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  1. The repressor element-1 silencing transcription factor (REST), a master transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in neuroblastoma. An elevated expression of RE...

    Authors: Janardhan Keshav Karapurkar, Min-Seong Kim, Jencia Carminha Colaco, Bharathi Suresh, Neha Sarodaya, Dong-Ho Kim, Chang-Hwan Park, Seok-Ho Hong, Kye-Seong Kim and Suresh Ramakrishna
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:121
  2. MET-driven acquired resistance is emerging with unanticipated frequency in patients relapsing upon molecular therapy treatments. However, the determination of MET amplification remains challenging using both stan...

    Authors: Francesca Bersani, Francesca Picca, Deborah Morena, Luisella Righi, Francesca Napoli, Mariangela Russo, Daniele Oddo, Giuseppe Rospo, Carola Negrino, Barbara Castella, Marco Volante, Angela Listì, Vanessa Zambelli, Federica Benso, Fabrizio Tabbò, Paolo Bironzo…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:120
  3. Prostate Cancer (PCa) represents one of the most commonly diagnosed neoplasms in men and is associated with significant morbidity and mortality. Therapy resistance and significant side effects of current treat...

    Authors: Achinto Saha, Shengyuan Zhao, Austin Kindall, Carly Wilder, Chelsea A. Friedman, Rachel Clark, George Georgiou, Everett Stone, Dawit Kidane and John DiGiovanni
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:119
  4. The failure of novel therapies effective in preclinical animal models largely reflects the fact that current models do not really mimic the pathological/therapeutic features of glioblastoma (GBM), in which the...

    Authors: Feng Liu, Qian Zhou, Hai-feng Jiang, Ting-ting Zhang, Cheng Miao, Xiao-hong Xu, Jia-xing Wu, Song-lin Yin, Shi-jie Xu, Jing-yi Peng, Pan-pan Gao, Xuan Cao, Feng Pan, Ximiao He and Xiao Qian Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:118
  5. There are few effective medications for treating colorectal cancer and liver metastases (CRLM). The interactions among glycolysis, epithelial-mesenchymal transition (EMT), and immune microenvironment contribut...

    Authors: Li Long, Wei Xiong, Fenwang Lin, Jiazhen Hou, Guihua Chen, Taoxing Peng, Yihao He, Rui Wang, Qin Xu and Yongzhuo Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:117
  6. Bronchial premalignant lesions (PMLs) are composed primarily of cells resembling basal epithelial cells of the airways, which through poorly understood mechanisms have the potential to progress to lung squamou...

    Authors: Boting Ning, Andrew M. Tilston-Lunel, Justice Simonetti, Julia Hicks-Berthet, Adeline Matschulat, Roxana Pfefferkorn, Avrum Spira, Matthew Edwards, Sarah Mazzilli, Marc E. Lenburg, Jennifer E. Beane and Xaralabos Varelas
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:116
  7. Patients with colorectal metastatic disease have a poor prognosis, limited therapeutic options, and frequent development of resistance. Strategies based on tumor-derived organoids are a powerful tool to assess...

    Authors: Lars Henrik Jensen, Silvia Regina Rogatto, Jan Lindebjerg, Birgitte Havelund, Cecilie Abildgaard, Luisa Matos do Canto, Chris Vagn-Hansen, Claus Dam, Søren Rafaelsen and Torben Frøstrup Hansen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:115
  8. Current clinical and observational evidence supports the EXTREME regimen as one of the standards of care for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) followed by the ...

    Authors: Kohei Okuyama, Tomofumi Naruse and Souichi Yanamoto
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:114
  9. Methylation of the p16 promoter resulting in epigenetic gene silencing—known as p16 epimutation—is frequently found in human colorectal cancer and is also common in normal-appearing colonic mucosa of aging indivi...

    Authors: Li Yang, Xiaomin Chen, Christy Lee, Jiejun Shi, Emily B. Lawrence, Lanjing Zhang, Yumei Li, Nan Gao, Sung Yun Jung, Chad J. Creighton, Jingyi Jessica Li, Ya Cui, Sumimasa Arimura, Yunping Lei, Wei Li and Lanlan Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:113
  10. Uterine leiomyosarcoma (uLMS) is a rare and aggressive gynaecological malignancy, with individuals with advanced uLMS having a five-year survival of < 10%. Mutations in the homologous recombination (HR) DNA re...

    Authors: Genevieve Dall, Cassandra J. Vandenberg, Ksenija Nesic, Gayanie Ratnayake, Wenying Zhu, Joseph H. A. Vissers, Justin BedÅ‘, Jocelyn Penington, Matthew J. Wakefield, Damien Kee, Amandine Carmagnac, Ratana Lim, Kristy Shield-Artin, Briony Milesi, Amanda Lobley, Elizabeth L. Kyran…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:112
  11. Chemoresistance is the main reason for the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Thus, there is an urgent need to screen out new targets and compounds to reverse chemotherapeutic resistance.

    Authors: Tianxing Zhou, Yongjie Xie, Xupeng Hou, Weiwei Bai, Xueyang Li, Ziyun Liu, Quan Man, Jingyan Sun, Danqi Fu, Jingrui Yan, Zhaoyu Zhang, Yifei Wang, Hongwei Wang, Wenna Jiang, Song Gao, Tiansuo Zhao…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:111
  12. Ufm1-specific ligase 1 (Ufl1) and Ufm1-binding protein 1 (Ufbp1), as putative targets of ubiquitin-fold modifier 1 (Ufm1), have been implicated in several pathogenesis-related signaling pathways. However, litt...

    Authors: Fanghui Chen, Le Sheng, Tianci Zhou, Li Yan, Reid Loveless, Honglin Li, Yong Teng and Yafei Cai
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:110
  13. We have previously reported that extracellular vesicles (EVs) derived from osteoblastic, osteoclastic and mixed prostate cancer cells promote osteoclast differentiation and inhibit osteoblast differentiation v...

    Authors: Lijuan Yu, Bingdong Sui, Xin Zhang, Jiayun Liu, Xiaoke Hao and Lei Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:109
  14. Tumor cells display augmented capability to maintain endoplasmic reticulum (ER) homeostasis and hijack ER stress pathway for malignant phenotypes under microenvironmental stimuli. Metabolic reprogramming is a ...

    Authors: Chenyu Hu, Zechang Xin, Xiaoyan Sun, Yang Hu, Chunfeng Zhang, Rui Yan, Yuying Wang, Min Lu, Jing Huang, Xiaojuan Du, Baocai Xing and Xiaofeng Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:108
  15. Ovarian cancer (OC) is known for exhibiting low response rates to immune checkpoint inhibitors that activate T cells. However, immunotherapies that activate B cells have not yet been extensively explored and m...

    Authors: Jonathan Zorea, Yair Motro, Roei D. Mazor, Yifat Koren Carmi, Ziv Shulman, Jamal Mahajna, Jacob Moran-Gilad and Moshe Elkabets
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:107
  16. The malaria protein VAR2CSA binds oncofetal chondroitin sulfate (ofCS), a unique chondroitin sulfate, expressed on almost all mammalian cancer cells. Previously, we produced a bispecific construct targeting of...

    Authors: Nanna Skeltved, Mie A. Nordmaj, Nicolai T. Berendtsen, Robert Dagil, Emilie M. R. Stormer, Nader Al-Nakouzi, Ke Jiang, Alexandra Aicher, Christopher Heeschen, Tobias Gustavsson, Swati Choudhary, Ismail Gögenur, Jan P. Christensen, Thor G. Theander, Mads Daugaard, Ali Salanti…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:106
  17. High-intensity chemotherapy regimens are often used in adult T-cell lymphoblastic lymphoma (T-LBL) patients. Nevertheless, the response rate remains unsatisfactory due to emergence of chemoresistance. Growing ...

    Authors: Wei-Juan Huang, Song-Bin Guo, Hui Shi, Xin-Ling Li, Yong Zhu, Mei Li, Li-Yan Song, Rong-Min Yu, Qing-Qing Cai and Xiao-Peng Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:105
  18. Authors: Zixian Huang, Xi Rui, Chen Yi, Yongju Chen, Rui Chen, Yancan Liang, Yan Wang, Weicheng Yao, Xiaoding Xu and Zhiquan Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:104

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:60

  19. Altered metabolism is a hallmark of cancer and presents a vulnerability that can be exploited in cancer treatment. Regulated cell death (RCD) plays a crucial role in cancer metabolic therapy. A recent study ha...

    Authors: Peijie Zheng, Chuntao Zhou, Yuemin Ding and Shiwei Duan
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:103
  20. Authors: Christopher B. Cole, Maria Pia Morelli, Massimo Fantini, Markku Miettinen, Patricia Fetsch, Cody Peer, William D. Figg, Tyler Yin, Nicole Houston, Ann McCoy, Stanley Lipkowitz, Alexandra Zimmer, Jung-min Lee, Miroslava Pavelova, Erin N. Villanueva, Kathryn Trewhitt…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:102

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:76

  21. Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer with an appalling overall survival of less than 5% (Zimmerman et al. J Thor Oncol 14:768-83, 2019). Patients typically respond to front line...

    Authors: Jasmine Chen, Aleks C. Guanizo, W. Samantha N. Jakasekara, Chaitanya Inampudi, Quinton Luong, Daniel J. Garama, Muhammad Alamgeer, Nishant Thakur, Michael DeVeer, Vinod Ganju, D. Neil Watkins, Jason E. Cain and Daniel J. Gough
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:100
  22. MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3, TFEB, or MITF. MiT-RCC represents a specific subtype o...

    Authors: Martin Lang, Laura S. Schmidt, Kelli M. Wilson, Christopher J. Ricketts, Carole Sourbier, Cathy D. Vocke, Darmood Wei, Daniel R. Crooks, Youfeng Yang, Benjamin K. Gibbs, Xiaohu Zhang, Carleen Klumpp-Thomas, Lu Chen, Rajarshi Guha, Marc Ferrer, Crystal McKnight…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:99
  23. Authors: Min Deng, Long Zhang, Wenying Zheng, Jiale Chen, Nan Du, Meiqi Li, Weiqing Chen, Yonghong Huang, Ning Zeng, Yuanbin Song and Yongming Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:98

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:9

  24. Although molecular targets such as HER2, TP53 and PIK3CA have been widely studied in esophageal cancer, few of them were successfully applied for clinical treatment. Therefore, it is urgent to discover novel a...

    Authors: Xuechao Jia, Penglei Wang, Chuntian Huang, Dengyun Zhao, Qiong wu, Bingbing Lu, Wenna Nie, Limeng Huang, Xueli Tian, Pan li, Kyle Vaughn Laster, Yanan Jiang, Xiang Li, Honglin Li, Zigang Dong and Kangdong Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:97
  25. Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide, but current treatment options remain limited and cause serious life-threatening side effects. Aberrant FGFR4 signaling has...

    Authors: Yiqi Yang, Yibo Zhang, Jieqiong Cao, Zijian Su, Fu Li, Peiguang Zhang, Bihui Zhang, Rongzhan Liu, Linhao Zhang, Junye Xie, Jingsheng Li, Jinting Zhang, Xiaojia Chen and An Hong
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:96
  26. Colorectal cancer (CRC) is the third most lethal cancer in the world, and its incidence is steadily rising. In this study, we investigated the induction of humoral immunity by a phytogalactolipid enriched frac...

    Authors: Han-Huei Lin, Yi-Shin Wu, Ting-Yan Jian, Jia-Yun Liao, Meng-Ting Chang, Lie-Fen Shyur and Yu-Ling Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:95
  27. Malignant breast cancer (BC) remains incurable mainly due to the cancer cell metastasis, which is mostly related to the status of Estrogen receptor alpha (ERα). However, our understanding of the mechanisms thr...

    Authors: Jinhui Lü, Qian Zhao, Yuefan Guo, Danni Li, Heying Xie, Cuicui Liu, Xin Hu, Suling Liu, Zhaoyuan Hou, Xunbin wei, Deyou Zheng, Richard G. Pestell and Zuoren Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:93
  28. One of the key limitations of targeted cancer therapies is the rapid onset of therapy resistance. Taking BRAF-mutant melanoma as paradigm, we previously identified the lipogenic regulator SREBP-1 as a central ...

    Authors: Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Mélanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:92
  29. Authors: Chunyan Gu, Yajun Wang, Lulin Zhang, Li Qiao, Shanliang Sun, Miaomiao Shao, Xiaozhu Tang, Pinggang Ding, Chao Tang, Yuhao Cao, Yanyan Zhou, Mengjie Guo, Rongfang Wei, Nianguang Li, Yibei Xiao, Jinao Duan…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:91

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:11

  30. Despite overall improvement in breast cancer patient outcomes from earlier diagnosis and personalised treatment approaches, some patients continue to experience recurrence and incurable metastases. It is there...

    Authors: Janelle L. Hancock, Murugan Kalimutho, Jasmin Straube, Malcolm Lim, Irma Gresshoff, Jodi M. Saunus, Jason S. Lee, Sunil R. Lakhani, Kaylene J. Simpson, Ashley I. Bush, Robin L. Anderson and Kum Kum Khanna
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:90
  31. Gastric cancer remains the leading cause of cancer death in the world. It is increasingly evident that long non-coding RNAs (lncRNAs) transcribed from the genome-wide association studies (GWAS)-identified gast...

    Authors: Nasha Zhang, Bowen Wang, Chi Ma, Jiajia Zeng, Teng Wang, Linyu Han and Ming Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:89
  32. Authors: Serena Mancarella, Grazia Serino, Isabella Gigante, Antonio Cigliano, Silvia Ribback, Paola Sanese, Valentina Grossi, Cristiano Simone, Raffaele Armentano, Matthias Evert, Diego F. Calvisi and Gianluigi Giannelli
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:88

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:65

  33. Authors: Xiaoge Gao, Pin Jiang, Qian Zhang, Qian Liu, Shuangshuang Jiang, Ling Liu, Maomao Guo, Qian Cheng, Junnian Zheng and Hong Yao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:87

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:362

  34. Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back-splicing. CircRNAs are abnormally express...

    Authors: Jianxia Wei, Mengna Li, Changning Xue, Shipeng Chen, Lemei Zheng, Hongyu Deng, Faqing Tang, Guiyuan Li, Wei Xiong, Zhaoyang Zeng and Ming Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:86
  35. Lipid metabolic reprogramming in colon cancer shows a potential impact on tumor immune microenvironment and is associated with response to immunotherapy. Therefore, this study aimed to develop a lipid metaboli...

    Authors: Lilong Liu, Min Mo, Xuehan Chen, Dongchen Chao, Yufan Zhang, Xuewei Chen, Yang Wang, Nan Zhang, Nan He, Xi Yuan, Honglei Chen and Jing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:85
  36. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-022-02588-8.

    Authors: Tangwei Wu, Xiaoyi Li, Ge Yan, Zheqiong Tan, Dan Zhao, Shuiyi Liu, Hui Wang, Yuan Xiang, Weiqun Chen, Hongda Lu, Xinghua Liao, Yong Li and Zhongxin Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:84
  37. Validated prognostic biomarkers for anti-angiogenic therapy using the anti-VEGF antibody Bevacizumab in ovarian cancer (OC) patients are still an unmet clinical need. The EGFR can contribute to cancer-associat...

    Authors: Luca Forlani, Loris De Cecco, Vittorio Simeon, Biagio Paolini, Marina Bagnoli, Sabrina Chiara Cecere, Anna Spina, Eleonora Citeroni, Eliana Bignotti, Domenica Lorusso, Laura Arenare, Daniela Russo, Carmine De Angelis, Laura Ardighieri, Giosuè Scognamiglio, Michele Del Sesto…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:83
  38. Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology research. 3D in vitro models are emerging as powerful tools consider...

    Authors: Peiyuan Mu, Shujuan Zhou, Tao Lv, Fan Xia, Lijun Shen, Juefeng Wan, Yaqi Wang, Hui Zhang, Sanjun Cai, Junjie Peng, Guoqiang Hua and Zhen Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:81
  39. FYN is a nonreceptor tyrosine kinase that regulates diverse pathological processes. The pro-cancer role of FYN in multiple malignancies has been elucidated. However, the mechanisms that FYN promotes gastric ca...

    Authors: SanFei Peng, YuHan Yin, YiZheng Zhang, Feng Zhu, Ge Yang and Yang Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:80
  40. We propose a new approach for designing personalized treatment for colorectal cancer (CRC) patients, by combining ex vivo organoid efficacy testing with mathematical modeling of the results.

    Authors: George M. Ramzy, Maxim Norkin, Thibaud Koessler, Lionel Voirol, Mathieu Tihy, Dina Hany, Thomas McKee, Frédéric Ris, Nicolas Buchs, Mylène Docquier, Christian Toso, Laura Rubbia-Brandt, Gaetan Bakalli, Stéphane Guerrier, Joerg Huelsken and Patrycja Nowak-Sliwinska
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:79
  41. Aerobic glycolysis, also known as the Warburg effect, is predominantly upregulated in a variety of solid tumors, including breast cancer. We have previously reported that methylglyoxal (MG), a very reactive by...

    Authors: Gaurav Dube, Assia Tiamiou, Martin Bizet, Yasmine Boumahd, Imène Gasmi, Rebekah Crake, Justine Bellier, Marie-Julie Nokin, Emilie Calonne, Rachel Deplus, Tom Wissocq, Olivier Peulen, Vincent Castronovo, François Fuks and Akeila Bellahcène
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:78
  42. Increasing evidence has revealed the key activity of protein disulfide isomerase A4 (PDIA4) in the endoplasmic reticulum stress (ERS) response. However, the role of PDIA4 in regulating glioblastoma (GBM)-speci...

    Authors: Zewei Tu, Chong Wang, Qing Hu, Chuming Tao, Zhansheng Fang, Li Lin, Kunjian Lei, Min Luo, Yilei Sheng, Xiaoyan Long, Jingying Li, Lei Wu, Kai Huang and Xingen Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:77
  43. NEO201 is a humanized IgG1 monoclonal antibody (mAb) generated against tumor-associated antigens from patients with colorectal cancer. NEO-201 binds to core 1 or extended core 1 O-glycans expressed by its targ...

    Authors: Christopher B. Cole, Maria Pia Morelli, Massimo Fantini, Markku Miettinen, Patricia Fetsch, Cody Peer, William D. Figg, Tyler Yin, Nicole Houston, Ann McCoy, Stanley Lipkowitz, Alexandra Zimmer, Jung-min Lee, Miroslava Pavelova, Erin N. Villanueva, Kathryn Trewhitt…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:76

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:102

  44. Increasing evidence suggests that FBXW7 has a high frequency of mutations in esophageal squamous cell carcinoma (ESCC). However, the function of FBXW7, especially the mutations, is not clear. This study was de...

    Authors: Yunzhi Pan, Jing Liu, Yingyin Gao, Yuqing Guo, Changxing Wang, Zhipan Liang, Meiying Wu, Yulan Qian, Yinyan Li, Jingyi Shen, Chenchen Lu and Sai Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:75
  45. Cisplatin (DDP)-based chemotherapy is commonly adopted as the first-line treatment for patients with oesophageal squamous cell carcinoma (OSCC), but the high rate of drug resistance limits its clinical applica...

    Authors: Kang Fang, Mingchuang Sun, Zhuyun Leng, Yuan Chu, Ziying Zhao, Zhaoxing Li, Yunwei Zhang, Aiping Xu, Zehua Zhang, Li Zhang, Tao Chen and Meidong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:73
  46. Although the aberrant activation of NOTCH1 pathway causes a malignant progression of renal cell carcinoma (RCC), the precise molecular mechanisms behind the potential action of pro-oncogenic NOTCH1/HES1 axis r...

    Authors: Shuangjie Liu, Lei Dou, Miao Miao, Xiaojun Man, Baojun Wei, Zhaowei Jiang, Yongze Ouyang, Toshinori Ozaki, Meng Yu and Yuyan Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:72

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