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  1. Uterine and ovarian carcinosarcomas (CS) are rare but highly aggressive gynecologic tumors which carry an extremely poor prognosis. We evaluated the expression levels of EpCAM and the in vitro activity of solitom...

    Authors: Francesca Ferrari, Stefania Bellone, Jonathan Black, Carlton L. Schwab, Salvatore Lopez, Emiliano Cocco, Elena Bonazzoli, Federica Predolini, Gulden Menderes, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz and Alessandro D. Santin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:123
  2. Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family involved in multiple malignancies. CMTM4 is a member of this family and is locat...

    Authors: Ting Li, Yingying Cheng, Pingzhang Wang, Wenyan Wang, Fengzhan Hu, Xiaoning Mo, Hongxia Lv, Tao Xu and Wenling Han
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:122
  3. Microspherule protein 1 (MCRS1) is a candidate oncogene and participates in various cellular processes, including growth, migration, senescence and transformation. MCRS1 is overexpressed in non-small cell lung...

    Authors: Minxia Liu, Kecheng Zhou, Yunchao Huang and Yi Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:121
  4. In women with macromastia, a type IV skin sparing mastectomy is often required to achieve an aesthetically pleasing reconstruction. The introduction of “skin-reducing mastectomy”, which inserts a permanent pro...

    Authors: Roy De Vita, Marcello Pozzi, Giovanni Zoccali, Maurizio Costantini, Pierpaolo Gullo, Ernesto Maria Buccheri and Antonio Varanese
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:120
  5. Tivantinib has been described as a highly selective inhibitor of MET and is currently in a phase III clinical trial for the treatment of hepatocellular carcinoma (HCC). However, the mechanism of tivantinib ant...

    Authors: Qingfeng Xiang, Zuojun Zhen, David YB Deng, Jingnan Wang, Yingjun Chen, Jieyuan Li, Yingfei Zhang, Fengjie Wang, Ningning Chen, Huanwei Chen and Yajin Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:118
  6. Neuron navigator 2 (NAV2) encodes a member of the neuron navigator gene family, which plays a role in tumorigenesis and cell migration. However, the prognostic value of NAV2 expression in colorectal cancer (CR...

    Authors: Fengbo Tan, Hong Zhu, Yiming Tao, Nanhui Yu, Qian Pei, Heli Liu, Yuan Zhou, Haifan Xu, Xiangping Song, Yuqiang Li, Zhongyi Zhou, Xiao He, Xingwen Zhang and Haiping Pei
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:117
  7. Accumulating evidence suggests the pro-inflammatory cytokine interleukin-6 (IL-6) in tumor microenvironment may promote the development of hepatocellular carcinoma (HCC). However, the underlying mechanism rema...

    Authors: Jun Wu, Jun Zhang, Bin Shen, Kai Yin, Jianwei Xu, Wencan Gao and Lihong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:116
  8. Osteosarcoma (OS) is a high-grade bone sarcoma with early metastasis potential, and the clinical chemotherapy drugs that are currently used for its treatment have some limitations. Recently, several studies ha...

    Authors: Yunlong Ma, Bin Zhu, Xiaoguang Liu, Huilei Yu, Lei Yong, Xiao Liu, Jia Shao and Zhongjun Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:115
  9. Peptide based vaccines may suffer from limited stability and inefficient delivery to professional antigen-presenting cells (APCs), such as dendritic cells (DCs). In order to overcome such limitations, several ...

    Authors: A. Petrizzo, C. Conte, M. Tagliamonte, M. Napolitano, K. Bifulco, V. Carriero, A. De Stradis, M. L. Tornesello, F. M. Buonaguro, F. Quaglia and L. Buonaguro
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:114
  10. The spread of mammographic screening programs has allowed an increasing amount of early breast cancer diagnosis. A modern approach to non-palpable breast lesions requires an accurate intraoperative localizatio...

    Authors: Giulia Anna Follacchio, Francesco Monteleone, Paolo Anibaldi, Giuseppe De Vincentis, Silvia Iacobelli, Raffaele Merola, Valerio D’Orazi, Massimo Monti and Vittorio Pasta
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:113
  11. Rhabdomyosarcoma (RMS) is the most commonly diagnosed malignant soft tissue tumour in children and adolescents. Aberrant expression of Anaplastic Lymphoma Kinase (ALK) and MET gene has been implicated in the m...

    Authors: Francesca Megiorni, Heather P. McDowell, Simona Camero, Olga Mannarino, Simona Ceccarelli, Milena Paiano, Paul D. Losty, Barry Pizer, Rajeev Shukla, Antonio Pizzuti, Anna Clerico and Carlo Dominici
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:112
  12. Dysregulated endocytosis of membrane proteins contributes significantly to several hallmarks of cancer. Basigin can enhance cancer progression, but its precise mechanism remains unclear. CD98 promotes cell spr...

    Authors: Bo Wu, Yi Wang, Xiang-Min Yang, Bao-Qing Xu, Fei Feng, Bin Wang, Qiang Liang, Yu Li, Yang Zhou, Jian-Li Jiang and Zhi-Nan Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:110
  13. Cancer-related immune antigens in the tumor microenvironment could represent an obstacle to agents targeting EGFR “cetuximab” or VEGF “bevacizumab” in metastatic colorectal cancer (mCRC) patients.

    Authors: Guido Giordano, Antonio Febbraro, Eugenio Tomaselli, Maria Lucia Sarnicola, Pietro Parcesepe, Domenico Parente, Nicola Forte, Alessio Fabozzi, Andrea Remo, Andrea Bonetti, Erminia Manfrin, Somayehsadat Ghasemi, Michele Ceccarelli, Luigi Cerulo, Flavia Bazzoni and Massimo Pancione
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:108
  14. Dual loading drug delivery system with tumor targeting efficacy and sequential release function provides a promising platform for anticancer drug delivery. Herein, we establ...

    Authors: Li Fan, Qian Yang, Jiali Tan, Youbei Qiao, Qiaofeng Wang, Jingya He, Hong Wu and Yongsheng Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:106

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:252

  15. Arrest of metastasising lung cancer cells to the brain microvasculature maybe mediated by interactions between ligands on circulating tumour cells and endothelial E-selectin adhesion molecules; a process likel...

    Authors: Srijana Rai, Zaynab Nejadhamzeeigilani, Nicholas J. Gutowski and Jacqueline L. Whatmore
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:105
  16. Neuroblastoma (NB) is one of the most common childhood malignancies. Currently, high risk NB carries a poor outcome and significant treatment related toxicities and, thus has been a focus for new therapeutics ...

    Authors: Anjali Singh, Yibing Ruan, Tanya Tippett and Aru Narendran
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:104
  17. Herein, we demonstrated the use of a newly generated anti FAT1 antibody (clone mAB198.3) for intracellular delivery of anionic gold NPs, to form active targeting Au nanoparticles with high payload characterist...

    Authors: Li Fan, Susanna Campagnoli, Hong Wu, Alberto Grandi, Matteo Parri, Elisa De Camilli, Guido Grandi, Giuseppe Viale, Piero Pileri, Renata Grifantini, Chaojun Song and Boquan Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:103
  18. Dysregulated long non-coding RNAs (lncRNAs) have been found to have oncogenic and/or tumor suppressive roles in the development and progression of cancer, implying their potentials as novel independent biomark...

    Authors: Meng Zhou, Hengqiang Zhao, Zhenzhen Wang, Liang Cheng, Lei Yang, Hongbo Shi, Haixiu Yang and Jie Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:102
  19. Several studies have found that DDR2 is up-regulated in many tumor types and facilitates tumor progression. However, the role of DDR2 in hepatocellular carcinoma (HCC) progression and its downstream signaling ...

    Authors: Binhui Xie, Weihao Lin, Junming Ye, Xiaonong Wang, Bing Zhang, Shiqiu Xiong, Heping Li and Guosheng Tan
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:101
  20. Aberrant expression of long noncoding RNAs (lncRNAs) has frequently been reported in cancer studies, including those of colorectal cancer (CRC). Increasing evidence suggests that lncRNAs are significantly corr...

    Authors: Jie Ding, Binbin Lu, Jianping Wang, Juan Wang, Yongguo Shi, Yifan Lian, Ya Zhu, Jirong Wang, Yingrui Fan, Zhaoxia Wang, Wei De and Keming Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:100
  21. Ursolic acid (UA), a pentacyclic triterpenoid, is known to have anti-tumor activity in various cancers including human non small cell lung cancer (NSCLC). However, the molecular mechanisms underlying the actio...

    Authors: Jingjing Wu, Shunyu Zhao, Qing Tang, Fang Zheng, YuQin Chen, LiJun Yang, Xiaobing Yang, Liuning Li, WanYin Wu and Swei Sunny Hann
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:99
  22. Hematopoietic Stem Cell Transplantation (HSCT) is known to induce the inhibitory immune receptor NKG2A on NK cells of donor origin. This occurs in allogeneic recipients, in both the haploidentical and HLA-matc...

    Authors: Alessandra Picardi, Andrea Mengarelli, Mirella Marino, Enzo Gallo, Maria Benevolo, Edoardo Pescarmona, Roberta Cocco, Rocco Fraioli, Elisa Tremante, Maria Concetta Petti, Paolo De Fabritiis and Patrizio Giacomini
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:98
  23. Interleukin-24(IL-24), also referred to as melanoma differentiation-associated gene-7(mda-7), is a unique member of the IL-10 gene family, which displays nearly ubiquitous cancer-specific toxicity. The most no...

    Authors: Jichen Li, Dezhao Yang, Wei Wang, Songlin Piao, Jianyu Zhou, Wuliji Saiyin, Changyu Zheng, Hongchen Sun and Yu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:97
  24. It is well-known that the treatment and monitoring methods are limited for advanced stage of endometrial carcinoma. Biological molecules with expression changes during tumor progression become potential therap...

    Authors: Lu Deng, Yiping Gao, Xiao Li, Mingbo Cai, Huimin Wang, Huiyu Zhuang, Mingzi Tan, Shuice Liu, Yingying Hao and Bei Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:96
  25. The epidermal growth factor receptor (EGFR) signaling pathway is important in regulating biological behaviors in many malignancies. We explored whether expression and activation of EGFR and several components ...

    Authors: Zhengfei Zhu, Weiwei Yu, Xiaolong Fu, Menghong Sun, Qiao Wei, Dali Li, Haiquan Chen, Jiaqing Xiang, Hecheng Li, Yawei Zhang, Weixin Zhao and Kuaile Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:95
  26. Colorectal cancer (CRC) is a major health problem in China and around the world. It is one of the leading causes of cancer-related deaths. Research groups are thus searching for novel and more efficient anti-C...

    Authors: Cai Xun, Min-Bin Chen, Li Qi, Zhang Tie-Ning, Xue Peng, Li Ning, Chen Zhi-Xiao and Wang Li-Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:94
  27. The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not always specific, do not selectively target cancer...

    Authors: Megan Walsh, Stefano Fais, Enrico Pierluigi Spugnini, Salvador Harguindey, Tareq Abu Izneid, Licia Scacco, Paula Williams, Cinzia Allegrucci, Cyril Rauch and Ziad Omran
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:93
  28. Increased understanding of the genetic aetiology of advanced non-small-cell lung cancer (aNSCLC) has facilitated personalised therapies that target specific molecular aberrations associated with the disease. B...

    Authors: James Sherwood, Simon Dearden, Marianne Ratcliffe and Jill Walker
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:92
  29. Elucidation of the downstream targets regulated by the metastasis-suppressive miRNAs can shed light on the metastatic processes in prostate cancer (PCa). We conducted microarray analyses and found that miR-195...

    Authors: Jia Guo, Min Wang and Xiuheng Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:91
  30. Blood platelet numbers are correlated with growth and aggressiveness of several tumor types, including hepatocellular carcinoma (HCC). We previously found that platelet lysates (hPLs) both stimulated HCC cell ...

    Authors: Catia Lippolis, Maria Grazia Refolo, Rosalba D’Alessandro, Nicola Carella, Caterina Messa, Aldo Cavallini and Brian Irving Carr
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:90
  31. When a patient concomitantly uses two or more drugs, a drug-drug interaction (DDI) can possibly occur, potentially leading to an increased or decreased clinical effect of a given treatment. Cancer patients are...

    Authors: Silvia Ussai, Riccardo Petelin, Antonio Giordano, Mario Malinconico, Donatella Cirillo and Francesca Pentimalli
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:89
  32. Discoidin domain receptors 1 (DDR1), a subtype of DDRs, has been reported as a critical modulator of cellular morphogenesis, differentiation, migration and invasion.

    Authors: Yanmiao Huo, Minwei Yang, Wei Liu, Jianyu Yang, Xueliang Fu, Dejun Liu, Jiao Li, Junfeng Zhang, Rong Hua and Yongwei Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:88
  33. Activation of wild-type p53 in response to genotoxic stress occurs through different mechanisms including protein conformation, posttranslational modifications, and nuclear localization, leading to DNA binding...

    Authors: Alessia Garufi, Valentina Ubertini, Francesca Mancini, Valerio D’Orazi, Silvia Baldari, Fabiola Moretti, Gianluca Bossi and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:87
  34. MicroRNAs are stable and easy to detect in plasma. The plasma levels of microRNAs are often changed in disease conditions, including cancer. This makes circulating microRNAs a novel class of biomarkers for can...

    Authors: Zanxi Fang, Jing Tang, Yongying Bai, Huayue Lin, Hanyu You, Hongwei Jin, Lingqing Lin, Pan You, Juan Li, Zhang Dai, Xianming Liang, Yuanhui Su, Qing Hu, Fen Wang and Zhong-Ying Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:86
  35. Acidity is a hallmark of malignant tumor, representing a very efficient mechanism of chemoresistance. Proton pump inhibitors (PPI) at high dosage have been shown to sensitize chemoresistant human tumor cells a...

    Authors: Bi-Yun Wang, Jian Zhang, Jia-Lei Wang, Si Sun, Zhong-Hua Wang, Lei-Ping Wang, Qun-Ling Zhang, Fang-Fang Lv, En-Ying Cao, Zhi-Min Shao, Stefano Fais and Xi-Chun Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:85

    The Research to this article has been published in Journal of Experimental & Clinical Cancer Research 2015 34:109

  36. At skin level, a cancerization field (CF) indicates some chronically photoexposed areas in which, besides a primary tumor, histological or biomolecular modifications without clinical signs are present. Active ...

    Authors: Luigi Laino, Fulvia Elia, Flora Desiderio, Alessandra Scarabello, Isabella Sperduti, Carlo Cota and Aldo DiCarlo
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:84
  37. T-cell Acute Lymphoblastic Leukemia (ALL) represents about 10–15 % of pediatric ALL cases. EZH2, one of the components of Polycomb group proteins (PRC2) complex, catalyzes the trimethylation of histone H3 lysi...

    Authors: V. D’Angelo, A. Iannotta, M. Ramaglia, A. Lombardi, M. R. Zarone, V. Desiderio, M. C. Affinita, G. Pecoraro, M. Di Martino, P. Indolfi, F. Casale and M. Caraglia
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:83
  38. Mesenchymal stromal cells (MSCs) are considered an important therapeutic tool in cancer therapy. They possess intrinsic therapeutic potential and can also be in vitro manipulated and engineered to produce therape...

    Authors: Augusto Pessina, Carlo Leonetti, Simona Artuso, Anna Benetti, Enrico Dessy, Luisa Pascucci, Daniela Passeri, Augusto Orlandi, Angiola Berenzi, Arianna Bonomi, Valentina Coccè, Valentina Ceserani, Anna Ferri, Marta Dossena, Pietro Mazzuca, Emilio Ciusani…
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:82
  39. Endoretroviruses account for circa 8 % of all transposable elements found in the genome of humans and other animals. They represent a genetic footprint of ancestral germ-cell infections of exoviruses that is t...

    Authors: David Díaz-Carballo, Ali Haydar Acikelli, Jacqueline Klein, Holger Jastrow, Philipp Dammann, Thomas Wyganowski, Cihan Guemues, Sebastian Gustmann, Walter Bardenheuer, Sascha Malak, Nora Sophia Tefett, Veria Khosrawipour, Urs Giger-Pabst, Andrea Tannapfel and Dirk Strumberg
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:81
  40. Zebrafish represent a vertebrate model organism that has been widely, and increasingly, employed over the last decade in the study of developmental processes, wound healing, microbe-host interactions, and drug...

    Authors: Shuai Zhao, Jian Huang and Jun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:80
  41. Long noncoding RNAs (lncRNAs) have recently emerged as important regulators in governing fundamental biological processes, and many of which are likely to have functional roles in tumorigenesis. Maternally exp...

    Authors: Weizhao Peng, Shuang Si, Qingxia Zhang, Chaofeng Li, Fang Zhao, Fang Wang, Jia Yu and Ren Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:79
  42. Considering previous data and the need to incorporate new biomarkers for the prognosis of solid tumours into the clinic, our aim in this work consists of evaluating the potential clinical use of telomeres and ...

    Authors: Tamara Fernández-Marcelo, Ana Gómez, Irene Pascua, Carmen de Juan, Jacqueline Head, Florentino Hernando, Jose-Ramón Jarabo, Joaquín Calatayud, Antonio-José Torres-García and Pilar Iniesta
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:78
  43. Metformin is the first line of oral antidiabetic drug in the biguanide class for treatment of type 2 diabetes. Increasing evidence has suggested that it is a potential anti-tumor drug. However, the mechanisms ...

    Authors: Qi Pan, Guo-Liang Yang, Jiang-Hua Yang, Shi-Long Lin, Ning Liu, Shan-Shan Liu, Meng-Yao Liu, Lian-Hua Zhang, Yi-Ran Huang, Ru-long Shen, Qiang Liu, Jian-Xin Gao and Juan-Jie Bo
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:77
  44. Aberrant microRNA (miRNA) expression plays an essential role in osteosarcoma (OS) pathogenesis. Recent studies have shown that dysregulation of miRNA expression is associated with increased tumorigenesis and p...

    Authors: Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Shinichi Ikeda, Tatsuya Iwasaki and Hiroshi Tsumura
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:76
  45. Transmembrane protein 158 (TMEM158) is a recently identified upregulated gene during Ras-induced senescence. Its association with various cancers has been recently reported. However, the expression and biologi...

    Authors: Zhongping Cheng, Jing Guo, Li Chen, Ning Luo, Weihong Yang and Xiaoyan Qu
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:75
  46. Liver tumors are increasingly treated with radioembolization. Here, we present first evidence of catheter design effect on particle-fluid dynamics and downstream branch targeting during microsphere administrat...

    Authors: Andor F. van den Hoven, Marnix G.E.H. Lam, Shaphan Jernigan, Maurice A.A.J. van den Bosch and Gregory D. Buckner
    Citation: Journal of Experimental & Clinical Cancer Research 2015 34:74

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