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  1. Despite the incorporation of novel therapeutics, advanced triple negative breast cancer (TNBC) still represents a relevant clinical problem. Considering this, as well as the clinical efficacy of antibody-drug ...

    Authors: Juan Carlos Montero, Elisa Calvo-Jiménez, Sofía del Carmen, Mar Abad, Alberto Ocaña and Atanasio Pandiella
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:106
  2. Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent in the treatment of this m...

    Authors: Milad Ashrafizadeh, Mahshid Deldar Abad Paskeh, Sepideh Mirzaei, Mohammad Hossein Gholami, Ali Zarrabi, Farid Hashemi, Kiavash Hushmandi, Mehrdad Hashemi, Noushin Nabavi, Francesco Crea, Jun Ren, Daniel J. Klionsky, Alan Prem Kumar and Yuzhuo Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:105
  3. Authors: Chenwei Wang, Yadi Liao, Wei He, Hong Zhang, Dinglan Zuo, Wenwu Liu, Zhiwen Yang, Jiliang Qiu, Yichuan Yuan, Kai Li, Yuanping Zhang, Yongjin Wang, Yunxing Shi, Yuxiong Qiu, Song Gao, Yunfei Yuan…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:104

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:113

  4. Hepatocellular carcinoma (HCC) is usually diagnosed at an advanced stage due to rapid progression. Glycolysis supports anabolic growth and metastasis to promote HCC progression. However, the molecular mechanis...

    Authors: Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du and Baocai Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:101
  5. DNA methylation is one of the most important epigenetic mechanisms to regulate gene expression, which is highly dynamic during development and specifically maintained in somatic cells. Aberrant DNA methylation...

    Authors: Wanxu Huang, Hua Li, Qingsong Yu, Wei Xiao and Dan Ohtan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:100

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:262

  6. Colorectal cancer (CRC) is one of the most common cancers worldwide. The diagnosis, prognosis and therapeutic monitoring of CRC depends largely on tissue biopsy. However, due to tumor heterogeneity and limitat...

    Authors: Afsheen Raza, Abdul Q. Khan, Varghese Philipose Inchakalody, Sarra Mestiri, Zeenath Safira K. M. Yoosuf, Takwa Bedhiafi, Dina Moustafa Abo El-Ella, Nassiba Taib, Shereena Hydrose, Shayista Akbar, Queenie Fernandes, Lobna Al-Zaidan, Roopesh Krishnankutty, Maysaloun Merhi, Shahab Uddin and Said Dermime
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:99
  7. Macropinocytosis, an important nutrient-scavenging pathway in certain cancer cells, allows cells to compensate for intracellular amino acid deficiency under nutrient-poor conditions. Ferroptosis caused by cyst...

    Authors: Jun-Kyu Byun, Seunghyeong Lee, Gil Won Kang, Yu Rim Lee, Soo Young Park, Im-Sook Song, Jae Won Yun, Jaebon Lee, Yeon-Kyung Choi and Keun-Gyu Park
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:98
  8. Treatment of Diffuse Large B Cell Lymphoma (DLBCL) patients with rituximab and the CHOP treatment regimen is associated with frequent intrinsic and acquired resistance. However, treatment with a CD47 monoclona...

    Authors: Ewa Cendrowicz, Lisa Jacob, Shirley Greenwald, Ami Tamir, Iris Pecker, Rinat Tabakman, Lucy Ghantous, Liat Tamir, Roy Kahn, Jasmine Avichzer, Alexandra Aronin, Shira Amsili, Elina Zorde-Khvalevsky, Yosi Gozlan, Martijn Vlaming, Gerwin Huls…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:97
  9. The cohesin complex controls faithful chromosome segregation by pairing sister chromatids after DNA replication until mitosis. In addition, it is crucial for hierarchal three-dimensional organization of the ge...

    Authors: Maddalena Di Nardo, Maria M. Pallotta and Antonio Musio
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:96
  10. Mitochondrial fusion and fission proteins have been nominated as druggable targets in cancer. Whether their inhibition is efficacious in triple negative breast cancer (TNBC) that almost invariably develops che...

    Authors: Margherita Zamberlan, Amandine Boeckx, Florian Muller, Federica Vinelli, Olivier Ek, Caterina Vianello, Emeline Coart, Keitaro Shibata, Aurélie Christian, Francesca Grespi, Marta Giacomello, Ingrid Struman, Luca Scorrano and Stéphanie Herkenne
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:95
  11. Authors: Lin Zhao, Yan Wang, Longyang Jiang, Miao He, Xuefeng Bai, Lifeng Yu and Minjie Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:94

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:25

  12. Authors: Wenli Fang, Ting Zhou, He Shi, Mengli Yao, Dian Zhang, Husun Qian, Qian Zeng, Yange Wang, Fangfang Jin, Chengsen Chai and Tingmei Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:93

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:4

  13. Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells undergoing a defective differentiation due to genomic and epigenetic impairments. Therefore, NB may arise at any final si...

    Authors: Mirco Ponzoni, Tiziana Bachetti, Maria Valeria Corrias, Chiara Brignole, Fabio Pastorino, Enzo Calarco, Veronica Bensa, Elena Giusto, Isabella Ceccherini and Patrizia Perri
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:92
  14. Histone deacetylases (HDACs) play crucial roles in cancers, but the role and mechanism of HDAC7 in NSCLC have not been fully understood.

    Authors: Kai Guo, Zhiqiang Ma, Yujiao Zhang, Lu Han, Changjian Shao, Yingtong Feng, Fei Gao, Shouyin Di, Zhipei Zhang, Jiao Zhang, Fabrizio Tabbò, Simon Ekman, Kenichi Suda, Federico Cappuzzo, Jing Han, Xiaofei Li…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:91
  15. Gemcitabine (GEM) is the first-line chemotherapeutic drug used to treat pancreatic ductal adenocarcinoma carcinoma (PDAC), but chemoresistance is often encountered clinically. Nrf2, an oxidative stress respons...

    Authors: Juan Zhang, Hong-Xi Xu, William Chi Shing Cho, Wah Cheuk, Yang Li, Qiong-Hui Huang, Wen Yang, Yan-Fang Xian and Zhi-Xiu Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:90
  16. Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma in which microenvironmental (niche) factors promote PDAC progression. In mouse models, reduction of the stroma increased the proporti...

    Authors: Tomohiko Shinkawa, Kenoki Ohuchida, Yuki Mochida, Kukiko Sakihama, Chika Iwamoto, Toshiya Abe, Noboru Ideno, Yusuke Mizuuchi, Koji Shindo, Naoki Ikenaga, Taiki Moriyama, Kohei Nakata, Yoshinao Oda and Masafumi Nakamura
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:89
  17. Resistance to standard therapy is a major reason for the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Developing novel therapy to overcome PDAC drug-resistance is urgently needed. CRABP-II was hi...

    Authors: Shuiliang Yu, Lei Wang, Danian Che, Mei Zhang, Ming Li, Mikihiko Naito, Wei Xin and Lan Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:88
  18. Epigenetic regulations frequently appear in Glioblastoma (GBM) and are highly associated with metabolic alterations. Especially, Histone deacetylases (HDACs) correlates with the regulation of tumorigenesis and...

    Authors: Sungmin Kwak, Seung-Ho Park, Sung-Hak Kim, Gi-Jun Sung, Ji-Hye Song, Ji-Hoon Jeong, Hyunhee Kim, Chang Hoon Ha, Seong Who Kim and Kyung-Chul Choi
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:87
  19. Circulating tumor cells (CTCs) are responsible for the metastatic dissemination of colorectal cancer (CRC) to the liver, lungs and lymph nodes. CTCs rarity and heterogeneity strongly limit the elucidation of t...

    Authors: Maria Laura De Angelis, Federica Francescangeli, Chiara Nicolazzo, Michele Signore, Alessandro Giuliani, Lidia Colace, Alessandra Boe, Valentina Magri, Marta Baiocchi, Antonio Ciardi, Francesco Scarola, Massimo Spada, Filippo La Torre, Paola Gazzaniga, Mauro Biffoni, Ruggero De Maria…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:86
  20. Multiple myeloma (MM) is an incurable plasma cell malignancy in the bone marrow (BM), while immunoglobulin D type of MM (IgD MM) is a very rare but most severe subtype in all MM cases. Therefore, systemic stud...

    Authors: Xiaozhu Tang, Zhendong Deng, Pinggang Ding, Wanting Qiang, Yue Lu, Shengyao Gao, Ye Hu, Ye Yang, Juan Du and Chunyan Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:85
  21. Pancreatic ductal adenocarcinoma (PDAC) represents an unmet clinical need due to the very poor prognosis and the lack of effective therapy. Here we investigated the potential of domatinostat (4SC-202), a new c...

    Authors: Maria Serena Roca, Tania Moccia, Federica Iannelli, Cristina Testa, Carlo Vitagliano, Michele Minopoli, Rosa Camerlingo, Giulia De Riso, Rossella De Cecio, Francesca Bruzzese, Mariarosaria Conte, Lucia Altucci, Elena Di Gennaro, Antonio Avallone, Alessandra Leone and Alfredo Budillon
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:83

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:138

  22. BCR-ABL-independent drug resistance is a barrier to curative treatment of chronic myeloid leukemia (CML). However, the molecular pathways underlying BCR-ABL-independent tyrosine kinase inhibitor (TKI) resistan...

    Authors: Taewoo Yang, Kyu-Young Sim, Gwang-Hoon Ko, Jae-Sook Ahn, Hyeoung-Joon Kim and Sung-Gyoo Park
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:82
  23. Tumor budding is included in the routine diagnosis of colorectal cancer (CRC) and is considered a tumor prognostic factor independent of TNM staging. This study aimed to identify the fibroblast-mediated effect...

    Authors: Ling-Fang Gao, Yan Zhong, Ting Long, Xia Wang, Jia-Xian Zhu, Xiao-Yan Wang, Zhi-Yan Hu and Zu-Guo Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:81
  24. Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men. From a therapeutic perspective it is no...

    Authors: Boris Klimovich, Laura Meyer, Nastasja Merle, Michelle Neumann, Alexander M. König, Nikolaos Ananikidis, Corinna U. Keber, Sabrina Elmshäuser, Oleg Timofeev and Thorsten Stiewe
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:80
  25. Dysfunctional p53 signaling is one of the major causes of hepatocellular carcinoma (HCC) tumorigenesis and development, but the mechanisms underlying p53 inactivation in HCC have not been fully clarified. The ...

    Authors: Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao and Chunyan Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:79
  26. Progression to stage IV disease remains the main cause of breast cancer-related deaths. Increasing knowledge on the hematogenous phase of metastasis is key for exploiting the entire window of opportunity to in...

    Authors: Emanuela Fina, Loredana Cleris, Matteo Dugo, Mara Lecchi, Chiara Maura Ciniselli, Daniele Lecis, Giulia Valeria Bianchi, Paolo Verderio, Maria Grazia Daidone and Vera Cappelletti
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:78
  27. Metabolic reprogramming is a hallmark of cancer. However, the roles of long noncoding RNAs (lncRNAs) in cancer metabolism, especially glucose metabolism remain largely unknown.

    Authors: Baoyu He, Hongli Pan, Fengque Zheng, Saiqiong Chen, Qingli Bie, Jinghe Cao, Rou Zhao, Jing Liang, Li Wei, Jianchao Zeng, Hui Li, Xing Cui, Yixuan Ding, Wei Chao, Tiantian Xiang, Yuhe Cheng…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:77
  28. Mitochondrial dynamics homeostasis is important for cell metabolism, growth, proliferation, and immune responses. The critical GTPase for mitochondrial fission, Drp1 is frequently upregulated in many cancers a...

    Authors: Yujia Li, Hui Chen, Qi Yang, Lixin Wan, Jing Zhao, Yuanyuan Wu, Jiaxin Wang, Yating Yang, Menglan Niu, Hongliang Liu, Junqi Liu, Hushan Yang, Shaogui Wan, Yanming Wang and Dengke Bao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:76
  29. The combination of pemetrexed and cisplatin remains the reference first-line systemic therapy for malignant pleural mesothelioma (MPM). Its activity is moderate because of tumor aggressiveness, immune-suppress...

    Authors: Iris Chiara Salaroglio, Dimas Carolina Belisario, Paolo Bironzo, Preeta Ananthanarayanan, Luisa Ricci, Sabrina Digiovanni, Simona Fontana, Francesca Napoli, Alberto Sandri, Chiara Facolmatà, Roberta Libener, Valentina Comunanza, Federica Grosso, Elena Gazzano, Francesco Leo, Riccardo Taulli…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:75
  30. Glioblastoma (GB) is the most common and highly malignant brain tumor characterized by aggressive growth and resistance to alkylating chemotherapy. Autophagy induction is one of the hallmark effects of anti-GB...

    Authors: Zhuang Li, Wen-Juan Fu, Xiao-Qing Chen, Shuai Wang, Ru-Song Deng, Xiao-Peng Tang, Kai-Di Yang, Qin Niu, Hong Zhou, Qing-Rui Li, Yong Lin, Mei Liang, Si-Si Li, Yi-Fang Ping, Xin-Dong Liu, Xiu-Wu Bian…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:74
  31. Integrin alpha 2 (ITGA2) has been recently reported to be an oncogene and to play crucial roles in tumor cell proliferation, invasion, metastasis, and angiogenesis. Our previous study showed that ITGA2 was ove...

    Authors: Hongkun Cai, Feng Guo, Shuang Wen, Xin Jin, Heshui Wu and Dianyun Ren
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:73
  32. Authors: Linglong Yin, Youhong Liu, Yuchong Peng, Yongbo Peng, Xiaohui Yu, Yingxue Gao, Bowen Yuan, Qianling Zhu, Tuoyu Cao, Leye He, Zhicheng Gong, Lunquan Sun, Xuegong Fan and Xiong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:72

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:153

  33. Pancreatic ductal adenocarcinoma (PDAC) is characterized by clusters of cancer cells surrounded by a dense desmoplastic stroma. However, little is known about stromal cell heterogeneity in the pancreatic tumor...

    Authors: Shangyou Zheng, Chonghui Hu, Hongcao Lin, Guolin Li, Renpeng Xia, Xiang Zhang, Dan Su, Zhihua Li, Quanbo Zhou and Rufu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:71
  34. Resistance of colorectal cancer (CRC) cells to radiotherapy considerably contributes to poor clinical outcomes of CRC patients. Microarray profiling in this study revealed the differentially expressed forkhead...

    Authors: Mei Yang, Qian Liu, Maolin Dai, Renqun Peng, Xinghui Li, Wei Zuo, Juhua Gou, Feixue Zhou, Shuangjiang Yu, Hao Liu and Min Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:70
  35. Glycolysis is a pivotal process in metabolic reprogramming of tumorigenesis. Previous research has indicated that lncRNAs might play crucial roles in glycolysis of various tumors. However, the function of lncR...

    Authors: Yuhang Hu, Jiang Tang, Fengyu Xu, Jinhuang Chen, Zhu Zeng, Shengbo Han, Fan Wang, Decai Wang, Mengqi Huang, Yong Zhao, Yan Huang, Wenfeng Zhuo and Gang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:69
  36. Epidemiological studies have confirmed that abnormal circadian rhythms are associated with tumorigenesis in breast cancer. However, few studies have investigated the pathological roles of rhythm genes in breas...

    Authors: Weiwei Yang, Jing Li, Minghui Zhang, Haichuan Yu, Yuan Zhuang, Lingyu Zhao, Lili Ren, Jinan Gong, Hongjie Bi, Lixuan Zeng, Yang Xue, Jinjin Yang, Yan Zhao, Shuoshuo Wang, Shuangshu Gao, Zitong Fu…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:67
  37. The interaction between programmed death receptor (PD-1) and its ligand (PD-L1) is essential for suppressing activated T-lymphocytes. However, the precise mechanisms underlying PD-L1 overexpression in tumours ...

    Authors: Yanyan Zhang, Shuyi Zhu, Yuanyuan Du, Fan Xu, Wenbo Sun, Zhi Xu, Xiumei Wang, Peipei Qian, Qin Zhang, Jifeng Feng and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:66
  38. Intrahepatic Cholangiocarcinoma (iCCA) is characterized by a strong stromal reaction playing a role in tumor progression. Thymus cell antigen 1 (THY1), also called Cluster of Differentiation 90 (CD90), is a key r...

    Authors: Serena Mancarella, Grazia Serino, Isabella Gigante, Antonio Cigliano, Silvia Ribback, Paola Sanese, Valentina Grossi, Cristiano Simone, Raffaele Armentano, Matthias Evert, Diego F. Calvisi and Gianluigi Giannelli
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:65
  39. Ion channels are emerging as promising oncological targets. The potassium channels Kv1.3 and IKCa are highly expressed in the plasma membrane and mitochondria of human chronic lymphocytic leukemia (CLL) cells,...

    Authors: Filippo Severin, Andrea Urbani, Tatiana Varanita, Magdalena Bachmann, Michele Azzolini, Veronica Martini, Marco Pizzi, Angelo Paolo Dei Tos, Federica Frezzato, Andrea Mattarei, Paolo Ghia, Maria Teresa Sabrina Bertilaccio, Erich Gulbins, Cristina Paradisi, Mario Zoratti, Gianpietro Carlo Semenzato…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:64
  40. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-021-02052-z.

    Authors: Haiyong Zhang, Jing Wu, Jinqiu Yuan, Huafu Li, Yawei Zhang, Wang Wu, Wei Chen, Chunming Wang, Sijun Meng, Songyao Chen, Mingyu Huo, Yulong He and Changhua Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:63
  41. Immunotherapy has emerged as a promising strategy for boosting antitumoral immunity. Blockade of immune checkpoints (ICs), which regulate the activity of cytotoxic T lymphocytes (CTLs) and natural killer (NK) ...

    Authors: Adrià Archilla-Ortega, Carla Domuro, Juan Martin-Liberal and Purificación Muñoz
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:62
  42. Colorectal cancer is one of the most frequent and deadly tumors. Among the key regulators of CRC growth and progression, the microenvironment has emerged as a crucial player and as a possible route for the dev...

    Authors: Eva Andreuzzi, Albina Fejza, Maurizio Polano, Evelina Poletto, Lucrezia Camicia, Greta Carobolante, Giulia Tarticchio, Federico Todaro, Emma Di Carlo, Melania Scarpa, Marco Scarpa, Alice Paulitti, Alessandra Capuano, Vincenzo Canzonieri, Stefania Maiero, Mara Fornasarig…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:60
  43. Head and Neck cancer (HNC) is a fatal malignancy with poor prognosis. Human Papillomavirus (HPV) infection is becoming the prominent cause of HNC in the western world, and studying the molecular mechanisms und...

    Authors: Simona Citro, Claudia Miccolo, Alessandro Medda, Lavinia Ghiani, Marta Tagliabue, Mohssen Ansarin and Susanna Chiocca
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:59
  44. Authors: Shou-Hua Wang, Fei Ma, Zhao-hui Tang, Xiao-Cai Wu, Qiang Cai, Ming-Di Zhang, Ming-Zhe Weng, Di Zhou, Jian-Dong Wang and Zhi-Wei Quan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:55

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:160

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