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  1. Research

    Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1

    The transcription factor sex-determining region Y-box protein 3 (SOX3) plays important roles in various types of cancer. However, its expression and function have not yet been elucidated in osteosarcoma (OS).

    Manle Qiu, Daoyun Chen, Chaoyong Shen, Ji Shen, Huakun Zhao and Yaohua He

    Journal of Experimental & Clinical Cancer Research 2017 36:46

    Published on: 23 March 2017

  2. Research

    MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2

    Accumulating evidence indicates that microRNA-27a (miR-27a) is involved in carcinogenesis and tumor progression. However, the exact function and molecular mechanism of miR-27a in gastric cancer remain unclear.

    Lei Ding, Shanyong Zhang, Mu Xu, Renwen Zhang, Pengcheng Sui and Qing Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:45

    Published on: 21 March 2017

  3. Research

    Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2

    Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. Chrysin is a natural flavone found in plant extracts which are wide...

    Dong Xu, Junzhe Jin, Hao Yu, Zheming Zhao, Dongyan Ma, Chundong Zhang and Honglei Jiang

    Journal of Experimental & Clinical Cancer Research 2017 36:44

    Published on: 20 March 2017

  4. Research

    Inhibition of autophagy enhances the selective anti-cancer activity of tigecycline to overcome drug resistance in the treatment of chronic myeloid leukemia

    Drug resistance and disease progression are still the major obstacles in the treatment of chronic myeloid leukemia (CML). Increasing researches have demonstrated that autophagy becomes activated when cancer ce...

    Ziyuan Lu, Na Xu, Bolin He, Chengyun Pan, Yangqing Lan, Hongsheng Zhou and Xiaoli Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:43

    Published on: 10 March 2017

  5. Research

    Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation

    Growing evidence suggests that hepatitis C virus (HCV) contributes to hepatocellular carcinoma (HCC) by directly modulating oncogenic signaling pathways. Protein phosphatase magnesium-dependent 1A (PPM1A) has ...

    Yali Zhou, Yan Zhao, Yaoying Gao, Wenjun Hu, Yan Qu, Ning Lou, Ying Zhu, Xiaoping Zhang and Hongmei Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:42

    Published on: 10 March 2017

  6. Research

    Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma

    Cancer stem cells (CSCs) are correlated with the initiation, chemoresistance and relapse of tumors. Notch pathway has been reported to function in CSCs maintenance, but whether it is involved in renal cell car...

    Wei Xiao, Zhiyong Gao, Yixing Duan, Wuxiong Yuan and Yang Ke

    Journal of Experimental & Clinical Cancer Research 2017 36:41

    Published on: 9 March 2017

  7. Research

    E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle

    Thyroid cancer is the most common malignancy of endocrine system, and papillary thyroid cancer (PTC) is the most common subtype. E2F8, a novel identified E2F family member, was reported to associate with progr...

    Jing Sun, Run Shi, Sha Zhao, Xiaona Li, Shan Lu, Hemei Bu, Xianghua Ma and Chuan Su

    Journal of Experimental & Clinical Cancer Research 2017 36:40

    Published on: 7 March 2017

  8. Research

    PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients

    Non-small cell lung cancer (NSCLC) is the most commonly diagnosed type of lung cancer that is associated with poor prognosis. In this study we explored the potential role of p53-induced gene 3 (PIG3) in the pr...

    Ming Li, Shanhu Li, Biao Liu, Meng-Meng Gu, Shitao Zou, Bei-Bei Xiao, Lan Yu, Wei-Qun Ding, Ping-Kun Zhou, Jundong Zhou and Zeng-Fu Shang

    Journal of Experimental & Clinical Cancer Research 2017 36:39

    Published on: 4 March 2017

  9. Research

    Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells

    CD133-positive cells in hepatocellular carcinoma (HCC) exhibit cancer stem cell (CSC)-like properties as well as resistance to chemotherapeutic agents and ionizing radiation; however, their function remains un...

    Yeonhwa Song, Jaewoo Jang, Tae-Hoon Shin, Sang Mun Bae, Jin-sun Kim, Kang Mo Kim, Seung-Jae Myung, Eun Kyung Choi and Haeng Ran Seo

    Journal of Experimental & Clinical Cancer Research 2017 36:38

    Published on: 3 March 2017

  10. Research

    Predictive biomarkers for the efficacy of peptide vaccine treatment: based on the results of a phase II study on advanced pancreatic cancer

    The purpose of the present study was to explore novel biomarkers that can predict the clinical outcome of patients before treatment or during vaccination. These would be useful for the selection of appropriate...

    Yoshitaro Shindo, Shoichi Hazama, Nobuaki Suzuki, Haruo Iguchi, Kazuhiro Uesugi, Hiroaki Tanaka, Atsushi Aruga, Takashi Hatori, Hidenobu Ishizaki, Yuzo Umeda, Toshiyoshi Fujiwara, Tetsuya Ikemoto, Mitsuo Shimada, Kazuhiko Yoshimatsu, Hiroko Takenouchi, Hiroto Matsui…

    Journal of Experimental & Clinical Cancer Research 2017 36:36

    Published on: 28 February 2017

  11. Research

    Prognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL

    Survival of adults with B-Acute Lymphoblastic Leukemia requires accurate risk stratification of patients in order to provide the appropriate therapy. Contemporary techniques, using clinical and cytogenetic var...

    Nataly Cruz-Rodriguez, Alba L. Combita, Leonardo J. Enciso, Lauren F. Raney, Paula L. Pinzon, Olga C. Lozano, Alba M. Campos, Niyireth Peñaloza, Julio Solano, Maria V. Herrera, Jovanny Zabaleta and Sandra Quijano

    Journal of Experimental & Clinical Cancer Research 2017 36:37

    Published on: 28 February 2017

  12. Research

    Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6

    Cancer cells are known to over-express TRAF6 that is critical for both AKT and TAK1 activations. The Really Interesting New Gene (RING) domain of TRAF6 is believed to be responsible for the E3 ligase activity,...

    Yonghao Qi, Ambara R. Pradipta, Miao Li, Xuan Zhao, Lulu Lu, Xuegang Fu, Jing Wei, Richard P. Hsung, Katsunori Tanaka and Lijun Zhou

    Journal of Experimental & Clinical Cancer Research 2017 36:35

    Published on: 23 February 2017

  13. Erratum

    Erratum to: CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling

    Dong-Fang Meng, Ping Xie, Li-Xia Peng, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Xing Lv, Lin Wang, Ming-Yuan Chen, Hai-Qiang Mai, Ling Guo, Xiang Guo, Li-Sheng Zheng, Li Cao, Jun-Ping Yang, Meng-Yao Wang…

    Journal of Experimental & Clinical Cancer Research 2017 36:33

    Published on: 20 February 2017

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:21

  14. Research

    Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization

    Solid tumours are less oxygenated than normal tissues. Consequently, cancer cells acquire to be adapted to a hypoxic environment. The poor oxygenation of solid tumours is also a major indicator of an adverse c...

    Tiziana Bruno, Mariacristina Valerio, Luca Casadei, Francesca De Nicola, Frauke Goeman, Matteo Pallocca, Valeria Catena, Simona Iezzi, Cristina Sorino, Agata Desantis, Cesare Manetti, Giovanni Blandino, Aristide Floridi and Maurizio Fanciulli

    Journal of Experimental & Clinical Cancer Research 2017 36:32

    Published on: 18 February 2017

  15. Erratum

    Erratum to: Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers

    Junjie Chen, Shenmeng Gao, Chunjing Wang, Zhonggai Wang, Huxiang Zhang, Kate Huang, Bin Zhou, Haiying Li, Zhijie Yu, Jianbo Wu and Chengshui Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:31

    Published on: 16 February 2017

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:173

  16. Research

    PEG10 overexpression induced by E2F-1 promotes cell proliferation, migration, and invasion in pancreatic cancer

    Overexpression of paternally expressed gene-10 (PEG10) is known to promote the progression of several carcinomas, however, its role in pancreatic cancer (PC) is unknown. We investigated the expression and func...

    Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Jing-Jing Zhang, Ji-Shu Wei, Xian Liu, Xin-Chun Liu, Wen-Tao Gao, Kui-Rong Jiang and Yi Miao

    Journal of Experimental & Clinical Cancer Research 2017 36:30

    Published on: 13 February 2017

  17. Research

    MicroRNA-381 inhibits the metastasis of gastric cancer by targeting TMEM16A expression

    MicroRNA-381 (miR-381) has been reported to play suppressive or promoting roles in different malignancies. However, the expression level, biological function, and underlying mechanisms of miR-381 in gastric ca...

    Qinghua Cao, Fang Liu, Kaiyuan Ji, Ni Liu, Yuan He, Wenhui Zhang and Liantang Wang

    Journal of Experimental & Clinical Cancer Research 2017 36:29

    Published on: 13 February 2017

  18. Research

    Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

    Metformin, an FDA-approved drug for the treatment of Type II diabetes, has emerged as a promising anti-cancer agent. Other biguanide analogs, including buformin and phenformin, are suggested to have similar pr...

    Amanda B. Parris, Qingxia Zhao, Erin W. Howard, Ming Zhao, Zhikun Ma and Xiaohe Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:28

    Published on: 13 February 2017

  19. Research

    Human breast adipose tissue: characterization of factors that change during tumor progression in human breast cancer

    Adipose microenvironment is involved in signaling pathways that influence breast cancer. We aim to characterize factors that are modified: 1) in tumor and non tumor human breast epithelial cell lines when incu...

    Sabrina Johanna Fletcher, Paula Alejandra Sacca, Mercedes Pistone-Creydt, Federico Andrés Coló, María Florencia Serra, Flavia Eliana Santino, Corina Verónica Sasso, Constanza Matilde Lopez-Fontana, Rubén Walter Carón, Juan Carlos Calvo and Virginia Pistone-Creydt

    Journal of Experimental & Clinical Cancer Research 2017 36:26

    Published on: 7 February 2017

  20. Research

    Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway

    Angiogenesis is a hallmark of cancer and plays a critical role in lung cancer progression, which involves interactions between cancer cells, endothelial cells and the surrounding microenvironment. However, the...

    Hao-Wei Cheng, Yi-Fang Chen, Jau-Min Wong, Chia-Wei Weng, Hsuan-Yu Chen, Sung-Liang Yu, Huei-Wen Chen, Ang Yuan and Jeremy J.W. Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:27

    Published on: 7 February 2017

  21. Research

    Regulation of submaxillary gland androgen-regulated protein 3A via estrogen receptor 2 in radioresistant head and neck squamous cell carcinoma cells

    Molecular mechanisms of intrinsic or acquired radioresistance serve as critical barrier for curative therapy of head and neck squamous cell carcinoma (HNSCC) and remain a major obstacle for progression-free an...

    Jennifer Grünow, Chao Rong, Jan Hischmann, Karim Zaoui, Christa Flechtenmacher, Klaus-Josef Weber, Peter Plinkert and Jochen Hess

    Journal of Experimental & Clinical Cancer Research 2017 36:25

    Published on: 6 February 2017

  22. Research

    Intracellular pH-responsive and rituximab-conjugated mesoporous silica nanoparticles for targeted drug delivery to lymphoma B cells

    One of the main problems in B cell lymphoma treatment is severe adverse effects and low therapeutic efficacy resulting from systemic chemotherapy. A pH-sensitive controlled drug release system based on mesopor...

    Shoubing Zhou, Dan Wu, Xiaodong Yin, Xiaoxiao Jin, Xiu Zhang, Shiya Zheng, Cailian Wang and Yanwen Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:24

    Published on: 6 February 2017

  23. Research

    Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells

    Recent evidence suggests that the aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas, including colorectal cancer (CRC). F...

    DeJie Wang, Guohui Hu, Ying Du, Cheng Zhang, Quqin Lu, Nonghua Lv and Shiwen Luo

    Journal of Experimental & Clinical Cancer Research 2017 36:23

    Published on: 2 February 2017

  24. Research

    Disulfiram overcomes bortezomib and cytarabine resistance in Down-syndrome-associated acute myeloid leukemia cells

    Children with Down syndrome (DS) have increased risk for developing AML (DS-AMKL), and they usually experience severe therapy-related toxicities compared to non DS-AMKL. Refractory/relapsed disease has very po...

    Ranjan Bista, David W. Lee, Oliver B. Pepper, David O. Azorsa, Robert J. Arceci and Eiman Aleem

    Journal of Experimental & Clinical Cancer Research 2017 36:22

    Published on: 1 February 2017

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