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  1. Dysregulation of eukaryotic translation elongation factor 1 delta (EEF1D) in cancers has been reported; however, the role and mechanisms of EEF1D in osteosarcoma remain poorly understood. The aim of this study...

    Authors: Dong-dong Cheng, Shi-jie Li, Bin Zhu, Shu-min Zhou and Qing-cheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:50
    Content type: Research Published on:

  2. Accumulating evidence confirm that aberrant microRNAs (miRNAs) expression contributes to hepatocellular carcinoma (HCC) development and progression. Previous study reported that miR-1468 showed an up-regulated...

    Authors: Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:49
    Content type: Research Published on:

  4. The United States Food and Drug Administration (FDA) recently approved the clinical use of two comprehensive ‘mid-size’ Next Generation Sequencing (NGS) panels calling actionable genomic aberrations in cancer....

    Authors: Matteo Allegretti, Alessandra Fabi, Simonetta Buglioni, Aline Martayan, Laura Conti, Edoardo Pescarmona, Gennaro Ciliberto and Patrizio Giacomini
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:47
    Content type: Commentary Published on:

  5. Cell adhesion molecules (CADMs) comprise of a protein family whose functions include maintenance of cell polarity and tumor suppression. Hypo-expression of CADM2 gene expression has been observed in several ca...

    Authors: Dongliang Li, Yongjian Zhang, He Zhang, Chao Zhan, Xin Li, Tu Ba, Zini Qiu, Fang E, Guixiang Lv, Chendan Zou, Chuxuan Wang, Lining Si, Chaoxia Zou, Qiang Li and Xu Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:46
    Content type: Research Published on:

  6. Castor zinc finger 1 (CASZ1) plays critical roles in various biological processes and pathologic conditions, including cancer. However, the prognostic importance and biologic functions of CASZ1 in hepatocellul...

    Authors: Ji-Long Wang, Meng-yuan Yang, Shuai Xiao, Bo Sun, Yi-Ming Li and Lian-Yue Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:45
    Content type: Research Published on:

  7. T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and plays a crucial part in tumor-induced immune suppression. However, the mechanism of TIM3 in regulating immunosuppression in head and nec...

    Authors: Jian-Feng Liu, Lei Wu, Lei-Lei Yang, Wei-Wei Deng, Liang Mao, Hao Wu, Wen-Feng Zhang and Zhi-Jun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:44
    Content type: Research Published on:

  8. Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limi...

    Authors: Jianjun Zhu, Mingpeng Jin, Jiaojiao Wang, Hui Zhang, Yousheng Wu, Deyang Li, Xiaoying Ji, Hushan Yang, Chun Yin, Tingting Ren and Jinliang Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:43
    Content type: Research Published on:

  9. Anti-CD105 mAb-conjugated immunoliposomes, loaded with secreted mouse endostatin gene, were developed for targeted tumor imaging and antiangiogenic gene therapy.

    Authors: Huiqin Zhuo, Baoshi Zheng, Jianming Liu, Yong Huang, Huiling Wang, Duo Zheng, Naiquan Mao, Jinyu Meng, Sufang Zhou, Liping Zhong and Yongxiang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:42
    Content type: Research Published on:

  10. Many types of cancers are devoid of the small leucine-rich proteoglycans: osteoglycin (OGN), but its role in tumorigenesis is poorly studied especially in colorectal cancers (CRC). Here we aim to evaluate the ...

    Authors: Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng and San-Jun Cai
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:41
    Content type: Research Published on:

  11. Wilms’ tumor 1-associating protein (WTAP) plays an important role in physiological processes and the development of tumor such as cell cycle regulation. The regulation of cell cycle is mainly dependent on cycl...

    Authors: Jingyuan Tang, Feng Wang, Gong Cheng, Shuhui Si, Xi Sun, Jie Han, Hao Yu, Wei Zhang, Qiang Lv, Ji-Fu Wei and Haiwei Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:40
    Content type: Research Published on:

  12. The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. Howev...

    Authors: Xiangrui Li, Zhijian Zhang, Yao Zhang, Yuxiang Cao, Huijun Wei and Zhihao Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:39
    Content type: Research Published on:

  13. With cancer stem cells (CSCs) became the research hotspot, emerging studies attempt to reveal the functions of these special subsets in tumorigenesis. Although various approaches have been used in CSCs researc...

    Authors: Y. T. Luo, J. Cheng, X. Feng, S. J. He, Y. W. Wang and Q. Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:38
    Content type: Review Published on:

  14. Ovarian cancer is the most leading cause of death and the third most common gynecologic malignancy in women. Traditional chemotherapy has inevitable drawbacks of nonspecific tumor targeting, high toxicity, and...

    Authors: Shu Yao, Li Li, Xuan-tao Su, Kai Wang, Zai-jun Lu, Cun-zhong Yuan, Jin-bo Feng, Shi Yan, Bei-hua Kong and Kun Song
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:29
    Content type: Research Published on:

  15. Doxorubicin is the preferred chemotherapeuticdrug for osteosarcoma treatment of which clinical efficacy is limited because of its chemo-resistance and cardiac toxicity. It is necessary to develop the combinati...

    Authors: Wanchun Wang, Ding Chen and Kewei Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:37
    Content type: Research Published on:

  16. Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased understanding of disease pathobiology and genomics has led to clinical investigation of novel targeted therapies and ratio...

    Authors: Silvia Boffo, Angela Damato, Luigi Alfano and Antonio Giordano
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:36
    Content type: Review Published on:

  17. In the publication of this article [1], there is an error in the first sentence of the Acknowledgements section.

    Authors: Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio and Lucia Cicchillitti
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:35
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:16

  18. CLCA2 was reported as a tumor suppressor and disregulated in breast cancer. However, its function in tumor growth and metastasis in NPC has rarely been reported. In this study, we investigated the functional a...

    Authors: Yuan-Yuan Qiang, Chang-Zhi Li, Rui Sun, Li-Sheng Zheng, Li-Xia Peng, Jun-Ping Yang, Dong-Fang Meng, Yan-Hong Lang, Yan Mei, Ping Xie, Liang Xu, Yun Cao, Wen-Wen Wei, Li Cao, Hao Hu, Qin Yang…
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:34
    Content type: Research Published on:

  19. Non-small-cell lung cancer (NSCLC) is currently the leading cause of cancer-related death. Accumulating evidences suggest that overcoming the therapeutic resistance in NSCLC is a big challenge. Recently, the o...

    Authors: Xing Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:33
    Content type: Commentary Published on:

  20. Extracellular matrix (ECM) is a mediator of tumor progression. However, whether the alterations of the intraperitoneal ECM prior to tumor establishment affects the malignant progression of ovarian cancer remai...

    Authors: Huiling Lai, Xuejiao Zhao, Yu Qin, Yi Ding, Ruqi Chen, Guannan Li, Marilyne Labrie, Zhiyong Ding, Jianfeng Zhou, Junbo Hu, Ding Ma, Yong Fang and Qinglei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:32
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:415

  21. ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and d...

    Authors: Xiaoran Guo, Kenneth K. W. To, Zhen Chen, Xiaokun Wang, Jianye Zhang, Min Luo, Fang Wang, Shirong Yan and Liwu Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:31
    Content type: Research Published on:

  23. Identification of novel MDM2 or p53 binding proteins may reveal undefined oncogenes, tumor suppressors, signaling pathways and possible treatment targets.

    Authors: Xingwang Xie, Xueyan Wang, Weijia Liao, Ran Fei, Nan Wu, Xu Cong, Qian Chen, Lai Wei, Yu Wang and Hongsong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:28
    Content type: Research Published on:

  24. Aberrant expression of transcription Factor AP-2 Gamma (TFAP2C) has been reported to be implicated in malignant process of many cancers. The purpose of this study is to investigate the clinical significance an...

    Authors: Xu Wang, Di Sun, Jiandong Tai, Si Chen, Miao Yu, Dong Ren and Lei Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:27
    Content type: Research Published on:

  25. Since Salinomycin (Sal) emerged its ability to target breast cancer stem cells in 2009, numerous experiments have been carried out to test Sal’s anticancer effects. What deserve to be mentioned is that Sal can...

    Authors: Jiang Jiang, Hailong Li, Eskandar Qaed, Jing Zhang, Yushu Song, Rong Wu, Xinmiao Bu, Qinyan Wang and Zeyao Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:26
    Content type: Review Published on:

  26. Pancreatic cancer characterizes high recurrence and poor prognosis. In clinical practice, radiotherapy is widely used for pancreatic cancer treatment. However, the outcome remains undesirable due to tumor repo...

    Authors: Chi Fang, Chen-yun Dai, Zhu Mei, Ming-jie Jiang, Dian-na Gu, Qian Huang and Ling Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:25
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:402

  27. Estrogen receptor alpha (ER alpha) is expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression. ER alpha positive breast cancer can be well controlled by ER alpha modulato...

    Authors: Huijie Yang, Na Yu, Juntao Xu, Xiaosheng Ding, Wei Deng, Guojin Wu, Xin Li, Yingxiang Hou, Zhenhua Liu, Yan Zhao, Min Xue, Sifan Yu, Beibei Wang, Xiumin Li, Gang Niu, Hui Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:24
    Content type: Research Published on:

  28. 14,15-epoxyeicosatrienoic acid (14,15-EET) is an important lipid signaling molecule involved in the regulation of tumor metastasis, however, the role and molecular mechanisms of 14,15-EET activity in breast ca...

    Authors: Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang and Jian-Hua Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:23
    Content type: Research Published on:

  29. 40–50% of colorectal cancer (CRC) patients develop metastatic disease; the presence of metastasis hinders the effective treatment of cancer through surgery, chemotherapy and radiotherapy, which makes 5-year su...

    Authors: Mengmeng Zhang, Fei Miao, Rong Huang, Wenjie Liu, Yuechao Zhao, Tao Jiao, Yalan Lu, Fan Wu, Xiaojuan Wang, Han Wang, Hong Zhao, Hongge Ju, Shiying Miao, Linfang Wang and Wei Song
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:22
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:60

  30. Prohibitin 1 (PHB) is a potential target for the treatment of urothelial carcinoma of the bladder (UCB). FL3 is a newly synthesized agent that inhibits cancer cell proliferation by targeting the PHB protein; h...

    Authors: Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou and Dan Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:21
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:291

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:115

  31. Antibody-Drug Conjugates (ADCs) are a class of cancer therapeutics that combines antigen specificity and potent cytotoxicity in a single molecule as they are comprised of an engineered antibody linked chemical...

    Authors: Cécile Chalouni and Sophia Doll
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:20
    Content type: Review Published on:

  32. Metastasis is one of the main reasons for treatment failure in endometrial cancer. Notably, high mobility group AT-hook 2 (HMGA2) has been recognized as a driving factor of tumour metastasis. microRNAs (miRNAs...

    Authors: Jian Ma, Da Li, Fan-Fei Kong, Di Yang, Hui Yang and Xiao-Xin Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:19
    Content type: Research Published on:

  33. Radioresistance is a major challenge during the treatment of NK/T cell lymphoma. This study aimed to investigate the potential role of MicroRNA-150 (miR-150) in increase the sensitivities of NK/T cell lymphoma...

    Authors: Shao Jie Wu, Jun Chen, BingYi Wu, Yu Jue Wang and Kun Yuan Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:18
    Content type: Research Published on:

  34. The tumour microenvironment is essential for cancer progress and metastasis. Integrin-β5 (ITGB5), a member of the integrin family, has been implicated to mediate the interactions of cells with the extracellula...

    Authors: Zhikun Lin, Ruiping He, Haifeng Luo, Chang Lu, Zhen Ning, Yuanhang Wu, Chuanchun Han, Guang Tan and Zhongyu Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:17
    Content type: Research Published on:

  35. Circulating cell-free DNA (cfDNA) and its integrity index may represent a rapid and noninvasive “liquid biopsy” biomarker, which gives important complementary information for diagnosis, prognosis, and treatmen...

    Authors: Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio and Lucia Cicchillitti
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:16
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:35

  36. MicroRNAs (miRNAs) have been shown to function in many different cellular processes, including proliferation, apoptosis, differentiation and development. miR-181a, -181b, -181c and -181d are miR-181 members of th...

    Authors: Leilei Zhang, Xiaoyu He, Fang Li, Hui Pan, Xiaolin Huang, Xuyang Wen, He Zhang, Bin Li, Shengfang Ge, Xiaofang Xu, Renbing Jia and Xianqun Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:15
    Content type: Research Published on:

  37. Hepatitis B virus (HBV) plays a critical role in the tumorigenic behavior of human hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) have been reported to participate in HCC development via the regulation of ...

    Authors: Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li and Hua Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:14
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:165

  38. Recently, the pesudogenes have emerged as critical regulators in human cancers tumorigenesis and progression, and been identified as a key revelation in post-genomic biology. However, the expression pattern, b...

    Authors: Yongcan Xu, Xiang Yu, Chenchen Wei, Fengqi Nie, Mingde Huang and Ming Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:13
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:233

  39. Oncogenic roles of epidermal growth factor receptor pathway substrate no.8 (EPS8) have been widely reported in various tumors, making targeting of EPS8 an appealing prospect. Here, we describe the role of EPS8...

    Authors: Yiran Chen, Xiaoling Xie, Anqin Wu, Lei Wang, Yuxing Hu, Honghao Zhang and Yuhua Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:12
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:233

  40. Small molecule ONC201 is an investigational anti-tumor agent that upregulates intra-tumoral TRAIL expression and the integrated stress response pathway. A Phase I clinical trial using ONC201 therapy in advance...

    Authors: Jessica Wagner, C. Leah Kline, Lanlan Zhou, Vladimir Khazak and Wafik S. El-Deiry
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:11
    Content type: Research Published on:

  41. The high incidence of recurrence and metastasis of hepatocellular carcinoma (HCC) necessitate the discovery of new predictive biomarkers of invasion and prognosis. Minichromosome maintenance complex component ...

    Authors: Mingyu Liu, Qiaoting Hu, Mengxian Tu, Xinyi Wang, Zike Yang, Guoxiong Yang and Rongcheng Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:10
    Content type: Research Published on:

  42. Autophagy is a dynamic physiological process that can generate energy and nutrients for cell survival during stress. Autophagy can regulate the migration and invasive ability in cancer cells. However, the conn...

    Authors: Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Yan Li, Lei Dong, Zhihong Zong, Xiangdong Hua, Dongming Su, Hangyu Li and Jingang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:9
    Content type: Research Published on:

  43. Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been recognized as a distinct leukemia entity in the 2016 World Health Organization (WHO) classification. The genetic events underlying oncoge...

    Authors: Hongjun Jin, Liyuan Yang, Lu Wang, Zailin Yang, Qian Zhan, Yao Tao, Qin Zou, Yuting Tang, Jingrong Xian, Shuaishuai Zhang, Yipei Jing and Ling Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:8
    Content type: Research Published on:

  44. Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephania tetrandra S. Moore. We previously demonstrated that tetrandrine exhibits potent antitumor effects in many types o...

    Authors: Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li and Wenhua Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:7
    Content type: Research Published on:

  45. Stress-Inducible Protein-1 (STIP1) is a co-chaperone that associates directly with heat shock proteins, and regulates motility of various types of cancer. In the present study, we investigated the role of STIP...

    Authors: Linlin Huang, Ertao Zhai, Shirong Cai, Yi Lin, Junbin Liao, Huilin Jin, Sui Peng, Lixia Xu, Minhu Chen and Zhirong Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:6
    Content type: Research Published on:

  46. Cancer remains as one of the leading cause of death worldwide. The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Although most studies have ...

    Authors: Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos and Kulmira Nurgali
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:5
    Content type: Review Published on:

  47. Pancreatic stellate cells (PSCs), a major component of the tumor microenvironment in pancreatic cancer, play roles in cancer progression as well as drug resistance. Culturing various cells in microfluidic (mic...

    Authors: Ji-Hyun Lee, Seul-Ki Kim, Iftikhar Ali Khawar, Su-Yeong Jeong, Seok Chung and Hyo-Jeong Kuh
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:4
    Content type: Research Published on:

  48. Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role in modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HC...

    Authors: Shaofei Chen, Jiarui Pu, Jie Bai, Yuping Yin, Ke Wu, Jiliang Wang, Xiaoming Shuai, Jinbo Gao, Kaixiong Tao, Guobin Wang and Hang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:3
    Content type: Research Published on:

  49. Osteosarcoma (OS) is the most common primary malignant tumor of bone, which preferentially develops lung metastasis. Although standard chemotherapy has significantly improved long-term survival over the past f...

    Authors: Angela De Luca, Lavinia Raimondi, Francesca Salamanna, Valeria Carina, Viviana Costa, Daniele Bellavia, Riccardo Alessandro, Milena Fini and Gianluca Giavaresi
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:2
    Content type: Review Published on:

  50. The receptors of Notch family play an important role in controlling the development, differentiation, and function of multiple cell types. The aim of this study is to investigate the role of Notch1 signaling u...

    Authors: Zike Yang, Yanxia Qi, Nan Lai, Jiahe Zhang, Zehong Chen, Mingyu Liu, Wan Zhang, Rongcheng Luo and Shijun Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:1
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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