Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines

Table 3 Effects of paclitaxel on deoxycytdine kinase and cytidine deaminase activity in solid tumor cell lines

Exposure/Cell line	H460	H520	H838
Control
%G0 + G1	66 ± 1.2	62 ± 2.1	80 ± 7.5
%G2 + M	8.0 ± 1.4	13.2 ± 1.0	4.8 ± 2.4
%S	26 ± 1.7	25 ± 1.3	15 ± 5.1
% Apoptosis	7.5 ± 1.7	3.2 ± 0.6	9.7 ± 7.2
PAC 24 h > GEM 24 h
%G0 + G1	17 ± 11	36 ± 6.4	23 ± 6.0
%G2 + M	25 ± 7.8	44 ± 6.4^a	15 ± 4.7
%S	58 ± 3.2	20 ± 2.3	41 ± 1.0
% Apoptosis	8.6 ± 5.1	2.1 ± 1.4	4.6 ± 1.0
GEM 24 h > PAC 24 h
%G0 + G1	13 ± 6.0	62 ± 4.9^a	23 ± 10.3
%G2 + M	30 ± 1.7	9.7 ± 1.6	9.8 ± 8.0
%S	56 ± 7.7	28.8 ± 3.5	43 ± 1.6
% Apoptosis	7.0 ± 4.9	3.4 ± 2.2	0.87 ± 0.05^a

Mean (± standard deviation) percentage of cells in each phase of the cell cycle after exposure to vehicle control or sequential paclitaxel → gemcitabine or gemcitabine → paclitaxel at 24 hours intervals. The mean represents three independent experiments with each experiment conducted in at least triplicate.
^a P < 0.05, paclitaxel vs. vehicle-control treated cells

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