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  1. Mannose, a natural hexose existing in daily food, has been demonstrated to preferentially inhibit the progression of tumors with low expression of phosphate mannose isomerase (PMI). However, its function in th...

    Authors: Sharui Ma, Na Wang, Rui Liu, Rui Zhang, Hui Dang, Yubo Wang, Simeng Wang, Zekun Zeng, Meiju Ji and Peng Hou
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:387
  2. Authors: Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao and Chuanchun Han
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:385

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:176

  3. Short or small interfering RNAs (siRNAs) and microRNA (miRNAs) are molecules similar in size and function able to inhibit gene expression based on their complementarity with mRNA sequences, inducing the degrad...

    Authors: Rossana Cuciniello, Stefania Filosa and Stefania Crispi
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:383

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:403

  4. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hallm...

    Authors: Emilia Alors-Perez, Ricardo Blázquez-Encinas, Sonia Alcalá, Cristina Viyuela-García, Sergio Pedraza-Arevalo, Vicente Herrero-Aguayo, Juan M. Jiménez-Vacas, Andrea Mafficini, Marina E. Sánchez-Frías, María T. Cano, Fernando Abollo-Jiménez, Juan A. Marín-Sanz, Pablo Cabezas-Sainz, Rita T. Lawlor, Claudio Luchini, Laura Sánchez…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:382
  5. Synovial sarcoma (SS) is an aggressive soft tissue tumor with limited therapeutic options in advanced stage. SS18-SSX fusion oncogenes, which are the hallmarks of SS, cause epigenetic rewiring involving histone d...

    Authors: Cinzia Lanzi, Enrica Favini, Laura Dal Bo, Monica Tortoreto, Noemi Arrighetti, Nadia Zaffaroni and Giuliana Cassinelli
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:381
  6. Despite  improvements in outcome, 15-25% of newly diagnosed multiple myeloma (MM) patients have treatment resistant high-risk (HR) disease with a poor survival. The lack of a genetic basis for HR has focused a...

    Authors: Hussein Ghamlouch, Eileen M. Boyle, Patrick Blaney, Yubao Wang, Jinyoung Choi, Louis Williams, Michael Bauer, Daniel Auclair, Benedetto Bruno, Brian A. Walker, Faith E. Davies and Gareth J. Morgan
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:380
  7. The incidence of bladder urothelial carcinoma (UC), a common malignancy of the urinary tract, is approximately three times higher in men than in women. High expression of the mitotic kinase BUB1 is associated ...

    Authors: Ning Jiang, Yihao Liao, Miaomiao Wang, Youzhi Wang, Keke Wang, Jianing Guo, Peikang Wu, Boqiang Zhong, Tao Guo and Changli Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:378
  8. Authors: Weidong Li, Xuesong Dong, Changjun He, Gang Tan, Ziyi Li, Bo Zhai, Jing Feng, Xian Jiang, Chang Liu, Hongchi Jiang and Xueying Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:377

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:183

  9. Nonsense-mediated mRNA decay (NMD) is a highly conserved cellular surveillance mechanism, commonly studied for its role in mRNA quality control because of its capacity of degrading mutated mRNAs that would pro...

    Authors: Roberta Bongiorno, Mario Paolo Colombo and Daniele Lecis
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:376
  10. The critical role of phosphoinositide 3-kinase (PI3K) activation in tumor cell biology has prompted massive efforts to develop PI3K inhibitors (PI3Kis) for cancer therapy. However, recent results from clinical...

    Authors: Xin Peng, Shaolu Zhang, Wenhui Jiao, Zhenxing Zhong, Yuqi Yang, Francois X. Claret, Moshe Elkabets, Feng Wang, Ran Wang, Yuxu Zhong, Zhe-Sheng Chen and Dexin Kong
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:374

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:396

  11. Gallbladder cancer (GBC) is known for its high malignancy and multidrug resistance. Previously, we uncovered that impaired integrity and stability of the elongator complex leads to GBC chemotherapy resistance,...

    Authors: Sunwang Xu, Cen Jiang, Ruirong Lin, Xiaopeng Wang, Xiaoqiang Hu, Wei Chen, Xiangjin Chen and Tao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:373
  12. Transmembrane serine protease 4 (TMPRSS4) is a cell surface–anchored serine protease. Elevated expression of TMPRSS4 correlates with poor prognosis in colorectal cancer, gastric cancer, prostate cancer, non–sm...

    Authors: Yunhee Lee, Junghwa Yoon, Dongjoon Ko, Minyeong Yu, Soojin Lee and Semi Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:372
  13. Brain metastasis (BM) is thought to be related to the mortality and poor prognosis of non-small cell lung cancer (NSCLC). Despite promising development of NSCLC treatment, the treatment of NSCLC BM is still no...

    Authors: Ruo-Yue Fan, Jia-Qi Wu, Yu-Yang Liu, Xiang-Yu Liu, Si-Tong Qian, Chong-Yong Li, Ping Wei, Zhe Song and Ming-Fang He
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:371
  14. Breast cancer is one of the most-common female malignancies with a high risk of relapse and distant metastasis. The distant metastasis of breast cancer exhibits organotropism, including brain, lung, liver and ...

    Authors: Cenzhu Wang, Kun Xu, Runtian Wang, Xin Han, Jinhai Tang and Xiaoxiang Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:370
  15. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13046-021-02172-6

    Authors: Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You and Qin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:368
  16. Chimeric antigen receptor (CAR) T-cell therapy has yielded impressive outcomes and transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell products have been approved by the U...

    Authors: Xinyi Xiao, Shengkang Huang, Sifei Chen, Yazhuo Wang, Qihang Sun, Xinjie Xu and Yuhua Li
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:367
  17. Authors: Shengming Deng, Guoxi Zhang, Jiajie Kuai, Peng Fan, Xuexiang Wang, Pei Zhou, Dan Yang, Xichen Zheng, Xiaomei Liu, Qunli Wu and Yuhui Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:366

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:260

  18. Authors: Pingfu Hou, Sen Meng, Minle Li, Tian Lin, Sufang Chu, Zhongwei Li, Junnian Zheng, Yuming Gu and Jin Bai
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:365

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:52

  19. Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumours worldwide. Sorafenib (SOR) is one of the most effective single-drug systemic therapy against advanced HCC, but the identifi...

    Authors: Ilaria Romito, Manuela Porru, Maria Rita Braghini, Luca Pompili, Nadia Panera, Annalisa Crudele, Daniela Gnani, Cristiano De Stefanis, Marco Scarsella, Silvia Pomella, Stefano Levi Mortera, Emmanuel de Billy, Adrian Libenzio Conti, Valeria Marzano, Lorenza Putignani, Manlio Vinciguerra…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:364

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:40

  20. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xuehui Wang, Changle Ji, Jiashu Hu, Xiaochong Deng, Wenfang Zheng, Yunhe Yu, Kaiyao Hua, Xiqian Zhou and Lin Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:363

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:29

  21. Approaches based on expression signatures of prostate cancer (PCa) have been proposed to predict patient outcomes and response to treatments. The transcription factor NF-Y participates to the progression from ...

    Authors: Silvia Belluti, Valentina Semeghini, Giovanna Rigillo, Mirko Ronzio, Daniela Benati, Federica Torricelli, Luca Reggiani Bonetti, Gianluca Carnevale, Giulia Grisendi, Alessia Ciarrocchi, Massimo Dominici, Alessandra Recchia, Diletta Dolfini and Carol Imbriano
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:362
  22. Cisplatin-based chemotherapy is a mainstay systematic therapy for advanced esophageal squamous cell carcinoma (ESCC), and cisplatin resistance, which is not uncommon, is the major barrier to improving patient ...

    Authors: Zhenchuan Liu, Shaorui Gu, Kaiqin Wu, Lei Li, Chenglai Dong, Wenli Wang and Yongxin Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:361

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:61

  23. Small nucleolar RNA host gene (SNHG) long noncoding RNAs (lncRNAs) are frequently dysregulated in human cancers and involved in tumorigenesis and progression. SNHG17 has been reported as a candidate oncogene i...

    Authors: Zehua Bian, Mingyue Zhou, Kaisa Cui, Fan Yang, Yulin Cao, Shengbai Sun, Bingxin Liu, Liang Gong, Jiuming Li, Xue Wang, Chaoqun Li, Surui Yao, Yuan Yin, Shenglin Huang, Bojian Fei and Zhaohui Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:360
  24. Highly expressed STOML2 has been reported in a variety of cancers, yet few have detailed its function and regulatory mechanism. This research aims to reveal regulatory mechanism of STOML2 and to provide eviden...

    Authors: Wenhui Ma, Yuehong Chen, Wenjun Xiong, Wenyi Li, Zhuoluo Xu, Ying Wang, Zhigang Wei, Tingyu Mou, Zhaokun Wu, Mingzhen Cheng, Yini Zou, Yu Zhu, Weijie Zhou, Feng Liu and Yan Geng
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:359
  25. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1114-2.

    Authors: Zhang Jia-Xing, He Wei-Ling, Feng Zi-Hao, Chen Dong-Liang, Gao Ying, He Ying, Qin Kai, Zheng Zhou-San, Chen Cui, Weng Hui-Wen, Yun Miao, Ye Sheng, Xu Rui-Hua and Xie Dan
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:358
  26. Diffuse large B-cell lymphoma (DLBCL) comprises at least two main biologically distinct entities: germinal center B-cell (GCB) and activated B-cell (ABC) subtype. Albeit sharing common lesions, GCB and ABC DLB...

    Authors: Giulio Sartori, Sara Napoli, Luciano Cascione, Elaine Yee Lin Chung, Valdemar Priebe, Alberto Jesus Arribas, Afua Adjeiwaa Mensah, Michela Dall’Angelo, Chiara Falzarano, Laura Barnabei, Mattia Forcato, Andrea Rinaldi, Silvio Bicciato, Margot Thome and Francesco Bertoni
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:357
  27. Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in...

    Authors: Ravi Chauhan, Ajaz A. Bhat, Tariq Masoodi, Puneet Bagga, Ravinder Reddy, Ashna Gupta, Zahoor Ahmad Sheikh, Muzafar A. Macha, Mohammad Haris and Mayank Singh
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:356
  28. The hopeful outcomes from 30 years of research in BH3-mimetics have indeed served a number of solid paradigms for targeting intermediates from the apoptosis pathway in a variety of diseased states. Not only ha...

    Authors: Paul A. Townsend, Maria V. Kozhevnikova, Olivier N. F. Cexus, Andrey A. Zamyatnin Jr and Surinder M. Soond
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:355
  29. Authors: Tao Qin, Bai Li, Xiaoyue Feng, Shujun Fan, Lei Liu, Dandan Liu, Jun Mao, Ying Lu, Jinfeng Yang, Xiaotang Yu, Qingqing Zhang, Jun Zhang, Bo Song, Man Li and Lianhong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:354

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:287

  30. Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Its therapy has not significantly improved during the past four decades despite intense research efforts. New molecularly targeted t...

    Authors: Hao Zhou, Wei Liu, Yongming Zhou, Zhenya Hong, Jian Ni, Xiaoping Zhang, Ziping Li, Mengyuan Li, Wenjuan He, Donghua Zhang, Xuexing Chen and Jianhua Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:353
  31. Angiogenesis plays an important role in the occurrence, development and metastasis of hepatocellular carcinoma (HCC). According to previous studies, miR-378a participates in tumorigenesis and tumor metastasis,...

    Authors: Bin Zhu, Jun-Jie Chen, Ying Feng, Jun-Ling Yang, Hua Huang, Wen Yuan Chung, Yi-Lin Hu and Wan-Jiang Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:352
  32. Growing evidence shows that long non-coding RNAs (lncRNAs) play significant roles in cancer development. However, the functions of most lncRNAs in human gastric cancer are still not fully understood. Here, we ...

    Authors: Ziwei Ji, Tianbin Tang, Mengxia Chen, Buyuan Dong, Wenjing Sun, Nan Wu, Hao Chen, Qian Feng, Xingyi Yang, Rong Jin and Lei Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:351
  33. Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding protein inducing dimerization with cytochrome P450, which mediates chemoresistance. Increased PGRMC1 expression is found in multiple types ...

    Authors: Ji Hyeon You, Jaewang Lee and Jong-Lyel Roh
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:350
  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Chunfeng Xie, Xu Zhou, Chunhua Liang, Xiaoting Li, Miaomiao Ge, Yue Chen, Juan Yin, Jianyun Zhu and Caiyun Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:349

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:266

  35. Resistance to oxaliplatin is a major obstacle for the management of locally advanced and metastatic colon cancer (CC). Although long noncoding RNAs (lncRNAs) play key roles in CC, the relationships between lnc...

    Authors: Qingguo Li, Huizhen Sun, Dakui Luo, Lu Gan, Shaobo Mo, Weixing Dai, Lei Liang, Yufei Yang, Midie Xu, Jing Li, Peiyong Zheng, Xinxiang Li, Yan Li and Ziliang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:348
  36. Glioblastoma (GBM; grade IV glioma) is characterized by a very short overall survival time and extremely low 5-year survival rates. We intend to promote experimental and clinical research on rationale and scie...

    Authors: Silvia Matteoni, Paola Matarrese, Barbara Ascione, Lucia Ricci-Vitiani, Roberto Pallini, Veronica Villani, Andrea Pace, Marco G. Paggi and Claudia Abbruzzese
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:347
  37. Disordered chromatin remodeling regulation has emerged as an essential driving factor for cancers. Imitation switch (ISWI) family are evolutionarily conserved ATP-dependent chromatin remodeling complexes, whic...

    Authors: Yanan Li, Han Gong, Pan Wang, Yu Zhu, Hongling Peng, Yajuan Cui, Heng Li, Jing Liu and Zi Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:346
  38. Fibroblast growth factors (FGFs) and their receptors (FGFRs) play critical roles in many biological processes and developmental functions. Chromosomal translocation of FGFRs result in the formation of chimeric...

    Authors: Lingfeng Chen, Yanmei Zhang, Lina Yin, Binhao Cai, Ping Huang, Xiaokun Li and Guang Liang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:345
  39. Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer agent when administered intravenously and in high doses (high-dose IVC). Early phase clinical trials have confirmed safet...

    Authors: Franziska Böttger, Andrea Vallés-Martí, Loraine Cahn and Connie R. Jimenez
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:343
  40. Although thousands of long noncoding RNAs (lncRNAs) have been annotated, only a few lncRNAs have been characterized functionally. In this study, we aimed to identify novel lncRNAs involved in the progression o...

    Authors: Donglan Huang, Ke Zhang, Wenying Zheng, Ruixin Zhang, Jiale Chen, Nan Du, Yuanyuan Xia, Yan Long, Yixue Gu, Jianhua Xu and Min Deng
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:342
  41. Histone epigenetic modification disorder is an important predisposing factor for the occurrence and development of many cancers, including colorectal cancer (CRC). The role of MYSM1, a metalloprotease that deu...

    Authors: Xu Chen, Wei Wang, Yufang Li, Yi Huo, Han Zhang, Fan Feng, Wenjin Xi, Tianze Zhang, Jinjian Gao, Fan Yang, Siyi Chen, Angang Yang and Tao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:341
  42. The zinc transporters Zrt- and Irt-related protein (ZIP/SLC39) are overexpressed in human tumors and correlate with poor prognosis; however, their contributions to carcinogenesis and chemoresistance in osteosa...

    Authors: Hongyu Li, Xin Shen, Mengjun Ma, Wenzhou Liu, Wen Yang, Peng Wang, Zhaopeng Cai, Rujia Mi, Yixuan Lu, Jiahao Zhuang, Yuhang Jiang, Yihui Song, Yanfeng Wu and Huiyong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:340
  43. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13046-021-02121-3

    Authors: Dian-Hui Xiu, Gui-Feng Liu, Shao-Nan Yu, Long-Yun Li, Guo-Qing Zhao, Lin Liu and Xue-Feng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:339
  44. Epithelial ovarian cancer (EOC) harbors distinct genetic features such as homologous recombination repair (HRR) deficiency, and therefore may respond to poly ADP-ribose polymerase inhibitors (PARPi). Over the ...

    Authors: Mengyu Tao and Xia Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:338

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