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  1. PET (Positron Emission Tomography) is a nuclear medicine imaging method, frequently used in oncology during the last years. It is a non-invasive technique that provides quantitative in vivo assessment of physi...

    Authors: Evelina Miele, Gian Paolo Spinelli, Federica Tomao, Angelo Zullo, Filippo De Marinis, Giulia Pasciuti, Luigi Rossi, Federica Zoratto and Silverio Tomao

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:52

    Content type: Review

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  2. p27Kip1 plays a major role as a negative regulator of the cell cycle. The regulation of p27Kip1 degradation is mediated by its specific ubiquitin ligase subunits S-phase kinase protein (Skp) 2 and cyclin-dependen...

    Authors: Zheng Liu, Qiang Fu, Jiaju Lv, Facheng Wang and Kejia Ding

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:51

    Content type: Research

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  3. CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells a...

    Authors: Ai-Rong Qian, Wei Zhang, Jian-Ping Cao, Peng-Fei Yang, Xiang Gao, Zhe Wang, Hui-Yun Xu, Yuan-Yuan Weng and Peng Shang

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:50

    Content type: Research

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  4. Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interactions between polymorphisms of repair genes and tobacco...

    Authors: Mayumi Kasahara, Kayo Osawa, Kana Yoshida, Aiko Miyaishi, Yasunori Osawa, Natsuko Inoue, Akimitsu Tsutou, Yoshiki Tabuchi, Kenichi Tanaka, Masahiro Yamamoto, Etsuji Shimada and Juro Takahashi

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:49

    Content type: Research

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  5. Second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to...

    Authors: Gustavo Martinez-Ruiz, Vilma Maldonado, Gisela Ceballos-Cancino, Juan P Reyes Grajeda and Jorge Melendez-Zajgla

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:48

    Content type: Review

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  6. Metastasis in breast cancer is a vital concern in treatment because most women with primary breast cancer have micrometastases to distant sites at diagnosis. As a member of the inhibitor of apoptosis protein (...

    Authors: Xing-Chen Peng, Li Yang, Li-Ping Yang, Yong-Qiu Mao, Han-Shuo Yang, Ji-Yan Liu, Dong-Mei Zhang, li-Juan Chen and Yu-Quan Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:46

    Content type: Research

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  7. Lung cancer is the commonest cause of cancer death in developed countries. Adenocarcinoma is becoming the most common form of lung cancer. Cigarette smoking is the main risk factor for lung cancer. Long-term c...

    Authors: David Stav, Ilan Bar and Judith Sandbank

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:45

    Content type: Research

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  8. Reactive oxygen species (ROS) are intricately involved in tumor progression through effects on proliferation, apoptosis and metastasis. But how ROS works is not well understood. In previous study, we found PUM...

    Authors: Xinying Wang, Jing Wang, Shiyong Lin, Yan Geng, Jide Wang and Bo Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:44

    Content type: Research

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  9. Valid interview data is critical to the final results of the study. The purpose of this study was to investigate the reliability of epidemiological data obtained in non-smoking female lung cancer case-control ...

    Authors: Desheng Huang, Peng Guan, Hailong Shi, Qincheng He and Baosen Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:43

    Content type: Research

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  10. To investigate the feasibility of gene therapy in treating Epstein-Barr virus (EBV)-associated cancer by employing the suicide gene, herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV), which uses t...

    Authors: Yang Lifang, Tang Min, Ai Midan and Cao Ya

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:42

    Content type: Research

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  11. To compare computed tomography (CT) with co-registered positron emission tomography-computed tomography (PET-CT) as the basis for delineating gross tumor volume (GTV) in unresectable, locally advanced pancreat...

    Authors: Erkan Topkan, Ali A Yavuz, Mehmet Aydin, Cem Onal, Fuat Yapar and Melek N Yavuz

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:41

    Content type: Research

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  12. β-(1,3)/(1,6) D-glucan, a component of the fungal cell wall, has been shown to stimulate the immune system, enhance hematopoiesis, amplify killing of opsonized tumor cells and increase neutrophil chemotaxis an...

    Authors: Alan B Weitberg

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:40

    Content type: Research

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  13. Patients with hereditary non-poliposys colorectal cancer (HNPCC) have better prognosis than sporadic colorectal cancer (CRC). Aim of our retrospective study was to compare the overall survival between sporadic...

    Authors: Vittoria Stigliano, Daniela Assisi, Maurizio Cosimelli, Raffaele Palmirotta, Diana Giannarelli, Marcella Mottolese, Lupe Sanchez Mete, Raffaello Mancini and Vincenzo Casale

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:39

    Content type: Case study

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  14. Lung cancer remains a major health challenge in the world. Survival for patients with stage I disease ranges between 40–70%. This suggests that a significant proportion of patients with stage I NSCLC may actua...

    Authors: Mara Campioni, Vincenzo Ambrogi, Eugenio Pompeo, Gennaro Citro, Mauro Castelli, Enrico P Spugnini, Antonio Gatti, Pierluigi Cardelli, Laura Lorenzon, Alfonso Baldi and Tommaso C Mineo

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:38

    Content type: Research

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  15. The management of hormone-refractory prostate cancer (HRPC) still remains as an important challenge of daily oncology practice. Docetaxel has proved to be a first line treatment choice. All-trans retinoic acid...

    Authors: Yuksel Kucukzeybek, Mustafa K Gul, Ercument Cengiz, Cigdem Erten, Burcak Karaca, Gurbuz Gorumlu, Harika Atmaca, Selim Uzunoglu, Bulent Karabulut, Ulus A Sanli and Ruchan Uslu

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:37

    Content type: Research

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  16. Infected cells recognize viral replication as a DNA damage stress and elicit the host surveillance mechanism to anti-virus infection. Modulation of the activity of tumor suppressor p53 is a key event in the re...

    Authors: Lina Sun, Ge Zhang, Zongfang Li, Tusheng Song, Chen Huang and Lusheng Si

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:35

    Content type: Research

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  17. Reported data indicate that cancer cells have increased rates of glucose metabolism, as determined by 18FDG-PET imaging in patients with malignancies. The results of many studies have demonstrated that the exp...

    Authors: Paola Parente, Antonella Coli, Guido Massi, Antonella Mangoni, Manuela M Fabrizi and Giulio Bigotti

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:34

    Content type: Research

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  18. Follicular dendritic cell (FDC) sarcoma is a rare neoplasm arising in lymph nodes but also in extranodal sites from accessory cells of the immune system that are essential for the function of antigen presentat...

    Authors: Francesco Pisani, Mirella Marino, Steno Sentinelli and Maria Concetta Petti

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:33

    Content type: Case report

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  19. Many kinds of Chinese herb had been confirmed to have the character of anti-tumor, clinical reports about anti-tumor effects of Chinese herb had also been found in recent years, but most of the reports were fo...

    Authors: Yun Lu, Chang-Sheng Li and Qian Dong

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:31

    Content type: Review

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  20. To develop a novel therapeutic strategy for human pancreatic cancer using a midkine promoter-based conditionally replicating adenovirus.

    Authors: Eiji Toyoda, Ryuichiro Doi, Kazuhiro Kami, Tomohiko Mori, Daisuke Ito, Masayuki Koizumi, Atsushi Kida, Kazuyuki Nagai, Tatsuo Ito, Toshihiko Masui, Michihiko Wada, Masatoshi Tagawa and Shinji Uemoto

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:30

    Content type: Research

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  21. The detection of sub-clinical breast lesions has increased with screening mammography. Biopsy techniques can offer precision and agility in its execution, as well as patient comfort. This trial compares radiog...

    Authors: Marcelo Moreno, Janete Eunice Wiltgen, Benito Bodanese, Ricardo Ludwig Schmitt, Bianca Gutfilen and Lea Mirian Barbosa da Fonseca

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:29

    Content type: Research

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  22. Deaths after percutaneous ethanol injection (PEI) into hepatocellular carcinoma (HCC) may occur within a few hours to a few days following the procedure because of hemoperitoneum and haemorrhage from oesophage...

    Authors: Enrico M Zardi, Francesco Di Matteo, Daniele Santini, Valentina Uwechie, Pierfilippo Crucitti, Massimiliano Carassiti, Antonio Picardi, Eleonora Perrella, Marco Caricato, Giuseppe Tonini, Roberto Coppola and Antonella Afeltra

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:28

    Content type: Review

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  23. The c-Myc and human telomerase reverse transcriptase gene (hTERT) gene are frequently deregulated and overexpressed in malignancy. hTERT activity is induced by c-Myc and strategies designed to inhibit c-Myc ex...

    Authors: Huang Hao, Yu Nancai, Fu Lei, Wei Xiong, Su Wen, Huang Guofu, Wu yanxia, Huang Hanju, Liu Qian and Xiao Hong

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:27

    Content type: Research

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    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2009 28:101

  24. To evaluate the relationship between Aberrant Crypt Foci (ACF) and tumorigenesis, we observed the sequential development from ACF to tumor in the colon of azoxymethane-exposed wistar rats.

    Authors: Qing Lu, Bo Jiang, Chen Lin and Tao Shan

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:26

    Content type: Research

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    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2008 27:47

  25. A novel human nuclear receptor interaction protein (NRIP) has recently been discovered by Chen SL et al, which may play a role in enhancing the transcriptional activity of steroid nuclear receptors in prostate...

    Authors: Chih-Ping Han, Ming-Yung Lee, Shu-Ling Tzeng, Chung-Chin Yao, Po-Hui Wang, Ya-Wen Cheng, Show-Li Chen, Teresa S Wu, Yeu-Sheng Tyan and Lai-Fong Kok

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:25

    Content type: Research

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  26. DNA-methyltransferase-3B (DNMT3B), which plays a role in DNA methylation, is usually aberrant expression involved in carcinogenesis. Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methyl...

    Authors: Hong Fan, Feng Zhang, Jiabo Hu, Dongsheng Liu and Zhujiang Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:24

    Content type: Research

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  27. Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix (ECM) and basement membrane. Expression of the heparanase gene is associated with...

    Authors: Xin Hong, Feng Jiang, Steven N Kalkanis, Zheng Gang Zhang, Xuepeng Zhang, Xuguang Zheng, Hao Jiang, Tom Mikkelsen and Michael Chopp

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:23

    Content type: Research

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  28. Homeodomain-interacting protein kinase-2 (HIPK2) plays an essential role in restraining tumor progression as it may regulate, by itself or within multiprotein complexes, many proteins (mainly transcription fac...

    Authors: Rosa Puca, Lavinia Nardinocchi and Gabriella D'Orazi

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:22

    Content type: Research

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  29. Cancer and its therapies increase the risk of venous thromboembolism. Compared to patients without cancer, patients with cancer anticoagulated for venous thromboembolism are more likely to develop recurrent th...

    Authors: Elie A Akl, Maddalena Barba, Sandeep Rohilla, Irene Terrenato, Francesca Sperati, Paola Muti and Holger J Schünemann

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:21

    Content type: Research

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  30. The objective was to understand the influence of Survivin plasmid with short hairpin RNA (shRNA) on the cell cycle, invasion, and the silencing effect of Survivin gene in the SW480 cell of colorectal carcinoma.

    Authors: Liu Zhonghong, Lin Lianjie, Zheng Changqing, He Ying, Jin Yu and Lin Yan

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:20

    Content type: Research

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  31. In these years a huge number of human transcripts has been found that do not code for proteins, named non-protein coding RNAs. In most cases, small (miRNAs, snoRNAs) and long RNAs (antisense RNA, dsRNA, and lo...

    Authors: Massimo Mallardo, Palmiro Poltronieri and Oscar Fernando D'Urso

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:19

    Content type: Review

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  32. Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions. Retinoids have been used as chemopreventive and anti...

    Authors: Krisztina Bogos, Ferenc Renyi-Vamos, Gabor Kovacs, Jozsef Tovari and Balazs Dome

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:18

    Content type: Review

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  33. Third world breast cancer is characterized by late presentation, occurrence at relatively young ages and dismal mortality. This poor outcome has encouraged patients to patronize quacks and alternative healers....

    Authors: Stanley NC Anyanwu

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:17

    Content type: Research

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  34. The paper reports the electric, magnetic and electromagnetic fields (emf) measurements carried out in the Regina Elena National Cancer Institute (NCI). Several devices, used in diagnostics and in medical cures, c...

    Authors: Anna Maria Di Nallo, Lidia Strigari, Claudia Giliberti, Angelico Bedini, Raffaele Palomba and Marcello Benassi

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:16

    Content type: Research

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  35. The cellular apoptosis susceptibility (CAS) protein is regarded as a proliferation-associated protein that associates with tumour proliferation as it associates with microtubule and functions in the mitotic sp...

    Authors: Ching-Fong Liao, Shue-Fen Luo, Li-Tzu Li, Chuang-Yu Lin, Ying-Chun Chen and Ming-Chung Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:15

    Content type: Research

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  36. In nuclear medicine, liquid radiopharmaceuticals for diagnostic or therapeutic purposes are administered to patients by using various types of syringes with different volumes. The activity of each "dose" must ...

    Authors: Lidia Strigari, Marcello Benassi, Pierino De Felice, Marco D'Andrea, Aldo Fazio, Sandro Nocentini, Annelisa d'Angelo and Alessia Ceccatelli

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:14

    Content type: Research

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  37. Multiple Myeloma (MM) is a B cell neoplasm characterized by the clonal proliferation of plasma cells. Skeletal complications are found in up to 80% of myeloma patients at presentation and are major cause of mo...

    Authors: Mehmet Sonmez, Tulin Akagun, Murat Topbas, Umit Cobanoglu, Bircan Sonmez, Mustafa Yilmaz, Ercument Ovali and Serdar Bedii Omay

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:11

    Content type: Research

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  38. Although some clinical and radiological features may predict malignancy presence in intraductal papillary mucinous pancreas neoplasms, preoperative diagnosis remains difficult. In this study we present 7 patie...

    Authors: Gian Luca Baiocchi, Nazario Portolani, Francesco Bertagna, Federico Gheza, Claudio Pizzocaro, Raffaele Giubbini and Stefano M Giulini

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:10

    Content type: Research

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  39. HIV infection is reported to be associated with some malignant lymphomas (ML) so called AIDS-related lymphomas (ARL), with an aggressive behavior and poor prognosis. The ML frequency, pathogenicity, clinical p...

    Authors: Amos R Mwakigonja, Ephata E Kaaya and Edward M Mgaya

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:9

    Content type: Research

    Published on:

  40. Controversy still exists in the indication and timing of surgical treatment of pulmonary hamartoma (PH). The objective of this study is to summarize the experience and the outcome of the surgical treatment for...

    Authors: Wei Guo, Yun-Ping Zhao, Yao-Guang Jiang, Ru-Wen Wang and Zheng Ma

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:8

    Content type: Research

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  41. We investigated the presence and distribution of the sentinel and the non-sentinel node micrometastases using complete serial sectioning and immunohistochemical staining (IHC), to inspect whether lymph node mi...

    Authors: Kaname Ishii, Shinichi Kinami, Kenichiro Funaki, Hideto Fujita, Itasu Ninomiya, Sachio Fushida, Takashi Fujimura, Genichi Nishimura and Masato Kayahara

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:7

    Content type: Research

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  42. Malignant Mesothelioma is an uncommon and very aggressive tumor that accounts for 1% of all the deaths secondary to malignancy in humans. Interestingly, this neoplasm has been occasionally described in compani...

    Authors: Enrico P Spugnini, Stefania Crispi, Alessandra Scarabello, Giovanni Caruso, Gennaro Citro and Alfonso Baldi

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:6

    Content type: Research

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  43. Five-fluorouracil (FU), mainly associated with leucovorin (L), plays an essential role in chemotherapy of colorectal carcinoma. Moreover, FU ± L has been found to increase the expression of tumor-associated ca...

    Authors: Salvatore P Prete, Mario Turriziani, Maria C Massara, Alessia De Rossi, Pierpaolo Correale, Liana De Vecchis, Francesco Torino, Laura Bonmassar and Angelo Aquino

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:5

    Content type: Research

    Published on:

  44. To determine the efficacy and safety of heparin (unfractionated heparin (UFH) or low-molecular-weight-heparin (LMWH)) and fondaparinux in improving the survival of patients with cancer.

    Authors: Elie A Akl, Frederiek F van Doormaal, Maddalena Barba, Ganesh Kamath, Seo Young Kim, Saskia Kuipers, Saskia Middeldorp, Victor Yosuico, Heather O Dickinson and Holger J Schünemann

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:4

    Content type: Research

    Published on:

  45. alpha-Methylacyl-CoA racemase (AMACR), an immunomarker for prostatic adenocarcinoma, has been shown to be expressed in a variety of other neoplasms. This study aims to evaluate immunohistochemical expression o...

    Authors: Wei Li, Philip T Cagle, Rafael C Botero, John J Liang, Zhaoping Zhang and Dongfeng Tan

    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:2

    Content type: Research

    Published on:

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