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Table 3 ERCC2 751 SNP in relation to risk of lung adenocarcinoma, stratified by environmental exposures

From: ERCC2, ERCC1 polymorphisms and haplotypes, cooking oil fume and lung adenocarcinoma risk in Chinese non-smoking females

Group

Cases n (%)

Controls n (%)

OR [95%CI]*

P value

Cooking oil fume exposure

    

Non exposure

    

   ERCC2 751 AA

137 (75.7)

181 (86.2)

1.00

--

   ERCC2 751 AC/CC

44 (24.3)

29 (13.8)

1.98 [1.18-3.32]

0.010

Exposure

    

   ERCC2 751 AA

83 (79.8)

61 (81.3)

1.00

--

   ERCC2 751 AC/CC

21 (20.2)

14 (18.7)

1.03 [0.48-2.21]

0.940

Fuel smoke exposure

    

Non exposure

    

   ERCC2 751 AA

150 (74.6)

182 (87.9)

1.00

--

   ERCC2 751 AC/CC

51 (25.4)

25 (12.1)

2.47 [1.46-4.18]

0.001

Exposure

    

   ERCC2 751 AA

70 (83.3)

60 (76.9)

1.00

--

   ERCC2 751 AC/CC

14 (16.7)

18 (23.1)

0.65 [0.30-1.41]

0.270

  1. Abbreviation: OR, odds ratio; CI, confidence interval.
  2. *ORs and 95%CIs were calculated by logistic regression, with the ERCC2 751 wild genotype (AA) as the reference group. ORs were adjusted for age.