gazdar and Alexander Pertsemlidis

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:75

    Content type: Research

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  18. The tumor suppressor gene CDKN2A generates at least three different transcriptional variants, each of which is thought to encode a tumor suppressor. However, the inhibitory activities of these variants have not y...

    Authors: Wei Zhang, Jing Zhu, Jing Bai, Hui Jiang, Fangli Liu, An Liu, Peng Liu, Guohua Ji, Rongwei Guan, Donglin Sun, Wei Ji, Yang Yu, Yan Jin, Xiangning Meng and Songbin Fu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:74

    Content type: Research

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  19. To retrospectively compare the diagnostic accuracy of magnetic resonance imaging (MRI) and multidetector-row computed tomography (MDCT) in the assessment of the mandibular invasion by squamous cell carcinoma (...

    Authors: Antonello Vidiri, Antonino Guerrisi, Raul Pellini, Valentina Manciocco, Renato Covello, Oreste Mattioni, Isabella Guerrisi, Salvatore Di Giovanni, Giuseppe Spriano and Marcello Crecco

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:73

    Content type: Research

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  20. Interleukin-10(IL-10) is a multifunctional cytokine with both immunosuppressive and antiangiogenic functions. Polymorphisms in the IL-10 gene promoter genetically determine interindividual differences in IL-10...

    Authors: Fanjun Kong, Jie Liu, Yongheng Liu, Bao Song, Hualing Wang and Wenchao Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:72

    Content type: Research

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  21. SPARC (secreted protein, acidic and rich in cysteine) is closely related with the progress, invasion and metastasis of malignant tumor and angiogenesis.

    Authors: Jian-fang Liang, Hong-kun Wang, Hong Xiao, Ning Li, Cai-xia Cheng, Yu-ze Zhao, Yan-bo Ma, Jian-zhong Gao, Rui-bing Bai and Hui-xia Zheng

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:71

    Content type: Research

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  22. Intra-arterial radioembolization with yttrium-90 microspheres ( 90Y-RE) is an increasingly used therapy for patients with unresectable liver malignancies. Over the last decade, radioactive holmium-166 poly(L-lact...

    Authors: Maarten LJ Smits, Johannes FW Nijsen, Maurice AAJ van den Bosch, Marnix GEH Lam, Maarten AD Vente, Julia E Huijbregts, Alfred D van het Schip, Mattijs Elschot, Wouter Bult, Hugo WAM de Jong, Pieter CW Meulenhoff and Bernard A Zonnenberg

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:70

    Content type: Research

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  23. Positron emission tomography imaging of lung cancers with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose is a non-invasive diagnostic, and prognostic tool that measures tumor metabolism. We have analyzed the effect ...

    Authors: Seong-Jang Kim, Sang-Hyun Hwang, In Joo Kim, Min Ki Lee, Chang Hun Lee, Sang-Yull Lee and Eun Yup Lee

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:69

    Content type: Research

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  24. This study aimed to investigate the efficacy of prophylactic amifostine in reducing the risk of severe radiation colitis in cancer patients receiving radical radiotherapy to the pelvis.

    Authors: Konstantinos H Katsanos, Evangelos Briasoulis, Pericles Tsekeris, Anna Batistatou, Maria Bai, Christos Tolis, Antonio Capizzello, Ioannis Panelos, Vasileios Karavasilis, Dimitrios Christodoulou and Epameinondas V Tsianos

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:68

    Content type: Research

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  25. Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects. Now, we updated the data and pe...

    Authors: Qiong Yang, De-Rong Xie, Zhi-Min Jiang, Wen Ma, Yuan-Dong Zhang, Zhuo-Fei Bi and Deng-Lin Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:67

    Content type: Research

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  26. The prognosis of gastric cancer patients is difficult to predict because of defects in establishing the surgical-pathological features. Cancer-associated fibroblasts (CAFs) have been found to play prominent ro...

    Authors: Kangkang Zhi, Xiaojun Shen, Hao Zhang and Jianwei Bi

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:66

    Content type: Research

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  27. In the province of Cadiz (Spain), the adjusted mortality rate for gastric cancer in the coastal town of Barbate is 10/100.000 inhabitants, whereas in the inland town of Ubrique, the rate is twice as high. The ...

    Authors: Juan-Bosco Lopez-Saez, Victoria Gómez-Biondi, Germán Santamaría-Rodriguez, Margarita Dominguez-Villar, Antonio Amaya-Vidal, Antonio Lorenzo-Peñuelas and Avelino Senra-Varela

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:65

    Content type: Research

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  28. This study aimed to examine whether EBV seropositive patients with lung cancer have an altered virus-specific CTL response, as compared to age-matched healthy controls and whether any variation in this respons...

    Authors: Vaios Karanikas, Maria Zamanakou, Faye Soukou, Theodora Kerenidi, Ioannis Tsougos, Kiki Theodorou, Panagiotis Georgoulias, Konstantinos I Gourgoulianis and Anastasios E Germenis

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:64

    Content type: Research

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  29. in recent years, Livin, a new member of IAPs family, is found to be a key molecule in cancers. Researchers consider Livin may become a new target for tumor therapy; however, the role of it in bladder cancer is...

    Authors: Liu Chuan, Wu Xiaohou, Luo Chunli, Hu Zili, Yin Zhikang, He Yunfeng, Du Hu, Zhang Weili, Jiang Qing and Lin Yanjun

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:63

    Content type: Research

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  30. The aims of this study were: to characterise and compare plasma concentrations of midkine (MDK) in normal healthy women with concentrations observed in women with ovarian cancer; and to establish and compare t...

    Authors: Gregory E Rice, Tracey A Edgell and Dominic J Autelitano

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:62

    Content type: Research

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  31. CD147 is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily. CD147 has been implicated in numerous physiological and pathological activities. Enriched on the surface of many tumo...

    Authors: Bo Wang, Yong-Fei Xu, Bang-Shun He, Yu-Qin Pan, Li-Rong Zhang, Chan Zhu, Li-Li Qu and Shu-Kui Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:61

    Content type: Research

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  32. Survival of laryngeal squamous cell carcinoma (LSCC) patients has remained unchanged over recent years due to its uncontrolled recurrence and local lymph node metastasis. Vasculogenic mimicry (VM) is an altern...

    Authors: Wei Wang, Peng Lin, Chunrong Han, Wenjuan Cai, Xiulan Zhao and Baocun Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:60

    Content type: Research

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  33. Secreted protein acidic and rich in cysteine (SPARC) plays a key role in the development of many tissues and organ types. Aberrant SPARC expression was found in a wide variety of human cancers, contributes to ...

    Authors: Jie Yin, Guowei Chen, Yucun Liu, Si Liu, Pengyuan Wang, Yuanlian Wan, Xin Wang, Jing Zhu and Hongqiao Gao

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:59

    Content type: Research

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  34. Although the addition of bevacizumab to 1st line chemotherapy provides a significant survival benefit for advanced colorectal cancer, the magnitudes of both advantages and toxicities have not been extensively inv...

    Authors: Fotios Loupakis, Emilio Bria, Vanja Vaccaro, Federica Cuppone, Michele Milella, Paolo Carlini, Chiara Cremolini, Lisa Salvatore, Alfredo Falcone, Paola Muti, Isabella Sperduti, Diana Giannarelli and Francesco Cognetti

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:58

    Content type: Research

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  35. Constitutively decreased TGFBR1 allelic expression is emerging as a potent modifier of colorectal cancer risk in mice and humans. This phenotype was first observed in mice, then in lymphoblastoid cell lines from ...

    Authors: Boris Pasche, Kari B Wisinski, Maureen Sadim, Virginia Kaklamani, Michael J Pennison, Qinghua Zeng, Naresh Bellam, Jacquelyn Zimmerman, Nengjun Yi, Kui Zhang, John Baron, Daniel O Stram and M Geoffrey Hayes

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:57

    Content type: Research

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  36. VEGF is a well-validated target for antiangiogenic intervention in cancer. To date, RNAi technology has been proven to be a promising approach for targeted therapy. DDP is frequently used as a first-line drug ...

    Authors: Yong P Ma, Yang Yang, Shuang Zhang, Xiang Chen, Na Zhang, Wei Wang, Zhi X Cao, Yu Jiang, Xia Zhao, Yu Q Wei and Hong X Deng

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:56

    Content type: Research

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  37. It has been demonstrated that certain NK-1 antagonists could reduce proliferation of several cancer cell lines, however, it is unknown whether SR140333 exerts proliferation inhibition in breast cancer cell line.

    Authors: Wei-Qing Huang, Ji-Gang Wang, Lei Chen, Hong-Jun Wei and Hua Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:55

    Content type: Research

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  38. DNA-damage-inducible transcript 3 (DDIT3), a candidate tumor suppressor gene (TSG), has been found involved in the regulation of cellular growth and differentiation. The epigenetic changes of TSGs are recently re...

    Authors: Ya-li Wang, Jun Qian, Jiang Lin, Dong-ming Yao, Zhen Qian, Zhao-hui Zhu and Jian-yong Li

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:54

    Content type: Research

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  39. MUC5AC is a secretory mucin normally expressed in the surface muconous cells of stomach and bronchial tract. It has been known that MUC5AC de novo expression occurred in the invasive ductal carcinoma and pancreat...

    Authors: Sadaaki Yamazoe, Hiroaki Tanaka, Tetsuji Sawada, Ryosuke Amano, Nobuya Yamada, Masaichi Ohira and Kosei Hirakawa

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:53

    Content type: Research

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  40. Non-small cell lung cancer (NSCLC) is the leading cause of cancer related mortality, any improvements in therapeutic strategies are urgently required. In this study we generated a novel 'suicide gene' armed on...

    Authors: Ju-Feng Zhang, Fang Wei, Hui-Ping Wang, Hui-Ming Li, Wei Qiu, Peng-Kang Ren, Xia-Fang Chen and Qian Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:52

    Content type: Research

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  41. Signal transducer and activator of transcription 3 (Stat3) is a member of the Janus-activated kinase(Jak)/Stat signaling pathway. Abnormal activation of Stat3 plays a critical role in metastasis and invasion i...

    Authors: Chen Huang, Guang Yang, Tao Jiang, Kejian Huang, Jun Cao and Zhengjun Qiu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:51

    Content type: Research

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  42. Fas/FasL system is a major regulator of apoptosis. The mechanisms by which Fas mediates cisplatin resistance remain unclear. The aim of this study is to explore the effect of Fas over-expression on cisplatin r...

    Authors: Wei Wu, Hai-dong Wang, Wei Guo, Kang Yang, Yun-ping Zhao, Yao-guang Jiang and Ping He

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:49

    Content type: Research

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  43. Glypican 3 (GPC-3) is an oncofoetal protein that is expressed in most hepatocellular carcinomas (HCC). Since it is a potential target for T cell immunotherapy, we investigated the generation of functional, GPC...

    Authors: James O'Beirne, Farzin Farzaneh and Phillip M Harrison

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:48

    Content type: Research

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  44. The main hindrance to the diffusion of proton therapy facilities is the high cost for gantry installations. An alternative technical option is provided by fixed-beam treatment rooms, where the patient is rotat...

    Authors: Salvatore Devicienti, Lidia Strigari, Marco D'Andrea, Marcello Benassi, Vincenzo Dimiccoli and Maurizio Portaluri

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:47

    Content type: Review

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  45. A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin exp...

    Authors: Dan-Dan Yu, Chun-Ting Wang, Hua-Shan Shi, Zhi-Yong Li, Li Pan, Qing-Zhong Yuan, Fei Leng, Yuan Wen, Xiang Chen and Yu-Quan Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:46

    Content type: Research

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  46. We performed expression profiling of two neuroblastoma cell lines, SK-N-BE(2) and SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and inhibitors of lipoxygenases (LOX) and cyclooxygenases (C...

    Authors: Petr Chlapek, Martina Redova, Karel Zitterbart, Marketa Hermanova, Jaroslav Sterba and Renata Veselska

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:45

    Content type: Research

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  47. To detect the expression of isocitrate dehydrogenase 1 (IDH1) and transformation-related protein 53 (p53) in osteosarcoma and analyze the correlation between them and the clinico-pathological features.

    Authors: Xiang Hu, Ai-Xi Yu, Bai-Wen Qi, Tao Fu, Gang Wu, Min Zhou, Jun Luo and Jun-Hua Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:43

    Content type: Research

    Published on:

  48. Calcifying epithelioma of Malherbe, or Pilomatricoma, is considered an uncommon cutaneous neoplasia, normally occurring in children as a solitary, firm, asymptomatic, hard, subcutaneous, slowly growing nodule ...

    Authors: Francesco M Solivetti, Fulvia Elia, Alessandra Drusco, Chiara Panetta, Ada Amantea and Aldo Di Carlo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:42

    Content type: Research

    Published on:

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