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  1. Cancer cells are known to secrete the stress molecules MICA and MICB that activate cytotoxicity by lymphocytes and NK cells through their NKG2D receptor as a mechanism of immunological defense. This work was u...

    Authors: Benny Weiss-Steider, Isabel Soto-Cruz, Christian A Martinez-Campos and Jorge Flavio Mendoza-Rincon
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:37
    Content type: Research Published on:

  2. Iodine 125 (125I) seed irradiation is an effective treatment for unresectable pancreatic cancers. However, the radiobiological mechanisms underlying brachytherapy remain unclear. Therefore, we investigated the in...

    Authors: Jian-xia Ma, Zhen-dong Jin, Pei-ren Si, Yan Liu, Zheng Lu, Hong-yu Wu, Xue Pan, Luo-wei Wang, Yan-fang Gong, Jun Gao and Li Zhao-shen
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:35
    Content type: Research Published on:

  3. Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer ...

    Authors: Zhen Li, Hiroki Tanaka, Floyd Galiano and Jonathan Glass
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:34
    Content type: Research Published on:

  6. Various angiogenic regulators are involved in angiogenesis cascade. Transcription factor Ets-1 plays important role in angiogenesis, remodeling of extracellular matrix, and tumor metastasis. Ets-1 target genes...

    Authors: Zijing Lin, Yu Liu, Yuhui Sun and Xiuping He
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:31
    Content type: Research Published on:

  7. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been widely used for the treatment of non-small cell lung cancer (NSCLC). KRAS and EGFR somatic mutations in NSCLC may predict resistanc...

    Authors: Leina Sun, Qiang Zhang, Huanling Luan, Zhongli Zhan, Changli Wang and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:30
    Content type: Research Published on:

  8. Ovarian cancer remains the leading cause of death from gynaecological malignancy. More than 60% of the patients are presenting the disease in stage III or IV. In spite of combination of chemotherapy and surger...

    Authors: Caroline van Haaften, Colin C Duke, Arij M Weerheim, Nico PM Smit, Paul MM van Haard, Firouz Darroudi and Baptist JMZ Trimbos
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:29
    Content type: Research Published on:

  9. To elucidate whether rapamycin, the inhibitor of mTOR (mammalian target of rapamycin), can potentiate the cytotoxic effect of docetaxel in lung cancer cells and to probe the mechanism underlying such enhancement.

    Authors: Huiyan Niu, Jiahe Wang, Hui Li and Ping He
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:28
    Content type: Research Published on:

  10. To evaluate the expression of EGFR and COX-2 and their correlation with prognosis in NSCLC

    Authors: Feng Li, Yongmei Liu, Huijiao Chen, Dianying Liao, Yali Shen, Feng Xu and Jin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:27
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:32

  11. Cyclooxygenase2 (COX-2), one isoform of cyclooxygenase proinflammatory enzymes, is responsible for tumor development, invasion and metastasis. Due to its role and frequent overexpression in a variety of human ...

    Authors: Qinghua Zhao, Chuan Wang, Jiaxue Zhu, Lei Wang, Shuanghai Dong, Guoqiao Zhang and Jiwei Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:26
    Content type: Research Published on:

  12. As the expression of human sperm protein 17 (Sp17) in normal tissue is limited and the function is obscure, its aberrant expression in malignant tumors makes it to be a candidated molecular marker for tumor im...

    Authors: Fang-qiu Li, Shi-xin Zhang, Lian-xiao An and Yue-qing Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:25
    Content type: Research Published on:

  13. The immune factors heat shock protein (HSP)/peptides (HSP/Ps) can induce both adaptive and innate immune responses. Treatment with HSP/Ps in cancer cell-bearing mice and cancer patients revealed antitumor immu...

    Authors: Quan-Yi Guo, Mei Yuan, Jiang Peng, Xue-Mei Cui, Ge Song, Xiang Sui and Shi-Bi Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:24
    Content type: Research Published on:

  14. Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis.

    Authors: Burkhard HA von Rahden, Stefan Kircher, Maria Lazariotou, Christoph Reiber, Luisa Stuermer, Christoph Otto, Christoph T Germer and Martin Grimm
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:23
    Content type: Research Published on:

  15. This study investigated the effects of Ulinastatin (UTI) and docataxel (Taxotere, TAX) on tumor growth and expression of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) in breas...

    Authors: Xiaoliang Zhao, Xin Sun, Feng Gao, Jie Luo and Zhijun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:22
    Content type: Research Published on:

  16. Epidemiological studies propose that obesity increases the risk of several cancers, including melanoma. Obesity increases the expression of leptin, a multifunctional peptide produced predominantly by adipocyte...

    Authors: Fatemehsadat Amjadi, Shaghaygh Haghjooy Javanmard, Hamid Zarkesh-Esfahani, Majid Khazaei and Manijeh Narimani
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:21
    Content type: Research Published on:

  17. Recently, miR-451 as a tumor suppressor has been reported in other studies. However, whether miR-451 can affect the sensitivity of non-small cell lung cancer (NSCLC) cells to cisplatin (DDP) remains unclear. T...

    Authors: Hai-Bo Bian, Xuan Pan, Jin-Song Yang, Zhao-Xia Wang and Wei De
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:20
    Content type: Research Published on:

  19. Lung cancer is one of the most common human cancers and the leading cause of cancer death worldwide. The identification of lung cancer associated genes is essential for lung cancer diagnosis and treatment.

    Authors: Liangan Chen, Zhixin Liang, Qing Tian, Chunsun Li, Xiuqing Ma, Yu Zhang, Zhen Yang, Ping Wang and Yanqin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:18
    Content type: Research Published on:

  20. Bostrycin is a novel compound isolated from marine fungi that inhibits proliferation of many cancer cells. However, the inhibitory effect of bostrycin on lung cancers has not been reported. This study is to in...

    Authors: Wei-Sheng Chen, Jun-Na Hou, Yu-Biao Guo, Hui-Ling Yang, Can-Mao Xie, Yong-Cheng Lin and Zhi-Gang She
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:17
    Content type: Research Published on:

  21. This retrospective analysis is focused on the efficacy and safety of radioimmunotherapy (RIT) with Zevalin® in nine patients with recurrent follicular lymphoma (FL) who were treated in a consolidation setting aft...

    Authors: Francesco Pisani, Carlo Ludovico Maini, Rosa Sciuto, Laura Dessanti, Mariella D'Andrea, Daniela Assisi and Maria Concetta Petti
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:16
    Content type: Case report Published on:

  22. This study aimed to investigate the molecular structural relationship between cell adhesive molecule CD44 and Lewis y antigen, and determine the effects of Lewis y antigen on CD44-mediated adhesion and spreadi...

    Authors: Lili Gao, Limei Yan, Bei Lin, Jian Gao, Xiuyun Liang, Yanyan Wang, Juanjuan Liu, Shulan Zhang and Iwamori Masao
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:15
    Content type: Research Published on:

  23. Cyclooxygenase-2 (COX-2) has recently been considered to promote lymphangiogenesis by up-regulating vascular endothelial growth factor-C (VEGF-C) in breast and lung cancer. However, the impact of COX-2 on lymp...

    Authors: Hong-Feng Gou, Xin-Chuan Chen, Jiang Zhu, Ming Jiang, Yu Yang, Dan Cao and Mei Hou
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:14
    Content type: Research Published on:

  26. Streptococcus bovis (S. bovis) bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus. 25 to 80% of patients with S. bovis/gallolyticus bacteremia have concomitant...

    Authors: Ahmed S Abdulamir, Rand R Hafidh and Fatimah Abu Bakar
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:11
    Content type: Review Published on:

  27. To evaluate the therapeutic strategies commonly employed in the clinic for the management of brain metastases (BMs) and to correlate disease outcome with type of treatment and therapeutic resources available a...

    Authors: Alessandra Fabi, Alessandra Felici, Giulio Metro, Alessandra Mirri, Emilio Bria, Stefano Telera, Luca Moscetti, Michelangelo Russillo, Gaetano Lanzetta, Giovanni Mansueto, Andrea Pace, Marta Maschio, Antonello Vidiri, Isabella Sperduti, Francesco Cognetti and Carmine M Carapella
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:10
    Content type: Research Published on:

  28. Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. Th...

    Authors: Daniele Lodi, Tommaso Iannitti and Beniamino Palmieri
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:9
    Content type: Review Published on:

  29. Hedgehog (Hh) signaling pathway is involved in regulation of many tissues development and oncogenesis. Recently, Hh signaling has been identified as a required functional pathway for leukemia stem cells(LSCs),...

    Authors: Bing Long, Huanling Zhu, Cuixia Zhu, Ting Liu and Wentong Meng
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:8
    Content type: Research Published on:

  30. To implement a new cost efficacy internal Service for blood component irradiation, we carried out specific procedures and quality assurance reports using the linear accelerators (LINACs) of the Regina Elena In...

    Authors: Paola Pinnarò, Antonella Soriani, Daniela D'Alessio, Carolina Giordano, Maria Laura Foddai, Valentina Pinzi and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:7
    Content type: Research Published on:

  31. Vascular endothelial growth factor (VEGF) expression is up-regulated via a cyclooxygenase-2 (COX-2)-dependent mechanism in non-small cell lung cancer (NSCLC), but the specific signaling pathway involved is unc...

    Authors: Honghe Luo, Zhenguang Chen, Hui Jin, Mei Zhuang, Tao Wang, Chunhua Su, Yiyan Lei, Jianyong Zou and Beilong Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:6
    Content type: Research Published on:

  32. SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various canc...

    Authors: Chan H Han, Yu-Jing Huang, Karen H Lu, Zhensheng Liu, Gordon B Mills, Qingyi Wei and Li-E Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:5
    Content type: Research Published on:

  33. The best method to deliver intraperitoneal chemotherapy (IPC) for peritoneal carcinomatosis from ovarian cancer is not well defined. The aim of this study was to assess the ability of hyperthermia and adrenali...

    Authors: Olivier Facy, François Radais, Sylvain Ladoire, Delphine Delroeux, Hervé Tixier, François Ghiringhelli, Patrick Rat, Bruno Chauffert and Pablo Ortega-Deballon
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:4
    Content type: Research Published on:

  34. An increasing body of evidence now implicates acetaldehyde as a major underlying factor for the carcinogenicity of alcoholic beverages and especially for oesophageal and oral cancer. Acetaldehyde associated wi...

    Authors: Dirk W Lachenmeier and Yulia B Monakhova
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:3
    Content type: Research Published on:

  35. Cancer-testis antigens (CTAs) are suitable targets for cancer-specific immunotherapy. The aim of the study is to investigate the expression of CTAs in intrahepatic cholagiocarcinoma (IHCC) and evaluate their p...

    Authors: Jin-xue Zhou, Yin Li, Sun-xiao Chen and An-mei Deng
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:2
    Content type: Research Published on:

  36. Telomerase plays an important role in cell proliferation and carcinogenesis and is believed to be a good target for anti-cancer drugs. Elimination of template function of telomerase RNA may repress the telomer...

    Authors: Yingying Lu, Junchao Gu, Dachuan Jin, Yanjing Gao and Mengbiao Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:1
    Content type: Research Published on:

  37. Anticancer activities of several substituted naphthalimides (1H-benz[de]isoquinoline-1,3-diones) are well documented. Some of them have undergone Phase I-II clinical trials. Presently a series of ten N-(hydrox...

    Authors: Asama Mukherjee, Sushanta Dutta, Muthiah Shanmugavel, Dilip M Mondhe, Parduman R Sharma, Shashank K Singh, Ajit K Saxena and Utpal Sanyal
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:175
    Content type: Research Published on:

  38. This study aimed to determine the miRNA profile in breast cancer stem cells (BCSCs) and to explore the functions of characteristic BCSC miRNAs.

    Authors: Jian-guo Sun, Rong-xia Liao, Jun Qiu, Jun-yu Jin, Xin-xin Wang, Yu-zhong Duan, Fang-lin Chen, Ping Hao, Qi-chao Xie, Zhi-xin Wang, De-zhi Li, Zheng-tang Chen and Shao-xiang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:174
    Content type: Research Published on:

  39. Primary and secondary drug resistance to imatinib and sunitinib in patients with gastrointestinal stromal tumors (GISTs) has led to a pressing need for new therapeutic strategies such as drug combinations. Mos...

    Authors: Maria Abbondanza Pantaleo, Giordano Nicoletti, Cristina Nanni, Chiara Gnocchi, Lorena Landuzzi, Carmelo Quarta, Stefano Boschi, Margherita Nannini, Monica Di Battista, Paolo Castellucci, Stefano Fanti, Pier Luigi Lollini, Elena Bellan, Mauro Castelli, Domenico Rubello and Guido Biasco
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:173
    Content type: Research Published on:

  40. Specific gene expression is tightly regulated by various transcription factors. Osteopontin (OPN) is a phosphoprotein that mediates hepatocellular carcinoma (HCC) progression and metastasis. However, the mecha...

    Authors: Rong-Xin Chen, Yun-Hong Xia, Tong-Chun Xue and Sheng-Long Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:172
    Content type: Research Published on:

  41. The present study was undertaken to relate the co-expression of prostate-associated antigens, PSMA and PSA, with the degree of vascularization in normal and pathologic (hyperplasia and cancer) prostate tissues...

    Authors: Awatef Ben Jemaa, Yosra Bouraoui, Sataa Sallami, Ahmed Banasr, Nawfel Ben Rais, Latifa Ouertani, Yassin Nouira, Ali Horchani and Ridha Oueslati
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:171
    Content type: Research Published on:

  42. The purpose of the study was to explore the anti-tumor effect of ultrasound -targeted microbubble destruction mediated herpes simplex virus thymidine kinase (HSV-TK) suicide gene system on mice hepatoma.

    Authors: Shiji Zhou, Shengwei Li, Zuojin Liu, Yong Tang, Zhigang Wang, Jianping Gong and Changan Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:170
    Content type: Research Published on:

  43. The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in micr...

    Authors: Ren Li, Niansong Qian, Kaishan Tao, Nan You, Xinchuan Wang and Kefeng Dou
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:169
    Content type: Research Published on:

  44. The Open Archive Initiative (OAI) refers to a movement started around the '90s to guarantee free access to scientific information by removing the barriers to research results, especially those related to the e...

    Authors: Elisabetta Poltronieri, Ivana Truccolo, Corrado Di Benedetto, Mauro Castelli, Mauro Mazzocut and Gaetana Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:168
    Content type: Research Published on:

  46. ChromograninA in prostate carcinoma (PC) indicate NE differentiation. This tumour is more aggressive and resistant to hormone therapy.

    Authors: Marialuisa Appetecchia, Aurela Meçule, Giuseppe Pasimeni, Concetta V Iannucci, Piero De Carli, Roberto Baldelli, Agnese Barnabei, Giovanni Cigliana, Isabella Sperduti and Michele Gallucci
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:166
    Content type: Research Published on:

  47. Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. Unfortunately, most patients re...

    Authors: Hoang Thanh Chi, Bui Thi Kim Ly, Takahiro Taguchi, Toshiki Watanabe and Yuko Sato
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:165
    Content type: Research Published on:

  48. More data about TACE and pTACE seem necessary to better define the global treatment strategy for HCC. Aim of our analysis was to evaluate the role of TACE, either with lipiodol (traditional) or drug-eluting mi...

    Authors: Mario Scartozzi, Gianluca Svegliati Baroni, Luca Faloppi, Marzia Di Pietro Paolo, Chiara Pierantoni, Roberto Candelari, Rossana Berardi, Stefania Antognoli, Cinzia Mincarelli, Andrea Risaliti, Cristina Marmorale, Ettore Antico, Antonio Benedetti and Stefano Cascinu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:164
    Content type: Research Published on:

  49. In spite of its establishment from the peripheral blood of a case with acute myeloid leukemia (AML)-M1, HPB-AML-I shows plastic adherence with spindle-like morphology. In addition, lipid droplets can be induce...

    Authors: Bambang Ardianto, Takeshi Sugimoto, Seiji Kawano, Shimpei Kasagi, Siti NA Jauharoh, Chiyo Kurimoto, Eiji Tatsumi, Keiko Morikawa, Shunichi Kumagai and Yoshitake Hayashi
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:163
    Content type: Research Published on:

  50. Somatostatin prevents cell proliferation by inducing apoptosis. Downregulation of the XAF1 transcript may occur during the development of prostate cancer. It is interesting to evaluate the potential regulatory ef...

    Authors: Zhaoquan Xing, Zunlin Zhou, Rong Yu, Shuling Li, Chunde Li, Sten Nilsson and Zhaoxu Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:162
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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