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  1. Enolase 2 (ENO2) is a crucial glycolytic enzyme in cancer metabolic process and acts as a “moonlighting” protein to play various functions in diverse cellular processes unrelated to glycolysis. ENO2 is highly ...

    Authors: Lixia Gao, Fan Yang, Dianyong Tang, Zhigang Xu, Yan Tang, Donglin Yang, Deping Sun, Zhongzhu Chen and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:1
    Content type: Research Published on:

  2. Recently genome-based studies revealed that the abnormality of Hippo signaling is pervasive in TNBC and played important role in cancer progression. RING finger protein 31 (RNF31) comes to RING family E3 ubiqu...

    Authors: Huijie Yang, Min Xue, Peng Su, Yan Zhou, Xin Li, Zhongbo Li, Yan Xia, Chenmiao Zhang, Mingxi Fu, Xiuxia Zheng, Guosheng Luo, Tian Wei, Xinxing Wang, Yinlu Ding, Jian Zhu and Ting Zhuang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:364
    Content type: Research Published on:

  3. Sushi domain-containing protein 4 (SUSD4) is a recently discovered protein with unknown cellular functions. We previously revealed that SUSD4 can act as complement inhibitor and as a potential tumor suppressor.

    Authors: Konstantinos S. Papadakos, Alexander Ekström, Piotr Slipek, Eleni Skourti, Steven Reid, Kristian Pietras and Anna M. Blom
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:363
    Content type: Research Published on:

  4. The standard therapies in lymphoma have predominantly focused on targeting tumor cells with less of a focus on the tumor microenvironment (TME), which plays a critical role in favoring tumor growth and surviva...

    Authors: Wern Lynn Ng, Stephen M. Ansell and Patrizia Mondello
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:362
    Content type: Review Published on:

  5. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0681-y.

    Authors: Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li and Hua Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:361
    Content type: Retraction Note Published on:

  6. Cellular senescence is a state of stable cell-cycle arrest with secretory features in response to cellular stress. Historically, it has been considered as an endogenous evolutionary homeostatic mechanism to el...

    Authors: Andreas Domen, Christophe Deben, Jasper Verswyvel, Tal Flieswasser, Hans Prenen, Marc Peeters, Filip Lardon and An Wouters
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:360
    Content type: Review Published on:

  7. Authors: Yuan Zhou, Haozhen Ren, Bo Dai, Jun Li, Longcheng Shang, Jianfei Huang and Xiaolei Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:359
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:324

  8. IFN-γ is a key mediator of tumor immunity that can induce macrophage polarization to suppress tumor growth. Cyclin G2 functions as a tumor suppressor in various cancer cells; however, its role in macrophages r...

    Authors: Lu Liu, Jinlan Gao, Xuesha Xing, Meixi Jiang, Qi Liu, Shusen Wang and Yang Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:358
    Content type: Research Published on:

  10. Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach to investigate autologous and treatment-induced antitumor immune response. Technical and computational breakthroughs, includi...

    Authors: Nicla Porciello, Ornella Franzese, Lorenzo D’Ambrosio, Belinda Palermo and Paola Nisticò
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:356
    Content type: Review Published on:

  11. High-grade serous ovarian carcinomas (HGSCs) are a heterogeneous subtype of epithelial ovarian cancers and include serous cancers arising in the fallopian tube and peritoneum. These cancers are now subdivided ...

    Authors: Xue Lu, Yaowu He, Rebecca L. Johnston, Devathri Nanayakarra, Sivanandhini Sankarasubramanian, J. Alejandro Lopez, Michael Friedlander, Murugan Kalimutho, John D. Hooper, Prahlad V. Raninga and Kum Kum Khanna
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:355
    Content type: Research Published on:

  12. Escaping from ER stress-induced apoptosis plays an important role in the progression of many tumours. However, its molecular mechanism in osteosarcoma remains incompletely understood.

    Authors: Yuan Wang, Shuo Zheng, Jian Han, Na Li, Renchen Ji, Xiaodong Li, Chuanchun Han, Wenzhi Zhao and Lu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:354
    Content type: Research Published on:

  13. Alternative splicing (AS) events are extensively involved in the progression of diverse tumors, but how serine/arginine-rich splicing Factor 10 (SRSF10) behaves in hepatocellular carcinoma (HCC) has not been s...

    Authors: Xiaoming Liu, Yongqiang Zheng, Mengqing Xiao, Xingyu Chen, Yuxing Zhu, Canxia Xu, Fen Wang, Zexian Liu and Ke Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:353
    Content type: Research Published on:

  14. Neuroblastoma (NB) is the most common extracranial solid tumor occurring during childhood and high-risk NB patients have a poor prognosis. The amplified MYCN gene serves as an important determinant of a high r...

    Authors: Kezhe Tan, Jialin Mo, Meng Li, Yu Dong, Yujie Han, Xi Sun, Yingxuan Ma, Kai Zhu, Wei Wu, Li Lu, Jiangbin Liu, Kewen Zhao, Lei Zhang, Yujie Tang and Zhibao Lv
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:352
    Content type: Research Published on:

  16. Salivary gland tumors (SGTs) include a large group of rare neoplasms in the head and neck region, and the heterogeneous and overlapping features among the subtypes frequently make diagnostic difficulties. Ther...

    Authors: Bo Wang, Jiaxing Gan, Zhengyan Liu, Zhixuan Hui, Jinhui Wei, Xiaolian Gu, Yabing Mu and Guangxiang Zang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:350
    Content type: Research Published on:

  17. To identify potential targets related to nicotinamide adenine dinucleotide (NAD+) metabolism in gliomas, we used RNA immunoprecipitation to identify a novel long noncoding RNA renamed malate dehydrogenase degr...

    Authors: Dong He, Tao Xin, Bo Pang, Jun Sun, Zi Hao Liu, Zhen Qin, Xiao Shuai Ji, Fan Yang, Yan Bang Wei, Zi Xiao Wang, Jia Jia Gao, Qi Pang and Qian Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:349
    Content type: Research Published on:

  18. Research has indicated that the emergence of Schwann cells around premalignant lesions of colon cancer might be an early indicator promoting the onset of tumorigenesis. The present study explored the communica...

    Authors: Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo and Gang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:348
    Content type: Research Published on:

  19. Esophageal squamous cell carcinoma (ESCC) is one of the most common digestive malignancies with relatively high morbidity and mortality. Emerging evidence suggests circular RNAs (circRNAs) play critical roles ...

    Authors: Chang Wang, Mingxia Zhou, Peiyu Zhu, Chenxi Ju, Jinxiu Sheng, Dan Du, Junhu Wan, Huiqing Yin, Yurong Xing, Hongle Li, Jing He and Fucheng He
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:347
    Content type: Research Published on:

  20. C-Jun, a critical component of AP-1, exerts essential functions in various tumors, including melanoma, and is believed to be a druggable target for cancer therapy. Unfortunately, no effective c-Jun inhibitors ...

    Authors: Pian Yu, Hui Wei, Kaixuan Li, Shiguo Zhu, Jie Li, Chao Chen, Detian Zhang, Yayun Li, Lei Zhu, Xiaoqing Yi, Nian Liu, Panpan Liu, Shuang Zhao, Xiang Chen and Cong Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:346
    Content type: Research Published on:

  21. N4-acetylcytidine (ac4C) as a significant RNA modification has been reported to maintain the stability of mRNA and to regulate the translation process. However, the roles of both ac4C and its ‘writer’ protein N-a...

    Authors: Chi Jin, Tuo Wang, Dongsheng Zhang, Peng Yang, Chuan Zhang, Wen Peng, Kangpeng Jin, Lu Wang, Jiahui Zhou, Chaofan Peng, Yuqian Tan, Jiangzhou Ji, Zhihao Chen, Qingyang Sun, Sheng Yang, Junwei Tang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:345
    Content type: Research Published on:

  22. Vaccine immunotherapy may improve survival in Glioblastoma (GBM). A multicenter phase II trial was designed to determine: (1) the success rate of manufacturing the Aivita GBM vaccine (AV-GBM-1), (2) Adverse Ev...

    Authors: Daniela A. Bota, Thomas H. Taylor, David E. Piccioni, Christopher M. Duma, Renato V. LaRocca, Santosh Kesari, Jose A. Carrillo, Mehrdad Abedi, Robert D. Aiken, Frank P. K. Hsu, Xiao-Tang Kong, Candace Hsieh, Peter G. Bota, Gabriel I. Nistor, Hans S. Keirstead and Robert O. Dillman
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:344
    Content type: Research Published on:

  23. Thymic malignancies are a heterogeneous group of rare cancers for which systemic chemotherapy is the standard treatment in the setting of advanced, recurrent or refractory diseases. Both environmental and gene...

    Authors: Paolo Mendogni, Roberta Affatato, Enrico Cabri, Michela Chiappa, Gloriana Ndembe, Davide Tosi, Alessandro Del Gobbo, Maddalena Fratelli, Eleonora Pardini, Iacopo Petrini, Lorenzo Rosso, Massimo Broggini and Mirko Marabese
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:343
    Content type: Commentary Published on:

  24. Authors: Rou Zhao, Baoyu He, Qingli Bie, Jinghe Cao, Haoran Lu, Zhixin Zhang, Jing Liang, Li Wei, Huabao Xiong and Bin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:342
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:322

  25. Authors: Ting Yang, Wei-Cong Chen, Pei-Cong Shi, Man-Ru Liu, Tao Jiang, Hu Song, Jia-Qi Wang, Rui-Zhi Fan, Dong-Sheng Pei and Jun Song
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:341
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:139

  26. Acute myeloid leukemia (AML) is an aggressive hematological cancer resulting from uncontrolled proliferation of differentiation-blocked myeloid cells. Seventy percent of AML patients are currently not cured wi...

    Authors: Katie Fooks, Gabriela Galicia-Vazquez, Victor Gife, Alejandro Schcolnik-Cabrera, Zaynab Nouhi, William W. L. Poon, Vincent Luo, Ryan N. Rys, Raquel Aloyz, Alexandre Orthwein, Nathalie A. Johnson, Laura Hulea and Francois E. Mercier
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:340
    Content type: Research Published on:

  27. Authors: Dan Jin, Jiwei Guo, Yan Wu, Weiwei Chen, Jing Du, Lijuan Yang, Xiaohong Wang, Kaikai Gong, Juanjuan Dai, Shuang Miao, Xuelin Li and Guoming Su
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:339
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:6

  28. Aberrant RNA editing of adenosine-to-inosine (A-to-I) has been linked to multiple human cancers, but its role in intrahepatic cholangiocarcinoma (iCCA) remains unknown. We conducted an exome-wide investigation...

    Authors: Chengming Gao, Guangming Zhou, Jie Shi, Peipei Shi, Liang Jin, Yuanfeng Li, Xiaowen Wang, Song Liao, Han Yan, Junjie Wu, Yiming Lu, Yun Zhai, Jinxu Zhang, Haitao Zhang, Hongxing Zhang, Chenning Yang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:338
    Content type: Research Published on:

  29. Altered glycolysis is the most fundamental metabolic change associated with the Warburg effect. Some glycolytic enzymes such as PKM2, the dominant pyruvate kinase in cancer cells, have been shown to engage in ...

    Authors: Yang Wu, Yichun Wang, Hanhui Yao, Heng Li, Fanzheng Meng, Qidong Li, Xiansheng Lin and Lianxin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:337
    Content type: Research Published on:

  30. The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM protei...

    Authors: Xu Yang, Yan Zhang, Zhiwei Xue, Yaotian Hu, Wenjing Zhou, Zhiyi Xue, Xuemeng Liu, Guowei Liu, Wenjie Li, Xiaofei Liu, Xingang Li, Mingzhi Han and Jian Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:336
    Content type: Research Published on:

  31. Hepatocellular carcinoma (HCC) is the world’s third leading cause of cancer-related death; due to the fast growth and high prevalence of tumor recurrence, the prognosis of HCC patients remains dismal. Long non...

    Authors: Yunshi Cai, Tao Lyu, Hui Li, Chang Liu, Kunlin Xie, Lin Xu, Wei Li, Hu Liu, Jiang Zhu, Yinghao Lyu, Xuping Feng, Tian Lan, Jiayin Yang and Hong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:335
    Content type: Research Published on:

  32. N6-methyladenosine (m6A) modification plays a critical role in progression of hepatocellular carcinoma (HCC), and aerobic glycolysis is a hallmark of cancer including HCC. However, the role of YTHDF3, one member ...

    Authors: Rong Zhou, Wen Ni, Chao Qin, Yunxia Zhou, Yuqing Li, Jianping Huo, Lijuan Bian, Aijun Zhou and Jianming Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:334
    Content type: Research Published on:

  33. Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression. Recent...

    Authors: Elisa Ventura, Christopher Xie, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano and Andrea Morrione
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:333
    Content type: Research Published on:

  34. The biological function of lncRNA ELF3-AS1 remains largely unknown in cancers. The cause of SNAI2 overexpression in tumor metastasis remains largely unclear. The molecular mechanisms underlying the high co-exp...

    Authors: Dandan Li, Li Shen, Xudong Zhang, Zhen Chen, Pan Huang, Congcong Huang and Shanshan Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:332
    Content type: Research Published on:

  35. Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant tumor characterized by an intensive desmoplastic reaction due to the exaggerated presence of the extracellular (ECM) matrix components. Liver fibrob...

    Authors: Serena Mancarella, Isabella Gigante, Grazia Serino, Elena Pizzuto, Francesco Dituri, Maria F. Valentini, Jingxiao Wang, Xin Chen, Raffaele Armentano, Diego F. Calvisi and Gianluigi Giannelli
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:331
    Content type: Research Published on:

  36. Glycolysis metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options. The ubiq...

    Authors: Liang Zhao, Min Kang, Xiaomeng Liu, Zhenran Wang, Yan Wang, Haiqiang Chen, Wenhui Liu, Shiqian Liu, Baibei Li, Chong Li, Antao Chang and Bo Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:330
    Content type: Research Published on:

  37. Aerobic glycolysis has been recognized as one of the growth-promoting metabolic alterations of cancer cells. Emerging evidence indicates that nuclear factor κB (NF-κB) plays significant roles in metabolic adap...

    Authors: Lingjun Chen, Xianyi Lin, Yiming Lei, Xuan Xu, Qi Zhou, Yan Chen, Huiling Liu, Jie Jiang, Yidong Yang, Fengping Zheng and Bin Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:329
    Content type: Research Published on:

  38. Radioresistance is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure. Previous studies have focused on the deficits in cellular apoptosis as a mechanism for radioresistance; however, additi...

    Authors: Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:328
    Content type: Research Published on:

  39. Central nervous system (CNS) metastases are a major cause of death in patients with cancer. Tumor cells must survive during their migration and dissemination in various sites and niches. The brain is considere...

    Authors: Maria M. Caffarel and Mounia S. Braza
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:327
    Content type: Review Published on:

  40. Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a combinatorial in situ immunomodulation strategy based on the administration of...

    Authors: Valeria Lucarini, Ombretta Melaiu, Silvia D’Amico, Fabio Pastorino, Patrizia Tempora, Marco Scarsella, Marco Pezzullo, Adele De Ninno, Valentina D’Oria, Michele Cilli, Laura Emionite, Paola Infante, Lucia Di Marcotullio, Maria Antonietta De Ioris, Giovanni Barillari, Rita Alaggio…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:326
    Content type: Research Published on:

  41. Improvement of efficacy of immune checkpoint blockade (ICB) remains a major clinical goal. Association of ICB with immunomodulatory epigenetic drugs is an option. However, epigenetic inhibitors show a heteroge...

    Authors: Andrea Anichini, Alessandra Molla, Gabriella Nicolini, Valentina Eleonora Perotti, Francesco Sgambelluri, Alessia Covre, Carolina Fazio, Maria Fortunata Lofiego, Anna Maria Di Giacomo, Sandra Coral, Antonella Manca, Maria Cristina Sini, Marina Pisano, Teresa Noviello, Francesca Caruso, Silvia Brich…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:325
    Content type: Research Published on:

  42. Aerotaxis, the chemotactism to oxygen, is well documented in prokaryotes. We previously reported for the first time that non-tumorigenic breast epithelial cells also display unequivocal directional migration t...

    Authors: Ivan Mikaelian, Rudy Gadet, Mathieu Deygas, Philippe Bertolino, Anca Hennino, Germain Gillet, Ruth Rimokh, Sid-Ali Berremila, Michel Péoc’h and Philippe Gonzalo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:324
    Content type: Research Published on:

  43. Intratumoral heterogeneity is the primary challenge in the treatment of glioblastoma (GBM). The presence of glioma stem cells (GSCs) and their conversion between different molecular phenotypes contribute to th...

    Authors: Zijie Gao, Jianye Xu, Yang Fan, Zongpu Zhang, Huizhi Wang, Mingyu Qian, Ping Zhang, Lin Deng, Jie Shen, Hao Xue, Rongrong Zhao, Teng Zhou, Xing Guo and Gang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:323
    Content type: Research Published on:

  44. Cancer stem cells (CSCs) are regarded as the "seed cells" for tumorigenesis, metastasis, recurrence and drug resistance. However, specific surface markers of CSCs of different origins have not been documented.

    Authors: Rou Zhao, Baoyu He, Qingli Bie, Jinghe Cao, Haoran Lu, Zhixin Zhang, Jing Liang, Li Wei, Huabao Xiong and Bin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:322
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:342

  45. Medulloblastoma (MB) patients with MYC oncogene amplification or overexpression exhibit extremely poor clinical outcomes and respond poorly to current therapies. Epigenetic deregulation is very common in MYC-d...

    Authors: Matthew J. Kling, Varun Kesherwani, Nitish K. Mishra, Gracey Alexander, Erin M. McIntyre, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter and Nagendra K. Chaturvedi
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:321
    Content type: Research Published on:

  47. In the last two decades, clinical oncology has been revolutionized by the advent of targeted drugs. However, the efficacy of these therapies is significantly limited by primary and acquired resistance, that re...

    Authors: Sabrina Rizzolio, Silvia Giordano and Simona Corso
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:319
    Content type: Review Published on:

  48. Tumour hypoxia is a known and extensively researched phenomenon that occurs in both solid and haematological malignancies. As cancer cells proliferate, demand for oxygen can outstrip supply reducing tumour oxy...

    Authors: Bill Harris, Sana Saleem, Natalie Cook and Emma Searle
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:318
    Content type: Review Published on:

  49. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1188-x.

    Authors: Zhikui Liu, Yufeng Wang, Liang Wang, Bowen Yao, Liankang Sun, Runkun Liu, Tianxiang Chen, Yongshen Niu, Kangsheng Tu and Qingguang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:317
    Content type: Retraction Note Published on:

  50. Bone metastasis occurs when tumour cells dissociate from primary tumours, enter the circulation (circulating tumour cells, CTCs), and colonize sites in bone (disseminated tumour cells, DTCs). The bone marrow s...

    Authors: Rongchen Dai, Mengfan Liu, Xincheng Xiang, Zhichao Xi and Hongxi Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:316
    Content type: Review Published on:

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Journal of Experimental & Clinical Cancer Research

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