Skip to main content

Articles

Page 46 of 75

  1. Glioma is a heterogeneous, invasive primary brain tumor with a wide range of patient survival and a lack of reliable prognostic biomarkers. Human telomerase reverse transcriptase (hTERT) has been reported in t...

    Authors: Guihong Li, Jing Shen, Junguo Cao, Guangtong Zhou, Ting Lei, Yuxue Sun, Haijun Gao, Yaonan Ding, Weidong Xu, Zhixin Zhan, Yong Chen and Haiyan Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:78
  2. Dying cells after irradiation could promote the repopulation of surviving cancer cells leading to tumor recurrence. We aim to define the role of dying cells in promoting pancreatic cancer cells metastasis foll...

    Authors: Xuelian Chen, Lirong Zhang, Yujie Jiang, Lian Song, Yanfang Liu, Fang Cheng, Xin Fan, Xiongfeng Cao, Aihua Gong, Dongqing Wang and Haitao Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:77
  3. By regulating target genes, microRNAs play essential roles in carcinogenesis and drug resistance in human pancreatic ductal adenocarcinoma (PDAC). Previous studies have shown that microRNA-10a-5p (miR-10a-5p) ...

    Authors: Guangbing Xiong, Hua Huang, Mengyu Feng, Gang Yang, Suli Zheng, Lei You, Lianfang Zheng, Ya Hu, Taiping Zhang and Yupei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:76

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:369

  4. Current insights into the effects of iron deficiency in tumour cells are not commensurate with the importance of iron in cell metabolism. Studies have predominantly focused on the effects of oxygen or glucose ...

    Authors: Maida De Bortoli, Elena Taverna, Elisa Maffioli, Patrizia Casalini, Francesco Crisafi, Vikas Kumar, Claudio Caccia, Dario Polli, Gabriella Tedeschi and Italia Bongarzone
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:75
  5. Controlling vascular growth is a challenging aim for the inhibition of tumor growth and metastasis. The amoeboid and mesenchymal types of invasiveness are two modes of migration interchangeable in cancer cells...

    Authors: Anastasia Chillà, Francesca Margheri, Alessio Biagioni, Mario Del Rosso, Gabriella Fibbi and Anna Laurenzana
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:74
  6. Despite SGK1 has been identified and characterized as a tumor-promoting gene, the functions and underlying mechanisms of SGK1 involved in metastasis regulation have not yet been investigated in cancer.

    Authors: Weiwei Liu, Xuchu Wang, Yiyun Wang, Yibei Dai, Yiyi Xie, Ying Ping, Binbin Yin, Pan Yu, Zhenping Liu, Xiuzhi Duan, Zhaoping Liao, Yuhua Chen, Chunhua Liu, Xiang Li and Zhihua Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:73
  7. Cell cycle regulators have gain attention as potential targets for anticancer therapy. Palbociclib is a selective inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6), which coordinate the G1-S transitio...

    Authors: Daniele Cretella, Andrea Ravelli, Claudia Fumarola, Silvia La Monica, Graziana Digiacomo, Andrea Cavazzoni, Roberta Alfieri, Alessandra Biondi, Daniele Generali, Mara Bonelli and Pier Giorgio Petronini
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:72
  8. Our previous work showed that some Rho GTPases, including Rho, Rac1 and Cdc42, play critical roles in gastric cancer (GC); however, how they are regulated in GC remains largely unknown. In this study, we aimed...

    Authors: Xiaowei Li, Mingzuo Jiang, Di Chen, Bing Xu, Rui Wang, Yi Chu, Weijie Wang, Lin Zhou, Zhijie Lei, Yongzhan Nie, Daiming Fan, Yulong Shang, Kaichun Wu and Jie Liang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:71
  9. Tumor microenvironments (TMEs) activate various axes/pathways, predominantly inflammatory and hypoxic responses, impact tumorigenesis, metastasis and therapeutic resistance significantly. Although molecular pa...

    Authors: Yen-Hsiu Yeh, Ho-Fu Hsiao, Yen-Cheng Yeh, Tien-Wen Chen and Tsai-Kun Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:70
  10. Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic duc...

    Authors: Zhengdong Jiang, Cancan Zhou, Liang Cheng, Bin Yan, Ke Chen, Xin Chen, Liang Zong, Jianjun Lei, Wanxing Duan, Qinhong Xu, Xuqi Li, Zheng Wang, Qingyong Ma and Jiguang Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:69
  11. Detecting an ALK fusion gene in patients with non-small cell lung cancer (NSCLC) could provide evidence to guide individualized therapy.

    Authors: Yongqing Tong, Zhijun Zhao, Bei Liu, Anyu Bao, Hongyun Zheng, Jian Gu, Mary McGrath, Ying Xia, Bihua Tan, Chunhua Song and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:68
  12. Drug resistance of B-cell precursor acute lymphoblastic leukemia (BP-ALL) cells is conferred by both intrinsic and extrinsic factors, which could be targeted to promote chemo-sensitization. Our previous studie...

    Authors: Helicia Paz, Eun Ji Joo, Chih-Hsing Chou, Fei Fei, Kevin H. Mayo, Hisham Abdel-Azim, Haike Ghazarian, John Groffen and Nora Heisterkamp
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:67
  13. The adipocyte remodeling, including of the morphological change, might indicate special pathological function. Our previous study found that the morphological remodeling of larger marrow adipocytes into small ...

    Authors: Wei Lu, Yun Wan, Zhiqiang Li, Bin Zhu, Chunrong Yin, Haiyan Liu, Shaoxin Yang, Yuanmei Zhai, Yehua Yu, Yanyu Wei and Jun Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:66
  14. PHD-finger domain protein 5A (PHF5A) is a highly conserved small transcriptional regulator also involved in pre-mRNA splicing; however, its biological functions and molecular mechanisms in non-small cell lung ...

    Authors: Yan Yang, Jian Zhu, Tiantian Zhang, Jing Liu, Yumei Li, Yue Zhu, Lingjie Xu, Rui Wang, Fang Su, Yurong Ou and Qiong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:65
  15. miR-141 is up-regulated and plays crucial roles in nasopharyngeal carcinoma (NPC). However, the molecular mechanism underlying the dysregulation of miR-141 is still obscure.

    Authors: Yukun Liu, Ran Zhao, Yanmei Wei, Mengna Li, Heran Wang, Weihong Niu, Yao Zhou, Yuanzheng Qiu, Songqing Fan, Yihao Zhan, Wei Xiong, Yanhong Zhou, Xiaoling Li, Zheng Li, Guiyuan Li and Ming Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:64
  16. Metformin is a commonly used drug for the treatment of diabetes. Accumulating evidence suggests that it exerts anti-tumor effects in many cancers, including multiple myeloma (MM); however, the underlying molec...

    Authors: Yan Wang, Wenbin Xu, Zixun Yan, Weili Zhao, Jianqing Mi, Junmin Li and Hua Yan
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:63
  17. The bcr-abl fusion gene is the pathological origin of chronic myeloid leukemia (CML) and plays a critical role in the resistance of imatinib. Thus, bcr-abl disruption-based novel therapeutic strategy may warra...

    Authors: Ningshu Huang, Zhenglan Huang, Miao Gao, Zhenhong Luo, Fangzhu Zhou, Lin Liu, Qing Xiao, Xin Wang and Wenli Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:62
  18. The epidermal growth factor receptor (EGFR) plays important roles in cell survival, growth, differentiation, and tumorigenesis. Dysregulation of the EGFR is a common mechanism in cancer progression especially ...

    Authors: Meng-Shih Weng, Jer-Hwa Chang, Wen-Yueh Hung, Yi-Chieh Yang and Ming-Hsien Chien
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:61
  19. In the publication of this article [1], there is an error in the Methods section at paragraph Cell culture and reagents and the Additional file2: Fig. S1 was erroneous linked.

    Authors: Mengmeng Zhang, Fei Miao, Rong Huang, Wenjie Liu, Yuechao Zhao, Tao Jiao, Yalan Lu, Fan Wu, Xiaojuan Wang, Han Wang, Hong Zhao, Hongge Ju, Shiying Miao, Linfang Wang and Wei Song
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:60

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:22

  20. CDK5RAP3 was initially isolated as a binding protein of the CDK5 activator p35. Although CDK5RAP3 has been shown to negatively regulate the Wnt/β-catenin signaling pathway in gastric cancer by repressing GSK-3...

    Authors: Chao-Hui Zheng, Jia-Bin Wang, Man-Qiang Lin, Peng-Yang Zhang, Li-Chao Liu, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Jian-Wei Xie, Ping Li and Chang-Ming Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:59
  21. Developing drugs that target KRAS, the most frequently mutated oncogene in cancer, has not been successful despite much concerted efforts dedicated towards it in the last thirty years. Considering the key role th...

    Authors: Manuela Porru, Luca Pompili, Carla Caruso, Annamaria Biroccio and Carlo Leonetti
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:57
  22. This study aims to clarify the underlying mechanism for the tumor suppressive function of lnc TUSC7 in chemotherapy resistance of esophageal squamous cell carcinoma (ESCC).

    Authors: Zhi-wei Chang, Yong-xu Jia, Wei-jie Zhang, Li-jie Song, Ming Gao, Ming-jun Li, Rui-hua Zhao, Jing Li, Ya-li Zhong, Qiao-zhi Sun and Yan-ru Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:56
  23. Precision medicine calls for an early indicator of treatment efficiency. Circulating tumor DNA (ctDNA) is a promising marker in this setting. Our prospective study explored the association between disease deve...

    Authors: C. B. Thomsen, T. F. Hansen, R. F. Andersen, J. Lindebjerg, L. H. Jensen and A. Jakobsen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:55
  24. Diabetic patients have a higher risk factor for colorectal cancer (CRC) metastasis. Stearoyl-CoA desaturase 1 (SCD1), the main enzyme responsible for producing monounsaturated fatty acids(MUFA) from saturated fat...

    Authors: Hui Ran, Yemin Zhu, Ruyuan Deng, Qi Zhang, Xisheng Liu, Ming Feng, Jie Zhong, Shuhai Lin, Xuemei Tong and Qing Su
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:54
  25. Ovarian cancer is a deadly disease. Inhibitors of apoptosis proteins (IAPs) are key regulators of apoptosis and are frequently dysregulated in ovarian cancer. Overexpression of IAPs proteins has been correlate...

    Authors: Bao-Xia Li, Heng-Bang Wang, Miao-Zhen Qiu, Qiu-Yun Luo, Han-Jie Yi, Xiang-Lei Yan, Wen-Tao Pan, Lu-Ping Yuan, Yu-Xin Zhang, Jian-Hua Xu, Lin Zhang and Da-Jun Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:53

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:108

  26. Multidrug resistance is the main obstacle for hepatocellular carcinoma (HCC) treatment. miR-32-5p is involved in HCC progression but its function in multidrug resistance is still unclear. Here we aim to find o...

    Authors: Xiao Fu, Mengjie Liu, Shengyang Qu, Jiequn Ma, Yamin Zhang, Tingting Shi, Hongqing Wen, Yujuan Yang, Shuhong Wang, Jing Wang, Kejun Nan, Yu Yao and Tao Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:52
  27. Triptolide is a structurally unique diterpene triepoxide with potent antitumor activity. However,the effect and mechanism of triptolide on hepatocellular carcinoma (HCC) is not well studied.

    Authors: Shu-Guang Li, Qian-Wei Shi, Ling-yan Yuan, Li-ping Qin, Yan Wang, Yu-Qing Miao, Zhe Chen, Chang-Quan Ling and Wen-xing Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:51
  28. Dysregulation of eukaryotic translation elongation factor 1 delta (EEF1D) in cancers has been reported; however, the role and mechanisms of EEF1D in osteosarcoma remain poorly understood. The aim of this study...

    Authors: Dong-dong Cheng, Shi-jie Li, Bin Zhu, Shu-min Zhou and Qing-cheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:50
  29. Accumulating evidence confirm that aberrant microRNAs (miRNAs) expression contributes to hepatocellular carcinoma (HCC) development and progression. Previous study reported that miR-1468 showed an up-regulated...

    Authors: Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:49
  30. The United States Food and Drug Administration (FDA) recently approved the clinical use of two comprehensive ‘mid-size’ Next Generation Sequencing (NGS) panels calling actionable genomic aberrations in cancer....

    Authors: Matteo Allegretti, Alessandra Fabi, Simonetta Buglioni, Aline Martayan, Laura Conti, Edoardo Pescarmona, Gennaro Ciliberto and Patrizio Giacomini
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:47
  31. Cell adhesion molecules (CADMs) comprise of a protein family whose functions include maintenance of cell polarity and tumor suppression. Hypo-expression of CADM2 gene expression has been observed in several ca...

    Authors: Dongliang Li, Yongjian Zhang, He Zhang, Chao Zhan, Xin Li, Tu Ba, Zini Qiu, Fang E, Guixiang Lv, Chendan Zou, Chuxuan Wang, Lining Si, Chaoxia Zou, Qiang Li and Xu Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:46
  32. Castor zinc finger 1 (CASZ1) plays critical roles in various biological processes and pathologic conditions, including cancer. However, the prognostic importance and biologic functions of CASZ1 in hepatocellul...

    Authors: Ji-Long Wang, Meng-yuan Yang, Shuai Xiao, Bo Sun, Yi-Ming Li and Lian-Yue Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:45
  33. T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and plays a crucial part in tumor-induced immune suppression. However, the mechanism of TIM3 in regulating immunosuppression in head and nec...

    Authors: Jian-Feng Liu, Lei Wu, Lei-Lei Yang, Wei-Wei Deng, Liang Mao, Hao Wu, Wen-Feng Zhang and Zhi-Jun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:44
  34. Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limi...

    Authors: Jianjun Zhu, Mingpeng Jin, Jiaojiao Wang, Hui Zhang, Yousheng Wu, Deyang Li, Xiaoying Ji, Hushan Yang, Chun Yin, Tingting Ren and Jinliang Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:43
  35. Anti-CD105 mAb-conjugated immunoliposomes, loaded with secreted mouse endostatin gene, were developed for targeted tumor imaging and antiangiogenic gene therapy.

    Authors: Huiqin Zhuo, Baoshi Zheng, Jianming Liu, Yong Huang, Huiling Wang, Duo Zheng, Naiquan Mao, Jinyu Meng, Sufang Zhou, Liping Zhong and Yongxiang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:42
  36. Many types of cancers are devoid of the small leucine-rich proteoglycans: osteoglycin (OGN), but its role in tumorigenesis is poorly studied especially in colorectal cancers (CRC). Here we aim to evaluate the ...

    Authors: Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng and San-Jun Cai
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:41
  37. Wilms’ tumor 1-associating protein (WTAP) plays an important role in physiological processes and the development of tumor such as cell cycle regulation. The regulation of cell cycle is mainly dependent on cycl...

    Authors: Jingyuan Tang, Feng Wang, Gong Cheng, Shuhui Si, Xi Sun, Jie Han, Hao Yu, Wei Zhang, Qiang Lv, Ji-Fu Wei and Haiwei Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:40
  38. The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. Howev...

    Authors: Xiangrui Li, Zhijian Zhang, Yao Zhang, Yuxiang Cao, Huijun Wei and Zhihao Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:39
  39. With cancer stem cells (CSCs) became the research hotspot, emerging studies attempt to reveal the functions of these special subsets in tumorigenesis. Although various approaches have been used in CSCs researc...

    Authors: Y. T. Luo, J. Cheng, X. Feng, S. J. He, Y. W. Wang and Q. Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:38
  40. Ovarian cancer is the most leading cause of death and the third most common gynecologic malignancy in women. Traditional chemotherapy has inevitable drawbacks of nonspecific tumor targeting, high toxicity, and...

    Authors: Shu Yao, Li Li, Xuan-tao Su, Kai Wang, Zai-jun Lu, Cun-zhong Yuan, Jin-bo Feng, Shi Yan, Bei-hua Kong and Kun Song
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:29
  41. Doxorubicin is the preferred chemotherapeuticdrug for osteosarcoma treatment of which clinical efficacy is limited because of its chemo-resistance and cardiac toxicity. It is necessary to develop the combinati...

    Authors: Wanchun Wang, Ding Chen and Kewei Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:37
  42. Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased understanding of disease pathobiology and genomics has led to clinical investigation of novel targeted therapies and ratio...

    Authors: Silvia Boffo, Angela Damato, Luigi Alfano and Antonio Giordano
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:36
  43. In the publication of this article [1], there is an error in the first sentence of the Acknowledgements section.

    Authors: Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio and Lucia Cicchillitti
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:35

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:16

  44. CLCA2 was reported as a tumor suppressor and disregulated in breast cancer. However, its function in tumor growth and metastasis in NPC has rarely been reported. In this study, we investigated the functional a...

    Authors: Yuan-Yuan Qiang, Chang-Zhi Li, Rui Sun, Li-Sheng Zheng, Li-Xia Peng, Jun-Ping Yang, Dong-Fang Meng, Yan-Hong Lang, Yan Mei, Ping Xie, Liang Xu, Yun Cao, Wen-Wen Wei, Li Cao, Hao Hu, Qin Yang…
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:34
  45. Non-small-cell lung cancer (NSCLC) is currently the leading cause of cancer-related death. Accumulating evidences suggest that overcoming the therapeutic resistance in NSCLC is a big challenge. Recently, the o...

    Authors: Xing Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:33
  46. Extracellular matrix (ECM) is a mediator of tumor progression. However, whether the alterations of the intraperitoneal ECM prior to tumor establishment affects the malignant progression of ovarian cancer remai...

    Authors: Huiling Lai, Xuejiao Zhao, Yu Qin, Yi Ding, Ruqi Chen, Guannan Li, Marilyne Labrie, Zhiyong Ding, Jianfeng Zhou, Junbo Hu, Ding Ma, Yong Fang and Qinglei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:32

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:415

  47. ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and d...

    Authors: Xiaoran Guo, Kenneth K. W. To, Zhen Chen, Xiaokun Wang, Jianye Zhang, Min Luo, Fang Wang, Shirong Yan and Liwu Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:31

Annual Journal Metrics

  • 2022 Citation Impact
    11.3 - 2-year Impact Factor
    11.5 - 5-year Impact Factor
    1.870 - SNIP (Source Normalized Impact per Paper)
    2.413 - SJR (SCImago Journal Rank)

    2023 Speed
    4 days submission to first editorial decision for all manuscripts (Median)
    100 days submission to accept (Median)

    2023 Usage 
    3,003,080 downloads
    3,022 Altmetric mentions