Sort by
Previous Page Page 1 of 52 Next Page
  1. Research

    HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition

    Homeobox B7 (HOXB7) has been identified associated with poor prognosis of hepatocellular carcinoma (HCC). However, the specific mechanism by which HOXB7 promotes the malignant progression of HCC remains to be ...

    Hong-bo Huan, Da-peng Yang, Xu-dong Wen, Xue-jiao Chen, Liang Zhang, Li-li Wu, Ping Bie and Feng Xia

    Journal of Experimental & Clinical Cancer Research 2017 36:86

    Published on: 24 June 2017

  2. Research

    High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation

    Oesophageal cancer is one of the most common malignancies worldwide,and oesophageal squamous cell carcinoma (ESCC) is the predominant histological type both globally and in China. Collagen triple helix repeat ...

    Chunni Wang, Zitong Li, Fei Shao, Xueying Yang, Xiaoli Feng, Susheng Shi, Yibo Gao and Jie He

    Journal of Experimental & Clinical Cancer Research 2017 36:84

    Published on: 23 June 2017

  3. Research

    PHF21B overexpression promotes cancer stem cell-like traits in prostate cancer cells by activating the Wnt/β-catenin signaling pathway

    PHF21B is newly identified to be involved in the tumor progression; however, its biological role and molecular mechanism in prostate cancer have not been defined. This study is aimed to study the role of PHF21...

    Qiji Li, Liping Ye, Wei Guo, Min Wang, Shuai Huang and Xinsheng Peng

    Journal of Experimental & Clinical Cancer Research 2017 36:85

    Published on: 23 June 2017

  4. Research

    MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells

    MicroRNAs (miRs) are involved in tumor progression by regulating tumor cells and tumor microenvironment. MiR21 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological impact on tumor micro...

    Zhong Zheng, Peng-Peng Xu, Li Wang, Hui-Jin Zhao, Xiang-Qin Weng, Hui-Juan Zhong, Bin Qu, Jie Xiong, Yan Zhao, Xue-Feng Wang, Anne Janin and Wei-Li Zhao

    Journal of Experimental & Clinical Cancer Research 2017 36:82

    Published on: 21 June 2017

  5. Research

    The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma

    5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer. However, the chemoresistance of tumor cells to 5-FU usually limits its clinical effectiveness. In this study, we explored the role of NLRP...

    Xiaodong Feng, Qingqiong Luo, Han Zhang, Han Wang, Wantao Chen, Guangxun Meng and Fuxiang Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:81

    Published on: 21 June 2017

  6. Review

    Type II CRISPR/Cas9 approach in the oncological therapy

    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect themselves from foreign nucleic acids. This complex s...

    A. Biagioni, A. Chillà, E. Andreucci, A. Laurenzana, F. Margheri, S. Peppicelli, M. Del Rosso and G. Fibbi

    Journal of Experimental & Clinical Cancer Research 2017 36:80

    Published on: 15 June 2017

  7. Research

    Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition

    Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25–30% of all cancer cases of the female genital tract. Currently, resistance to traditional chemotherapy is a gre...

    Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng and Jinbao Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:79

    Published on: 15 June 2017

  8. Research

    ANGPTL1 attenuates colorectal cancer metastasis by up-regulating microRNA-138

    Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cance...

    Haiyan Chen, Qian Xiao, Yeting Hu, Liubo Chen, Kai Jiang, Yang Tang, Yinuo Tan, Wangxiong Hu, Zhanhuai Wang, Jinjie He, Yue Liu, Yibo Cai, Qi Yang and Kefeng Ding

    Journal of Experimental & Clinical Cancer Research 2017 36:78

    Published on: 12 June 2017

  9. Research

    Angiotensin II type 2 receptor promotes apoptosis and inhibits angiogenesis in bladder cancer

    Bladder cancer (BCa) is the ninth most common form of cancer in the world. There is a continuing need not only for improving the accuracy of diagnostic markers but also for the development of new treatment str...

    Nana Pei, Yingying Mao, Pengfei Wan, Xinglu Chen, Andrew Li, Huiying Chen, Jinlong Li, Renqiang Wan, Yanling Zhang, Hongyan Du, Baihong Chen, Guangyu Jiang, Minghan Xia, Colin Sumners, Guixue Hu, Dongsheng Gu…

    Journal of Experimental & Clinical Cancer Research 2017 36:77

    Published on: 9 June 2017

  10. Research

    In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells

    Epilepsy is a frequent symptom in patients with glioma. Although treatment with antiepileptic drugs is generally effective in controlling seizures, drug-resistant patients are not uncommon. Multidrug resistanc...

    Ambra Rizzo, Sara Donzelli, Vita Girgenti, Andrea Sacconi, Chiara Vasco, Andrea Salmaggi, Giovanni Blandino, Marta Maschio and Emilio Ciusani

    Journal of Experimental & Clinical Cancer Research 2017 36:76

    Published on: 6 June 2017

  11. Research

    ERβ1 inhibits metastasis of androgen receptor-positive triple-negative breast cancer by suppressing ZEB1

    Increasing evidence has indicated an important role for estrogen receptor beta 1 (ERβ1) in breast cancer. However, the role of ERβ1 in the metastasis of androgen receptor (AR)-positive triple-negative breast c...

    Wei Song, Lin Tang, Yumei Xu, Qian Sun, Fang Yang and Xiaoxiang Guan

    Journal of Experimental & Clinical Cancer Research 2017 36:75

    Published on: 5 June 2017

  12. Research

    Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells

    Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential. Regulatory mechanisms implic...

    Zoltán Hujber, Gábor Petővári, Norbert Szoboszlai, Titanilla Dankó, Noémi Nagy, Csilla Kriston, Ildikó Krencz, Sándor Paku, Olivér Ozohanics, László Drahos, András Jeney and Anna Sebestyén

    Journal of Experimental & Clinical Cancer Research 2017 36:74

    Published on: 2 June 2017

  13. Research

    Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation

    Epidemiologic data in volcanic areas suggest that environmental factors might be involved in the increase of thyroid cancer (TC) incidence. Recent reports indicate that several heavy metals and metalloids are ...

    Emilia Luca, Laura Fici, Anna Ronchi, Ferdinando Marandino, Esther Diana Rossi, Maria Emiliana Caristo, Pasqualino Malandrino, Marco Russo, Alfredo Pontecorvi, Riccardo Vigneri and Fabiola Moretti

    Journal of Experimental & Clinical Cancer Research 2017 36:73

    Published on: 2 June 2017

  14. Research

    FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells

    Autophagy is a conserved catabolic process to degrade cellular organelles. The role of autophagy in cancer development is complex. Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the mos...

    Hong Yuan, Zi-Ming Li, Jiaxiang Shao, Wen-Xiang Ji, Weiliang Xia and Shun Lu

    Journal of Experimental & Clinical Cancer Research 2017 36:72

    Published on: 30 May 2017

  15. Review

    hrHPV E5 oncoprotein: immune evasion and related immunotherapies

    The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene i...

    Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros and Aldo Venuti

    Journal of Experimental & Clinical Cancer Research 2017 36:71

    Published on: 25 May 2017

  16. Research

    CIP2A mediates fibronectin-induced bladder cancer cell proliferation by stabilizing β-catenin

    Fibronectin (FN) is associated with tumorigenesis and progression in bladder cancer, however, the underlying mechanisms causing this remain largely unknown. Furthermore, cancerous inhibitor of protein phosphat...

    Fengbin Gao, Tianyuan Xu, Xianjin Wang, Shan Zhong, Shanwen Chen, Minguang Zhang, Xiaohua Zhang, Yifan Shen, Xiaojing Wang, Chen Xu and Zhoujun Shen

    Journal of Experimental & Clinical Cancer Research 2017 36:70

    Published on: 18 May 2017

  17. Erratum

    Erratum to: Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase

    Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola…

    Journal of Experimental & Clinical Cancer Research 2017 36:69

    Published on: 16 May 2017

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:193

  18. Research

    Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer

    Patients with metastatic or relapsed gallbladder cancer generally have a poor prognosis. Therefore, targeting metastasis is one arm of therapeutic strategies to treat gallbladder cancer.

    Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong and Yingbin Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:68

    Published on: 15 May 2017

  19. Research

    Novel glycolipid agents for killing cisplatin-resistant human epithelial ovarian cancer cells

    Chemotherapy resistance is one of the major factors contributing to mortality from human epithelial ovarian cancer (EOC). Identifying drugs that can effectively kill chemotherapy-resistant EOC cells would be a...

    Amani I. Moraya, Jennifer L. Ali, Pranati Samadder, Lisa Liang, Ludivine Coudière Morrison, Tamra E. Werbowetski-Ogilvie, Makanjuola Ogunsina, Frank Schweizer, Gilbert Arthur and Mark W. Nachtigal

    Journal of Experimental & Clinical Cancer Research 2017 36:67

    Published on: 12 May 2017

  20. Research

    AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer

    AHNAK, also known as desmoyokin, is a giant protein with the molecular size of approximately 700 kDa and exerts diverse functions in different types of cancer.

    Bo Chen, Jin Wang, Danian Dai, Qingyu Zhou, Xiaofang Guo, Zhi Tian, Xiaojia Huang, Lu Yang, Hailin Tang and Xiaoming Xie

    Journal of Experimental & Clinical Cancer Research 2017 36:65

    Published on: 12 May 2017

  21. Research

    Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma

    The involvement of lipid metabolism in tumourigenesis and the progression of clear cell renal cell carcinoma (ccRCC) have been reported. However, the role of phospholipid profile alterations in ccRCC has not y...

    Yiqing Du, Qiang Wang, Xingzhong Zhang, Xiaofeng Wang, Caipeng Qin, Zhengzuo Sheng, Huaqi Yin, Changtao Jiang, Jing Li and Tao Xu

    Journal of Experimental & Clinical Cancer Research 2017 36:66

    Published on: 12 May 2017

  22. Research

    Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis

    As a relatively conservative transcriptional regulator in biological evolution, heat shock factor 1 (HSF1) is activated by, and regulates the expression of heat shock proteins (HSPs) in response to a variety o...

    Wenjin Liang, Yong Liao, Jing Zhang, Qi Huang, Wei Luo, Jidong Yu, Jianhua Gong, Yi Zhou, Xuan Li, Bo Tang, Songqing He and Jinghong Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:64

    Published on: 8 May 2017

  23. Research

    FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients

    Epithelial ovarian cancer (EOC) is a spectrum of different diseases, which makes their treatment a challenge. Forkhead box M1 (FOXM1) is an oncogene aberrantly expressed in many solid cancers including serous ...

    Renata A. Tassi, Paola Todeschini, Eric R. Siegel, Stefano Calza, Paolo Cappella, Laura Ardighieri, Moris Cadei, Mattia Bugatti, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Laura Tassone, Donatella Guarino, Concetta Santonocito, Ettore D. Capoluongo, Luca Beltrame…

    Journal of Experimental & Clinical Cancer Research 2017 36:63

    Published on: 8 May 2017

Previous Page Page 1 of 52 Next Page
JECCR logo