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  1. Glioblastoma multiforme (GBM) is the most common and aggressive form of astrocytoma among adult brain tumors. Multiple studies have shown that long non-coding RNAs (lncRNAs) play important roles in acting as m...

    Authors: Weining Wu, Tianfu Yu, Youzhi Wu, Wei Tian, Junxia Zhang and Yingyi Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:133
  2. Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed, we elaborated the impact of CD44v6 and Tspan8 on the ...

    Authors: Zhe Wang, Hanxue Sun, Jan Provaznik, Thilo Hackert and Margot Zöller
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:132
  3. Dysfunction of p53 is a key cause of cancer development, while CCDC106 can reduce p53 stability and is associated with lung cancer. However, the roles of CCDC106 in other cancer types and its upstream regulato...

    Authors: Yichong Ning, Chunqing Wang, Xin Liu, Yan Du, Shunlian Liu, Kaili Liu, Jianlin Zhou and Chang Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:131
  4. Human hepatocellular carcinoma (HCC) lacks effective curative therapy and there is an urgent need to develop a novel molecular-targeted therapy for HCC. Selective tyrosine kinase inhibitors have shown promise ...

    Authors: Teng Luo, Shou-Guo Zhang, Ling-Fei Zhu, Fei-Xiang Zhang, Wei Li, Ke Zhao, Xiao-Xue Wen, Miao Yu, Yi-Qun Zhan, Hui Chen, Chang-Hui Ge, Hui-Ying Gao, Lin Wang, Xiao-Ming Yang and Chang-Yan Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:130
  5. Non-small cell lung cancer (NSCLC) patients with sensitive epidermal growth factor receptor (EGFR) mutations are successfully treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs); however, resistance to tr...

    Authors: Quanfu Huang, Qiuguo Wang, Dong Li, Xiao Wei, Yijuan Jia, Zheng Zhang, Bo Ai, Xiaonian Cao, Tao Guo and Yongde Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:129
  6. Cell-to-cell communication has a critical role during tumor development and progression, allowing cancer cell to re-program not only the surrounding tumor microenvironment, but also cells located at distant si...

    Authors: Claudia Chiodoni, Maria Teresa Di Martino, Francesca Zazzeroni, Michele Caraglia, Massimo Donadelli, Stefania Meschini, Carlo Leonetti and Katia Scotlandi
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:128

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:425

  7. Mechanistic target of rapamycin (mTOR) pathway is essential for the growth of gastric cancer (GC), but mTOR inhibitor everolimus was not effective for the treatment of GCs. The Cancer Genome Atlas (TCGA) resea...

    Authors: Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:127
  8. Cancer stem cells (CSCs) play an important role in the development of pancreatic cancer. We previously showed that the microRNA miR-137 is downregulated in clinical samples of pancreatic cancer, and its expres...

    Authors: Zhiwei He, Xingjun Guo, She Tian, Changhao Zhu, Shiyu Chen, Chao Yu, Jianxin Jiang and Chengyi Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:126
  9. Folate receptors and transporters and one-carbon metabolism continue to be important areas of study given their essential roles in an assortment of diseases and as targets for treatment of cancer and inflammat...

    Authors: Barbara Frigerio, Claudia Bizzoni, Gerrit Jansen, Christopher P. Leamon, Godefridus J. Peters, Philip S. Low, Larry H. Matherly and Mariangela Figini
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:125
  10. Gastric cancer is the second most common cause of cancer-related mortality; thus, the mechanisms underlying tumor metastasis and growth in gastric cancer need to be extensively explored.

    Authors: Duan-Bo Shi, Ran-Ran Ma, Hui Zhang, Feng Hou, Xiang-Yu Guo and Peng Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:124
  11. Though immune checkpoint blockade (ICB) against PD-1 has shown success in the treatment of lung cancer, not all patients respond. We have previously shown that adoptive transfer of double negative T (DNT) cell...

    Authors: Linan Fang, Dalam Ly, Si-si Wang, Jong Bok Lee, Hyeonjeong Kang, Hao Xu, Junlin Yao, Ming-sound Tsao, Wei Liu and Li Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:123
  12. Metastatic lung cancer is a life-threatening condition that develops when cancer in another area of the body metastasizes, or spreads, to the lung. Despite advances in our understanding of primary lung oncogen...

    Authors: Yuanping Xiong, Leilei He, Chloe Shay, Liwei Lang, Jenni Loveless, Jieqing Yu, Ron Chemmalakuzhy, Hongqun Jiang, Manran Liu and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:122
  13. The p38 mitogen-activated protein kinase (p38MAPK) pathway has been implicated in a variety of pathological conditions including inflammation and metastasis. Post-transcriptional regulation of genes harboring ...

    Authors: Sourabh Soni, Prince Anand and Yogendra S. Padwad
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:121
  14. Cysteine-rich intestinal protein 1 (CRIP1) is highly expressed in human intestine and aberrantly expressed in several types of tumor. However, studies on CRIP1 are limited and its role on tumor development and...

    Authors: Lanzhi Zhang, Rui Zhou, Weibin Zhang, Xueqing Yao, Weidong Li, Lijun Xu, Xuegang Sun and Liang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:120
  15. Xp11.2 translocation renal cell carcinoma (tRCC) is mainly caused by translocation of the TFE3 gene located on chromosome Xp11.2 and is characterized by overexpression of the TFE3 fusion gene. Patients are dia...

    Authors: Xiaoqin Yin, Bo Wang, Weidong Gan, Wenyuan Zhuang, Zou Xiang, Xiaodong Han and Dongmei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:119
  16. Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children with poor survival. New treatment approaches are urgently needed to improve treatment efficacy in RMS patients. DMAMCL is a novel agent...

    Authors: Ning Xu, Zhongyan Hua, Gen Ba, Simeng Zhang, Zhihui Liu, Carol J. Thiele and Zhijie Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:118
  17. Angiotensin II (ANGII) and its receptor (AGTR1) have been proposed as significant contributors to metastasis in multiple cancers. Further, high AGTR1 levels are associated with poor epithelial ovarian cancer (...

    Authors: Qingyu Zhang, Shan Yu, Melody Man Ting Lam, Terence Chuen Wai Poon, Litao Sun, Yufei Jiao, Alice Sze Tsai Wong and Leo Tsz On Lee
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:116
  18. The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (I...

    Authors: Neel I. Nissen, Morten Karsdal and Nicholas Willumsen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:115
  19. Mast cells are being increasingly recognized as critical components in the tumor microenvironment. Protein Kinase D (PKD) is essential for the progression of prostate cancer, but its role in prostate cancer mi...

    Authors: Wanfu Xu, Jiabi Qian, Fangyin Zeng, Songyu Li, Wenjing Guo, Liping Chen, Guihuan Li, Zhishuai Zhang, Qiming Jane Wang and Fan Deng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:114
  20. RING finger protein 38 (RNF38), a member of the RNF protein family, has just emerged as a vital driver of cancer progression. However, the oncogenic mechanisms of RNF38 remain unexplored.

    Authors: Rui Peng, Peng-Fei Zhang, Xuan Yang, Chuan-Yuan Wei, Xiao-Yong Huang, Jia-Bin Cai, Jia-Cheng Lu, Chao Gao, Hai-Xiang Sun, Qiang Gao, Dou-Sheng Bai, Guo-Ming Shi, Ai-Wu Ke and Jia Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:113
  21. FAT4 functions as a tumor suppressor, and previous findings have demonstrated that FAT4 can inhibit the epithelial-to-mesenchymal transition (EMT) and the proliferation of gastric cancer cells. However, few st...

    Authors: Ran Wei, Yuhong Xiao, Yi Song, Huiping Yuan, Jun Luo and Wei Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:112
  22. The effect of competing endogenous RNA (ceRNA) can regulate gene expression by competitively binding microRNAs. Fascin-1 (FSCN1) plays an important role in the regulation of cellular migration and invasion dur...

    Authors: Ruxu Gao, Naiwen Zhang, Jianyu Yang, Yuyan Zhu, Zhe Zhang, Jianfeng Wang, Xiaolong Xu, Zeliang Li, Xiankui Liu, Zhenhua Li, Jun Li, Chuize Kong and Jianbin Bi
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:111
  23. Epithelial ovarian cancer (EOC) is one of the most malignant gynecological tumors worldwide. Deregulation of long non-coding RNAs (lncRNAs) has been implicated in various oncogenic processes in multiple cancer...

    Authors: Shanshan Dong, Ranran Wang, Hui Wang, Qi Ding, Xiao Zhou, Jing Wang, Keqiang Zhang, Ying Long, Shan Lu, Ting Hong, Huayi Ren, Kee Wong, Xiaowu Sheng, Yu Wang and Yong Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:110
  24. Breast cancer is the most common cancer among women worldwide, and approximately 70% of breast cancers are hormone receptor-positive and express estrogen receptor-α (ERα) or/and progesterone receptor. ERα has ...

    Authors: Bo-Wen Liu, Zhi-Hao Yu, Ao-Xiang Chen, Jiang-Rui Chi, Jie Ge, Yue Yu and Xu-Chen Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:109
  25. Cancer cells are characterized by chromosomal instability (CIN) and it is thought that errors in pathways involved in faithful chromosome segregation play a pivotal role in the genesis of CIN. Cohesin forms a ...

    Authors: Patrizia Sarogni, Orazio Palumbo, Adele Servadio, Simonetta Astigiano, Barbara D’Alessio, Veronica Gatti, Dubravka Cukrov, Silvia Baldari, Maria Michela Pallotta, Paolo Aretini, Felice Dell’Orletta, Silvia Soddu, Massimo Carella, Gabriele Toietta, Ottavia Barbieri, Gabriella Fontanini…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:108
  26. Pancreatic cancer (PC) represents one of the most aggressive forms of cancer. The role of long non-coding RNAs (lncRNAs) has been highlighted in various malignancies including PC. The aim of the present study ...

    Authors: Xu-Bo Wu, Xia Feng, Qi-Meng Chang, Cheng-Wu Zhang, Zhi-Fei Wang, Jie Liu, Zhi-Qiu Hu, Jia-Zhe Liu, Wei-Ding Wu, Zi-Ping Zhang and Xi-Qiang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:107
  27. The epithelial-mesenchymal transition (EMT) is crucial for metastasis and positively regulated by calcium-related signaling. The melastatin-related transient receptor potential 7 (TRPM7) regulates a non-select...

    Authors: Lu Liu, Nayiyuan Wu, Ying Wang, Xiaoyun Zhang, Bing Xia, Jie Tang, Jingting Cai, Zitong Zhao, Qianjin Liao and Jing Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:106
  28. Metastasis remains the biggest obstacle for breast cancer treatment. Therefore, identification of specific biomarker of metastasis is very necessary. The RNA binding protein 3 (RBMS3) acts as a tumor suppresso...

    Authors: Lei Zhu, Pei-Wen Xi, Xiao-Xia Li, Xi Sun, Wen-Bin Zhou, Tian-Song Xia, Liang Shi, Yue Hu, Qiang Ding and Ji-Fu Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:105

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:21

  29. Tripartite Motif 29 (TRIM29) has been newly identified as being implicated in cancer progression. However, the biological role and molecular mechanism of TRIM29 in the invasion and metastasis of colorectal can...

    Authors: Juntao Sun, Tianyu Zhang, Mengmeng Cheng, Liwen Hong, Chen Zhang, Mengfan Xie, Peijun Sun, Rong Fan, Zhengting Wang, Lei Wang and Jie Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:104

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:145

  30. Tumor suppressor p53 protein is frequently mutated in a large majority of cancers. These mutations induce local or global changes in protein structure thereby affecting its binding to DNA. The structural diffe...

    Authors: Durai Sundar, Yue Yu, Shashank P. Katiyar, Jayarani F. Putri, Jaspreet Kaur Dhanjal, Jia Wang, Anissa Nofita Sari, Evangelos Kolettas, Sunil C. Kaul and Renu Wadhwa
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:103
  31. Emerging evidence has demonstrated that WISP2 is critically involved in cell proliferation, migration, invasion and metastasis in cancers. However, the function of WISP2 in esophageal squamous cell carcinoma (...

    Authors: Da-Min Chai, Yan-Zi Qin, Shi-Wu Wu, Li Ma, Yuan-Yuan Tan, Xiang Yong, Xiao-Li Wang, Z. Peter Wang and Yi-Sheng Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:102
  32. Deregulation of ubiquitin ligases is related to the malignant progression of human cancers. F-box only protein 22 (FBXO22), an F-box E3 ligase, is a member of the F-box protein family. However, the biological ...

    Authors: Long Zhang, Jin Chen, Deng Ning, Qiumeng Liu, Chao Wang, Zhaoqi Zhang, Liang Chu, Chengpeng Yu, Hui-fang Liang, Bixiang Zhang and Xiaoping Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:101
  33. Evidence suggests that fatty acid receptor FFAR4 plays a tumor-promoting role in adipose tissue-adjacent malignancies, but its clinical relevance remains unexplored. Here, we investigated the clinical signific...

    Authors: Xiao Chu, Qi Zhou, Yingchun Xu, Jingting Jiang, Qing Li, Qianjun Zhou, Qiong Wu, Min Jin, Hui Wang, Yuting Gu, Xue Wang, Bei Wang, Songbing He, Xiaozhou He, Changping Wu, Fengchun Zhang…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:100
  34. Glioma, characterized by its undesirable prognosis and poor survival rate, is a serious threat to human health and lives. MicroRNA-9 (miR-9) is implicated in the regulation of multiple tumors, while the mechan...

    Authors: Xu Chen, Fan Yang, Tianze Zhang, Wei Wang, Wenjin Xi, Yufang Li, Dan Zhang, Yi Huo, Jianning Zhang, Angang Yang and Tao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:99
  35. Circular RNAs (circRNAs) play important roles in tumourigenesis and tumour progression. However, the expression profiles and functions of circRNAs in hepatocellular carcinoma (HCC) are largely unclear.

    Authors: Liangliang Xu, Xinfu Feng, Xiangyong Hao, Peng Wang, Yanfang Zhang, Xiaobo Zheng, Lian Li, Shengsheng Ren, Ming Zhang and Mingqing Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:98
  36. Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients...

    Authors: Daniela Criscuolo, Francesco Morra, Riccardo Giannella, Roberta Visconti, Aniello Cerrato and Angela Celetti
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:91
  37. Epithelial-mesenchymal transition (EMT)-associated proteins play key roles in cancer progression and metastasis with the involvement of microRNAs (miRNAs). This study aims to assess the role of miR-506 working...

    Authors: Tian-Song Liang, Ying-Juan Zheng, Juan Wang, Jing-Yi Zhao, Dao-Ke Yang and Zhang-Suo Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:97
  38. Drug resistance is common in cancer chemotherapy. This study investigates the role of Glycerol kinase 5 (GK5) in mediating gefitinib resistance in NSCLC.

    Authors: Jian Zhou, Guimei Qu, Ge Zhang, Zuoren Wu, Jing Liu, Dawei Yang, Jing Li, Meijia Chang, Hengshan Zeng, Jie Hu, Tao Fang, Yuanlin Song and Chunxue Bai
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:96
  39. Brain metastasis (BM) is associated with poor prognosis, recurrence, and death in patients with non-small cell lung cancer (NSCLC). Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been reported to be in...

    Authors: Chunhua Wei, Xiaomin Dong, Hui Lu, Fan Tong, Lingjuan Chen, Ruiguang Zhang, Jihua Dong, Yu Hu, Gang Wu and Xiaorong Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:95
  40. Breast cancer is one the most common cancers, making it the second leading cause of cancer-related death among women. Long non-coding RNAs (lncRNAs), with tightly regulated expression patterns, also serve as t...

    Authors: Dian-Hui Xiu, Gui-Feng Liu, Shao-Nan Yu, Long-Yun Li, Guo-Qing Zhao, Lin Liu and Xue-Feng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:94

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:204

  41. Zoledronic acid is the most potent osteoclast inhibitor and is widely used for advanced cancer patients with bone metastasis, but its role on cancer stem cells (CSCs) remains unclear. In the present study, we ...

    Authors: Li Wang, Yanyang Liu, Yueling Zhou, Jiantao Wang, Li Tu, Zhen Sun, Xiujie Wang and Feng Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:93
  42. Hepatocellular carcinoma (HCC) with stemness features are pivotal for tumorigenesis, chemoresistance, and progression. Long non-coding RNAs have been implicated in the regulation of HCC stemness features; howe...

    Authors: Yi Zhang, Bo Tang, Jun Song, Shuiping Yu, Yang Li, Huizhao Su and Songqing He
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:92
  43. The muscle invasive form of urothelial bladder cancer (UBC) is a deadly disease. Currently, the therapeutic approach of UBC is mostly based on surgery and standard chemotherapy.

    Authors: Francesco Morra, Francesco Merolla, Daniela Criscuolo, Luigi Insabato, Riccardo Giannella, Gennaro Ilardi, Aniello Cerrato, Roberta Visconti, Stefania Staibano and Angela Celetti
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:90
  44. Targeting the c-Met signaling pathway has become a therapeutic strategy in multiple types of cancer. We unveiled a novel c-Met regulating mechanism that could be applied as a modality for oral squamous cell ca...

    Authors: Wei-Chieh Huang, Te-Hsuan Jang, Shiao-Lin Tung, Tzu-Chen Yen, Shih-Hsuan Chan and Lu-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:89
  45. Over-expression and over-activation of immunosuppressive enzyme indoleamine 2, 3 -dioxygenase 1 (IDO1) is a key mechanism of cancer immune escape. However, the regulation of IDO1 has not been fully studied. Th...

    Authors: Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang and Qing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:88
  46. PD-1/PD-L1 checkpoint blockades have achieved significant progress in several kinds of tumours. Pembrolizumab, which targets PD-1, has been approved as a first-line treatment for advanced non-small cell lung c...

    Authors: Xin Wang, Gaochao Guo, Hui Guan, Yang Yu, Jie Lu and Jinming Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:87
  47. Diffuse large B cell lymphoma (DLBCL) is the most common form of lymphoma. Although durable remissions can be achieved in more than half of these patients, DLBCL remains a significant clinical challenge, with ...

    Authors: Yizi He, Jiao Li, Ning Ding, Xiaogan Wang, Lijuan Deng, Yan Xie, Zhitao Ying, Weiping Liu, Lingyan Ping, Chen Zhang, Yuqin Song and Jun Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:86
  48. Despite the increasing progress in targeted and immune based-directed therapies for other solid organ malignancies, currently there is no targeted therapy available for TNBCs. A number of mechanisms have been ...

    Authors: Murugan Kalimutho, Debottam Sinha, Deepak Mittal, Sriganesh Srihari, Devathri Nanayakkara, Shagufta Shafique, Prahlad Raninga, Purba Nag, Kate Parsons and Kum Kum Khanna
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:85
  49. A promising arsenal of histone deacetylase (HDAC)-targeted treatment has emerged in the past decade, as the abnormal targeting or retention of HDACs to DNA regulatory regions often occurs in many cancers. Head...

    Authors: Leilei He, Lixia Gao, Chloe Shay, Liwei Lang, Fenglin Lv and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:84
  50. Aberrant EVI1 expression is frequently reported in cancer studies; however, its role in nasopharyngeal carcinoma (NPC) has not been examined in detail. The aim of the present study is to investigate the involv...

    Authors: Yaoyong Lu, Yingying Liang, Xin Zheng, Xubin Deng, Wendong Huang and Gong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:82

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