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  1. Arrest of metastasising lung cancer cells to the brain microvasculature maybe mediated by interactions between ligands on circulating tumour cells and endothelial E-selectin adhesion molecules; a process likel...

    Authors: Srijana Rai, Zaynab Nejadhamzeeigilani, Nicholas J. Gutowski and Jacqueline L. Whatmore
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:105
  2. Neuroblastoma (NB) is one of the most common childhood malignancies. Currently, high risk NB carries a poor outcome and significant treatment related toxicities and, thus has been a focus for new therapeutics ...

    Authors: Anjali Singh, Yibing Ruan, Tanya Tippett and Aru Narendran
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:104
  3. Herein, we demonstrated the use of a newly generated anti FAT1 antibody (clone mAB198.3) for intracellular delivery of anionic gold NPs, to form active targeting Au nanoparticles with high payload characterist...

    Authors: Li Fan, Susanna Campagnoli, Hong Wu, Alberto Grandi, Matteo Parri, Elisa De Camilli, Guido Grandi, Giuseppe Viale, Piero Pileri, Renata Grifantini, Chaojun Song and Boquan Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:103
  4. Dysregulated long non-coding RNAs (lncRNAs) have been found to have oncogenic and/or tumor suppressive roles in the development and progression of cancer, implying their potentials as novel independent biomark...

    Authors: Meng Zhou, Hengqiang Zhao, Zhenzhen Wang, Liang Cheng, Lei Yang, Hongbo Shi, Haixiu Yang and Jie Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:102
  5. Several studies have found that DDR2 is up-regulated in many tumor types and facilitates tumor progression. However, the role of DDR2 in hepatocellular carcinoma (HCC) progression and its downstream signaling ...

    Authors: Binhui Xie, Weihao Lin, Junming Ye, Xiaonong Wang, Bing Zhang, Shiqiu Xiong, Heping Li and Guosheng Tan
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:101
  6. Aberrant expression of long noncoding RNAs (lncRNAs) has frequently been reported in cancer studies, including those of colorectal cancer (CRC). Increasing evidence suggests that lncRNAs are significantly corr...

    Authors: Jie Ding, Binbin Lu, Jianping Wang, Juan Wang, Yongguo Shi, Yifan Lian, Ya Zhu, Jirong Wang, Yingrui Fan, Zhaoxia Wang, Wei De and Keming Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:100
  7. Ursolic acid (UA), a pentacyclic triterpenoid, is known to have anti-tumor activity in various cancers including human non small cell lung cancer (NSCLC). However, the molecular mechanisms underlying the actio...

    Authors: Jingjing Wu, Shunyu Zhao, Qing Tang, Fang Zheng, YuQin Chen, LiJun Yang, Xiaobing Yang, Liuning Li, WanYin Wu and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:99
  8. Hematopoietic Stem Cell Transplantation (HSCT) is known to induce the inhibitory immune receptor NKG2A on NK cells of donor origin. This occurs in allogeneic recipients, in both the haploidentical and HLA-matc...

    Authors: Alessandra Picardi, Andrea Mengarelli, Mirella Marino, Enzo Gallo, Maria Benevolo, Edoardo Pescarmona, Roberta Cocco, Rocco Fraioli, Elisa Tremante, Maria Concetta Petti, Paolo De Fabritiis and Patrizio Giacomini
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:98
  9. Interleukin-24(IL-24), also referred to as melanoma differentiation-associated gene-7(mda-7), is a unique member of the IL-10 gene family, which displays nearly ubiquitous cancer-specific toxicity. The most no...

    Authors: Jichen Li, Dezhao Yang, Wei Wang, Songlin Piao, Jianyu Zhou, Wuliji Saiyin, Changyu Zheng, Hongchen Sun and Yu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:97
  10. It is well-known that the treatment and monitoring methods are limited for advanced stage of endometrial carcinoma. Biological molecules with expression changes during tumor progression become potential therap...

    Authors: Lu Deng, Yiping Gao, Xiao Li, Mingbo Cai, Huimin Wang, Huiyu Zhuang, Mingzi Tan, Shuice Liu, Yingying Hao and Bei Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:96
  11. The epidermal growth factor receptor (EGFR) signaling pathway is important in regulating biological behaviors in many malignancies. We explored whether expression and activation of EGFR and several components ...

    Authors: Zhengfei Zhu, Weiwei Yu, Xiaolong Fu, Menghong Sun, Qiao Wei, Dali Li, Haiquan Chen, Jiaqing Xiang, Hecheng Li, Yawei Zhang, Weixin Zhao and Kuaile Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:95
  12. Colorectal cancer (CRC) is a major health problem in China and around the world. It is one of the leading causes of cancer-related deaths. Research groups are thus searching for novel and more efficient anti-C...

    Authors: Cai Xun, Min-Bin Chen, Li Qi, Zhang Tie-Ning, Xue Peng, Li Ning, Chen Zhi-Xiao and Wang Li-Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:94
  13. The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not always specific, do not selectively target cancer...

    Authors: Megan Walsh, Stefano Fais, Enrico Pierluigi Spugnini, Salvador Harguindey, Tareq Abu Izneid, Licia Scacco, Paula Williams, Cinzia Allegrucci, Cyril Rauch and Ziad Omran
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:93
  14. Increased understanding of the genetic aetiology of advanced non-small-cell lung cancer (aNSCLC) has facilitated personalised therapies that target specific molecular aberrations associated with the disease. B...

    Authors: James Sherwood, Simon Dearden, Marianne Ratcliffe and Jill Walker
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:92
  15. Elucidation of the downstream targets regulated by the metastasis-suppressive miRNAs can shed light on the metastatic processes in prostate cancer (PCa). We conducted microarray analyses and found that miR-195...

    Authors: Jia Guo, Min Wang and Xiuheng Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:91
  16. Blood platelet numbers are correlated with growth and aggressiveness of several tumor types, including hepatocellular carcinoma (HCC). We previously found that platelet lysates (hPLs) both stimulated HCC cell ...

    Authors: Catia Lippolis, Maria Grazia Refolo, Rosalba D’Alessandro, Nicola Carella, Caterina Messa, Aldo Cavallini and Brian Irving Carr
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:90
  17. When a patient concomitantly uses two or more drugs, a drug-drug interaction (DDI) can possibly occur, potentially leading to an increased or decreased clinical effect of a given treatment. Cancer patients are...

    Authors: Silvia Ussai, Riccardo Petelin, Antonio Giordano, Mario Malinconico, Donatella Cirillo and Francesca Pentimalli
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:89
  18. Discoidin domain receptors 1 (DDR1), a subtype of DDRs, has been reported as a critical modulator of cellular morphogenesis, differentiation, migration and invasion.

    Authors: Yanmiao Huo, Minwei Yang, Wei Liu, Jianyu Yang, Xueliang Fu, Dejun Liu, Jiao Li, Junfeng Zhang, Rong Hua and Yongwei Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:88
  19. Activation of wild-type p53 in response to genotoxic stress occurs through different mechanisms including protein conformation, posttranslational modifications, and nuclear localization, leading to DNA binding...

    Authors: Alessia Garufi, Valentina Ubertini, Francesca Mancini, Valerio D’Orazi, Silvia Baldari, Fabiola Moretti, Gianluca Bossi and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:87
  20. MicroRNAs are stable and easy to detect in plasma. The plasma levels of microRNAs are often changed in disease conditions, including cancer. This makes circulating microRNAs a novel class of biomarkers for can...

    Authors: Zanxi Fang, Jing Tang, Yongying Bai, Huayue Lin, Hanyu You, Hongwei Jin, Lingqing Lin, Pan You, Juan Li, Zhang Dai, Xianming Liang, Yuanhui Su, Qing Hu, Fen Wang and Zhong-Ying Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:86
  21. Acidity is a hallmark of malignant tumor, representing a very efficient mechanism of chemoresistance. Proton pump inhibitors (PPI) at high dosage have been shown to sensitize chemoresistant human tumor cells a...

    Authors: Bi-Yun Wang, Jian Zhang, Jia-Lei Wang, Si Sun, Zhong-Hua Wang, Lei-Ping Wang, Qun-Ling Zhang, Fang-Fang Lv, En-Ying Cao, Zhi-Min Shao, Stefano Fais and Xi-Chun Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:85

    The Research to this article has been published in Journal of Experimental & Clinical Cancer Research 2015 34:109

  22. At skin level, a cancerization field (CF) indicates some chronically photoexposed areas in which, besides a primary tumor, histological or biomolecular modifications without clinical signs are present. Active ...

    Authors: Luigi Laino, Fulvia Elia, Flora Desiderio, Alessandra Scarabello, Isabella Sperduti, Carlo Cota and Aldo DiCarlo
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:84
  23. T-cell Acute Lymphoblastic Leukemia (ALL) represents about 10–15 % of pediatric ALL cases. EZH2, one of the components of Polycomb group proteins (PRC2) complex, catalyzes the trimethylation of histone H3 lysi...

    Authors: V. D’Angelo, A. Iannotta, M. Ramaglia, A. Lombardi, M. R. Zarone, V. Desiderio, M. C. Affinita, G. Pecoraro, M. Di Martino, P. Indolfi, F. Casale and M. Caraglia
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:83
  24. Mesenchymal stromal cells (MSCs) are considered an important therapeutic tool in cancer therapy. They possess intrinsic therapeutic potential and can also be in vitro manipulated and engineered to produce therape...

    Authors: Augusto Pessina, Carlo Leonetti, Simona Artuso, Anna Benetti, Enrico Dessy, Luisa Pascucci, Daniela Passeri, Augusto Orlandi, Angiola Berenzi, Arianna Bonomi, Valentina Coccè, Valentina Ceserani, Anna Ferri, Marta Dossena, Pietro Mazzuca, Emilio Ciusani…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:82
  25. Endoretroviruses account for circa 8 % of all transposable elements found in the genome of humans and other animals. They represent a genetic footprint of ancestral germ-cell infections of exoviruses that is t...

    Authors: David Díaz-Carballo, Ali Haydar Acikelli, Jacqueline Klein, Holger Jastrow, Philipp Dammann, Thomas Wyganowski, Cihan Guemues, Sebastian Gustmann, Walter Bardenheuer, Sascha Malak, Nora Sophia Tefett, Veria Khosrawipour, Urs Giger-Pabst, Andrea Tannapfel and Dirk Strumberg
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:81
  26. Zebrafish represent a vertebrate model organism that has been widely, and increasingly, employed over the last decade in the study of developmental processes, wound healing, microbe-host interactions, and drug...

    Authors: Shuai Zhao, Jian Huang and Jun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:80
  27. Long noncoding RNAs (lncRNAs) have recently emerged as important regulators in governing fundamental biological processes, and many of which are likely to have functional roles in tumorigenesis. Maternally exp...

    Authors: Weizhao Peng, Shuang Si, Qingxia Zhang, Chaofeng Li, Fang Zhao, Fang Wang, Jia Yu and Ren Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:79
  28. Considering previous data and the need to incorporate new biomarkers for the prognosis of solid tumours into the clinic, our aim in this work consists of evaluating the potential clinical use of telomeres and ...

    Authors: Tamara Fernández-Marcelo, Ana Gómez, Irene Pascua, Carmen de Juan, Jacqueline Head, Florentino Hernando, Jose-Ramón Jarabo, Joaquín Calatayud, Antonio-José Torres-García and Pilar Iniesta
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:78
  29. Metformin is the first line of oral antidiabetic drug in the biguanide class for treatment of type 2 diabetes. Increasing evidence has suggested that it is a potential anti-tumor drug. However, the mechanisms ...

    Authors: Qi Pan, Guo-Liang Yang, Jiang-Hua Yang, Shi-Long Lin, Ning Liu, Shan-Shan Liu, Meng-Yao Liu, Lian-Hua Zhang, Yi-Ran Huang, Ru-long Shen, Qiang Liu, Jian-Xin Gao and Juan-Jie Bo
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:77
  30. Aberrant microRNA (miRNA) expression plays an essential role in osteosarcoma (OS) pathogenesis. Recent studies have shown that dysregulation of miRNA expression is associated with increased tumorigenesis and p...

    Authors: Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Shinichi Ikeda, Tatsuya Iwasaki and Hiroshi Tsumura
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:76
  31. Transmembrane protein 158 (TMEM158) is a recently identified upregulated gene during Ras-induced senescence. Its association with various cancers has been recently reported. However, the expression and biologi...

    Authors: Zhongping Cheng, Jing Guo, Li Chen, Ning Luo, Weihong Yang and Xiaoyan Qu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:75
  32. Liver tumors are increasingly treated with radioembolization. Here, we present first evidence of catheter design effect on particle-fluid dynamics and downstream branch targeting during microsphere administrat...

    Authors: Andor F. van den Hoven, Marnix G.E.H. Lam, Shaphan Jernigan, Maurice A.A.J. van den Bosch and Gregory D. Buckner
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:74
  33. Growing evidence suggests that microRNAs (miRNAs) play an important role in tumor development, progression and metastasis. Aberrant miR-106b expression has been reported in several cancers. However, the role a...

    Authors: Guang-jun Zhang, Jian-shui Li, He Zhou, Hua-xu Xiao, Yu Li and Tong Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:73
  34. Primitive sarcoma of the breast is a rare and challenging disease at high risk of recurrence and with poor prognosis. There are controversies in the diagnosis and management of such solid tumor due to its rari...

    Authors: Vittorio Pasta, Massimo Monti, Michela Cialini, Massimo Vergine, Paolo Urciuoli, Annunziata Iacovelli, Silvio Rea and Valerio D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:72
  35. Vitamin D3 and its analogues have recently been shown to enhance the anti-tumour effects of 5- Fluorouracil (5-FU) both in vitro and in xenograft mouse model of colon cancer. This study measured the potential ...

    Authors: Bassem Refaat, Adel Galal El-Shemi, Osama Adnan Kensara, Amr Mohamed Mohamed, Shakir Idris, Jawwad Ahmad and Athar Khojah
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:71
  36. The role of human papillomavirus (HPV) may be involved in the development of esophageal cancer (EC) and the polymorphic immune response gene transporter associated with antigen processing (TAP) may be involved...

    Authors: Ningjing Zou, Lan Yang, Ling Chen, Tingting Li, Tingting Jin, Hao Peng, Shumao Zhang, Dandan Wang, Ranran Li, Chunxia Liu, Jinfang Jiang, Lianghai Wang, Weihua Liang, Jianming Hu, Shugang Li, Chuanyue Wu…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:70
  37. The evasion of cell death is one of the hallmarks of cancer, contributing to both tumor progression and resistance to therapy. Dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine...

    Authors: Martina Broecker-Preuss, Jan Viehof, Holger Jastrow, Nina Becher-Boveleth, Dagmar Fuhrer and Klaus Mann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:69
  38. Acute myeloid leukemia (AML) is a heterogeneous neoplasm of the bone marrow with poor prognosis. In clinical practice new prognostic factors are still needed. MicroRNAs (miRs), small endogenous noncoding RNAs,...

    Authors: Aleksandra Butrym, Justyna Rybka, Dagmara Baczyńska, Andrzej Tukiendorf, Kazimierz Kuliczkowski and Grzegorz Mazur
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:68
  39. Hypoxia is a common feature of solid tumors, including HCC. And hypoxia has been reported to play an important role in HCC progression. However, the potential mechanism of miRNAs in hypoxia mediating HCC progr...

    Authors: Chengli Du, Xiaoyu Weng, Wendi Hu, Zhen Lv, Heng Xiao, Chaofeng Ding, Owusu-anash K. Gyabaah, Haiyang Xie, Lin Zhou, Jian Wu and Shusen Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:67
  40. The Yin Yang 1 (YY1) transcription factor has been identified to target a plethora of potential target genes, which are important for cell proliferation and differentiation. Although the role that YY1 plays in...

    Authors: Guowei Zhao, Qiang Li, Aiqin Wang and Jian Jiao
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:66
  41. Halofuginone (HF) is a low-molecular-weight alkaloid that has been demonstrated to interfere with Metalloproteinase-2 (MMP-2) and Tumor Growth Factor-β (TGF-β) function and, to present antiangiogenic, antiprol...

    Authors: Patricia A. Assis, Lorena L. De Figueiredo-Pontes, Ana Silvia G. Lima, Vitor Leão, Larissa A. Cândido, Carolina T. Pintão, Aglair B. Garcia, Fabiano P. Saggioro, Rodrigo A Panepucci, Fernando Chahud, Arnon Nagler, Roberto P. Falcão and Eduardo M. Rego
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:65
  42. The role of insulin in the pathogenesis of cancer has been increasingly emphasized because of the high incidence of obesity and metabolic syndrome and their correlated complication including cancer. This study...

    Authors: Zhao Wei, Li Liang, Liu Junsong, Chen Rui, Chang Shuai, Qiu Guanglin, He Shicai, Wang Zexing, Wang Jin, Che Xiangming and Wang Shufeng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:64
  43. The purpose of this study was to develop a cost-effective approach for the determination of EGFR and KRAS mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) and colorectal ...

    Authors: Guohua Xie, Fang Xie, Ping Wu, Xiangliang Yuan, Yanhui Ma, Yunchuan Xu, Li Li, Ling Xu, Ming Yang and Lisong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:63
  44. There is growing evidence that emerging malignancies in solid tissues might be kept under control by physical intercellular contacts with normal fibroblasts.

    Authors: Andrey Alexeyenko, Twana Alkasalias, Tatiana Pavlova, Laszlo Szekely, Vladimir Kashuba, Helene Rundqvist, Peter Wiklund, Lars Egevad, Peter Csermely, Tamas Korcsmaros, Hayrettin Guven and George Klein
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:62
  45. Piwi-interacting RNAs (piRNAs) are small RNAs of 27–30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role in cancerogenesis. This study is...

    Authors: Jonas Busch, Bernhard Ralla, Monika Jung, Zofia Wotschofsky, Elena Trujillo-Arribas, Philipp Schwabe, Ergin Kilic, Annika Fendler and Klaus Jung
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:61
  46. Developmental pluripotency-associated 4 (Dppa4) gene plays an important role in self-renewal and pluripotency sustainability in embryonic stem cells. It is re-expressed in several malignant tumors and is ident...

    Authors: Meng Zhang, Feifei Cui, Su Lu, Huijun Lu, Yingming Xue, Jingtao Wang, Jian Chen, Senlin Zhao, Shaofei Ma, Yu Zhang, Yang Yu, Zhihai Peng and Huamei Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:60
  47. Our pilot study using miRNA PCR array found that miRNA-29b (miR-29b) is differentially expressed in primary cultured CD133-positive A549 cells compared with CD133-negative A549 cells.

    Authors: Hongyan Wang, Xiaoying Guan, Yongsheng Tu, Shaoqiu Zheng, Jie Long, Shuhua Li, Cuiling Qi, Xiaobin Xie, Huiqiu Zhang and Yajie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:59
  48. Three-dimensional (3D) culture models are considered to recapitulate the cell microenvironment in solid tumors, including the extracellular matrix (ECM), cell-cell interactions, and signal transduction. These ...

    Authors: Chujie Bai, Min Yang, Zhengfu Fan, Shu Li, Tian Gao and Zhiwei Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:58
  49. The primary glioblastoma multiforme (GBM) is the most malignant form of astrocytic tumor with an average survival of approximately 12–14 months. The search for novel and more efficient chemo-agents against thi...

    Authors: Li-sen Qin, Pi-feng Jia, Zhi-qing Zhang and Shi-ming Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:57
  50. Treatment of blast phase chronic myeloid leukemia (BP-CML) remains a challenge, and the median survival is less than 6 months. Because effective treatments are lacking, we studied tight targeting of blast cris...

    Authors: Bailing Zu, Yi Shi, Min Xu, Guoling You, Zhenglan Huang, Miao Gao and Wenli Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:56

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:57

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