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  1. Drug resistance limits the treatment effect of cisplatin-based chemotherapy in head and neck squamous cell carcinoma (HNSCC), and the underlying mechanism is not fully understood. The aim of this study was to ...

    Authors: Teng Xu, Yuemei Yang, Zhihong Chen, Jinsong Wang, Xiaolei Wang, Yang Zheng, Chao Wang, Yachen Wang, Zaiou Zhu, Xu Ding, Junbo Zhou, Gang Li, Hongchuang Zhang, Wei Zhang, Yunong Wu and Xiaomeng Song
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:190
  2. The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World of RNA diagnostics and therapeut...

    Authors: Giovanni Blandino, Roberto Dinami, Marco Marcia, Eleni Anastasiadou, Brid M. Ryan, Alina Catalina Palcau, Luigi Fattore, Giulia Regazzo, Rosanna Sestito, Rossella Loria, Ana Belén Díaz Méndez, Maria Chiara Cappelletto, Claudio Pulito, Laura Monteonofrio, George A. Calin, Gabriella Sozzi…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:189
  3. Lung cancer is one of the most frequent causes of cancer-related deaths worldwide. Drug repurposing and nano-drug delivery systems are attracting considerable attention for improving anti-cancer therapy. Serta...

    Authors: Ruolan Liu, Qiong Li, Siyuan Qin, Ling Qiao, Mei Yang, Shanshan Liu, Edouard C. Nice, Wei Zhang, Canhua Huang, Shaojiang Zheng and Wei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:188
  4. Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradu...

    Authors: Ioanna Mourkioti, Aikaterini Polyzou, Dimitris Veroutis, George Theocharous, Nefeli Lagopati, Emanuela Gentile, Vasiliki Stravokefalou, Dimitris-Foivos Thanos, Sophia Havaki, Dimitris Kletsas, Theocharis Panaretakis, Christopher J. Logothetis, Dimitris Stellas, Russell Petty, Giovanni Blandino, Angelos Papaspyropoulos…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:187
  5. The emergence of resistance to the highly successful BCL2-directed therapy is a major unmet need in acute myeloid leukemia (AML), an aggressive malignancy with poor survival rates. Towards identifying therapeu...

    Authors: Tarang Gaur, Ramulu Poddutoori, Leena Khare, Bhausaheb Bagal, Sonal Rashmi, Nikhil Patkar, Prashant Tembhare, Subramanian PG, Dhanlaxmi Shetty, Amit Dutt, Qi Zhang, Marina Konopleva, Uwe Platzbeckar, Sudeep Gupta, Susanta Samajdar, Murali Ramchandra…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:186
  6. Authors: Yonghao Zhan, Junhao Lin, Yuchen Liu, Mingwei Chen, Xiaoying Chen, Chengle Zhuang, Li Liu, Wen Xu, Zhicong Chen, Anbang He, Qiaoxia Zhang, Xiaojuan Sun, Guoping Zhao and Weiren Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:185

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:83

  7. Fructose is a very common sugar found in natural foods, while current studies demonstrate that high fructose intake is significantly associated with increased risk of multiple cancers and more aggressive tumor...

    Authors: Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang and Ruifang Niu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:184
  8. Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote tumorigenesis and malignancy by a...

    Authors: MengTing Wang, QingYang Chen, ShuJie Wang, Han Xie, Jun Liu, RuiXiang Huang, YuFei Xiang, YanYi Jiang, DaSheng Tian and ErBao Bian
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:183
  9. Anaplastic thyroid carcinoma (ATC) was a rare and extremely malignant endocrine cancer with the distinct hallmark of high proportion of cancer stem cell-like characteristics. Therapies aiming to cancer stem-li...

    Authors: Tong Xu, Chaozhuang Zhu, Jinming Chen, Feifeng Song, Xinxin Ren, Shanshan Wang, Xiaofen Yi, Yiwen Zhang, Wanli Zhang, Qing Hu, Hui Qin, Yujia Liu, Song Zhang, Zhuo Tan, Zongfu Pan, Ping Huang…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:182
  10. Authors: Zhifei Ma, Hao Chen, Zhijun Xia, Jing You, Chencheng Han, Siwei Wang, Wenjia Xia, Yongkang Bai, Tongyan Liu, Lin Xu, Guoren Zhou, Youtao Xu and Rong Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:180

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:169

  11. Authors: Kai Li, Zi-Yang Peng, Shan Gao, Qing-Shi Wang, Rui Wang, Xiang Li, Guo-Dong Xiao, Jing Zhang, Hong Ren, Shou-Ching Tang and Xin Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:179

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:325

  12. Macrophages take center stage in the tumor microenvironment, a niche composed of extracellular matrix and a heterogeneous group of cells, including immune ones. They can evolve during tumor progression and acq...

    Authors: Anna Maria Lucianò, Marta Di Martile, Ana B. Pérez-Oliva, Marica Di Caprio, Maria Laura Foddai, Simonetta Buglioni, Victoriano Mulero and Donatella Del Bufalo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:178
  13. Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits ar...

    Authors: Yaxian Wang, Xinyang Zhong, Xuefeng He, Zijuan Hu, Huixia Huang, Jiayu Chen, Keji Chen, Senlin Zhao, Ping Wei and Dawei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:177
  14. The mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has proved to be an efficient treatment option for cases harboring BRAFV600 muta...

    Authors: Corinna Kosnopfel, Simone Wendlinger, Heike Niessner, Johannes Siewert, Tobias Sinnberg, Angelika Hofmann, Jonas Wohlfarth, David Schrama, Marion Berthold, Claudia Siedel, Birgit Sauer, Aarthi Jayanthan, Georg Lenz, Sandra E. Dunn, Bastian Schilling and Birgit Schittek
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:175
  15. Cancer is the main cause of death worldwide and metastasis is a major cause of poor prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a multiplex process, including EMT throug...

    Authors: Mohammad Ahmad, Louis-Bastien Weiswald, Laurent Poulain, Christophe Denoyelle and Matthieu Meryet-Figuiere
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:173
  16. The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the functional role of B. adolescentis and its possible...

    Authors: Yifeng Lin, Lina Fan, Yadong Qi, Chaochao Xu, Dingjiacheng Jia, Yao Jiang, Shujie Chen and Liangjing Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:172

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:212

  17. Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer treatment modalities that are widely used due to their demonstrated efficacy against tumors and favorable safety profiles ...

    Authors: Ting-Wan Kao, Geng-Hao Bai, Tian-Li Wang, Ie-Ming Shih, Chi-Mu Chuang, Chun-Liang Lo, Meng-Chen Tsai, Li-Yun Chiu, Chu-Chien Lin and Yao-An Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:171
  18. Approximately 20–50% of patients presenting with localized colorectal cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is a major prognostic determinant. Here, we have...

    Authors: Mario Cioce, Maria Rita Fumagalli, Sara Donzelli, Frauke Goeman, Valeria Canu, Daniela Rutigliano, Giulia Orlandi, Andrea Sacconi, Claudio Pulito, Alina Catalina Palcau, Maurizio Fanciulli, Aldo Morrone, Maria Grazia Diodoro, Marco Caricato, Anna Crescenzi, Martina Verri…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:170
  19. Circular RNAs (circRNAs) contribute to multiple biological functions and are also involved in pathological conditions such as cancer. However, the role of circRNAs in metabolic reprogramming, especially upon e...

    Authors: Zhifei Ma, Hao Chen, Zhijun Xia, Jing You, Chencheng Han, Siwei Wang, Wenjia Xia, Yongkang Bai, Tongyan Liu, Lin Xu, Guoren Zhou, Youtao Xu and Rong Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:169

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:180

  20. Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent form of skin cancer, showing a rapid increasing incidence worldwide. Although most cSCC can be cured by surgery, a sizeable number of cases...

    Authors: Marika Quadri, Natascia Tiso, Francesco Musmeci, Maria I. Morasso, Stephen R. Brooks, Luca Reggiani Bonetti, Rossana Panini, Roberta Lotti, Alessandra Marconi, Carlo Pincelli and Elisabetta Palazzo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:167
  21. Increasing evidence suggests a vital role of the pre-metastatic niche in the formation of distant metastasis of many cancers. However, how the pre-metastatic niche is formed and promotes pulmonary metastasis o...

    Authors: Chong Zhang, Qing Li, Qi Xu, Wei Dong, Chunmei Li, Bin Deng, Jiao Gong, Li-Zhen Zhang and Junfei Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:166
  22. The majority of women with epithelial ovarian cancer (OvCa) are diagnosed with metastatic disease, resulting in a poor 5-year survival of 31%. Obesity is a recognized non-infectious pandemic that increases OvC...

    Authors: Yueying Liu, Jing Yang, Tyvette S. Hilliard, Zhikun Wang, Jeff Johnson, Wanrui Wang, Elizabeth I. Harper, Connor Ott, Caitlin O’Brien, Leigh Campbell, Brian Crowley, Stephen Grisoli, Nicholas M. Stavrou, Anna Juncker-Jensen and M. Sharon Stack
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:165
  23. The receptor for advanced glycation-end products (RAGE) and its ligands have been implicated in obesity and associated inflammatory processes as well as in metabolic alterations like diabetes. In addition, RAG...

    Authors: Marianna Talia, Francesca Cirillo, Asia Spinelli, Azzurra Zicarelli, Domenica Scordamaglia, Lucia Muglia, Salvatore De Rosis, Damiano Cosimo Rigiracciolo, Gianfranco Filippelli, Ida Daniela Perrotta, Mariano Davoli, Rosanna De Rosa, Rachele Macirella, Elvira Brunelli, Anna Maria Miglietta, Bruno Nardo…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:164
  24. Autologous tumor cell-based vaccines (ATVs) aim to prevent and treat tumor metastasis by activating patient-specific tumor antigens to induce immune memory. However, their clinical efficacy is limited. Mannan-...

    Authors: Juan Ye, Herui Wang, Rogelio Medina, Samik Chakraborty, Mitchell Sun, Alex Valenzuela, Xueyu Sang, Yaping Zhang, Ondrej Uher, Jan Zenka, Karel Pacak and Zhengping Zhuang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:163
  25. A growing body of research has revealed the connection of metabolism reprogramming and tumor progression, yet how metabolism reprogramming affects inter-patient heterogeneity and prognosis in head and neck squ...

    Authors: Jiezhong Guan, Xi Xu, Guo Qiu, Chong He, Xiaoyue Lu, Kang Wang, Xinyu Liu, Yuanyuan Li, Zihang Ling, Xuan Tang, Yujie Liang, Xiaoan Tao, Bin Cheng and Bo Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:162
  26. After diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression. However, systematic study about the relationshi...

    Authors: Yan Wang, Xiang Wang, Kai Wang, Ji Qi, Yu Zhang, Xu Wang, Long Zhang, Yi Zhou, Linbo Gu, Rutong Yu and Xiuping Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:161
  27. Endothelial-mesenchymal transition (EndoMT) is an emerging adaptive process that modulates lymphatic endothelial function to drive aberrant lymphatic vascularization in the tumour microenvironment (TME); howev...

    Authors: Wen-Fei Wei, Hui-Ling Zhou, Pei-Yu Chen, Xiao-Lan Huang, Long Huang, Luo-Jiao Liang, Chu-Hong Guo, Chen-Fei Zhou, Lan Yu, Liang-Sheng Fan and Wei Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:160
  28. The management of advanced clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and the construction of more reliable prognostic prediction models and the further elucidation...

    Authors: Yawei Xu, Lei Li, Wuping Yang, Kenan Zhang, Zedan Zhang, Chaojian Yu, Jianhui Qiu, Lin Cai, Yanqing Gong, Zheng Zhang, Jingcheng Zhou and Kan Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:159
  29. Authors: Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li and Shiyang Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:158

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:138

  30. Pancreatic ductal adenocarcinoma (PDAC) tends to undergo distant metastasis, especially liver metastasis, leading to a poor prognosis. Metabolic remodelling and epigenetic reprogramming are two important hallm...

    Authors: Jinshou Yang, Bo Ren, Jie Ren, Gang Yang, Yuan Fang, Xing Wang, Feihan Zhou, Lei You and Yupei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:155
  31. Osteosarcoma (OS) is the most common primary bone tumor in children and adolescent. Surgery and multidrug chemotherapy are the standard of treatment achieving 60–70% of event-free survival for localized diseas...

    Authors: Caterina Cascini, Chiara Ratti, Laura Botti, Beatrice Parma, Valeria Cancila, Adriana Salvaggio, Cristina Meazza, Claudio Tripodo, Mario P. Colombo and Claudia Chiodoni
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:154
  32. Authors: Changhong Li, Kui Zhang, Guangzhao Pan, Haoyan Ji, Chongyang Li, Xiaowen Wang, Xin Hu, Ruochen Liu, Longfei Deng, Yi Wang, Liqun Yang and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:153

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:125

  33. Immune checkpoint blockade (ICB) treatment of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV) infection may activate viral-specific T cells to attack HBV infected hepatocytes and thus indu...

    Authors: Lulu Liu, Junwei Liu, Pan Li, Jijun Luo, Rui Qin, Qiao Peng, Bin Li, Xuyong Wei, Tian Wang, Hongyu Shi, Ming-Da Wang, Chao Li, Weijia Fang, Wei Chen, Xiao Xu, Tian Yang…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:152
  34. Glycolysis is the key hallmark of cancer and maintains malignant tumor initiation and progression. The role of N6-methyladenosine (m6A) modification in glycolysis is largely unknown. This study explored the bi...

    Authors: Wei Wei, Zhong-Yuan Zhang, Bin Shi, Yike Cai, Hou-Shun Zhang, Chun-Lei Sun, Yun-Fei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, Guan-Min Jiang and Hao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:151

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2024 43:26

  35. The incidence of colorectal cancer and cancer death rate are increasing every year, and the affected population is becoming younger. Traditional Chinese medicine therapy has a unique effect in prolonging survi...

    Authors: Fangyuan Zhou, Haiyang Gao, Luorui Shang, Jinxiao Li, Mengqi Zhang, Shuhan Wang, Runze Li, Lin Ye and Shenglan Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:150
  36. Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA editing destabilizes endogenous dsRNAs, which are ...

    Authors: Jing Yuan, Li Xu, Hai-Juan Bao, Jie-lin Wang, Yang Zhao and Shuo Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:149
  37. AXL is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases family (RTKs), and its abnormal expression has been linked to clinicopathological features and poor prognosis of cancer patients. Th...

    Authors: Yaoxiang Tang, Hongjing Zang, Qiuyuan Wen and Songqing Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:148
  38. The epithelial-to-mesenchymal transition (EMT) is a trans-differentiation process that endows epithelial cells with mesenchymal properties, including motility and invasion capacity; therefore, its aberrant rea...

    Authors: Laura Amicone, Alessandra Marchetti and Carla Cicchini
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:147
  39. Invasive adenocarcinoma (IAC), which is typically preceded by minimally invasive adenocarcinoma (MIA), is the dominant pathological subtype of early-stage lung adenocarcinoma (LUAD). Identifying the molecular ...

    Authors: Yanan Cui, Jun Li, Pengpeng Zhang, Dandan Yin, Ziyu Wang, Jiali Dai, Wei Wang, Erbao Zhang and Renhua Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:146
  40. Metabolic reprogramming is a well-known marker of cancer, and it represents an early event during hepatocellular carcinoma (HCC) development. The recent approval of several molecular targeted agents has revolu...

    Authors: Christian Bergamini, Ilaria Leoni, Nicola Rizzardi, Mattia Melli, Giuseppe Galvani, Camelia Alexandra Coada, Catia Giovannini, Elisa Monti, Irene Liparulo, Francesca Valenti, Manuela Ferracin, Matteo Ravaioli, Matteo Cescon, Francesco Vasuri, Fabio Piscaglia, Massimo Negrini…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:145
  41. Hypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), characterized by a hypoxic tumor microenvironment, respond poorly to ther...

    Authors: E. C. de Heer, C. E. Zois, E. Bridges, B. van der Vegt, H. Sheldon, W. A. Veldman, M. C. Zwager, T. van der Sluis, S. Haider, T. Morita, O. Baba, C. P. Schröder, S. de Jong, A. L. Harris and M. Jalving
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:143

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:220

  42. Cuproptosis and ferroptosis are the two newly defined metal-related regulated cell death. However, the crosstalk between cuproptosis and ferroptosis is obscure.

    Authors: Weikai Wang, Kaizhong Lu, Xin Jiang, Qi Wei, Liyuan Zhu, Xian Wang, Hongchuan Jin and Lifeng Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:142

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