Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis

Table 1 Correlation between biomarkers and primary tumor characteristics

	CXCR4 cytoplasmic expression			CXCR4 nuclear expression			CCR7 expression			EGFR expression
	Low	High	P	Low	High	P	Low	High	P	Low	High	P
	(n)	(n)		(n)	(n)		(n)	(n)		(n)	(n)
age			.842			.409			.169			.299
<50	43	51		38	56		37	57		49	45
≥50	47	59		49	57		52	54		63	43
tumor size			.539			.106			.945			.525
D≤2	27	41		36	32		31	37		38	30
2<D≤5	50	56		39	67		46	60		62	44
D>5	13	13		12	14		12	14		12	14
grade			.068			.985			.786			.030*
I	6	8		6	8		6	8		9	5
II	59	73		58	74		61	71		81	51
III	25	29		23	31		22	32		22	32
stage			.148			.052			.086			.088
I	22	17		23	16		23	16		22	17
II	61	77		58	80		60	78		82	56
III	7	13		6	14		5	15		8	12
IV	0	3		0	3		1	2		0	3
LN			<.001**			.199			<.001**			.046*
negative	59	41		48	52		59	41		63	37
positive	31	69		39	61		30	70		49	51
N			.437			.534			.341			.770
N≤3	11	30		18	23		10	31		21	20
3<N≤10	11	16		11	16		11	16		14	13
N>10	9	23		10	22		9	23		14	18
ER			.256			.117			.319			.087
negative	49	51		49	51		48	52		50	50
positive	41	59		38	62		41	59		62	38
PR			.115			.084			.249			.466
negative	51	50		50	51		49	52		54	47
positive	39	60		37	62		40	59		58	41
HER2/neu			.039*			.852			.099			.005**
negative	75	78		66	26		73	80		94	59
positive	15	32		21	87		16	31		18	29

D represents the diameter of tumor, LN represents lymph node status, N represents the amoumt of lymph node excised, grade means the histological grade, and stage means the clinical stage. *P < 0.05, **P < 0.01

ISSN: 1756-9966