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  1. In cancer patients, MUC1 glycoprotein may carry Lewis y which could be involved in immune response. Purposes: 1- to evaluate the presence of Lewis y and MUC1 in circulating immune complexes (Lewis y/CIC and MU...

    Authors: Marina Isla Larrain, Sandra Demichelis, Marina Crespo, Ezequiel Lacunza, Alberto Barbera, Aldo Cretón, Francisco Terrier, Amada Segal-Eiras and María Virginia Croce

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:121

    Content type: Research

    Published on:

  2. Germ cell testicular tumors have survival rate that diminishes with high tumor marker levels, such as human chorionic gonadotropin (hCG). hCG may regulate vascular neoformation through vascular endothelial gro...

    Authors: Oscar Arrieta, Rosa Mayela Michel Ortega, Julián Ángeles-Sánchez, Cynthia Villarreal-Garza, Alejandro Avilés-Salas, José G Chanona-Vilchis, Elena Aréchaga-Ocampo, Arturo Luévano-González, Miguel Ángel Jiménez and José Luis Aguilar

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:120

    Content type: Research

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  3. This study was designed to explore the feasibility, safety, and outcomes of pre-operative oxaliplatin-dacarbazine combination therapy for the treatment of advanced soft tissue sarcoma (STS) of the limb.

    Authors: Xiang-Yun Zong, Yang Yu and Hong-Jian Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:119

    Content type: Research

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  4. Vimentin is one of the cytoplasmic intermediate filament proteins which are the major component of the cytoskeleton. In our study we checked the usefulness of vimentin expression in identifying cases of breast...

    Authors: Renata U Kusinska, Radzislaw Kordek, Elzbieta Pluciennik, Andrzej K Bednarek, Janusz H Piekarski and Piotr Potemski

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:118

    Content type: Research

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  5. Recently, the use of hypo-fractionated treatment schemes for the prostate cancer has been encouraged due to the fact that α/β ratio for prostate cancer should be low. However a major concern on the use of hypo...

    Authors: Simona Marzi, Biancamaria Saracino, Maria G Petrongari, Stefano Arcangeli, Sara Gomellini, Giorgio Arcangeli, Marcello Benassi and Valeria Landoni

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:117

    Content type: Research

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  6. Recently, maintaining higher relative dose intensity (RDI) of chemotherapeutic drugs has become a widespread practice in an attempt to achieve better outcomes in the treatment of aggressive lymphoma. The addit...

    Authors: Yoshiki Terada, Hirohisa Nakamae, Ran Aimoto, Hiroshi Kanashima, Erina Sakamoto, Mizuki Aimoto, Eri Inoue, Hideo Koh, Takahiko Nakane, Yasunobu Takeoka, Masahiko Ohsawa, Ki-Ryang Koh, Takahisa Yamane, Yoshitaka Nakao, Kensuke Ohta, Atsuko Mugitani…

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:116

    Content type: Research

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  7. Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. A number of studies have conducted on the association of TP53 codon 72 polymorphisms with susceptibility to bre...

    Authors: Wenlei Zhuo, Yunsong Zhang, Zhaolan Xiang, Lei Cai and Zhengtang Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:115

    Content type: Research

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  8. The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperativ...

    Authors: Enrico P Spugnini, Gennaro Citro and Alfonso Baldi

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:114

    Content type: Review

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  9. Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Development of anti-cancer targeted therapies from biologics is increasingly being utiliz...

    Authors: Jeffrey B Hoag, Aimel Azizi, Timothy J Doherty, Jason Lu, Rudolph E Willis and Mark E Lund

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:113

    Content type: Research

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  10. Liver cancer is a common malignancy with a high mortality rate. Given the poor prognosis associated with this cancer, many patients seek additional therapies that may improve quality of life or survival. Sever...

    Authors: Ping Wu, Jean Jacques Dugoua, Oghenowede Eyawo and Edward J Mills

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:112

    Content type: Research

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  11. APMCF1 is a novel human gene first cloned from apoptotic MCF-7 cells. Our previous study found ectogenic APMCF1 could induce G1 arrest in hepatocarcinoma cell line HHCC. In order to search its broad expression...

    Authors: Yaqing Zhang, Qinlong Li, Feng Zhu, Jihong Cui, Kainan Li, Qing Li, Ruian Wang, Wenyong Wang, Weihua Wang and Wei Yan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:111

    Content type: Research

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  12. Despite multidisciplinary treatment, lung cancer remains a highly lethal disease due to poor response to chemotherapy. The identification of therapeutic agents with synergistic effects with traditional drugs i...

    Authors: Hecheng Li, XiaoLi Zhu, Yawei Zhang, Jiaqing Xiang and Haiquan Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:110

    Content type: Research

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  13. Combination chemotherapy with oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) has become a standard regimen for colorectal cancer. An increase of adverse events with combination chemotherapy is predicted i...

    Authors: Shinichi Sugimoto, Kuniyuki Katano, Akiyoshi Kanazawa, Hiroshi Yoshimura, Akihiko Kidani, Hiroshi Takeda, Masato Makino, Nobuhiro Ozaki, Tsuneo Tanaka and Masahide Ikeguchi

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:109

    Content type: Research

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  14. Barrett's mucosa is the precursor of esophageal adenocarcinoma. The molecular mechanisms behind Barrett's carcinogenesis are largely unknown. Experimental models of longstanding esophageal reflux of duodenal-g...

    Authors: Giuseppe Ingravallo, Luigi Dall'Olmo, Daniela Segat, Matteo Fassan, Claudia Mescoli, Emanuela Dazzo, Carlo Castoro, Lorenzo Polimeno, Christian Rizzetto, Maurizio David Baroni, Giovanni Zaninotto, Ermanno Ancona and Massimo Rugge

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:108

    Content type: Research

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  15. Liver cancr is a heterogeneous disease in terms of etiology, biologic and clinical behavior. Very little is known about how many genes concur at the molecular level of tumor development, progression and aggres...

    Authors: Yue-Fang Liu, Bin-Shan Zha, Hui-Lin Zhang, Xiao-Jing Zhu, Yu-Hua Li, Jin Zhu, Xiao-Hong Guan, Zhen-Qing Feng and Jian-Ping Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:107

    Content type: Research

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  16. Genetic instability is known as a cause of oncogenesis. Though Rad18 is reported to function in a post replication mismatch repair system, the relation between the status of Rad18 and human tumorigenesis has n...

    Authors: Tadahiko Nakamura, Shinji Ishikawa, Yoshikatsu Koga, Youhei Nagai, Yu Imamura, Kouei Ikeda, Takeshi Mori, Hiroaki Nomori and Hideo Baba

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:106

    Content type: Review

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  17. Osteosarcoma is a highly malignant bone tumor and is the most commonly encountered malignant bone tumor in children and adolescents. Furthermore, significant numbers of patients eventually develop pulmonary me...

    Authors: Zeng Feng Xin, Yang Kyung Kim and Sung Taek Jung

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:105

    Content type: Research

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  18. Non-synonymous single nucleotide polymorphisms (SNPs) within vital DNA repair genes may cause reduction of activity leaving the genome unrepaired resulting in genomic instability and cancer.

    Authors: Amit Kumar Mitra, Neetu Singh, Vivek Kumar Garg, Rashmi Chaturvedi, Mandira Sharma and Srikanta Kumar Rath

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:104

    Content type: Research

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  19. A reliable and precise classification is essential for successful diagnosis and treatment of cancer. Gene expression microarrays have provided the high-throughput platform to discover genomic biomarkers for ca...

    Authors: Peng Guan, Desheng Huang, Miao He and Baosen Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:103

    Content type: Research

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  20. Opioid analgesics are generally used to combat the pain associated with cancerous conditions. These agents not only inhibit respiratory function and cause constipation, but also induce other significant side e...

    Authors: Hyo-Jeong Lee, Jae-Ho Lee, Eun-Ok Lee, Hyo-Jung Lee, Kwan-Hyun Kim, Sun-Hyung Kim, Keun-Sung Lee, Hee-Jae Jung and Sung-Hoon Kim

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:102

    Content type: Research

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    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2009 28:137

  21. Authors: Huang Hao, Yu Nancai, Fu Lei, Wei Xiong, Su Wen, Huang Guofu, Wu yanxia, Huang Hanju, Liu Qian and Xiao Hong

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:101

    Content type: Retraction Note

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2008 27:27

  22. Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in ...

    Authors: Huaifu Li, Guofeng Ruan, Zhijun Li, Ziwei Liu, Xiaoqing Zheng, Hao zheng, Guangming Cheng, Benyi Li and Ming Zhan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:100

    Content type: Research

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  23. Imatinib, a tyrosine kinase inhibitor currently approved for treatment of several malignancies, has been shown to be a substrate for multiple efflux-transporter proteins, including ABCB1 (P-glycoprotein) and A...

    Authors: Erin R Gardner, Nicola F Smith, William D Figg and Alex Sparreboom

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:99

    Content type: Research

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  24. The prognostic value of HER2 expression in patients with advanced non-small cell lung cancer remains controversial. The relationship between HER2 expression, and platinum resistance and patient survival, was i...

    Authors: Zuleyha Calikusu, Yesim Yildirim, Zafer Akcali, Hakan Sakalli, Nebil Bal, Ilker Unal and Ozgur Ozyilkan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:97

    Content type: Research

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  25. Resveratrol is a non flavonoid polyphenol compound present in many plants and fruits and, at especially high concentrations, in the grape berries of Vitis vinifera. This compound has a strong bioactivity and its ...

    Authors: Valerio Berardi, Francesca Ricci, Mauro Castelli, Gaspare Galati and Gianfranco Risuleo

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:96

    Content type: Research

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  26. To compare intracavitary brachytherapy (ICBT) planning methods for cervical cancer, based on either orthogonal radiographs (conventional plan) or CT sections (CT plan); the comparison focused on target volume ...

    Authors: Cem Onal, Gungor Arslan, Erkan Topkan, Berrin Pehlivan, Melek Yavuz, Ezgi Oymak and Aydin Yavuz

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:95

    Content type: Research

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  27. Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that t...

    Authors: Xiaoxiang Guan, Hui Zhao, Jiangong Niu, Dongfeng Tan, Jaffer A Ajani and Qingyi Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:94

    Content type: Research

    Published on:

  28. Selenite is a promising anticancer agent which has been shown to induce apoptosis in malignant mesothelioma cells in a phenotype-dependent manner, where cells of the chemoresistant sarcomatoid phenotype are mo...

    Authors: Gustav Nilsonne, Eric Olm, Adam Szulkin, Filip Mundt, Agnes Stein, Branka Kocic, Anna-Klara Rundlöf, Aristi P Fernandes, Mikael Björnstedt and Katalin Dobra

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:92

    Content type: Research

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  29. Platinum-based neoadjuvant chemotherapy (NAC) is new therapeutic strategy for locally advanced cervical carcinoma, but the variables used to predict NAC response are still infrequently reported. The aim of our...

    Authors: Xiao-Dong Cheng, Wei-Guo Lu, Feng Ye, Xiao-Yun Wan and Xing Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:91

    Content type: Research

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  30. Type 2 diabetes (T2D) is associated with obesity and has been shown recently to be associated with tumors/cancer. HNF1-beta and JAZF1 genes are associated with T2D and prostate cancer. We have previously shown th...

    Authors: Ramachandran Meenakshisundaram, Nunzia Piumelli, Laura Pierpaoli and Claudia Gragnoli

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:90

    Content type: Research

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  31. Lung cancer is the leading cause of death from cancer worldwide. Conventional studies mainly think that insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) may promote and inhibit tumor gr...

    Authors: Bo Chen, Shan Liu, Wei Xu, Xueli Wang, Weihong Zhao and Jianqing Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:89

    Content type: Research

    Published on:

  32. To show magnetic resonance imaging (MRI) texture appearance change in non-Hodgkin lymphoma (NHL) during treatment with response controlled by quantitative volume analysis.

    Authors: Lara CV Harrison, Tiina Luukkaala, Hannu Pertovaara, Tuomas O Saarinen, Tomi T Heinonen, Ritva Järvenpää, Seppo Soimakallio, Pirkko-Liisa I Kellokumpu-Lehtinen, Hannu J Eskola and Prasun Dastidar

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:87

    Content type: Research

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  33. We aimed to determine the incidence of women's breast cancer in Italy without using statistical approximations.

    Authors: Prisco Piscitelli, Antonio Santoriello, Franco M Buonaguro, Massimo Di Maio, Giovanni Iolascon, Francesca Gimigliano, Alessandra Marinelli, Alessandro Distante, Giuseppe Serravezza, Emiliano Sordi, Katia Cagossi, Fabrizio Artioli, Michele Santangelo, Alfredo Fucito, Raffaele Gimigliano, Maria Luisa Brandi…

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:86

    Content type: Research

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  34. No satisfactory biomarkers are currently available to screen for nasopharyngeal carcinoma (NPC). We have developed and evaluated surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (S...

    Authors: Yuan-Jiao Huang, Chao Xuan, Bei-Bei Zhang, Ming Liao, Kai-Feng Deng, Min He and Jin-Min Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:85

    Content type: Research

    Published on:

  35. Intracellular levels of zinc have shown a strong inverse correlation to growth and malignancy of prostate cancer. To date, studies of zinc supplementation in prostate cancer have been equivocal and have not ac...

    Authors: Maulik R Shah, Christopher L Kriedt, Nathan H Lents, Mary K Hoyer, Nimah Jamaluddin, Claudette Klein and Joseph Baldassare

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:84

    Content type: Research

    Published on:

  36. The aim of this study was to determine a predictive indicator of gemcitabine (GEM) efficacy in unresectable pancreatic cancer using tissue obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy...

    Authors: Reiko Ashida, Bunzo Nakata, Minoru Shigekawa, Nobumasa Mizuno, Akira Sawaki, Kosei Hirakawa, Tetsuo Arakawa and Kenji Yamao

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:83

    Content type: Research

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  37. MircoRNAs(miRNAs) are short, endogenously non-coding RNAs. The abnormal expression of miRNAs may be valuable for the diagnosis and treatment of tumors.

    Authors: Hongchun Luo, Hongbin Zhang, Zhenzhen Zhang, Xia Zhang, Bo Ning, Jinjun Guo, Na Nie, Bo Liu and Xiaoling Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:82

    Content type: Research

    Published on:

  38. Colorectal cancer is a one of the most common alimentary malignancies. Survivin has been proved by many studies to be an ideal target for cancer gene therapy because of its strong anti-apoptotic effect. The re...

    Authors: Wei Shen, Chun-Yi Wang, Xue-Hu Wang and Zhong-Xue Fu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:81

    Content type: Research

    Published on:

  39. The incidence of hepatocellular carcinoma is increasing in many countries. The estimated number of new cases annually is over 500,000, and the yearly incidence comprises between 2.5 and 7% of patients with liv...

    Authors: AlaaEddeen M Seufi, Safinz S Ibrahim, Tarek K Elmaghraby and Elsayed E Hafez

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:80

    Content type: Research

    Published on:

  40. FBG2 (F-BOX6) gene is an important member in ubiquitin metabolic system F-BOX family, and forms E3 complex with the other members in the family. But its role in gastric cancer is still not clear. In the presen...

    Authors: Lin Zhang, Yanhong Hou, Mengwei Wang, Benyan Wu and Nan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:78

    Content type: Research

    Published on:

  41. opioid and somatostatin receptors (SSTRs) that can assemble as heterodimer were individually reported to modulate malignant cell proliferation and to favour apoptosis. Materials and methods: SSTRs and opioid r...

    Authors: Céline Kerros, Thibault Cavey, Brigitte Sola, Philippe Jauzac and Stéphane Allouche

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:77

    Content type: Research

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  42. We observed that paclitaxel altered the pharmacokinetic properties of gemcitabine in patients with non-small cell lung cancer (NSCLC) and limited the accumulation of gemcitabine and its metabolites in various ...

    Authors: Stacy S Shord and Shitalben R Patel

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:76

    Content type: Research

    Published on:

  43. Angiogenesis plays an important role in tumor growth, invasion, and eventually metastasis. Antiangiogenic strategies have been proven to be a promising approach for clinical therapy for a variety of tumors. As...

    Authors: Li-Ping Yang, Ping Cheng, Xing-Chen Peng, Hua-Shan Shi, Wei-Hong He, Feng-Yu Cui, Shun-Tao Luo, Yu-Quan Wei and Li Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:75

    Content type: Research

    Published on:

  44. Centromere protein H (CENP-H) is one of the fundamental components of the human active kinetochore. Recently, CENP-H was identified to be associated with tumorigenesis. This study was aimed to investigate the ...

    Authors: Wen-Ting Liao, Chun-Ping Yu, Dong-Hui Wu, Ling Zhang, Li-Hua Xu, Gui-Xiang Weng, Mu-Sheng Zeng, Li-Bing Song and Jin-Song Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:74

    Content type: Research

    Published on:

  45. Reactive oxygen species (ROS) are closely associated with the intracellular signal cascade, thus strongly implicating involvement in tumor progression. However, the mechanism by which ROS are generated and how...

    Authors: Kyung Hee Lee, Sang Woon Kim and Jae-Ryong Kim

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:73

    Content type: Research

    Published on:

  46. The relapse of cancer after radiotherapy is a clinical knotty problem. Previous studies have demonstrated that the elevation of several factors is likely in some way to lead to the development of treatment tol...

    Authors: Degang Shi, Genming Shi, Gang Huang, Jiren Zhang and Eric Lartigau

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:72

    Content type: Research

    Published on:

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