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  1. Tumors are diseases characterized by uncontrolled cell growth and, in spite of the progress of medicine over the years, continue to represent a major threat to the health, requiring new therapies. Several synt...

    Authors: Carmen Petronzi, Michela Festa, Antonella Peduto, Maria Castellano, Jessica Marinello, Antonio Massa, Anna Capasso, Giovanni Capranico, Annalisa La Gatta, Mario De Rosa, Michele Caraglia and Rosanna Filosa
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:24
    Content type: Research Published on:

  2. Diagnostic imaging plays a relevant role in the care of patients with breast cancer (BC). Positron Emission Tomography (PET) with 18F-fluoro-2-deoxy-D-glucose (FDG) has been widely proven to be a clinical tool...

    Authors: Valentina Bravatà, Alessandro Stefano, Francesco P Cammarata, Luigi Minafra, Giorgio Russo, Stefania Nicolosi, Sabina Pulizzi, Cecilia Gelfi, Maria C Gilardi and Cristina Messa
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:23
    Content type: Research Published on:

  4. Peritumoral activated hepatic stellate cells (HSCs) are versatile myofibroblast-like cells closely related with hepatocellular carcinoma (HCC) progression. So far, comprehensive comparison of gene expression o...

    Authors: Rui Liao, Han Wu, Yong Yi, Jia-Xing Wang, Xiao-Yan Cai, Hong-Wei He, Yun-Feng Cheng, Jian Zhou, Jia Fan, Jian Sun and Shuang-Jian Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:22
    Content type: Research Published on:

  5. Growing evidences indicate microRNAs play important roles in cancer development, progression, metastasis and may constitute robust biomarkers for cancer prognosis. The aim of this study was to identify the cli...

    Authors: Ming-Qi Fan, Chi-Bing Huang, Yan Gu, Ya Xiao, Jin-Xin Sheng and Lin Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:21
    Content type: Research Published on:

  6. Depletion of calcium (Ca2+) from the endoplasmic reticulum (ER) activates the ubiquitous store-operated Ca2+ entry (SOCE) pathway which sustains long-term Ca2+ signals and is critical for cellular functions. Stro...

    Authors: Guilin Li, Zhenxing Zhang, Renzhi Wang, Wenbin Ma, Ying Yang, Junji Wei and Yanping Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:20
    Content type: Research Published on:

  7. Toll-like receptor (TLR) agonists have important properties that can be exploited for immunotherapy against tumors. Locally injected immunostimulatory oligodeoxynucleotides containing CpG motifs (CpG-ODNs), wh...

    Authors: Rym Ben Abdelwahed, Jérémie Cosette, Sabrina Donnou, Lucile Crozet, Hanane Ouakrim, Wolf Herman Fridman, Catherine Sautès-Fridman, Aouni Mahjoub and Sylvain Fisson
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:18
    Content type: Research Published on:

  8. SOX7 is a transcription factor belonging to the SOX family. Its role in lung cancer is unknown.

    Authors: Takahide Hayano, Manoj Garg, Dong Yin, Makoto Sudo, Norihiko Kawamata, Shuo Shi, Wenwen Chien, Ling-wen Ding, Geraldine Leong, Seiichi Mori, Dong Xie, Patrick Tan and H Phillip Koeffler
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:17
    Content type: Research Published on:

  9. We explore the clinical and prognostic significance of expression of vascular endothelial growth factor receptor (VEGFR)-2, platelet-derived growth factor receptor (PDGFR)-β, and c-Met in patients with hepatoc...

    Authors: Jie Sheng Chu, Fei Jiao Ge, Bo Zhang, Yan Wang, Nicola Silvestris, Lie Jun Liu, Chuan Hua Zhao, Li Lin, Anna Elisabetta Brunetti, Ya Li Fu, Jun Wang, Angelo Paradiso and Jian Ming Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:16
    Content type: Research Published on:

  10. The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results wer...

    Authors: Yanlong Yang, Yuanliang Xie and Lei Xian
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:15
    Content type: Review Published on:

  11. Metabolic Syndrome (MS) has been correlated to breast carcinogenesis. MS is common in the general population (34%) and increases with age and body mass index. Although the link between obesity, MS and hormone ...

    Authors: Immacolata Capasso, Emanuela Esposito, Francesca Pentimalli, Maurizio Montella, Anna Crispo, Nicola Maurea, Massimiliano D’Aiuto, Alfredo Fucito, Maria Grimaldi, Ernesta Cavalcanti, Giuseppe Esposito, Giuseppe Brillante, Sergio Lodato, Tonino Pedicini, Giuseppe D’Aiuto, Gennaro Ciliberto…
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:14
    Content type: Research Published on:

  12. In a prospective multicenter phase II trial of radioembolization with yttrium-90 (90Y-RE) in chemorefractory liver-dominant metastatic colorectal cancer (mCRC), we showed that median survival was 12.6 months (95%...

    Authors: Elisa Melucci, Maurizio Cosimelli, Livio Carpanese, Giuseppe Pizzi, Francesco Izzo, Francesco Fiore, Rita Golfieri, Emanuela Giampalma, Isabella Sperduti, Cristiana Ercolani, Rosa Sciuto, Raffaello Mancini, Carlo Garufi, Maria Grazia Diodoro and Marcella Mottolese
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:13
    Content type: Research Published on:

  13. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies and tends to be relatively resistant to conventional therapies. Activated Ras oncogene mutations are found in up to 90% ...

    Authors: Niranjan Awasthi, Changhua Zhang, Stefan Hinz, Margaret A Schwarz and Roderich E Schwarz
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:12
    Content type: Research Published on:

  14. To investigate the role of HER-2/neu-mediated COX-2/P450arom signal in estrogen-dependent endometrial carcinoma.

    Authors: Shu Li, XiaoXin Ma, Li Ma, Cuicui Wang, YuanQi He and ZhiJuan Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:11
    Content type: Research Published on:

  15. Bladder transitional cell carcinoma greatly threatens human health all over the world. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows a strong apoptosis-inducing effect on a variety of c...

    Authors: Youguang Zhao, Ying Li, Liang Wang, Hang Yang, Qingtang Wang, Haiyan Qi, Shadan Li, Peng Zhou, Ping Liang, Qiwu Wang and Xiaowei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:10
    Content type: Research Published on:

  16. Although a previous meta-analysis reported no association between metabolic syndrome (MetS) and prostate cancer risk, a number of studies suggest that MetS may be associated with the aggressiveness and progres...

    Authors: Yu-zhu Xiang, Hui Xiong, Zi-lian Cui, Shao-bo Jiang, Qing-hua Xia, Yong Zhao, Guan-bin Li and Xun-bo Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:9
    Content type: Research Published on:

  17. MYST1 (also known as hMOF), a member of the MYST family of histone acetyltransferases (HATs) as an epigenetic mark of active genes, is mainly responsible for histone H4K16 acetylation in the cells. Recent stud...

    Authors: Yong Wang, Rui Zhang, Donglu Wu, Zhihua Lu, Wentao Sun, Yong Cai, Chunxi Wang and Jingji Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:8
    Content type: Research Published on:

  18. Malignant mesothelioma is an aggressive, treatment-resistant tumor arising from mesothelium of pleura, peritoneum and pericardium. Despite current combined regimen, its prognosis remains dismal, calling for mo...

    Authors: Yi Zhang, Jianxing He, Fang Zhang, Hui Li, Dongsheng Yue, Changli Wang, David M Jablons, Biao He and Natalie Lui
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:7
    Content type: Research Published on:

  19. Although surgery and anesthesia induce immunesuppression, remains largely unknown whether various anesthetic techniques have different immunosuppressive effects on cancer patients. Therefore, the aim of this s...

    Authors: Maria Sofra, Paola Cordiali Fei, Luana Fabrizi, Maria Elena Marcelli, Claudia Claroni, Michele Gallucci, Fabrizio Ensoli and Ester Forastiere
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:6
    Content type: Research Published on:

  20. An adenovirus that expresses both interleukin (IL)-12 and granulocyte-macrophage colony-stimulating-factor (GM-CSF) has been proven to be very effective in treating several tumors, but causes serious normal ti...

    Authors: Fang Wei, Huiping Wang, Jufeng Zhang, Xiafang Chen, Chuanyuan Li and Qian Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:5
    Content type: Research Published on:

  21. The paper intends to help scientific authors to make the best choice of journals in which to publish, by describing and comparing journal features in the area of oncology. For this purpose, the authors identif...

    Authors: Elisabetta Poltronieri, Elena Bravo, Tiziana Camerini, Maurizio Ferri, Roberto Rizzo, Renata Solimini and Gaetana Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:4
    Content type: Research Published on:

  22. Hepatocellular carcinoma (HCC) is a typical malignancy in a background of chronic inflammation. Th17 cells (a major source of IL-17) constitute crucial components of infiltrating inflammatory/immune cells in H...

    Authors: Rui Liao, Jian Sun, Han Wu, Yong Yi, Jia-Xing Wang, Hong-Wei He, Xiao-Yan Cai, Jian Zhou, Yun-Feng Cheng, Jia Fan and Shuang-Jian Qiu
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:3
    Content type: Research Published on:

  23. Esophagogastric junctional (EGJ) cancer occurs in the mucosa near the esophagogastric junction, and has characteristics of both esophageal and gastric malignancies; its optimal treatment strategy is controvers...

    Authors: Hiroaki Ito, Haruhiro Inoue, Noriko Odaka, Hitoshi Satodate, Michitaka Suzuki, Shumpei Mukai, Yusuke Takehara, Hiroyuki Kida and Shin-ei Kudo
    Citation: Journal of Experimental & Clinical Cancer Research 2013 32:2
    Content type: Research Published on:

  25. Lobular breast carcinoma usually shows poor responsiveness to chemotherapies and often lacks targeted therapies. Since FGFR1 expression has been shown to play pivotal roles in primary breast cancer tumorigenes...

    Authors: Eleonora Brunello, Matteo Brunelli, Giuseppe Bogina, Anna Caliò, Erminia Manfrin, Alessia Nottegar, Marco Vergine, Annamaria Molino, Emilio Bria, Francesco Massari, Giampaolo Tortora, Sara Cingarlini, Serena Pedron, Marco Chilosi, Giuseppe Zamboni, Keith Miller…
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:103
    Content type: Research Published on:

  26. Acquired radioresistance of cancer cells remains a fundamental barrier to attaining the maximal efficacy of radiotherapy for the treatment of breast cancer. Anti-apoptotic proteins, such as Bcl-2 and Bcl-xL, p...

    Authors: Ji-Yu Li, Yu-Yang Li, Wei Jin, Qing Yang, Zhi-Ming Shao and Xing-Song Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:102
    Content type: Research Published on:

  27. Alpha B-crystallin (αB-crystallin) has been suggested to play an important role in the development of solid tumors. However, the association between αB-crystallin expression and clinicopathological characteris...

    Authors: Yuan Mao, Da-Wei Zhang, Hong Lin, Lin Xiong, Ying Liu, Qing-Dong Li, Jun Ma, Qing Cao, Ren-Jie Chen, Jin Zhu and Zhen-Qing Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:101
    Content type: Research Published on:

  28. The genetic pathways of aggressive changes of bone tumors are still poorly understood. It is very important to analyze DNA copy number alterations (DCNAs), to identify the molecular events in the step of progr...

    Authors: Masahiko Kanamori, Akimi Sano, Taketoshi Yasuda, Takeshi Hori and Kayo Suzuki
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:100
    Content type: Research Published on:

  29. Ku80 is crucially implicated in DNA repair, apoptosis, and chemoresistance. In this study, we aimed to assess the expression of Ku80 in clinical lung adenocarcinoma specimens, and investigate its role in the r...

    Authors: Qingshan Ma, Ping Li, Minyu Xu, Jinzhi Yin, Zhenzhong Su, Wei Li and Jie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:99
    Content type: Research Published on:

  30. Cdx2 is a homeobox domain-containing transcription factor that is important in the development and differentiation of the intestinal cells, and served as a potential biomarker of tumor progression in early int...

    Authors: Xiao-Tong Wang, Wei-Yuan Wei, Fan-Biao Kong, Chao Lian, Wen Luo, Qiang Xiao and Yu-Bo Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:98
    Content type: Review Published on:

  31. Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a poor prognosis. MicroRNAs (miRNAs) are a class of small non-coding RNAs, approximately 21–25 nucleotides in length. Recently, some researc...

    Authors: Qiong Wang, Pengcun Li, Ailin Li, Wei Jiang, Hong Wang, Jinhuan Wang and Keliang Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:97
    Content type: Research Published on:

  32. Where population coverage is limited, the exclusive use of Cancer Registries might limit ascertainment of incident cancer cases. We explored the potentials of Nationwide hospital discharge records (NHDRs) to c...

    Authors: Prisco Piscitelli, Maddalena Barba, Massimo Crespi, Massimo Di Maio, Antonio Santoriello, Massiliamo D’Aiuto, Alfredo Fucito, Arturo Losco, Francesca Pentimalli, Pasquale Maranta, Giovanna Chitano, Alberto Argentiero, Cosimo Neglia, Alessandro Distante, Gian luca Di Tanna, Maria Luisa Brandi…
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:96
    Content type: Research Published on:

  33. Epidemiological studies revealed significantly lower mortality rates in cancer patients receiving cardiac glycosides, which turned on interest in the anticancer properties of these drugs. However, cardiac glyc...

    Authors: Francesca Cuozzo, Marisa Raciti, Laura Bertelli, Rosanna Parente and Livia Di Renzo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:95
    Content type: Research Published on:

  34. DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. However, the tumorigenesis role and clinical significance...

    Authors: Xiao-Lin Zhu, Zhang-Feng Wang, Wen-Bin Lei, Hui-Wen Zhuang, Wei-Jian Hou, Yi-Hui Wen and Wei-Ping Wen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:94
    Content type: Research Published on:

  35. Recent studies indicate that Transforming Growth Factor beta (TGF β) correlated with pulmonary metastasis of cancers. However, the correlation between TGF β and pulmonary metastasis of hepatocellular carcinoma...

    Authors: Guo-Cai Li, Qing-Hai Ye, Qiong-Zhu Dong, Ning Ren, Hu-Liang Jia and Lun-Xiu Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:93
    Content type: Research Published on:

  36. Leukemia, a heterogeneous clonal disorder of hematopoietic progenitor cells, presents a world-wide health problem, especially in childhood. F1F0 ATPase, an inner mitochondrial enzyme, is expressed on the plasm...

    Authors: Zhao Wen-Li, Wang Jian, Tao Yan-Fang, Feng Xing, Li Yan-Hong, Zhu Xue-Ming, Zhang Min, Ni Jian and Pan Jian
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:92
    Content type: Research Published on:

  37. In recent decades, melanoma incidence has been increasing in European countries; in 2006, there were approximately 60,000 cases leading to 13,000 deaths. Within Europe there is some geographical variation in t...

    Authors: Michele Maio, Paolo Ascierto, Alessandro Testori, Ruggero Ridolfi, Emilio Bajetta, Paola Queirolo, Michele Guida, Antonella Romanini, Vanna Chiarion-Sileni, Jacopo Pigozzo, Anna Maria Di Giacomo, Mario Calandriello, Guido Didoni, Marck van Baardewijk, Cyril Konto and Carlo Lucioni
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:91
    Content type: Research Published on:

  38. Type IV collagen (ColIV) is the most important scaffold for the basement membrane (BM) proteins, and plays an important role in regulating and limiting tumour invasion and metastasis.

    Authors: Hai-Xia Fan, Hai-Xia Li, Dong Chen, Zhong-Xiuzi Gao and Jin-Hua Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:90
    Content type: Research Published on:

  39. p73 and p63 are two structural and functional homologs of p53, and their biological functions in cancer progression have attracted attention due to the presence of variants generated by genetic polymorphisms. ...

    Authors: Xiao Guan, Ning Zhang, Yongshuo Yin, Beihua Kong, Qifeng Yang, Zhiyan Han and Xingsheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:89
    Content type: Research Published on:

  40. Among patients undergoing follow-up after surgery for melanoma, ultrasound (US) very often reveals lymph nodes in groin area, that do not show clear characters of a metastatic lesion yet that have atypical US ...

    Authors: Francesco M Solivetti, Fulvia Elia, Dario Graceffa and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:88
    Content type: Research Published on:

  41. Prognosis of advanced ovarian carcinomas (AOC) remains poor with a 5-year survival of 30%. Benefit from high-dose chemotherapy (HDC) in this disease has not been demonstrated to date.

    Authors: Renaud Sabatier, Anthony Gonçalves, François Bertucci, Maria-Antonietta Capiello, Frédérique Rousseau, Eric Lambaudie, Christian Chabannon, Patrice Viens and Jean-Marc Extra
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:87
    Content type: Research Published on:

  42. Exposure to anthracyclines (ANT) during childhood represents a high risk for development of late cardiotoxicity. Cardiotoxicity is usually detected only when clinical symptoms or progressive cardiac dysfunctio...

    Authors: Beata Mladosievicova, Dagmar Urbanova, Eva Radvanska, Peter Slavkovsky and Iveta Simkova
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:86
    Content type: Research Published on:

  43. Glioma is the most common primary malignant central nervous system tumor in adult, and is usually not curable in spite of various therapeutic approaches. Clarification of the oncogenic process in its early sta...

    Authors: Tomoo Matsutani, Takaki Hiwasa, Masaki Takiguchi, Takashi Oide, Mitoshi Kunimatsu, Naokatsu Saeki and Yasuo Iwadate
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:85
    Content type: Research Published on:

  44. Mesothelin, a secreted protein, is overexpressed in some cancers, including pancreatic cancer. Rescent studies have shown that overexpression of mesothelin significantly increased tumor cell proliferation, and...

    Authors: Chunning Zheng, Wei Jia, Yong Tang, HuiLiang Zhao, Yingsheng Jiang and Shaochuan Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:84
    Content type: Research Published on:

  45. Metastasis via the lymphatic system is promoted by lymphangiogenesis. Alterations of the lymphatic channels during the progression of metastasis to regional lymph nodes (LNs) remain unexplored. To examine whet...

    Authors: Ryuki Ozasa, Jun Ohno, Teruaki Iwahashi and Kunihisa Taniguchi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:83
    Content type: Research Published on:

  46. Neuro-oncological population well expresses the complexity of neurological disability due to the multiple neurological deficits that affect these patients. Moreover, due to the therapeutical opportunities surv...

    Authors: Michelangelo Bartolo, Chiara Zucchella, Andrea Pace, Alessandro Marco De Nunzio, Mariano Serrao, Giorgio Sandrini and Francesco Pierelli
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:82
    Content type: Research Published on:

  48. It is well known that genetic alternation of epidermal growth factor receptor (EGFR) plays critical roles in tumorgenesis of lung cancer and can predict outcome of non-small-cell lung cancer treatment, especially...

    Authors: Jian Zhu, Yuyan Wang, Jianchun Duan, Hua Bai, Zhijie Wang, Lai Wei, Jun Zhao, Minglei Zhuo, Shuhang Wang, Lu Yang, Tongtong An, Meina Wu and Jie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:80
    Content type: Research Published on:

  49. It is mandatory to confirm the absence of mutations in the KRAS gene before treating metastatic colorectal cancers with epidermal growth factor receptor inhibitors, and similar regulations are being considered fo...

    Authors: Sylwia Jancik, Jiri Drabek, Jitka Berkovcova, Yong Zhong Xu, Marcela Stankova, Jiri Klein, Vitezslav Kolek, Josef Skarda, Tomas Tichy, Ivona Grygarkova, Danuta Radzioch and Marian Hajduch
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:79
    Content type: Research Published on:

  50. The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above t...

    Authors: Laure Bobyk, Magali Edouard, Pierre Deman, Julia Rousseau, Jean-François Adam, Jean-Luc Ravanat, François Estève, Jacques Balosso, Rolf F Barth and Hélène Elleaume
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:78
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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