Figure 11

Effects of PD 98059 or SB 203580 on HGF-mediated up-regulation of uPA. Serum-starved cells were pretreated with or without H₂O₂ (100 μM) for 30 min and then treated with PD 98059 (5, 10 and 20 μM) or SB 203580 (1, 5 and 10 μM). After incubation for 24 h, uPA in culture media was measured by Western blot analysis. Representative data from 3 independent experiments were shown.