Figure 1From: Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombusThe expression of CXCR4 in tumor tissue and adjacent liver tissue reflects the characteristic pathology of cancer. (A-C) Representative images of CXCR4 staining. Tumor tissue was treated with the CXCR4 antibody. The red cells are represented as CXCR4-positive cells. (A) Negative CXCR4-staining cells; (B) Weakly positive staining cells; (C) Positive staining cells. Statistical analysis indicated that 73.9% of all 23 cases were negative, and 6 cases, which occupied 26.1% of all cases, were positive. Magnification: ×200. (D) Representative images of CXCR4 staining. Adjacent liver tissue was treated with the CXCR4 antibody. The red cells indicate CXCR4-positive cells. The CXCR4 cells expressed in inflamed hepatic tissue were mainly located in the cell membrane and cytoplasm. Magnification: 400×. (E-G) CXCR4-positive cells expressed in inflamed hepatic tissue. (E) CXCR4-positive cells located in the liver nucleus; (F) CXCR4-positive cells located in bile canaliculi endothelial cells; (G) CXCR4-positive cells located in hepatic sinusoid endothelial tissue. Magnification: ×400. (H) Negative CXCR4 staining in HCC tissue without PVTT. (I) Positive CXCR4 staining in HCC tissue without PVTT. (J-K) The percentage of positive CXCR4-cells expressed in PVTT tissue is 52.2%. In Figure J, CXCR4 was stained as weakly positive, as opposed to Figure K, which showed positive staining. Magnification: ×200.Back to article page