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  1. In hepatocellular carcinoma (HCC), CD133+/CD44+ cells are one subgroup with high stemness and responsible for metastatic relapse and resistance to treatment. Our previous studies have demonstrated that osteopo...

    Authors: Xiaomei Gao, Yuanyuan Sheng, Jing Yang, Chaoqun Wang, Rui Zhang, Ying Zhu, Ze Zhang, Kaili Zhang, Shican Yan, Haoting Sun, Jinwang Wei, Xuan Wang, Xinxin Yu, Yu Zhang, Qin Luo, Yan Zheng…
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:179

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:266

  2. Colorectal cancer (CRC) is a commonly diagnosed digestive malignancy worldwide. Ras-related protein 1A (RAP1A) is a member of the Ras superfamily of small GTPases and has been recently identified as a novel on...

    Authors: Liguo Liu, Xuebing Yan, Dapeng Wu, Yi Yang, Mengcheng Li, Yang Su, Wenchao Yang, Zezhi Shan, Yuping Gao and Zhiming Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:178
  3. Adaptation to ER stress has been indicated to play an important role in resistance to therapy in human melanoma. However, the relationship between adaptation to ER stress and cell metastasis in human melanoma ...

    Authors: Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao and Chuanchun Han
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:176

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:385

  4. Focal adhesion plays an essential role in tumour invasiveness and metastasis. Hippo component YAP has been widely reported to be involved in many aspects of tumour biology. However, its role in focal adhesion ...

    Authors: Jie Shen, Beibei Cao, Yatao Wang, Chenshen Ma, Zhuo Zeng, Liang Liu, Xiaolan Li, Deding Tao, Jianping Gong and Daxing Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:175

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:271

  5. The development of radioresistance is one of main causes for therapeutic failure of prostate cancer (PCa). The present study aims to investigate the function and the related mechanism by which HZ08 sensitizes ...

    Authors: Yanyan Zhang, Zhi Xu, Jiaji Ding, Chunli Tan, Weizi Hu, Yunman Li, Wenlong Huang and Yong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:174
  6. The pathophysiological roles and the therapeutic potentials of Myc family are reviewed in this article. The physiological functions and molecular machineries in stem cells, including embryonic stem (ES) cells ...

    Authors: Go J. Yoshida
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:173

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:285

  7. Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in hepatocellular cancer (HCC) is largely unk...

    Authors: Ning Bai, Eming Peng, Xingsheng Qiu, Ning Lyu, Zhejia Zhang, Yiming Tao, Xinying Li and Zhiming Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:172
  8. Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become a major obstacle in improving the clinical outcome of patients with metastatic and advanced-stage esophageal squamous cell car...

    Authors: Min Kang, Meiping Ren, Yan Li, Yuqiong Fu, Minmin Deng and Changping Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:171
  9. Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene, resulting from the t(9;22) chromosomal translocation. Imatinib (gleeve...

    Authors: Francesca Monteleone, Simona Taverna, Riccardo Alessandro and Simona Fontana
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:170
  10. Increasing studies confirmed that abnormal lncRNAs expression play a critical role in cervical cancer (CC) development and progression. LncRNA TPT1-AS1, a novel lncRNA, its role and underlying mechanisms invol...

    Authors: Hui Jiang, Guanqun Huang, Nianzhang Zhao, Ting Zhang, Mengni Jiang, Yueming He, Xinke Zhou and Xianhan Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:169
  11. Glioblastoma (GBM) is a primary brain tumor with a 5-year survival rate of ≤5%. We have shown earlier that GBM-antibody-linked curcumin (CC) and also phytosomal curcumin (CCP) rescue 50–60% of GBM-bearing mice...

    Authors: Sumit Mukherjee, Angela Fried, Rahman Hussaini, Richard White, Juliet Baidoo, Sri Yalamanchi and Probal Banerjee
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:168
  12. Aberrant expression of Wiskott–Aldrich syndrome protein interacting protein family member 1 (WIPF1) contributes to the invasion and metastasis of several malignancies. However, the role of WIPF1 in human pancr...

    Authors: Yu Pan, Fengchun Lu, Ping Xiong, Maoen Pan, Zheyang Zhang, Xianchao Lin, Minggui Pan and Heguang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:167
  13. The KRAS mutation is the driving force of pancreatic ductal adenocarcinoma (PDAC). Downstream effectors of KRAS signal pathways are crucial to the development of PDAC. The purpose of this study was to investig...

    Authors: Yan Sun, Wenfang Peng, Weiwei He, Man Luo, Guilin Chang, Jiping Shen, Xiaoping Zhao and Yu Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:166
  14. Aberrant activation of β-catenin and Yes-associated protein (YAP) signaling pathways has been associated with hepatocellular carcinoma (HCC) progression. The LIM domain protein Ajuba regulates β-catenin and YA...

    Authors: Min Liu, Ke Jiang, Guibin Lin, Peng Liu, Yumei Yan, Tian Ye, Gang Yao, Martin P. Barr, Dapeng Liang, Yang Wang, Peng Gong, Songshu Meng and Haozhe Piao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:165
  15. Tongue squamous cell carcinoma (TSCC) is the most common oral cancer. Neoadjuvant systemic treatment before or after surgery for advanced TSCC is considered one of the most crucial factors in reducing mortalit...

    Authors: Yixue Gu, Hao Liu, Fangren Kong, Jiahui Ye, Xiaoting Jia, Zhijie Zhang, Nan Li, Jiang Yin, Guopei Zheng and Zhimin He
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:164
  16. Biomarkers are an integral part of cancer management due to their use in risk assessment, screening, differential diagnosis, prognosis, prediction of response to treatment, and monitoring progress of disease. ...

    Authors: Michelle H. Townsend, Gajendra Shrestha, Richard A. Robison and Kim L. O’Neill
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:163
  17. Exosomes are critically involved in cancer development and progression. The exosomal contents have been suggested as ideal cancer biomarkers. In this study, we investigated the expression of exosomal proteins ...

    Authors: Hailong Fu, Huan Yang, Xu Zhang, Bo Wang, Jiahui Mao, Xia Li, Mei Wang, Bin Zhang, Zixuan Sun, Hui Qian and Wenrong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:162
  18. Oxaliplatin belongs to the platinum-based drug family and has shown promise in treating cancer by binding to DNA to induce cytotoxicity. However, individual patients show diverse therapeutic responses toward o...

    Authors: Huei-Yu Chen, Atikul Islam, Tien-Ming Yuan, Shi-Wen Chen, Pei-Fen Liu and Pin Ju Chueh
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:161
  19. Bone metastasis is a leading cause of morbidity and mortality in advanced prostate cancer (PCa). Downexpression of miR-133a-3p has been found to contribute to the progression, recurrence and distant metastasis...

    Authors: Yubo Tang, Jincheng Pan, Shuai Huang, Xinsheng Peng, Xuenong Zou, Yongxiang Luo, Dong Ren, Xin Zhang, Ronggang Li, Peiheng He and Qingde Wa
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:160
  20. Paired box 8 (PAX8) has been documented to be downregulated in gastric cancer. However, its biological function in this malignancy is poorly understood.

    Authors: Liyan Wang, Xiaotong Bo, Qinghua Zheng, Wenhong Ge, Yanhua Liu and Bin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:159
  21. Brain invasion by glioblastoma (GBM) determines recurrence and prognosis in patients, which is, in part, attributed to increased mesenchymal transition. Here, we report evidence favoring such a role for the Pr...

    Authors: Xiupeng Xu, Zhongyuan Bao, Yinlong Liu, Kuan Jiang, Tongle Zhi, Dong Wang, Liang Fan, Ning Liu and Jing Ji
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:158
  22. Lycorine has been revealed to inhibit the development of many kinds of malignant tumors, including glioblastoma multiforme (GBM). Although compelling evidences demonstrated Lycorine’s inhibition on cancers thr...

    Authors: Jia Shen, Tao Zhang, Zheng Cheng, Ni Zhu, Hua Wang, Li Lin, Zexia Wang, Haotian Yi and Meichun Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:157
  23. Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, pl...

    Authors: Ganlu Deng, Shan Zeng, Yanling Qu, Qingqing Luo, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Changjing Cai, Yaojie Fu and Hong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:156
  24. In the publication of this article [1], there is an error in the Figure caption of Figs. 2, 3 and 4. This has now been included in this correction. The authors declare that these corrections do not change the ...

    Authors: Mei Yi, Junjun Li, Shengnan Chen, Jing Cai, Yuanyuan Ban, Qian Peng, Ying Zhou, Zhaoyang Zeng, Shuping Peng, Xiaoling Li, Wei Xiong, Guiyuan Li and Bo Xiang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:155

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:118

  25. Uncontrolled proliferation is thought to be the most fundamental characteristic of cancer. Detailed knowledge of cancer cell proliferation mechanisms would not only benefit understanding of cancer progression,...

    Authors: Mingkun Chen, Rongpei Wu, Gang Li, Cundong Liu, Lei Tan, Kanghua Xiao, Yunlin Ye and Zike Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:154
  26. The poly ADP ribose polymerase (PARP) inhibitor olaparib has been approved for treating prostate cancer (PCa) with BRCA mutations, and veliparib, another PARP inhibitor, is being tested in clinical trials. How...

    Authors: Linglong Yin, Youhong Liu, Yuchong Peng, Yongbo Peng, Xiaohui Yu, Yingxue Gao, Bowen Yuan, Qianling Zhu, Tuoyu Cao, Leye He, Zhicheng Gong, Lunquan Sun, Xuegong Fan and Xiong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:153

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:72

  27. As novel biomarkers for various cancers, microRNAs negatively regulate genes expression via promoting mRNA degradation and suppressing mRNA translation. miR-589 has been reported to be deregulated in several h...

    Authors: Feifei Zhang, Kaitao Li, Mingxin Pan, Weidong Li, Juan Wu, Mingyi Li, Liang Zhao and Hui Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:152
  28. Colorectal cancer (CRC) is one of the most prevalent malignancies in the world and developed drug resistance has represented one of the most challenging tasks for management. The current therapeutic regimens m...

    Authors: Mao-Hua Cai, Xiao-Gang Xu, Shi-Li Yan, Ze Sun, Yin Ying, Bai-Kui Wang and Yue-Xing Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:151
  29. The natural history of mantle cell lymphoma (MCL) is a continuous process with the vicious cycle of remission and recurrence. Because MCL cells are most vulnerable before their exposure to therapeutic agents, ...

    Authors: Haige Ye, Aakash Desai, Shengjian Huang, Dayoung Jung, Richard Champlin, Dongfeng Zeng, Fangfang Yan, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed and Michael L. Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:150
  30. The long non-coding RNAs (lncRNAs) have participated in the promotion of hepatocellular carcinoma (HCC) initiation and progression. Nevertheless, the biological role and underlying mechanism of LINC01287 in HC...

    Authors: Yichao Mo, Longguang He, Zeru Lai, Zhiheng Wan, Qinshou Chen, Sibo Pan, Liangfu Li, Dasheng Li, Junwei Huang, Fan Xue and Siyao Che
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:149
  31. Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a poor prognosis. The epithelial-to-mesenchymal transition (EMT) is crucial for increasing the metastasis of OSCC. Recently, s...

    Authors: Wenlu Li, Dandan Zhu and Shuaihua Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:148
  32. Exosomes are small vesicles containing a wide range of functional proteins, mRNA and miRNA. Exosomal miRNAs from cancer cells play crucial roles in mediating cell-cell communication and tumor-microenvironment ...

    Authors: Juan Lu, Qi-Hui Liu, Fan Wang, Jia-Jie Tan, Yue-Qin Deng, Xiao-Hong Peng, Xiong Liu, Bao Zhang, Xia Xu and Xiang-Ping Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:147
  33. The disruption of E-cadherin-mediated adhesion is considered an important driver of tumor progression. Nevertheless, numerous studies have demonstrated that E-cadherin promotes growth- or invasion-related sign...

    Authors: Katia Rea, Francesca Roggiani, Loris De Cecco, Francesco Raspagliesi, Maria Luisa Carcangiu, Joyce Nair-Menon, Marina Bagnoli, Ileana Bortolomai, Delia Mezzanzanica, Silvana Canevari, Antonis Kourtidis, Panos Z. Anastasiadis and Antonella Tomassetti
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:146
  34. Next-generation sequencing of the exome and genome of prostate cancers has identified numerous genetic alterations. SPOP (Speckle-type POZ Protein) is one of the most frequently mutated genes in primary prostate ...

    Authors: Jian Ma, Kun Chang, Jingtao Peng, Qing Shi, Hualei Gan, Kun Gao, Kai Feng, Fujiang Xu, Hailiang Zhang, Bo Dai, Yao Zhu, Guohai Shi, Yijun Shen, Yiping Zhu, Xiaojian Qin, Yao Li…
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:145
  35. Serine/threonine protein kinase 25 (STK25) is critical in regulating whole-body glucose and insulin homeostasis and the accumulation of ectopic lipids. The Warburg effect, also known as aerobic glycolysis, is ...

    Authors: Fan Wu, Pin Gao, Wei Wu, Zaozao Wang, Jie Yang, Jiabo Di, Beihai Jiang and Xiangqian Su
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:144
  36. Treatment strategies targeting tumor-associated macrophages (TAMs) have been proposed in cancer areas. The functional alterations of macrophages in the microenvironment during the tumorigenesis of human epithe...

    Authors: Meng Xiao, Jianjun Zhang, Wanjun Chen and Wantao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:143
  37. JS-K is a nitric oxide (NO) donor and could generate intracellularly high levels of NO. The study explores PP2A as a tumor suppressor is a major determinant mediating JS-K-caused apoptosis in human hepatocellu...

    Authors: Ling Liu, Zile Huang, Jingjing Chen, Jiangang Wang and Shuying Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:142
  38. Metastasis is the leading cause of cancer mortality and is a major hurdle for lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a crucial role in the metastatic cascade ...

    Authors: Yongwen Li, Hongbing Zhang, Hao Gong, Yin Yuan, Ying Li, Cong Wang, Weiting Li, Zihe Zhang, Minghui Liu, Hongyu Liu and Jun Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:141
  39. Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK c...

    Authors: Anais Del Curatolo, Fabiana Conciatori, Ursula Cesta Incani, Chiara Bazzichetto, Italia Falcone, Vincenzo Corbo, Sabrina D’Agosto, Adriana Eramo, Giovanni Sette, Isabella Sperduti, Teresa De Luca, Mirko Marabese, Senji Shirasawa, Ruggero De Maria, Aldo Scarpa, Massimo Broggini…
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:140
  40. Patients with endometrial cancer (EC) and presumably with good prognosis may develop a recurrence indicating that the classification of this tumor is still not definitive and that new markers are needed to ide...

    Authors: Giacomo Corrado, Valentina Laquintana, Rossella Loria, Mariantonia Carosi, Laura de Salvo, Isabella Sperduti, Ashanti Zampa, Lucia Cicchillitti, Giulia Piaggio, Giuseppe Cutillo, Rita Falcioni and Enrico Vizza
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:139
  41. Melanoma is a malignant tumor with high misdiagnosis rate and poor prognosis. The bio-targeted therapy is a prevailing method in the treatment of melanoma; however, the accompanying drug resistance is inevitab...

    Authors: An-dong Liu, Hui Xu, Ya-nan Gao, Dan-ni Luo, Zhao-feng Li, Courtney Voss, Shawn S. C. Li and Xuan Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:138
  42. The immune system is composed of immune as well as non-immune cells. As this system is a well-established component of human papillomavirus- (HPV)-related carcinogenesis, high risk human papillomavirus (hrHPV)...

    Authors: Marconi Rego Barros Jr, Cristiane Moutinho Lagos de Melo, Maria Luiza Carneiro Moura Gonçalves Rego Barros, Rita de Cássia Pereira de Lima, Antonio Carlos de Freitas and Aldo Venuti
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:137
  43. Upregulated fibroblast growth factor 19 (FGF19) expression in human hepatocellular carcinoma (HCC) specimens is associated with tumor progression and poor prognosis. Nonalcoholic steatohepatitis (NASH) patient...

    Authors: Guozhen Cui, Robert C. Martin, Hang Jin, Xingkai Liu, Harshul Pandit, Hengjun Zhao, Lu Cai, Ping Zhang, Wei Li and Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:136
  44. Expression of COP9 signalosome subunit 3 (COPS3), an oncogene overexpressed in osteosarcoma, has been demonstrated to be significantly correlated with tumor metastasis. However, the underlying mechanism by whi...

    Authors: Fan Zhang, Taiqiang Yan, Wei Guo, Kunkun Sun, Shidong Wang, Xing Bao, Kuisheng Liu, Bingxin Zheng, Hongliang Zhang and Tingting Ren
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:135
  45. Long non-coding RNAs (lncRNAs) have emerged as important regulators of human cancers. However, the functional roles of lncRNAs and the mechanisms responsible for their aberrant expression in gastric cancer (GC...

    Authors: Xu Zhang, Wei Liang, Jibin Liu, Xueyan Zang, Jianmei Gu, Lei Pan, Hui Shi, Min Fu, Zhenhua Huang, Yu Zhang, Hui Qian, Pengcheng Jiang and Wenrong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:134
  46. In non-small cell lung cancer (NSCLC), estrogen (E2) significantly promotes NSCLC cell growth via estrogen receptor beta (ERβ). Discovery and elucidation of the mechanism underlying estrogen-promoted NSCLC pro...

    Authors: Quanfu Huang, Zheng Zhang, Yongde Liao, Changyu Liu, Sheng Fan, Xiao Wei, Bo Ai and Jing Xiong
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:133
  47. Glioblastoma (GBM) is the most common, malignant, and lethal primary brain tumor in adults accounting for about 50% of all gliomas. Up to now, the chemotherapy approaches for GBM were limited. 3-O-acetyl-11-ke...

    Authors: Wan Li, Jinyi Liu, Weiqi Fu, Xiangjin Zheng, Liwen Ren, Shiwei Liu, Jinhua Wang, Tengfei Ji and Guanhua Du
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:132

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:236

  48. Despite advances in diagnosis and treatment, the survival of non-small cell lung cancer (NSCLC) patients remains poor. There is therefore a strong need to identify potential molecular targets for the treatment...

    Authors: Haicheng Tang, Jianjie Zhu, Wenwen Du, Shunlin Liu, Yuanyuan Zeng, Zongli Ding, Yang Zhang, Xueting Wang, Zeyi Liu and Jianan Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:131
  49. The aberrant expression of microRNAs (miRNAs) has emerged as important hallmarks of cancer. However, the molecular mechanisms underlying the differences of miRNA expression remain unclear. Many studies have re...

    Authors: Yue Fu, Xinchun Liu, Qiuyang Chen, Tongtai Liu, Cheng Lu, Jun Yu, Yi Miao and Jishu Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:130
  50. Targeting poly ADP-ribose polymerase (PARP) has been recently identified as a promising option against gastric cancer (GC). However, PARP inhibitors alone achieve limited efficacy. Combination strategies, espe...

    Authors: Xiaoting Lin, Dongshao Chen, Cheng Zhang, Xiaotian Zhang, Zhongwu Li, Bin Dong, Jing Gao and Lin Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:129

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