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  1. Runt-related transcription factor 1 (RUNX1) plays the roles of an oncogene and an anti-oncogene in epithelial tumours, and abnormally elevated RUNX1 has been suggested to contribute to the carcinogenesis of co...

    Authors: Qingyuan Li, Qiuhua Lai, Chengcheng He, Yuxin Fang, Qun Yan, Yue Zhang, Xinke Wang, Chuncai Gu, Yiqing Wang, Liangying Ye, Lu Han, Xin Lin, Junsheng Chen, Jianqun Cai, Aimin Li and Side Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:334
  2. Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting tremendous potential for treatment in a broad spectrum of ...

    Authors: Lawrence H. Cheung, Yunli Zhao, Ana Alvarez-Cienfuegos, Khalid A. Mohamedali, Yu J. Cao, Walter N. Hittelman and Michael G. Rosenblum
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:332
  3. In the original publication of this article [1], the Gene Expression Omnibus (GEO) accession code GSE79772 is wrong. The correct accession code should be GSE86213.

    Authors: Yinfang Wang, Yanli Hou, Weiwei Zhang, Angel A. Alvarez, Yongrui Bai, Bo Hu, Shi-Yuan Cheng, Kun Yang, Yanxin Li and Haizhong Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:331

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:147

  4. RelA/p65 a crucial member of NF-κB signaling pathway plays diverse role in mediating oncogenesis. Limited knowledge prevails on the mechanistic insights of RelA gene regulation. RNA helicase p68 apart from bei...

    Authors: Veenita Khare, Shaheda Tabassum, Uttara Chatterjee, Sandip Chatterjee and Mrinal K. Ghosh
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:330
  5. Kinesins play important roles in the development and progression of many human cancers. The functions and underlying mechanisms of kinesin family member C1 (KIFC1), a member of the kinesin-14 family, in the pa...

    Authors: Kai Teng, Shi Wei, Chi Zhang, Jiewei Chen, Jinbin Chen, Kanghua Xiao, Jun Liu, Miaomiao Dai, Xinyuan Guan, Jingping Yun and Dan Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:329

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:135

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:442

  6. Tumor heterogeneity results in differential response to therapy due to the existence of plastic tumor cells, called cancer stem cells (CSCs), which exhibit the property of resistance to therapy, invasion and m...

    Authors: Pavana Thomas, Annapurna Pranatharthi, Cecil Ross and Sweta Srivastava
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:328
  7. Malignant tumors are often multifactorial. Epidemiological studies have shown that hyperglycemia raises the prevalence and mortality of certain malignancies, like breast, liver, bladder, pancreatic, colorectal...

    Authors: Wenjie Li, Xuehui Zhang, Hui Sang, Ying Zhou, Chunyu Shang, Yongqing Wang and Hong Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:327
  8. Prostate cancer (PCa) is the second leading cause of cancer-related death in the Western population. The use in oncology of positron emission tomography/computed tomography (PET/CT) with emerging radiopharmace...

    Authors: B. Frigerio, S. Morlino, E. Luison, E. Seregni, A. Lorenzoni, A. Satta, R. Valdagni, A. Bogni, C. Chiesa, M. Mira, S. Canevari, A. Alessi and M. Figini
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:326
  9. Sodium/iodide symporter (NIS)-mediated iodide uptake plays an important physiological role in regulating thyroid gland function, as well as in diagnosing and treating Graves’ disease and thyroid cancer. High-m...

    Authors: Wenwen Chai, Fanghua Ye, Li Zeng, Yanling Li and Liangchun Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:325
  10. The human ether a-go-go-related gene 1 (HERG1) is involved in tumor progression; however, its role in esophageal squamous cell carcinoma (ESCC) is not well studied. This study investigated HERG1 function in ES...

    Authors: Hongqiang Wang, Xuchun Yang, Yan Guo, Lin Shui, Shi Li, Yifeng Bai, Yu Liu, Ming Zeng and Jianling Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:324
  11. Numerous studies have presented that curcumin could have a positive effect in the prevention of cancer and then in tumor therapy. Several hypotheses have highlighted that curcumin could decreases tumor growth ...

    Authors: Alexandre Vallée, Yves Lecarpentier and Jean-Noël Vallée
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:323
  12. CDK4/6 inhibitors are a promising treatment strategy in tumor therapy but are hampered by resistance mechanisms. This study was performed to reveal predictive markers, mechanisms of resistance and to develop r...

    Authors: Zhichao Tong, Anuja Sathe, Benedikt Ebner, Pan Qi, Christian Veltkamp, Juergen E. Gschwend, Per Sonne Holm and Roman Nawroth
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:322
  13. Recurrence and metastasis are the leading causes of tumour-related death in patients with oesophageal squamous cell carcinoma (ESCC). Tumour-infiltrating natural killer cells (NK cells) display powerful cytoto...

    Authors: Jian Wu, Feng-xia Gao, Chao Wang, Mei Qin, Fei Han, Tao Xu, Zhi Hu, Yang Long, Xue-mei He, Xin Deng, De-lian Ren and Tian-yang Dai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:321
  14. Acquired resistance remains a limitation of the clinical use of 5-fluorouracil (5-FU). Because exosomes, are important vesicles participating in intercellular communication, their contribution to the developme...

    Authors: Qian Zhang, Rui-Xian Liu, Ka-Wo Chan, Jiancong Hu, Jingdan Zhang, Lili Wei, Huiliu Tan, Xiangling Yang and Huanliang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:320
  15. Despite a good and overall prognosis, papillary thyroid cancer (PTC) can still affect the quality of life of many patients, and can even be life-threatening due to its invasiveness and metastasis. Emerging stu...

    Authors: Yao Yao, Xinyuan Chen, Hong Yang, Wei Chen, Yichun Qian, Zhongyi Yan, Tian Liao, Weiping Yao, Wenlan Wu, Tonghua Yu, Yun Chen and Yuan Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:318

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:56

  16. Molecular markers for prostate cancer (PCa) are required to improve the early definition of patient outcomes. Atypically large extracellular vesicles (EVs), referred as “Large Oncosomes” (LO), have been identi...

    Authors: Chiara Ciardiello, Alessandra Leone, Paola Lanuti, Maria S. Roca, Tania Moccia, Valentina R. Minciacchi, Michele Minopoli, Vincenzo Gigantino, Rossella De Cecio, Massimo Rippa, Lucia Petti, Francesca Capone, Carlo Vitagliano, Maria R. Milone, Biagio Pucci, Rita Lombardi…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:317
  17. Sorafenib is the first-line treatment for advanced-stage hepatocellular carcinoma (HCC). Several studies have shown that the up-regulation of β-catenin plays a role in sorafenib resistance in HCC; however, the...

    Authors: Ling Deng, Jingyuan Sun, Xiaohui Chen, Li Liu and Dehua Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:316
  18. Adenosine deaminases acting on RNA (ADARs) are involved in adenosine-to-inosine (A-to-I) editing and implicated in tumorigenesis and prognosis. Emerging evidence has indicated that ADAR1, an ADAR family member...

    Authors: Xue Liu, Yu Fu, Jiadong Huang, Meng Wu, Zhenxing Zhang, Rongyao Xu, Ping Zhang, Shouwei Zhao, Laikui Liu and Hongbing Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:315
  19. IDO1 (Indoleamine 2,3-dioxygenase 1) inhibits host anti-tumor immune response by exhausting tryptophan in tumor microenvironment, but the pathogenic mechanisms of IDO1 in gastric cancer (GC) cells need to be f...

    Authors: Zhen Xiang, Jun Li, Shuzheng Song, Jiexuan Wang, Wei Cai, Wenjun Hu, Jun Ji, Zhenggang Zhu, Lu Zang, Ranlin Yan and Yingyan Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:314
  20. Breast cancer is the most common malignancy in women worldwide. Among the breast cancer subtypes, triple-negative breast cancer (TNBC) is the most aggressive and the most difficult to treat. One of the master ...

    Authors: Rossella Zanin, Silvia Pegoraro, Gloria Ros, Yari Ciani, Silvano Piazza, Fleur Bossi, Roberta Bulla, Cristina Zennaro, Federica Tonon, Dejan Lazarevic, Elia Stupka, Riccardo Sgarra and Guidalberto Manfioletti
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:313
  21. Glioblastoma is the most aggressive and most lethal primary brain tumor in the adulthood. Current standard therapies are not curative and novel therapeutic options are urgently required. Present knowledge sugg...

    Authors: F. Berardinelli, M. Tanori, D. Muoio, M. Buccarelli, A. di Masi, S. Leone, L. Ricci-Vitiani, R. Pallini, M. Mancuso and A. Antoccia
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:311
  22. Exosomes from cancer cells or immune cells, carrying bio-macromolecules or microRNAs (miRNAs), participate in tumor pathogenesis and progression by modulating microenvironment. Our study aims to investigate th...

    Authors: Zi Yin, Tingting Ma, Bowen Huang, Lehang Lin, Yu Zhou, Jinhai Yan, Yiping Zou and Sheng Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:310
  23. Triple negative breast cancer (TNBC) is a breast cancer subgroup characterized by a lack of hormone receptors’ expression and no HER2 overexpression. These molecular features both drastically reduce treatment ...

    Authors: Matilde Clarissa Malfatti, Lorenzo Gerratana, Emiliano Dalla, Miriam Isola, Giuseppe Damante, Carla Di Loreto, Fabio Puglisi and Gianluca Tell
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:309
  24. At present, it is generally believed that leukemia stem cells are the source of AML, so the killing of leukemia stem cells has become important. Previous studies have suggested that HHT combined with ATO can s...

    Authors: Ming Tan, Qian Zhang, Xiaohong Yuan, Yuanzhong Chen and Yong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:308

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:407

  25. We reported previously that phenethyl isothiocyanate (PEITC), a dietary compound, can reactivate p53R175H mutant in vitro and in SK-BR-3 (p53R175H) breast xenograft model resulting in tumor inhibition. Because of...

    Authors: Monika Aggarwal, Rahul Saxena, Nasir Asif, Elizabeth Sinclair, Judy Tan, Idalia Cruz, Deborah Berry, Bhaskar Kallakury, Quynhchi Pham, Thomas T. Y. Wang and Fung-Lung Chung
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:307
  26. HER2-overexpressing metastatic breast cancers are challenging practice in oncology when they become resistant to anti-HER2 therapies such as trastuzumab. In these clinical situations, HER2-overexpression persi...

    Authors: Toni Nunes, Thomas Pons, Xue Hou, Khanh Van Do, Benoît Caron, Marthe Rigal, Mélanie Di Benedetto, Bruno Palpant, Christophe Leboeuf, Anne Janin and Guilhem Bousquet
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:306
  27. The mechanism underlying breast cancer stem cell (BCSCs) characteristics remains to be fully elucidated. Accumulating evidence implies that long noncoding RNAs (lncRNAs) play a pivotal role in regulating BCSCs...

    Authors: Ang Zheng, Xinyue Song, Lin Zhang, Lin Zhao, Xiaoyun Mao, Minjie Wei and Feng Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:305
  28. Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due to the paucity of effective targeted therapy. ESCC is believed to arise from cancer stem cells (CSCs) t...

    Authors: Yue Zhao, Ji Zhu, Bowen Shi, Xinyu Wang, Qijue Lu, Chunguang Li and Hezhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:304
  29. Gut microbiota and the tumor microenvironment are thought to be critical factors that modulate the processes of liver diseases, including hepatocellular carcinoma (HCC). Interleukin-25 (IL-25) promotes type 2 ...

    Authors: Qiao Li, Lei Ma, Shunli Shen, Yu Guo, Qinghua Cao, Xiuqin Cai, Juan Feng, Yuan Yan, Tianyu Hu, Shiya Luo, Lin Zhou, Baogang Peng, Zhonghan Yang and Yunpeng Hua
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:303
  30. Diabetes is recognized to be a risk factor of pancreatic cancer, but the mechanism has not been fully elucidated. Sterol regulatory element binding protein 1 (SREBP1) is an important transcription factor invol...

    Authors: Cancan Zhou, Weikun Qian, Jie Li, Jiguang Ma, Xin Chen, Zhengdong Jiang, Liang Cheng, Wanxing Duan, Zheng Wang, Zheng Wu, Qingyong Ma and Xuqi Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:302
  31. Colorectal cancer (CRC) remains the fourth most common cause of cancer-related mortality worldwide. We aimed to identify key molecules and signalling pathways mediating CRC growth and metastasis. Polypyrimidin...

    Authors: Pingfu Hou, Fang Chen, Hongmei Yong, Tian Lin, Jingjing Li, Yu Pan, Tao Jiang, Minle Li, Yansu Chen, Jun Song, Junnian Zheng and Jin Bai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:301
  32. Cancer is fundamentally a deregulation of cell growth and proliferation. Cancer cells often have perturbed metabolism that leads to the alteration of metabolic intermediates. Dehydrogenase/reductase member 2 (...

    Authors: Xiangjian Luo, Namei Li, Xu Zhao, Chaoliang Liao, Runxin Ye, Can Cheng, Zhijie Xu, Jing Quan, Jikai Liu and Ya Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:300
  33. Programmed death 1 (PD-1) blockade has great effect in the prevention of oral precancerous lesions, but the drug resistance has also been observed. The determinants of immune resistance during the malignant tr...

    Authors: Liling Wen, Huanzi Lu, Qiusheng Li, Qunxing Li, Shuqiong Wen, Dikan Wang, Xi Wang, Juan Fang, Jun Cui, Bin Cheng and Zhi Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:299

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:147

  34. Gliomas are the most common primary tumors in central nervous system. Despite advances in diagnosis and therapy, the prognosis of glioma remains gloomy. Autophagy is a cellular catabolic process that degrades ...

    Authors: Zhi-peng Wen, Wen-jing Zeng, Yan-hong Chen, He Li, Jie-ya Wang, Quan Cheng, Jing Yu, Hong-hao Zhou, Zheng-zheng Liu, Jian Xiao and Xiao-ping Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:298
  35. Ubiquitin-like protein 4A (UBL4A) plays a significant role in protein metabolism and the maintenance of cellular homeostasis. In cancer, UBL4A represses tumorigenesis and is involved in various signaling pathw...

    Authors: Hongze Chen, Le Li, Jisheng Hu, Zhongjie Zhao, Liang Ji, Chundong Cheng, Guangquan Zhang, Tao zhang, Yilong Li, Hua Chen, Shangha Pan and Bei Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:297
  36. Karyopherin nuclear transport receptors play important roles in tumour development and drug resistance and have been reported as potential biomarkers and therapeutic targets for tumour treatment. However, IPO5...

    Authors: Wenjuan Zhang, Yanxia Lu, Xiaomin Li, Jianming Zhang, Weihao Lin, Wei Zhang, Lin Zheng and Xuenong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:296
  37. High-grade endometrioid and serous endometrial cancers (ECs) are an aggressive subtype of ECs without effective therapies. The reciprocal communication between tumor cells and their surrounding microenvironmen...

    Authors: Peixin Dong, Ying Xiong, Junming Yue, Daozhi Xu, Kei Ihira, Yosuke Konno, Noriko Kobayashi, Yukiharu Todo and Hidemichi Watari
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:295
  38. In the era of personalized therapy, functional annotation of less frequent genetic aberrations will be instrumental in adapting effective therapeutic in clinic. Overexpression of Melanoma associated antigen A3...

    Authors: Biswajit Das and Shantibhusan Senapati
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:294
  39. Signal transducer and activator of transcription 3 (STAT3) is an oncogene, which upregulates in approximately 70% of human cancers. Autophagy is an evolutionarily conserved process which maintains cellular hom...

    Authors: Shichong Lin, Lehe Yang, Yulei Yao, Lingyuan Xu, Youqun Xiang, Haiyang Zhao, Liangxing Wang, Zhigui Zuo, Xiaoying Huang and Chengguang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:293
  40. Bladder cancer progression has been associated with dysfunctional repair of double-strand breaks (DSB), a deleterious type of DNA lesions that fuel genomic instability. Accurate DSB repair relies on two distin...

    Authors: Christin Richter, Stephan Marquardt, Fanghua Li, Alf Spitschak, Nico Murr, Berdien A. H. Edelhäuser, George Iliakis, Brigitte M. Pützer and Stella Logotheti
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:292
  41. Glioma is one of the most aggressive malignant brain tumors which is characterized with highly infiltrative growth and poor prognosis. NKAP (NF-κB activating protein) is a widely expressed 415-amino acid nucle...

    Authors: Guangyan Gu, Taihong Gao, Lu Zhang, Xiuyang Chen, Qi Pang, Yanan Wang, Dan Wang, Jie Li and Qian Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:291
  42. This commentary wishes to highlight the latest discoveries in the mutant p53 field that have been discussed in the 8th p53 Mutant Workshop 2019, held in Lyon. TP53 mutant (mutp53) proteins are involved in the pat...

    Authors: Silvia Di Agostino, Giulia Fontemaggi, Sabrina Strano, Giovanni Blandino and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:290
  43. Glioblastoma (GBM) cells with stem cell-like properties are called glioma stem cells (GSCs). GSCs display highly treatment resistance and are responsible for tumor recurrence. Napabucasin (BBI608), a novel sma...

    Authors: Dongfeng Han, Tianfu Yu, Nan Dong, Bo Wang, Fei Sun and Dehua Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:289
  44. In the original publication of this article [1], there is a mistake in Figure 7. The tags of TGF-beta and calycosin in Western blotting electrophoresis images are reversed.

    Authors: Qun Wang, Weijun Lu, Tao Yin and Li Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:288

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:240

  45. Drug resistance represents the major reason of pharmacological treatment failure. It is supported by a broad spectrum of mechanisms, whose molecular bases have been frequently correlated to aberrant protein ph...

    Authors: Christian Borgo and Maria Ruzzene
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:287
  46. CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear.

    Authors: Fuqiang Wang, Wenxing Zhao, Yuehong Gao, Jiechao Zhou, Huifang Li, Guanyun Zhang, Dong Guo, Chengrong Xie, Jie Li, Zhenyu Yin and Jie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:286
  47. Anti-angiogenic therapies demonstrate anti-tumor effects by decreasing blood supply to tumors and inhibiting tumor growth. However, anti-angiogenic therapy may leads to changes in tumor microenvironment and in...

    Authors: Weilong Zhong, Wendong Yang, Yuan Qin, Wenguang Gu, Yinyin Xue, Yuanhao Tang, Hengwei Xu, Hongzhi Wang, Chao Zhang, Changhua Wang, Bo Sun, Yanrong Liu, Huijuan Liu, Honggang Zhou, Shuang Chen, Tao Sun…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:285
  48. In the original publication of this article [1], there are two errors.

    Authors: Xihong Liu, Peiyuan Zhao, Xiujuan Wang, Lei Wang, Yingjun Zhu, Yadi Song and Wei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:284

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:184

  49. Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin-17 (...

    Authors: Bing Yang, Aiwen Wu, Yingqi Hu, Cuijian Tao, Ji Ming Wang, Youyong Lu and Rui Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:283
  50. Lung cancer is the most common cause of cancer-related mortality worldwide despite diagnostic improvements and the development of targeted therapies, notably including epidermal growth factor receptor (EGFR) t...

    Authors: Yi-Ying Wu, Hung-Chang Wu, Jia-En Wu, Kuo-Yen Huang, Shuenn-Chen Yang, Si-Xuan Chen, Chao-Jung Tsao, Keng-Fu Hsu, Yuh-Ling Chen and Tse-Ming Hong
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:282

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