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Table 2 Biodistribution of 99mTc-HYNIC-Annexin-V in EL4 lymphoma and the number of apoptotic cells after single-dose irradiations

From: In vivo99mTc-HYNIC-annexin V imaging of early tumor apoptosis in mice after single dose irradiation

  

Dose

(Gy)

  

p

 
 

0

2

4

8

0 vs.2

2 vs.4

4 vs.8

%ID/g

0.160 ± 0.013

0.272 ± 0.021

0.312 ± 0.020

0.355 ± 0.025

<0.001

0.017

0.009

T/B

0.729 ± 0.037

1.252 ± 0.086

1.396 ± 0.021

1.661 ± 0.072

<0.001

0.005

<0.001

T/M

2.575 ± 0.154

4.522 ± 0.554

5.191 ± 0.511

7.138 ± 0.266

<0.001

0.039

<0.001

Apoptotic cells

1.405 ± 0.191

2.459 ± 0.370

4.364 ± 0.778

6.953 ± 0.673

0.002

0.004

0.002

  1. Results expressed as mean ± SD. %ID/g = percentage injected dose per gram of tumor tissue; T: 99mTc-HYNIC annexin-V uptake in tumor; B: 99mTc-HYNIC-annexin V uptake in blood; M: 99mTc-HYNIC annexin-V uptake in muscle. Apoptotic cells were counted as the number of TUNEL positive cells per mm2 of each examined section.