Table 2 Meta-analysis of the HIF-1α 1790 G/A polymorphism and cancer association.
From: Hypoxia-inducible factor-1α gene polymorphisms and cancer risk: a meta-analysis
Genetic contrasts | Group and subgroups under analysis | Studies (n) | Q test P value | Model seclected | OR (95% CI) | P |
|---|---|---|---|---|---|---|
A versus G | Overall | 12 | <0.00001 | Random | 1.61 (0.75, 3.45) | 0.22 |
Overall in HWE | 11 | 0.0002 | Random | 1.32 (0.54, 3.24) | 0.54 | |
Caucasian | 9 | 0.04 | Random | 3.08 (1.49, 6.36) | 0.002 | |
Caucasian in HWE | 8 | 0.02 | Random | 2.15 (0.66, 7.02) | 0.20 | |
East Asian | 2 | 0.33 | Fixed | 0.58 (0.24, 1.40) | 0.23 | |
Female* | 5 | 0.07 | Random | 0.65 (0.07, 6.05) | 0.71 | |
Male (prostate cancer)** | 2 | 0.64 | Fixed | 0.96 (0.49, 1.90) | 0.91 | |
Breast cancer | 2 | 0.45 | Fixed | 0.28 (0.08,0.90) | 0.03 | |
Other cancers | 10 | 0.0004 | Random | 2.31 (1.12, 4.75) | 0.02 | |
Other cancers in HWE | 9 | 0.002 | Random | 1.97 (0.79, 4.90) | 0.15 | |
(AA+AG) versus GG | Overall | 12 | <0.00001 | Random | 1.56 (0.66, 3.65) | 0.31 |
Overall in HWE | 11 | 0.0004 | Random | 1.25 (0.53, 2.97) | 0.61 | |
Caucasian | 9 | 0.002 | Random | 2.60 (1.03, 6.59) | 0.04 | |
Caucasian in HWE | 8 | 0.004 | Random | 1.80 (0.50, 6.54) | 0.37 | |
East Asian | 2 | 0.41 | Fixed | 0.61 (0.25, 1.51) | 0.29 | |
Female* | 5 | 0.08 | Random | 0.68 (0.07, 6.30) | 0.74 | |
Male (prostate cancer) ** | 2 | 0.64 | Fixed | 0.96 (0.49, 1.90) | 0.91 | |
Breast cancer | 2 | 0.41 | Fixed | 0.29 (0.09, 0.97) | 0.04 | |
Other cancers | 10 | <0.00001 | Random | 2.22 (0.95, 5.20) | 0.06 | |
Other cancers in HWE | 9 | 0.002 | Random | 1.78 (0.72, 4.43) | 0.21 |