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  1. Osteosarcoma is the most common primary bone tumor in children and adolescents. Unfortunately, osteosarcoma treatments often fail due to the development of chemoresistance, of which the underlying molecular me...

    Authors: Xin Xiao, Wei Wang, Yuqian Li, Di Yang, Xiaokang Li, Chao Shen, Yan Liu, Xianzhu Ke, Shuo Guo and Zheng Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:201
  2. The function of preadipocytes in the progression of early stage breast cancer has not been fully elucidated at the molecular level. To delineate the role of preadipocytes in breast cancer progression, we inves...

    Authors: Hoe Suk Kim, Minji Jung, Sul Ki Choi, Jisu Woo, Yin Ji Piao, Eun Hye Hwang, Hyelim Kim, Seung Ja Kim and Woo Kyung Moon
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:200
  3. Metastasis rather than the primary cancer determines the survival of cancer patients. Activation of Akt plays a critical role in the epithelial-to-mesenchymal transition (EMT), the initial step in lung cancer ...

    Authors: Jer-Hwa Chang, Chao-Wen Cheng, Yi-Chieh Yang, Wan-Shen Chen, Wen-Yueh Hung, Jyh-Ming Chow, Pai-Sheng Chen, Michael Hsiao, Wei-Jiunn Lee and Ming-Hsien Chien
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:199
  4. Phosphatase and tensin homolog (PTEN) is an important tumor suppressor gene, and its encoded protein has activities of both a protein phosphatase and a lipid phosphatase. However, the substitution effect of pr...

    Authors: Wenting Xu, Zhen Yang, Chuan Xie, Yin Zhu, Xu Shu, Zhe Zhang, Nianshuang Li, Na Chai, Song Zhang, Kaichun Wu, Yongzhan Nie and Nonghua Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:198
  5. Bone tissue is one of the main sites for breast metastasis; patients diagnosed with advanced breast cancer mostly develop bone metastasis characterized by severe osteolytic lesions, which heavily influence the...

    Authors: Valeria Carina, Viviana Costa, Stefania Pagani, Angela De Luca, Lavinia Raimondi, Daniele Bellavia, Stefania Setti, Milena Fini and Gianluca Giavaresi
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:197
  6. Interleukin-33 (IL-33) participates in various types of diseases including cancers. Previous studies of this cytokine in cancers mainly focused on its regulation on immune responses by which IL-33 modulated ca...

    Authors: Yongkui Li, Jie Shi, Shanshan Qi, Jian Zhang, Dong Peng, Zhenzhen Chen, Guobin Wang, Zheng Wang and Lin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:196

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:15

  7. The high incidence and mortality of lung tumours is a major health problem. Therefore, the identification both of biomarkers predicting efficacy for therapies in use and of novel efficacious therapeutic agents...

    Authors: Irene Ferrer, Álvaro Quintanal-Villalonga, Sonia Molina-Pinelo, Jose Manuel Garcia-Heredia, Marco Perez, Rocío Suárez, Santiago Ponce-Aix, Luis Paz-Ares and Amancio Carnero
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:195
  8. Cancer cells maintain energy metabolism mainly by glycolysis, even under sufficient oxygen conditions. It gives cancer cells better growth advantages under complicated internal environment. KPNA2 is a novel on...

    Authors: Jie Li, Qian Liu, Zihao Liu, Qian Xia, Zihao Zhang, Rui Zhang, Taihong Gao, Guangyan Gu, Yanan Wang, Dan Wang, Xiuyang Chen, Yihang Yang, Dong He and Tao Xin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:194
  9. Holliday junction recognition protein (HJURP) has been implicated in many cancers including hepatocellular carcinoma (HCC). However, the underlying mechanism by which HJURP promotes HCC cell proliferation rema...

    Authors: Tianchi Chen, Hechen Huang, Yuan Zhou, Lei Geng, Tian Shen, Shengyong Yin, Lin Zhou and Shusen Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:193
  10. Epstein-Barr virus (EBV) is widely found in nasopharyngeal carcinoma (NPC) tissue and associated with poor prognosis of patients. EBV nuclear antigen 1 (EBNA1) is expressed in all NPC tumors and plays multiple...

    Authors: Heng Zhou, Yu Liu, Chao Wang, Limei Liu, Huan Wang, Yaqian Zhang, Cong Long and Xiaoping Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:192
  11. Murine breast cancer models relying on intraductal tumor cell inoculations are attractive because they allow the study of breast cancer from early ductal carcinoma in situ to metastasis. Using a fully immunoco...

    Authors: Jonas Steenbrugge, Koen Breyne, Kristel Demeyere, Olivier De Wever, Niek N. Sanders, Wim Van Den Broeck, Cecile Colpaert, Peter Vermeulen, Steven Van Laere and Evelyne Meyer
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:191
  12. Exosomes derived from tumor cells (TEXs) are involved in both immune suppression, angiogenesis, metastasis and anticancer stimulatory, but the biological characteristics and role of diffuse large B cell lympho...

    Authors: Zhenzhen Chen, Liangshun You, Lei Wang, Xianbo Huang, Hui Liu, Ju ying Wei, Li Zhu and Wenbin Qian
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:190
  13. Makorin RING zinc finger-2 (MKRN2) belongs to the makorin RING zinc finger family and is a novel ubiquitin E3 ligase targeting the p65 subunit of NF-κB to negatively regulate inflammatory responses; however, the ...

    Authors: Jun Jiang, Yitong Xu, Hongjiu Ren, Muli Wudu, Qiongzi Wang, Xin Song, Hongbo Su, Xizi Jiang, Lihong Jiang and Xueshan Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:189
  14. Over the last two or three decades, the pace of development of treatments for osteosarcoma tends has been slow. Novel effective therapies for osteosarcoma are still lacking. Previously, we reported that tumor-...

    Authors: Guo-sheng Zhao, Zi-ran Gao, Qiao Zhang, Xue-feng Tang, Yang-fan Lv, Zhao-si Zhang, Yuan Zhang, Qiu-lin Tan, Dong-bin Peng, Dian-ming Jiang and Qiao-Nan Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:188
  15. Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlyi...

    Authors: Hongshun Shi, Hui Li, Ronghua Yuan, Wen Guan, Xiaomei Zhang, Shaoyang Zhang, Wenliang Zhang, Fang Tong, Li Li, Zhihong Song, Changwei Wang, Shulan Yang and Haihe Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:187
  16. Gallbladder cancer (GBC) is a highly malignant cancer with poor prognosis. Several long noncoding RNAs (lncRNAs) have been reported to be involved in the tumorigenesis and progression of GBC. However, the expr...

    Authors: Liang Yang, Qingxiang Gao, Xiaoxiong Wu, Feiling Feng and Kaiyun Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:186
  17. Tumor cells transfer into endothelial cells by epithelial–endothelial transition (EET), which is characterized by vasculagenic mimicry (VM) in morphology. VM can change tumor microcirculation, progression, and...

    Authors: Ting Xiao, Qiang Zhang, Shumin Zong, Wei-long Zhong, Yuan Qin, Zhun Bi, Shuang Chen, Hui-juan Liu, Jun-jie Wei, Bi-jiao Zhou, Lu-meng Wang, Hong-gang Zhou, Yan-rong Liu, Tao Sun and Cheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:185
  18. Isoliquiritigenin (ISL), a natural flavonoid isolated from the root of licorice (Glycyrrhiza uralensis), has shown various pharmacological properties including anti-oxidant, anti-inflammatory and anti-cancer acti...

    Authors: Shijian Xiang, Huoji Chen, Xiaojun Luo, Baichao An, Wenfeng Wu, Siwei Cao, Shifa Ruan, Zhuxian Wang, Lidong Weng, Hongxia Zhu and Qiang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:184
  19. ANXA2 (Annexin A2) is a pleiotropic calcium-dependent phospholipid binding protein that is abnormally expressed in various cancers. We previously found that ANXA2 is upregulated in esophageal squamous cell car...

    Authors: Sai Ma, Chen-Chen Lu, Li-Yan Yang, Juan-Juan Wang, Bo-Shi Wang, Hong-Qing Cai, Jia-Jie Hao, Xin Xu, Yan Cai, Yu Zhang and Ming-Rong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:183
  20. Human telomerase reverse transcriptase (hTERT) is highly expressed in over 80% of tumors, including human epithelial ovarian cancer (EOC). However, the mechanisms through which hTERT is up-regulated in EOC and...

    Authors: Yong-Bin Liu, Ying Mei, Jing Long, Yu Zhang, Dong-Li Hu and Hong-Hao Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:182
  21. Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Gliobla...

    Authors: Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You and Qin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:181
  22. Glioma is the most common primary central nervous system tumor derived from glial cells. Kininogen-1 (KNG1) can exert antiangiogenic properties and inhibit proliferation of endothelial cells. The effect of KNG...

    Authors: Jinfang Xu, Jun Fang, Zhonghao Cheng, Longlong Fan, Weiwei Hu, Feng Zhou and Hong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:180
  23. In hepatocellular carcinoma (HCC), CD133+/CD44+ cells are one subgroup with high stemness and responsible for metastatic relapse and resistance to treatment. Our previous studies have demonstrated that osteopo...

    Authors: Xiaomei Gao, Yuanyuan Sheng, Jing Yang, Chaoqun Wang, Rui Zhang, Ying Zhu, Ze Zhang, Kaili Zhang, Shican Yan, Haoting Sun, Jinwang Wei, Xuan Wang, Xinxin Yu, Yu Zhang, Qin Luo, Yan Zheng…
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:179

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:266

  24. Colorectal cancer (CRC) is a commonly diagnosed digestive malignancy worldwide. Ras-related protein 1A (RAP1A) is a member of the Ras superfamily of small GTPases and has been recently identified as a novel on...

    Authors: Liguo Liu, Xuebing Yan, Dapeng Wu, Yi Yang, Mengcheng Li, Yang Su, Wenchao Yang, Zezhi Shan, Yuping Gao and Zhiming Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:178
  25. Recent studies show that exosomes are involved in intercellular communication and that abundant circular RNAs (circRNAs) are present within exosomes. However, whether these exosomal circRNAs contribute to tumo...

    Authors: Jie Li, Zhonghu Li, Peng Jiang, Minjie Peng, Xi Zhang, Kai Chen, Hui Liu, Huaqiang Bi, Xiangde Liu and Xiaowu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:177
  26. Adaptation to ER stress has been indicated to play an important role in resistance to therapy in human melanoma. However, the relationship between adaptation to ER stress and cell metastasis in human melanoma ...

    Authors: Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao and Chuanchun Han
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:176

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:385

  27. Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved in many aspects of tumour biology. However, its role in focal adhesion ...

    Authors: Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong and Daxing Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:175

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:271

  28. The development of radioresistance is one of main causes for therapeutic failure of prostate cancer (PCa). The present study aims to investigate the function and the related mechanism by which HZ08 sensitizes ...

    Authors: Yanyan Zhang, Zhi Xu, Jiaji Ding, Chunli Tan, Weizi Hu, Yunman Li, Wenlong Huang and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:174
  29. The pathophysiological roles and the therapeutic potentials of Myc family are reviewed in this article. The physiological functions and molecular machineries in stem cells, including embryonic stem (ES) cells ...

    Authors: Go J. Yoshida
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:173

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:285

  30. Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in hepatocellular cancer (HCC) is largely unk...

    Authors: Ning Bai, Eming Peng, Xingsheng Qiu, Ning Lyu, Zhejia Zhang, Yiming Tao, Xinying Li and Zhiming Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:172
  31. Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become a major obstacle in improving the clinical outcome of patients with metastatic and advanced-stage esophageal squamous cell car...

    Authors: Min Kang, Meiping Ren, Yan Li, Yuqiong Fu, Minmin Deng and Changping Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:171
  32. Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, resulting from the t(9;22) chromosomal translocation. Imatinib (gleeve...

    Authors: Francesca Monteleone, Simona Taverna, Riccardo Alessandro and Simona Fontana
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:170
  33. Increasing studies confirmed that abnormal lncRNAs expression play a critical role in cervical cancer (CC) development and progression. LncRNA TPT1-AS1, a novel lncRNA, its role and underlying mechanisms invol...

    Authors: Hui Jiang, Guanqun Huang, Nianzhang Zhao, Ting Zhang, Mengni Jiang, Yueming He, Xinke Zhou and Xianhan Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:169
  34. Glioblastoma (GBM) is a primary brain tumor with a 5-year survival rate of ≤5%. We have shown earlier that GBM-antibody-linked curcumin (CC) and also phytosomal curcumin (CCP) rescue 50–60% of GBM-bearing mice...

    Authors: Sumit Mukherjee, Angela Fried, Rahman Hussaini, Richard White, Juliet Baidoo, Sri Yalamanchi and Probal Banerjee
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:168
  35. Aberrant expression of Wiskott–Aldrich syndrome protein interacting protein family member 1 (WIPF1) contributes to the invasion and metastasis of several malignancies. However, the role of WIPF1 in human pancr...

    Authors: Yu Pan, Fengchun Lu, Ping Xiong, Maoen Pan, Zheyang Zhang, Xianchao Lin, Minggui Pan and Heguang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:167
  36. The KRAS mutation is the driving force of pancreatic ductal adenocarcinoma (PDAC). Downstream effectors of KRAS signal pathways are crucial to the development of PDAC. The purpose of this study was to investig...

    Authors: Yan Sun, Wenfang Peng, Weiwei He, Man Luo, Guilin Chang, Jiping Shen, Xiaoping Zhao and Yu Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:166
  37. Aberrant activation of β-catenin and Yes-associated protein (YAP) signaling pathways has been associated with hepatocellular carcinoma (HCC) progression. The LIM domain protein Ajuba regulates β-catenin and YA...

    Authors: Min Liu, Ke Jiang, Guibin Lin, Peng Liu, Yumei Yan, Tian Ye, Gang Yao, Martin P. Barr, Dapeng Liang, Yang Wang, Peng Gong, Songshu Meng and Haozhe Piao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:165
  38. Tongue squamous cell carcinoma (TSCC) is the most common oral cancer. Neoadjuvant systemic treatment before or after surgery for advanced TSCC is considered one of the most crucial factors in reducing mortalit...

    Authors: Yixue Gu, Hao Liu, Fangren Kong, Jiahui Ye, Xiaoting Jia, Zhijie Zhang, Nan Li, Jiang Yin, Guopei Zheng and Zhimin He
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:164
  39. Biomarkers are an integral part of cancer management due to their use in risk assessment, screening, differential diagnosis, prognosis, prediction of response to treatment, and monitoring progress of disease. ...

    Authors: Michelle H. Townsend, Gajendra Shrestha, Richard A. Robison and Kim L. O’Neill
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:163
  40. Exosomes are critically involved in cancer development and progression. The exosomal contents have been suggested as ideal cancer biomarkers. In this study, we investigated the expression of exosomal proteins ...

    Authors: Hailong Fu, Huan Yang, Xu Zhang, Bo Wang, Jiahui Mao, Xia Li, Mei Wang, Bin Zhang, Zixuan Sun, Hui Qian and Wenrong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:162
  41. Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward o...

    Authors: Huei-Yu Chen, Atikul Islam, Tien-Ming Yuan, Shi-Wen Chen, Pei-Fen Liu and Pin Ju Chueh
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:161
  42. Bone metastasis is a leading cause of morbidity and mortality in advanced prostate cancer (PCa). Downexpression of miR-133a-3p has been found to contribute to the progression, recurrence and distant metastasis...

    Authors: Yubo Tang, Jincheng Pan, Shuai Huang, Xinsheng Peng, Xuenong Zou, Yongxiang Luo, Dong Ren, Xin Zhang, Ronggang Li, Peiheng He and Qingde Wa
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:160
  43. Paired box 8 (PAX8) has been documented to be downregulated in gastric cancer. However, its biological function in this malignancy is poorly understood.

    Authors: Liyan Wang, Xiaotong Bo, Qinghua Zheng, Wenhong Ge, Yanhua Liu and Bin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:159
  44. Brain invasion by glioblastoma (GBM) determines recurrence and prognosis in patients, which is, in part, attributed to increased mesenchymal transition. Here, we report evidence favoring such a role for the Pr...

    Authors: Xiupeng Xu, Zhongyuan Bao, Yinlong Liu, Kuan Jiang, Tongle Zhi, Dong Wang, Liang Fan, Ning Liu and Jing Ji
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:158
  45. Lycorine has been revealed to inhibit the development of many kinds of malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences demonstrated Lycorine’s inhibition on cancers thr...

    Authors: Jia Shen, Tao Zhang, Zheng Cheng, Ni Zhu, Hua Wang, Li Lin, Zexia Wang, Haotian Yi and Meichun Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:157
  46. Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, pl...

    Authors: Ganlu Deng, Shan Zeng, Yanling Qu, Qingqing Luo, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Changjing Cai, Yaojie Fu and Hong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:156
  47. In the publication of this article [1], there is an error in the Figure caption of Figs. 2, 3 and 4. This has now been included in this correction. The authors declare that these corrections do not change the ...

    Authors: Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li and Bo Xiang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:155

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:118

  48. Uncontrolled proliferation is thought to be the most fundamental characteristic of cancer. Detailed knowledge of cancer cell proliferation mechanisms would not only benefit understanding of cancer progression,...

    Authors: Mingkun Chen, Rongpei Wu, Gang Li, Cundong Liu, Lei Tan, Kanghua Xiao, Yunlin Ye and Zike Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:154
  49. The poly ADP ribose polymerase (PARP) inhibitor olaparib has been approved for treating prostate cancer (PCa) with BRCA mutations, and veliparib, another PARP inhibitor, is being tested in clinical trials. How...

    Authors: Linglong Yin, Youhong Liu, Yuchong Peng, Yongbo Peng, Xiaohui Yu, Yingxue Gao, Bowen Yuan, Qianling Zhu, Tuoyu Cao, Leye He, Zhicheng Gong, Lunquan Sun, Xuegong Fan and Xiong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:153

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:72

  50. As novel biomarkers for various cancers, microRNAs negatively regulate genes expression via promoting mRNA degradation and suppressing mRNA translation. miR-589 has been reported to be deregulated in several h...

    Authors: Feifei Zhang, Kaitao Li, Mingxin Pan, Weidong Li, Juan Wu, Mingyi Li, Liang Zhao and Hui Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:152

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