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  1. Liver cancr is a heterogeneous disease in terms of etiology, biologic and clinical behavior. Very little is known about how many genes concur at the molecular level of tumor development, progression and aggres...

    Authors: Yue-Fang Liu, Bin-Shan Zha, Hui-Lin Zhang, Xiao-Jing Zhu, Yu-Hua Li, Jin Zhu, Xiao-Hong Guan, Zhen-Qing Feng and Jian-Ping Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:107

    Content type: Research

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  2. Genetic instability is known as a cause of oncogenesis. Though Rad18 is reported to function in a post replication mismatch repair system, the relation between the status of Rad18 and human tumorigenesis has n...

    Authors: Tadahiko Nakamura, Shinji Ishikawa, Yoshikatsu Koga, Youhei Nagai, Yu Imamura, Kouei Ikeda, Takeshi Mori, Hiroaki Nomori and Hideo Baba

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:106

    Content type: Review

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  3. Osteosarcoma is a highly malignant bone tumor and is the most commonly encountered malignant bone tumor in children and adolescents. Furthermore, significant numbers of patients eventually develop pulmonary me...

    Authors: Zeng Feng Xin, Yang Kyung Kim and Sung Taek Jung

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:105

    Content type: Research

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  4. Non-synonymous single nucleotide polymorphisms (SNPs) within vital DNA repair genes may cause reduction of activity leaving the genome unrepaired resulting in genomic instability and cancer.

    Authors: Amit Kumar Mitra, Neetu Singh, Vivek Kumar Garg, Rashmi Chaturvedi, Mandira Sharma and Srikanta Kumar Rath

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:104

    Content type: Research

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  5. A reliable and precise classification is essential for successful diagnosis and treatment of cancer. Gene expression microarrays have provided the high-throughput platform to discover genomic biomarkers for ca...

    Authors: Peng Guan, Desheng Huang, Miao He and Baosen Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:103

    Content type: Research

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  6. Opioid analgesics are generally used to combat the pain associated with cancerous conditions. These agents not only inhibit respiratory function and cause constipation, but also induce other significant side e...

    Authors: Hyo-Jeong Lee, Jae-Ho Lee, Eun-Ok Lee, Hyo-Jung Lee, Kwan-Hyun Kim, Sun-Hyung Kim, Keun-Sung Lee, Hee-Jae Jung and Sung-Hoon Kim

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:102

    Content type: Research

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    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2009 28:137

  7. Authors: Huang Hao, Yu Nancai, Fu Lei, Wei Xiong, Su Wen, Huang Guofu, Wu yanxia, Huang Hanju, Liu Qian and Xiao Hong

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:101

    Content type: Retraction Note

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2008 27:27

  8. Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in ...

    Authors: Huaifu Li, Guofeng Ruan, Zhijun Li, Ziwei Liu, Xiaoqing Zheng, Hao zheng, Guangming Cheng, Benyi Li and Ming Zhan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:100

    Content type: Research

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  9. Imatinib, a tyrosine kinase inhibitor currently approved for treatment of several malignancies, has been shown to be a substrate for multiple efflux-transporter proteins, including ABCB1 (P-glycoprotein) and A...

    Authors: Erin R Gardner, Nicola F Smith, William D Figg and Alex Sparreboom

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:99

    Content type: Research

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  10. The prognostic value of HER2 expression in patients with advanced non-small cell lung cancer remains controversial. The relationship between HER2 expression, and platinum resistance and patient survival, was i...

    Authors: Zuleyha Calikusu, Yesim Yildirim, Zafer Akcali, Hakan Sakalli, Nebil Bal, Ilker Unal and Ozgur Ozyilkan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:97

    Content type: Research

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  11. Resveratrol is a non flavonoid polyphenol compound present in many plants and fruits and, at especially high concentrations, in the grape berries of Vitis vinifera. This compound has a strong bioactivity and its ...

    Authors: Valerio Berardi, Francesca Ricci, Mauro Castelli, Gaspare Galati and Gianfranco Risuleo

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:96

    Content type: Research

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  12. To compare intracavitary brachytherapy (ICBT) planning methods for cervical cancer, based on either orthogonal radiographs (conventional plan) or CT sections (CT plan); the comparison focused on target volume ...

    Authors: Cem Onal, Gungor Arslan, Erkan Topkan, Berrin Pehlivan, Melek Yavuz, Ezgi Oymak and Aydin Yavuz

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:95

    Content type: Research

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  13. Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that t...

    Authors: Xiaoxiang Guan, Hui Zhao, Jiangong Niu, Dongfeng Tan, Jaffer A Ajani and Qingyi Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:94

    Content type: Research

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  14. Selenite is a promising anticancer agent which has been shown to induce apoptosis in malignant mesothelioma cells in a phenotype-dependent manner, where cells of the chemoresistant sarcomatoid phenotype are mo...

    Authors: Gustav Nilsonne, Eric Olm, Adam Szulkin, Filip Mundt, Agnes Stein, Branka Kocic, Anna-Klara Rundlöf, Aristi P Fernandes, Mikael Björnstedt and Katalin Dobra

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:92

    Content type: Research

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  15. Platinum-based neoadjuvant chemotherapy (NAC) is new therapeutic strategy for locally advanced cervical carcinoma, but the variables used to predict NAC response are still infrequently reported. The aim of our...

    Authors: Xiao-Dong Cheng, Wei-Guo Lu, Feng Ye, Xiao-Yun Wan and Xing Xie

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:91

    Content type: Research

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  16. Type 2 diabetes (T2D) is associated with obesity and has been shown recently to be associated with tumors/cancer. HNF1-beta and JAZF1 genes are associated with T2D and prostate cancer. We have previously shown th...

    Authors: Ramachandran Meenakshisundaram, Nunzia Piumelli, Laura Pierpaoli and Claudia Gragnoli

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:90

    Content type: Research

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  17. Lung cancer is the leading cause of death from cancer worldwide. Conventional studies mainly think that insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) may promote and inhibit tumor gr...

    Authors: Bo Chen, Shan Liu, Wei Xu, Xueli Wang, Weihong Zhao and Jianqing Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:89

    Content type: Research

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  18. To show magnetic resonance imaging (MRI) texture appearance change in non-Hodgkin lymphoma (NHL) during treatment with response controlled by quantitative volume analysis.

    Authors: Lara CV Harrison, Tiina Luukkaala, Hannu Pertovaara, Tuomas O Saarinen, Tomi T Heinonen, Ritva Järvenpää, Seppo Soimakallio, Pirkko-Liisa I Kellokumpu-Lehtinen, Hannu J Eskola and Prasun Dastidar

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:87

    Content type: Research

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  19. We aimed to determine the incidence of women's breast cancer in Italy without using statistical approximations.

    Authors: Prisco Piscitelli, Antonio Santoriello, Franco M Buonaguro, Massimo Di Maio, Giovanni Iolascon, Francesca Gimigliano, Alessandra Marinelli, Alessandro Distante, Giuseppe Serravezza, Emiliano Sordi, Katia Cagossi, Fabrizio Artioli, Michele Santangelo, Alfredo Fucito, Raffaele Gimigliano, Maria Luisa Brandi…

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:86

    Content type: Research

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  20. No satisfactory biomarkers are currently available to screen for nasopharyngeal carcinoma (NPC). We have developed and evaluated surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (S...

    Authors: Yuan-Jiao Huang, Chao Xuan, Bei-Bei Zhang, Ming Liao, Kai-Feng Deng, Min He and Jin-Min Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:85

    Content type: Research

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  21. Intracellular levels of zinc have shown a strong inverse correlation to growth and malignancy of prostate cancer. To date, studies of zinc supplementation in prostate cancer have been equivocal and have not ac...

    Authors: Maulik R Shah, Christopher L Kriedt, Nathan H Lents, Mary K Hoyer, Nimah Jamaluddin, Claudette Klein and Joseph Baldassare

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:84

    Content type: Research

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  22. The aim of this study was to determine a predictive indicator of gemcitabine (GEM) efficacy in unresectable pancreatic cancer using tissue obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy...

    Authors: Reiko Ashida, Bunzo Nakata, Minoru Shigekawa, Nobumasa Mizuno, Akira Sawaki, Kosei Hirakawa, Tetsuo Arakawa and Kenji Yamao

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:83

    Content type: Research

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  23. MircoRNAs(miRNAs) are short, endogenously non-coding RNAs. The abnormal expression of miRNAs may be valuable for the diagnosis and treatment of tumors.

    Authors: Hongchun Luo, Hongbin Zhang, Zhenzhen Zhang, Xia Zhang, Bo Ning, Jinjun Guo, Na Nie, Bo Liu and Xiaoling Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:82

    Content type: Research

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  24. Colorectal cancer is a one of the most common alimentary malignancies. Survivin has been proved by many studies to be an ideal target for cancer gene therapy because of its strong anti-apoptotic effect. The re...

    Authors: Wei Shen, Chun-Yi Wang, Xue-Hu Wang and Zhong-Xue Fu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:81

    Content type: Research

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  25. The incidence of hepatocellular carcinoma is increasing in many countries. The estimated number of new cases annually is over 500,000, and the yearly incidence comprises between 2.5 and 7% of patients with liv...

    Authors: AlaaEddeen M Seufi, Safinz S Ibrahim, Tarek K Elmaghraby and Elsayed E Hafez

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:80

    Content type: Research

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  26. FBG2 (F-BOX6) gene is an important member in ubiquitin metabolic system F-BOX family, and forms E3 complex with the other members in the family. But its role in gastric cancer is still not clear. In the presen...

    Authors: Lin Zhang, Yanhong Hou, Mengwei Wang, Benyan Wu and Nan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:78

    Content type: Research

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  27. opioid and somatostatin receptors (SSTRs) that can assemble as heterodimer were individually reported to modulate malignant cell proliferation and to favour apoptosis. Materials and methods: SSTRs and opioid r...

    Authors: Céline Kerros, Thibault Cavey, Brigitte Sola, Philippe Jauzac and Stéphane Allouche

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:77

    Content type: Research

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  28. We observed that paclitaxel altered the pharmacokinetic properties of gemcitabine in patients with non-small cell lung cancer (NSCLC) and limited the accumulation of gemcitabine and its metabolites in various ...

    Authors: Stacy S Shord and Shitalben R Patel

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:76

    Content type: Research

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  29. Angiogenesis plays an important role in tumor growth, invasion, and eventually metastasis. Antiangiogenic strategies have been proven to be a promising approach for clinical therapy for a variety of tumors. As...

    Authors: Li-Ping Yang, Ping Cheng, Xing-Chen Peng, Hua-Shan Shi, Wei-Hong He, Feng-Yu Cui, Shun-Tao Luo, Yu-Quan Wei and Li Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:75

    Content type: Research

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  30. Centromere protein H (CENP-H) is one of the fundamental components of the human active kinetochore. Recently, CENP-H was identified to be associated with tumorigenesis. This study was aimed to investigate the ...

    Authors: Wen-Ting Liao, Chun-Ping Yu, Dong-Hui Wu, Ling Zhang, Li-Hua Xu, Gui-Xiang Weng, Mu-Sheng Zeng, Li-Bing Song and Jin-Song Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:74

    Content type: Research

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  31. Reactive oxygen species (ROS) are closely associated with the intracellular signal cascade, thus strongly implicating involvement in tumor progression. However, the mechanism by which ROS are generated and how...

    Authors: Kyung Hee Lee, Sang Woon Kim and Jae-Ryong Kim

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:73

    Content type: Research

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  32. The relapse of cancer after radiotherapy is a clinical knotty problem. Previous studies have demonstrated that the elevation of several factors is likely in some way to lead to the development of treatment tol...

    Authors: Degang Shi, Genming Shi, Gang Huang, Jiren Zhang and Eric Lartigau

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:72

    Content type: Research

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  33. Hepatocellular carcinoma (HCC) is a lethal malignancy with high rate of metastasis and poor prognosis. There are no effective managements to block metastasis of HCC. Programmed cell death 4 (PDCD4) is found to...

    Authors: Shuhong Zhang, Jianfeng Li, Ying Jiang, Yijun Xu and Chengyong Qin

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:71

    Content type: Research

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  34. Insulin-like growth factor binding protein (IGFBPs) have been as potential tumor suppressors in the occurrence and development of tumors. Cellular Fas-associated death domain-like interleukin-1β-converting enz...

    Authors: Xue-Jing Hou, You-Zhong Zhang, Xin Liu, Li-Hua Meng and Yun-Bo Qiao

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:70

    Content type: Research

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  35. Chemo-radiotherapy, a combination of chemotherapy and radiotherapy, is the most frequent treatment for patients with esophageal cancer. In the process of radiotherapy, the radiosensitive cancer will become a r...

    Authors: Li Xie, Xianrang Song, Jinming Yu, Ling Wei, Bao Song, Xingwu Wang and Liyan Lv

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:68

    Content type: Research

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  36. The α6β4 integrin is overexpressed in the basal subtype of breast cancer and plays an important role in tumor cell motility and invasion. EGFR is also overexpressed in the basal subtype of breast cancer, and c...

    Authors: Michael Z Gilcrease, Xiao Zhou, Xiaolin Lu, Wendy A Woodward, Brian E Hall and Phillip J Morrissey

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:67

    Content type: Research

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  37. Molecularly targeted agents for the treatment of solid tumors had entered the market in the last 5 years, with a great impact upon both the scientific community and the society. Many randomized phase III trial...

    Authors: Emilio Bria, Massimo Di Maio, Paolo Carlini, Federica Cuppone, Diana Giannarelli, Francesco Cognetti and Michele Milella

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:66

    Content type: Review

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  38. An increasing number of studies have shown that ERK and PI3-K/AKT signaling pathways are involved in various human cancers including hepatocellular carcinoma and cholangiocarcinoma. However, few studies have e...

    Authors: Qinglong Li and Zhulin Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:65

    Content type: Research

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  39. Non-coding RNA molecules, such as microRNAs, may play an important role in carcinogenesis. Recent studies have indicated that microRNAs are involved in initiation and progression of various malignancies. Howev...

    Authors: Tao Yu, Xiao-yi Wang, Ren-guo Gong, An Li, Sen Yang, Yu-tang Cao, Yu-ming Wen, Chang-mei Wang and Xin-zhu Yi

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:64

    Content type: Research

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  40. A novel multi-drug resistance gene named as HA117 has been screened and cloned in multidrug resisitant leukemia cell lines in our previous research, but its function is still unknown. In this study, HA117 gene...

    Authors: Yuxia Guo, Gaihuan Zheng, Xianqing Jin, Youhua Xu, Qing Luo, Xiaomei Liu, Zhenzhen Zhao and Yong Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:63

    Content type: Research

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  41. The pathogenesis of biliary cancers is ill-defined. This study investigates changes in gene expression and copy number in biliary cancers and correlates these changes with anatomical site of origin, histopatho...

    Authors: George Miller, Nicholas D Socci, Deepti Dhall, Michael D'Angelica, Ronald P DeMatteo, Peter J Allen, Bhuvanesh Singh, Yuman Fong, Leslie H Blumgart, David S Klimstra and William R Jarnagin

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:62

    Content type: Research

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  42. Seizure control doesn't represent the only challenging goal in patients with brain tumor-related epilepsy. Side effects have often taken precedence for patients' quality of life.

    Authors: Marta Maschio, Loredana Dinapoli, Antonello Vidiri, Andrea Pace, Alessandra Fabi, Alfredo Pompili, Maria Carmine Carapella and Bruno Jandolo

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:60

    Content type: Research

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  43. There are around 350 million of hepatitis B surface antigen (HBsAg) carriers worldwide, and among them, high risk of developing hepatocellular carcinoma (HCC) has been identified by epidemiological studies. To...

    Authors: Xiaochen Tian, Jinjun Li, Zhang-Mei Ma, Chao Zhao, Da-Fang Wan and Yu-Mei Wen

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:58

    Content type: Research

    Published on:

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