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  1. Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibi...

    Authors: Yasuhiro Kidera, Masanobu Tsubaki, Yuzuru Yamazoe, Kaori Shoji, Haruyuki Nakamura, Mitsuhiko Ogaki, Takao Satou, Tatsuki Itoh, Misako Isozaki, Junichi Kaneko, Yoshihiro Tanimori, Masashi Yanae and Shozo Nishida
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:127
    Content type: Research Published on:

  2. Lung cancer is a malignant carcinoma which has the highest morbidity and mortality in Chinese population. Gefitinib, a tyrosine kinase (TK) inhibitor of epidermal growth factor receptor (EGFR), displays anti-t...

    Authors: Yong-Mei Yin, Yi-Ting Geng, Yong-Feng Shao, Xiao-Li Hu, Wei Li, Yong-Qian Shu and Zhao-Xia Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:126
    Content type: Research Published on:

  3. Several studies demonstrated that epidermal growth factor receptor (EGFR) gene copy number (GCN) correlates to the response to tyrosine kinase inhibitors in non small cell lung cancer (NSCLC) and to anti-EGFR ...

    Authors: Giovanni Simone, Anita Mangia, Andrea Malfettone, Vincenza Rubini, Michele Siciliano, Anna Di Benedetto, Irene Terrenato, Flavia Novelli and Marcella Mottolese
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:125
    Content type: Research Published on:

  4. Epithelial ovarian cancer is one of the most malignant cancers in women because metastasis occurs in the most of patients by the time of diagnosis. Cancer cells have strong capacity to form angiogenesis or vas...

    Authors: Pengfei Zhu, Yanxia Ning, Liangqing Yao, Mo Chen and Congjian Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:124
    Content type: Research Published on:

  5. RhoA and RhoC have been proved to be over-expressed in many solid cancers, including colorectal cancer. The reduction of RhoA and RhoC expression by RNA interference (RNAi) resulted growth inhibition of cancer ce...

    Authors: Haibo Wang, Gang Zhao, Xiangping Liu, Aihua Sui, Kun Yang, Ruyong Yao, Zongbao Wang and Qiang Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:123
    Content type: Research Published on:

  6. To investigate the mechanisms of multidrug resistance of brain tumors, to identify the site of cellular expression of P-gp in human brains in situ and to morphologically determine whether an association may ex...

    Authors: Zhenhua Guo, Jin Zhu, Lihua Zhao, Qing Luo and Xianqing Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:122
    Content type: Research Published on:

  7. Anti-CD20 monoclonal antibody treatment has not only increased survival and cure rates in many non-Hodgkin lymphomas, but also has prompted an explosion in the development of novel antibodies and biologically ...

    Authors: Yihu Zheng, Kang Yu, Jimei Du, Lei Jiang, Shenghui Zhang, Yixiang Han, Panpan Yu and Yingxia Tan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:121
    Content type: Research Published on:

  8. The advent of global gene expression profiling has generated unprecedented insight into our molecular understanding of cancer, including breast cancer. For example, human breast cancer patients display signifi...

    Authors: Robin M Hallett, Anna Dvorkin, Christine M Gabardo and John A Hassell
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:120
    Content type: Research Published on:

  9. Slug, Snail, and Twist are transcription factors that regulate the expression of tumor suppressors such as E-cadherin. In this study, we aimed to examine the expression of these transcription factors in human ...

    Authors: Qinchao Yu, Kejun Zhang, Xinsheng Wang, Xiangping Liu and Zemi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:119
    Content type: Research Published on:

  10. Drug resistance remains a great challenge in the treatment of gastric cancer. The goal of this study was to explore the anti-tumor effects and mechanism of cytokine-induced killer (CIK) cell combined with oxal...

    Authors: Qun Zhao, Hui Zhang, Yong Li, Jun Liu, Xiaojie Hu and Liqiao Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:118
    Content type: Research Published on:

  11. Emerging evidence suggests that ataxia telangiectasia-mutated (ATM) is involved in numerous damage repair signaling pathways and cell-cycle checkpoints. Heterozygous carriers of ATM-mutations have an increased ri...

    Authors: Lin-Bo Gao, Xin-Min Pan, Hong Sun, Xia Wang, Li Rao, Li-Juan Li, Wei-Bo Liang, Mei-Li Lv, Wen-Zhong Yang and Lin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:117
    Content type: Research Published on:

  12. Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hype...

    Authors: Jang Hyun Lee, Jae-Kyung Pyon, Dong Wook Kim, Sang Han Lee, Hae Seon Nam, Chul Han Kim, Sang Gue Kang, Yoon Jin Lee, Mi Youn Park, Dong Jun Jeong and Moon Kyun Cho
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:116
    Content type: Research Published on:

  13. To compare the biological characteristics of three types of human hepatocellular carcinoma multi-drug resistant cell sub-lines Bel-7402/ADM models established by three methods.

    Authors: Xingguo Zhong, Maoming Xiong, Xiangling Meng and Renhua Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:115
    Content type: Research Published on:

  14. Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus. It was found that CBX7 expression was upregul...

    Authors: Xiao-Wei Zhang, Li Zhang, Wei Qin, Xiao-Hong Yao, Lei-Zhen Zheng, Xin Liu, Jin Li and Wei-Jian Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:114
    Content type: Research Published on:

  16. Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of se...

    Authors: Xiao-yun Mao, Chui-feng Fan, Hua-chuan Zheng, Jing Wei, Fan Yao and Feng Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:112
    Content type: Research Published on:

  17. GTPase regulator associated with the focal adhesion kinase (GRAF), a putative tumor suppressor gene, is found inactivated in hematopoietic malignancies by either genetic or epigenetic abnormalities. However, the ...

    Authors: Zhen Qian, Jun Qian, Jiang Lin, Dong-ming Yao, Qin Chen, Run-bi Ji, Yun Li, Gao-fei Xiao and Jian-yong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:111
    Content type: Research Published on:

  18. The cellular apoptosis susceptibility (CSE1L/CAS) protein is highly expressed in cancer, and its expression is positively correlated with high cancer stage, high cancer grade, and worse outcomes of patients. C...

    Authors: Cheng-Jeng Tai, Chung-Huei Hsu, Shing-Chuan Shen, Woan-Ruoh Lee and Ming-Chung Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:110
    Content type: Review Published on:

  19. The incidence of malignant melanoma (MM) was occurring at a faster rate than for most neoplasm worldwide, and melanoma metastasis is still the most formidable problem. So it is necessarily to find some biomark...

    Authors: Man Li, Baogang Zhang, Baocun Sun, Xuan Wang, Xinchao Ban, Tao Sun, Zhiyong Liu and Xiulan Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:109
    Content type: Research Published on:

  21. To evaluate the expression of BCL-2 and BAD genes in tissues of breast carcinoma and investigate the relationship between the expression of BCL-2 and BAD in breast cancer cells with chemosensitivity.

    Authors: Bing Yu, Xin Sun, Hong-yan Shen, Feng Gao, Yuan-ming Fan and Zhi-jun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:107
    Content type: Research Published on:

  22. Previous studies have shown that heat shock proteins (HSPs) were upregulated in various types of tumors and were associated with histological grade, recurrence and metastasis of malignant tumors. In this study...

    Authors: Jing Xu, Kangkai Wang, Xin Zhang, Yuanzheng Qiu, Donghai Huang, Wei Li, Xianzhong Xiao and Yongquan Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:106
    Content type: Research Published on:

  23. Authors: Ondrej Slaby, Jana Jancovicova, Radek Lakomy, Marek Svoboda, Alexandr Poprach, Pavel Fabian, Leos Kren, Jaroslav Michalek and Rostislav Vyzula
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:105
    Content type: Erratum Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2010 29:90

  24. Drug resistance remains a great challenge in the treatment of pancreatic cancer. The goal of this study was to determine whether TGF-β1 is associated with drug resistance in pancreatic cancer.

    Authors: Ying Chen, Guanzhen Yu, Danghui Yu and Minghua Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:104
    Content type: Research Published on:

  25. Recently, the anti-tumor activity of N-myc downstream-regulated gene 2 (NDRG2) was shown decreased expression in clear cell renal cell carcinoma (CCRCC), but the role of the down-expression of NDRG2 has not be...

    Authors: Jian-Jun Ma, Cheng-Gong Liao, Xue Jiang, Hua-Dong Zhao, Li-Bo Yao and Ting-Yi Bao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:103
    Content type: Research Published on:

  26. Ovarian cancer is the most fatal gynecologic malignancies in the world. Although, platinum based treatments are widely used, the disease becomes treatment refractory within two years, and novel treatment optio...

    Authors: Bulent Karabulut, Burcak Karaca, Umut Varol, Ugur Muslu, Burcu Cakar, Harika Atmaca, Aslı Kısım, Selim Uzunoglu and Ruchan Uslu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:102
    Content type: Research Published on:

  27. Sulfotransferase (SULT) plays an important role in the formation of estrogen which is usually conferred as a risk factor for breast cancer. Polymorphism of the SULT1A1 may be closely associated with breast can...

    Authors: Yiwei Jiang, Liheng Zhou, Tingting Yan, Zhenzhou Shen, Zhimin Shao and Jinsong Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:101
    Content type: Research Published on:

  28. Currently definitive 5-fluorouracil (5-FU)/cisplatin (CDDP) -based chemotherapy is recognized as one of the most promising treatments for esophageal cancer. A series of studies performed found genetic polymorp...

    Authors: Akiko Kuwahara, Motohiro Yamamori, Megumi Fujita, Tatsuya Okuno, Takao Tamura, Kaori Kadoyama, Noboru Okamura, Tsutomu Nakamura and Toshiyuki Sakaeda
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:100
    Content type: Research Published on:

  29. Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also ...

    Authors: Bo Chen, Xueli Wang, Weihong Zhao and Jianqing Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:99
    Content type: Research Published on:

  30. The novel gene HA117 is a multidrug resistance (MDR) gene expressed by all-trans retinoic acid-resistant HL-60 cells. In the present study, we compared the multidrug resistance of the HA117 with that of the cl...

    Authors: Lihua Zhao, Xianqing Jin, Youhua Xu, Yuxia Guo, Rui Liang, Zhenhua Guo, Tingfu Chen, Yanhui Sun and Xionghui Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:98
    Content type: Research Published on:

  32. Activating mutations in Kit receptor tyrosine kinase or the related platelet-derived growth factor receptor (PDGFR) play an important role in the pathogenesis of gastrointestinal stromal tumors (GIST).

    Authors: Sean Caenepeel, Lisa Renshaw-Gegg, Angelo Baher, Tammy L Bush, Will Baron, Todd Juan, Raffi Manoukian, Andrew S Tasker, Anthony Polverino and Paul E Hughes
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:96
    Content type: Research Published on:

  33. Hypertension (HT) and hand-foot skin reactions (HFSR) may be related to the activity of bevacizumab and sorafenib. We hypothesized that these toxicities would correspond to favorable outcome in these drugs, th...

    Authors: Lokesh Jain, Tristan M Sissung, Romano Danesi, Elise C Kohn, William L Dahut, Shivaani Kummar, David Venzon, David Liewehr, Bevin C English, Caitlin E Baum, Robert Yarchoan, Giuseppe Giaccone, Jürgen Venitz, Douglas K Price and William D Figg
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:95
    Content type: Research Published on:

  34. To explore the therapeutic effects of thymidine kinase (TK) expressed by enhanced vector pGL3-basic- hTERTp-TK-EGFP-CMV driven by human telomerase reverse transcriptase promoter (hTERTp) as well as cytomegalov...

    Authors: Cong-Xiang Shen, Zhong Wen, Yu-Hong Qian, Shao-Feng Mu and Xiao-Fang Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:94
    Content type: Research Published on:

  35. Nm23 gene was isolated as a metastatic suppressor gene. The antimetastatic effect of Nm23 has been an enigma for more than 10 years. Little is known about its molecular mechanisms. In this study we overexpress...

    Authors: Shangyang She, Boying Xu, Min He, Xiuwan Lan and Qiuyan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:93
    Content type: Research Published on:

  36. Tumor cell expression of Toll-like receptors (TLRs) can promote inflammation and cell survival in the tumor microenvironment. Toll-like receptor 4 (TLR4) signaling in tumor cells can mediate tumor cell immune ...

    Authors: Huan Yang, Huiqin Zhou, Ping Feng, Xiaoni Zhou, Huiyan Wen, Xiaofang Xie, Haiying Shen and Xueming Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:92
    Content type: Research Published on:

  37. Preclinical toxicity of adaphostin has been related to oxidative stress. This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant r...

    Authors: Nicole D Fer, Robert H Shoemaker and Anne Monks
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:91
    Content type: Research Published on:

  38. MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies have shown altered expression levels of several microRNAs in renal cell carcinoma.

    Authors: Ondrej Slaby, Jana Jancovicova, Radek Lakomy, Marek Svoboda, Alexandr Poprach, Pavel Fabian, Leos Kren, Jaroslav Michalek and Rostislav Vyzula
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:90
    Content type: Research Published on:

  39. ECRG4 has been shown to be a candidate tumor suppressor in several tumors, but its role in glioma remains poorly understood. In this study, we examined the mRNA expression of ECRG4 and investigated its biologi...

    Authors: Wei Li, Xinrui Liu, Bo Zhang, Dongxue Qi, Lihong Zhang, Yuhong Jin and Hongfa Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:89
    Content type: Research Published on:

  40. This study explored the expression and function of Slug in human extrahepatic hilar cholangiocarcinoma (EHC) to identify its role in tumor progression.

    Authors: Ke-jun Zhang, Dong-sheng Wang, Shao-yan Zhang, Xue-long Jiao, Chun-wei Li, Xin-sheng Wang, Qin-chao Yu and Hai-ning Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:88
    Content type: Research Published on:

  41. Thymoquinone (TQ) is a compound extracted from Black Caraway seeds of Nigella Sativa and is active against various cancers. Cisplatin (CDDP) is the most active chemotherapeutic agent in Lung Cancer. Here we repor...

    Authors: Syed H Jafri, Jonathan Glass, Runhua Shi, Songlin Zhang, Misty Prince and Heather Kleiner-Hancock
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:87
    Content type: Research Published on:

  42. Various strains of Bacillus thuringiensis (Bt) have been found to produce parasporal proteins that are cytotoxic to human cancer cells. This study aims to establish the binding affinity of purified Bt 18 toxin fo...

    Authors: Rebecca SY Wong, Shar M Mohamed, Vishna D Nadarajah and Ibrahim Azmi T Tengku
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:86
    Content type: Research Published on:

  43. To determine the expression of bone morphogenetic protein-2 (BMP-2) and its receptors BMPRIA, BMPRIB, and BMPRII in epithelial ovarian cancer (EOC) and to analyze their influence on the prognosis of ovarian ca...

    Authors: Ying Ma, Lin Ma, Quan Guo and Shulan Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:85
    Content type: Research Published on:

  44. Orthotopic models are important in cancer research. Here we developed orthotopic xenograft mouse model of metastatic lung cancer and glioblastoma with a specially designed system.

    Authors: Xi Feng Fei, Quan Bin Zhang, Jun Dong, Yi Diao, Zhi Min Wang, Ru Jun Li, Zi Cheng Wu, Ai Dong Wang, Qing Lan, Shi Ming Zhang and Qiang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:84
    Content type: Research Published on:

  45. The diagnosis of lymph node metastasis in esophageal cancer by the presence and number of metastatic lymph nodes is an extremely important prognostic factor. In addition, the indication of non-surgical therapy...

    Authors: Tatsuya Tanaka, Hideyuki Ishiguro, Yoshiyuki Kuwabara, Masahiro Kimura, Akira Mitsui, Takeyasu Katada, Midori Shiozaki, Yasuhiro Naganawa, Yoshitaka Fujii and Hiromitsu Takeyama
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:83
    Content type: Research Published on:

  46. Breast cancer is one of the most common diseases affecting women. Inherited susceptibility genes, BRCA1 and BRCA2, are considered in breast, ovarian and other common cancers etiology. BRCA1 and BRCA2 genes have b...

    Authors: Safinaz S Ibrahim, Elsayed E Hafez and Mervat M Hashishe
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:82
    Content type: Research Published on:

  47. We have previously reported that Myeov (MYEloma OVerexpressed gene) expression is enhanced in colorectal cancer (CRC) and that it promotes CRC cell proliferation and invasion. The role of Myeov in CRC migratio...

    Authors: Garrett Lawlor, Peter P Doran, Padraic MacMathuna and David W Murray
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:81
    Content type: Research Published on:

  48. Breast cancer stem cells (BCSCs) have been recently identified in breast carcinoma as CD44+CD24- cells, which exclusively retain tumorigenic activity and display stem cell-like properties. Using a mammosphere cul...

    Authors: Mingzhu Huang, Yuqing Li, Huanle Zhang and Feifei Nan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:80
    Content type: Research Published on:

  49. Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. Cx26 is considered to be a tumor suppressor gene. However, recent studies revealed that over expression of Cx26 ...

    Authors: Shinya Nomura, Kiyoshi Maeda, Eiji Noda, Toru Inoue, Shinya Fukunaga, Hisashi Nagahara and Kosei Hirakawa
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:79
    Content type: Research Published on:

  50. Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (D...

    Authors: Feng Ye, Yan Yu, Yuting Hu, Weiguo Lu and Xing Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:78
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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